Links to Exploration step
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of chronic kidney disease on the healing of titanium implants</title><author><name sortKey="Zou, Huawei" sort="Zou, Huawei" uniqKey="Zou H" first="Huawei" last="Zou">Huawei Zou</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Xuefeng" sort="Zhao, Xuefeng" uniqKey="Zhao X" first="Xuefeng" last="Zhao">Xuefeng Zhao</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Sun, Ningyuan" sort="Sun, Ningyuan" uniqKey="Sun N" first="Ningyuan" last="Sun">Ningyuan Sun</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Shiwen" sort="Zhang, Shiwen" uniqKey="Zhang S" first="Shiwen" last="Zhang">Shiwen Zhang</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Sato, Tadatoshi" sort="Sato, Tadatoshi" uniqKey="Sato T" first="Tadatoshi" last="Sato">Tadatoshi Sato</name><affiliation><nlm:aff id="A2">Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, Haiyang" sort="Yu, Haiyang" uniqKey="Yu H" first="Haiyang" last="Yu">Haiyang Yu</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Qianming" sort="Chen, Qianming" uniqKey="Chen Q" first="Qianming" last="Chen">Qianming Chen</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Weber, Hans Peter" sort="Weber, Hans Peter" uniqKey="Weber H" first="Hans-Peter" last="Weber">Hans-Peter Weber</name><affiliation><nlm:aff id="A3">Department of Prosthodontics and Operative Dentistry, Tufts University School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Dard, Michel" sort="Dard, Michel" uniqKey="Dard M" first="Michel" last="Dard">Michel Dard</name><affiliation><nlm:aff id="A4">New York University, College of Dentistry, Department of Periodontology and Implant Dentistry, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Yuan, Quan" sort="Yuan, Quan" uniqKey="Yuan Q" first="Quan" last="Yuan">Quan Yuan</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Lanske, Beate" sort="Lanske, Beate" uniqKey="Lanske B" first="Beate" last="Lanske">Beate Lanske</name><affiliation><nlm:aff id="A2">Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23876979</idno><idno type="pmc">3812922</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812922</idno><idno type="RBID">PMC:3812922</idno><idno type="doi">10.1016/j.bone.2013.07.014</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">002731</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002731</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of chronic kidney disease on the healing of titanium implants</title><author><name sortKey="Zou, Huawei" sort="Zou, Huawei" uniqKey="Zou H" first="Huawei" last="Zou">Huawei Zou</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Zhao, Xuefeng" sort="Zhao, Xuefeng" uniqKey="Zhao X" first="Xuefeng" last="Zhao">Xuefeng Zhao</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Sun, Ningyuan" sort="Sun, Ningyuan" uniqKey="Sun N" first="Ningyuan" last="Sun">Ningyuan Sun</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Zhang, Shiwen" sort="Zhang, Shiwen" uniqKey="Zhang S" first="Shiwen" last="Zhang">Shiwen Zhang</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Sato, Tadatoshi" sort="Sato, Tadatoshi" uniqKey="Sato T" first="Tadatoshi" last="Sato">Tadatoshi Sato</name><affiliation><nlm:aff id="A2">Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Yu, Haiyang" sort="Yu, Haiyang" uniqKey="Yu H" first="Haiyang" last="Yu">Haiyang Yu</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Chen, Qianming" sort="Chen, Qianming" uniqKey="Chen Q" first="Qianming" last="Chen">Qianming Chen</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation></author><author><name sortKey="Weber, Hans Peter" sort="Weber, Hans Peter" uniqKey="Weber H" first="Hans-Peter" last="Weber">Hans-Peter Weber</name><affiliation><nlm:aff id="A3">Department of Prosthodontics and Operative Dentistry, Tufts University School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Dard, Michel" sort="Dard, Michel" uniqKey="Dard M" first="Michel" last="Dard">Michel Dard</name><affiliation><nlm:aff id="A4">New York University, College of Dentistry, Department of Periodontology and Implant Dentistry, NY, USA</nlm:aff></affiliation></author><author><name sortKey="Yuan, Quan" sort="Yuan, Quan" uniqKey="Yuan Q" first="Quan" last="Yuan">Quan Yuan</name><affiliation><nlm:aff id="A1">State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</nlm:aff></affiliation><affiliation><nlm:aff id="A2">Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author><author><name sortKey="Lanske, Beate" sort="Lanske, Beate" uniqKey="Lanske B" first="Beate" last="Lanske">Beate Lanske</name><affiliation><nlm:aff id="A2">Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</nlm:aff></affiliation></author></analytic><series><title level="j">Bone</title><idno type="ISSN">8756-3282</idno><idno type="eISSN">1873-2763</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Chronic kidney disease (CKD) has become a worldwide public health problem. However, its effect on osseointegration of dental implants is largely unknown. The aim of this study is to investigate whether CKD impairs the quality of the osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in mice, and serum levels of BUN, FGF23, PTH and ALP were significantly increased. For <italic>in vitro</italic> tests, bone marrow mesenchymal stem cells (BMMSCs) were obtained and cultured on titanium discs. There was no significant difference in term of expression of osteogenic marker genes including Osx, Col-1, Ocn, and Opn, as quantified by qPCR. Moreover, Alizarin Red S staining showed comparable mineralized nodules formation. Histomorphometrical analysis of experimental implants inserted in the femurs of CKD mice revealed a trend of decreased BIC ratio at 2-week healing. The strength of bone-implant integration, as measured by a push-in method, was significantly lower for the CKD group at 2 weeks, although a comparable level was reached at 4 weeks. These results demonstrated that CKD only negatively affects the osseointegration of titanium implants at the early stage.