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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxyethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants in Minipigs: Part I: Immediate Stability and Function</title><author><name sortKey="Hasturk, Hatice" sort="Hasturk, Hatice" uniqKey="Hasturk H" first="Hatice" last="Hasturk">Hatice Hasturk</name><affiliation><nlm:aff id="A1">Department of Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff></affiliation></author><author><name sortKey="Kantarci, Alpdogan" sort="Kantarci, Alpdogan" uniqKey="Kantarci A" first="Alpdogan" last="Kantarci">Alpdogan Kantarci</name><affiliation><nlm:aff id="A1">Department of Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff></affiliation></author><author><name sortKey="Ghattas, Mazen" sort="Ghattas, Mazen" uniqKey="Ghattas M" first="Mazen" last="Ghattas">Mazen Ghattas</name></author><author><name sortKey="Schmidt, Marcella" sort="Schmidt, Marcella" uniqKey="Schmidt M" first="Marcella" last="Schmidt">Marcella Schmidt</name><affiliation><nlm:aff id="A2">Brodie Laboratory for Craniofacial Genetics, Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Giordano, Russell A" sort="Giordano, Russell A" uniqKey="Giordano R" first="Russell A." last="Giordano">Russell A. Giordano</name><affiliation><nlm:aff id="A3">Department of Restorative Sciences/Biomaterials, Boston University</nlm:aff></affiliation></author><author><name sortKey="Ashman, Arthur" sort="Ashman, Arthur" uniqKey="Ashman A" first="Arthur" last="Ashman">Arthur Ashman</name><affiliation><nlm:aff id="A4">Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Diekwisch, Thomas G" sort="Diekwisch, Thomas G" uniqKey="Diekwisch T" first="Thomas G." last="Diekwisch">Thomas G. Diekwisch</name><affiliation><nlm:aff id="A2">Brodie Laboratory for Craniofacial Genetics, Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Van Dyke, Thomas" sort="Van Dyke, Thomas" uniqKey="Van Dyke T" first="Thomas" last="Van Dyke">Thomas Van Dyke</name><affiliation><nlm:aff id="A1">Department of Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21342001</idno><idno type="pmc">4642450</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642450</idno><idno type="RBID">PMC:4642450</idno><idno type="doi">10.1902/jop.2011.100617</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">002698</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002698</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxyethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants in Minipigs: Part I: Immediate Stability and Function</title><author><name sortKey="Hasturk, Hatice" sort="Hasturk, Hatice" uniqKey="Hasturk H" first="Hatice" last="Hasturk">Hatice Hasturk</name><affiliation><nlm:aff id="A1">Department of Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff></affiliation></author><author><name sortKey="Kantarci, Alpdogan" sort="Kantarci, Alpdogan" uniqKey="Kantarci A" first="Alpdogan" last="Kantarci">Alpdogan Kantarci</name><affiliation><nlm:aff id="A1">Department of Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff></affiliation></author><author><name sortKey="Ghattas, Mazen" sort="Ghattas, Mazen" uniqKey="Ghattas M" first="Mazen" last="Ghattas">Mazen Ghattas</name></author><author><name sortKey="Schmidt, Marcella" sort="Schmidt, Marcella" uniqKey="Schmidt M" first="Marcella" last="Schmidt">Marcella Schmidt</name><affiliation><nlm:aff id="A2">Brodie Laboratory for Craniofacial Genetics, Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Giordano, Russell A" sort="Giordano, Russell A" uniqKey="Giordano R" first="Russell A." last="Giordano">Russell A. Giordano</name><affiliation><nlm:aff id="A3">Department of Restorative Sciences/Biomaterials, Boston University</nlm:aff></affiliation></author><author><name sortKey="Ashman, Arthur" sort="Ashman, Arthur" uniqKey="Ashman A" first="Arthur" last="Ashman">Arthur Ashman</name><affiliation><nlm:aff id="A4">Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY</nlm:aff></affiliation></author><author><name sortKey="Diekwisch, Thomas G" sort="Diekwisch, Thomas G" uniqKey="Diekwisch T" first="Thomas G." last="Diekwisch">Thomas G. Diekwisch</name><affiliation><nlm:aff id="A2">Brodie Laboratory for Craniofacial Genetics, Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL</nlm:aff></affiliation></author><author><name sortKey="Van Dyke, Thomas" sort="Van