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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A pre-clinical murine model of oral implant osseointegration</title>
<author><name sortKey="Mouraret, S" sort="Mouraret, S" uniqKey="Mouraret S" first="S." last="Mouraret">S. Mouraret</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hunter, D J" sort="Hunter, D J" uniqKey="Hunter D" first="D. J." last="Hunter">D. J. Hunter</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bardet, C" sort="Bardet, C" uniqKey="Bardet C" first="C." last="Bardet">C. Bardet</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Dental School University Paris Descartes PRES Sorbonne Paris Cité, EA 2496 Montrouge, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brunski, J B" sort="Brunski, J B" uniqKey="Brunski J" first="J. B." last="Brunski">J. B. Brunski</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bouchard, P" sort="Bouchard, P" uniqKey="Bouchard P" first="P." last="Bouchard">P. Bouchard</name>
<affiliation><nlm:aff id="A2">Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Helms, J A" sort="Helms, J A" uniqKey="Helms J" first="J. A." last="Helms">J. A. Helms</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23886841</idno>
<idno type="pmc">4962868</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4962868</idno>
<idno type="RBID">PMC:4962868</idno>
<idno type="doi">10.1016/j.bone.2013.07.021</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002732</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002732</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A pre-clinical murine model of oral implant osseointegration</title>
<author><name sortKey="Mouraret, S" sort="Mouraret, S" uniqKey="Mouraret S" first="S." last="Mouraret">S. Mouraret</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A2">Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hunter, D J" sort="Hunter, D J" uniqKey="Hunter D" first="D. J." last="Hunter">D. J. Hunter</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bardet, C" sort="Bardet, C" uniqKey="Bardet C" first="C." last="Bardet">C. Bardet</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A3">Dental School University Paris Descartes PRES Sorbonne Paris Cité, EA 2496 Montrouge, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brunski, J B" sort="Brunski, J B" uniqKey="Brunski J" first="J. B." last="Brunski">J. B. Brunski</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bouchard, P" sort="Bouchard, P" uniqKey="Bouchard P" first="P." last="Bouchard">P. Bouchard</name>
<affiliation><nlm:aff id="A2">Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris, France</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Helms, J A" sort="Helms, J A" uniqKey="Helms J" first="J. A." last="Helms">J. A. Helms</name>
<affiliation><nlm:aff id="A1">Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Bone</title>
<idno type="ISSN">8756-3282</idno>
<idno type="eISSN">1873-2763</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones. This disconnect between clinical practice and experimental research hampers our understanding of bone formation around oral implants and how this process can be improved. We postulated that oral implant osseointegration would be fundamentally equivalent to implant osseointegration elsewhere in the body. Mice underwent implant placement in the edentulous ridge anterior to the first molar and peri-implant tissues were evaluated at various timepoints after surgery.</p>
<p id="P2">Our hypothesis was disproven; oral implant osseointegration is substantially different from osseointegration in long bones. For example, in the maxilla peri-implant pre-osteoblasts are derived from cranial neural crest whereas in the tibia peri-implant osteoblasts are derived from mesoderm. In the maxilla, new osteoid arises from periostea of the maxillary bone but in the tibia the new osteoid arises from the marrow space. Cellular and molecular analyses indicate that osteoblast activity and mineralization proceeds from the surfaces of the native bone and osteoclastic activity is responsible for extensive remodeling of the new peri-implant bone. In addition to histologic features of implant osseointegration, molecular and cellular assays conducted in a murine model provide new insights into the sequelae of implant placement and the process by which bone is generated around implants.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8504048</journal-id>
<journal-id journal-id-type="pubmed-jr-id">1710</journal-id>
<journal-id journal-id-type="nlm-ta">Bone</journal-id>
<journal-id journal-id-type="iso-abbrev">Bone</journal-id>
<journal-title-group><journal-title>Bone</journal-title>
</journal-title-group>
<issn pub-type="ppub">8756-3282</issn>
<issn pub-type="epub">1873-2763</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23886841</article-id>
<article-id pub-id-type="pmc">4962868</article-id>
<article-id pub-id-type="doi">10.1016/j.bone.2013.07.021</article-id>
<article-id pub-id-type="manuscript">NIHMS708822</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>A pre-clinical murine model of oral implant osseointegration</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Mouraret</surname>
<given-names>S.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hunter</surname>
<given-names>D.J.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bardet</surname>
<given-names>C.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref ref-type="aff" rid="A3">c</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Brunski</surname>
<given-names>J.B.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bouchard</surname>
<given-names>P.</given-names>
</name>
<xref ref-type="aff" rid="A2">b</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Helms</surname>
<given-names>J.A.</given-names>
</name>
<xref ref-type="aff" rid="A1">a</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>a</label>
Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA 94305, USA</aff>
<aff id="A2"><label>b</label>
Department of Periodontology, Service of Odontology, Rothschild Hospital, AP-HP, Paris 7 Denis, Diderot University, U.F.R. of Odontology, Paris, France</aff>
<aff id="A3"><label>c</label>
Dental School University Paris Descartes PRES Sorbonne Paris Cité, EA 2496 Montrouge, France</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding author. Fax: +1 650 736 4374. <email>jhelms@stanford.edu</email>
(J.A. Helms)</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>5</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>27</day>
<month>7</month>
<year>2016</year>
</pub-date>
<volume>58</volume>
<fpage>177</fpage>
<lpage>184</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.bone.2013.07.021</pmc-comment>
<permissions><license license-type="open-access"><license-p>Open access under CC BY-NC-ND license.</license-p>
</license>
</permissions>
<abstract><p id="P1">Many of our assumptions concerning oral implant osseointegration are extrapolated from experimental models studying skeletal tissue repair in long bones. This disconnect between clinical practice and experimental research hampers our understanding of bone formation around oral implants and how this process can be improved. We postulated that oral implant osseointegration would be fundamentally equivalent to implant osseointegration elsewhere in the body. Mice underwent implant placement in the edentulous ridge anterior to the first molar and peri-implant tissues were evaluated at various timepoints after surgery.</p>
<p id="P2">Our hypothesis was disproven; oral implant osseointegration is substantially different from osseointegration in long bones. For example, in the maxilla peri-implant pre-osteoblasts are derived from cranial neural crest whereas in the tibia peri-implant osteoblasts are derived from mesoderm. In the maxilla, new osteoid arises from periostea of the maxillary bone but in the tibia the new osteoid arises from the marrow space. Cellular and molecular analyses indicate that osteoblast activity and mineralization proceeds from the surfaces of the native bone and osteoclastic activity is responsible for extensive remodeling of the new peri-implant bone. In addition to histologic features of implant osseointegration, molecular and cellular assays conducted in a murine model provide new insights into the sequelae of implant placement and the process by which bone is generated around implants.</p>
</abstract>
<kwd-group><kwd>Dental</kwd>
<kwd>Histology</kwd>
<kwd>Maxilla</kwd>
<kwd>Oral cavity</kwd>
<kwd>Mice</kwd>
<kwd>Model</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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