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8504048</journal-id><journal-id journal-id-type="pubmed-jr-id">1710</journal-id><journal-id journal-id-type="nlm-ta">Bone</journal-id><journal-id journal-id-type="iso-abbrev">Bone</journal-id><journal-title-group><journal-title>Bone</journal-title></journal-title-group><issn pub-type="ppub">8756-3282</issn><issn pub-type="epub">1873-2763</issn></journal-meta><article-meta><article-id pub-id-type="pmid">23876979</article-id><article-id pub-id-type="pmc">3812922</article-id><article-id pub-id-type="doi">10.1016/j.bone.2013.07.014</article-id><article-id pub-id-type="manuscript">NIHMS521939</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Effect of chronic kidney disease on the healing of titanium implants</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zou</surname><given-names>Huawei</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN2" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Zhao</surname><given-names>Xuefeng</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref rid="FN2" ref-type="author-notes">1</xref></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Ningyuan</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Shiwen</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Sato</surname><given-names>Tadatoshi</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Yu</surname><given-names>Haiyang</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Qianming</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Weber</surname><given-names>Hans-Peter</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Dard</surname><given-names>Michel</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Yuan</surname><given-names>Quan</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="aff" rid="A2">b</xref><xref rid="FN1" ref-type="author-notes">*</xref></contrib><contrib contrib-type="author"><name><surname>Lanske</surname><given-names>Beate</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib></contrib-group><aff id="A1"><label>a</label>State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China</aff><aff id="A2"><label>b</label>Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, MA, USA</aff><aff id="A3"><label>c</label>Department of Prosthodontics and Operative Dentistry, Tufts University School of Dental Medicine, Boston, MA, USA</aff><aff id="A4"><label>d</label>New York University, College of Dentistry, Department of Periodontology and Implant Dentistry, NY, USA</aff><author-notes><corresp id="FN1"><label>*</label>Corresponding author at: State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, 14 Third Section, Renmin Nan Road, Chengdu 610041, China. <email>yuanquan@scu.edu.cn</email> (Q. Yuan)</corresp><fn id="FN2" fn-type="equal"><label>1</label><p>These authors contributed equally to this work.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>23</day><month>10</month><year>2013</year></pub-date><pub-date pub-type="epub"><day>19</day><month>7</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>10</month><year>2013</year></pub-date><volume>56</volume><issue>2</issue><elocation-id>10.1016/j.bone.2013.07.014</elocation-id><permissions><copyright-statement>© 2013 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2013</copyright-year></permissions><abstract><p id="P1">Chronic kidney disease (CKD) has become a worldwide public health problem. However, its effect on osseointegration of dental implants is largely unknown. The aim of this study is to investigate whether CKD impairs the quality of the osseointegration of titanium implants. Uremia was induced by 5/6 nephrectomy in mice, and serum levels of BUN, FGF23, PTH and ALP were significantly increased. For <italic>in vitro</italic> tests, bone marrow mesenchymal stem cells (BMMSCs) were obtained and cultured on titanium discs. There was no significant difference in term of expression of osteogenic marker genes including Osx, Col-1, Ocn, and Opn, as quantified by qPCR. Moreover, Alizarin Red S staining showed comparable mineralized nodules formation. Histomorphometrical analysis of experimental implants inserted in the femurs of CKD mice revealed a trend of decreased BIC ratio at 2-week healing. The strength of bone-implant integration, as measured by a push-in method, was significantly lower for the CKD group at 2 weeks, although a comparable level was reached at 4 weeks. These results demonstrated that CKD only negatively affects the osseointegration of titanium implants at the early stage.</p></abstract><kwd-group><kwd>Dental implants</kwd><kwd>Chronic kidney diseases</kwd><kwd>Bone mineralization</kwd><kwd>Osseointegration</kwd><kwd>Parathyroid hormone (PTH)</kwd><kwd>Fibroblast growth factor 23 (FGF23)</kwd></kwd-group><funding-group><award-group><funding-source country="United States">National Institute of Diabetes and Digestive and Kidney Diseases : NIDDK</funding-source><award-id>R01 DK073944 || DK</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002731 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 002731 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Pmc
|étape= Corpus
|type= RBID
|clé=
|texte=
}}
| This area was generated with Dilib version V0.6.32. |  |