Dyke, Thomas" uniqKey="Van Dyke T" first="Thomas" last="Van Dyke">Thomas Van Dyke</name><affiliation><nlm:aff id="A1">Department of Periodontology, The Forsyth Institute, Cambridge, MA</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of periodontology</title><idno type="ISSN">0022-3492</idno><idno type="eISSN">1943-3670</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The present study is designed as a proof-of-concept study to evaluate light/chemical hardening technology and a newly formulated polymethylmethacrylate, polyhydroxyethylmethacrylate, and calcium hydroxide (PPCH) plus polyanhydride (PA) (PPCH-PA) composite graft material as a bone substitute compared to positive and negative controls in a minipig model.</p></sec><sec id="S2"><title>Methods</title><p id="P2">PPCH-PA (composite graft); PPCH alone (positive control), PA alone (positive control), and no graft (negative control) were compared. Four mandibular premolar teeth per quadrant were extracted; a total of 48 implants were placed into sockets in three minipigs. Abutments were placed protruding into the oral cavity 4 mm in height for immediate loading. Crestal areas and intrabony spaces were filled with PPCH-PA, PPCH, or PA using a three-phase delivery system in which all graft materials were hardened by a light cure. In the negative control group, implant sites were left untreated. At 12 weeks, block sections containing implants were obtained. Evaluations included periodontal probing, pullout-force load, and stability measurements to determine implant stability, radiographs to examine bone levels, and scanning electron microscopy (SEM)–energy-dispersed spectroscopy to determine bone-to-implant contact.</p></sec><sec id="S3"><title>Results</title><p id="P3">Probing measurements did not reveal any pathologic pocket formation or bone loss. Radiographs revealed that immediate implant placement and loading resulted in bone at or slightly apical to the first thread of the implant in all groups at 12 weeks. Stability test values showed a relative clinical stability for all implants (range: −7 to +1); however, implants augmented with PPCH-PA exhibited a statistically significantly greater stability compared to all other groups (<italic>P</italic> <0.05). The newly formed bone in PPCH-PA–treated sites was well organized with less marrow spaces and well-distributed osteocytes. SEM revealed a tighter implant–socket interface in the PPCH-PA group compared to other groups with reduced microfissures and implant–bone interface fractures during pullout testing, whereas implants treated with PA or no graft showed ≈10-μm microfissures between the implant and bone with fractures of the intrathread bone.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The newly formulated chemically hardened graft material PPCH-PA was useful in immediate implant placement after tooth extraction and resulted in greater stability and a well-organized implant–bone interface with immediate loading, especially in those areas where cancellous bone was present. The results of this proof-of-concept study warranted further research investigating different healing times and longer durations.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8000345</journal-id><journal-id journal-id-type="pubmed-jr-id">5144</journal-id><journal-id journal-id-type="nlm-ta">J Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Periodontol.</journal-id><journal-title-group><journal-title>Journal of periodontology</journal-title></journal-title-group><issn pub-type="ppub">0022-3492</issn><issn pub-type="epub">1943-3670</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21342001</article-id><article-id pub-id-type="pmc">4642450</article-id><article-id pub-id-type="doi">10.1902/jop.2011.100617</article-id><article-id pub-id-type="manuscript">NIHMS735290</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>The Use of Light/Chemically Hardened Polymethylmethacrylate, Polyhydroxyethylmethacrylate, and Calcium Hydroxide Graft Material in Combination With Polyanhydride Around Implants in Minipigs: Part I: Immediate Stability and Function</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Hasturk</surname><given-names>Hatice</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Kantarci</surname><given-names>Alpdogan</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Ghattas</surname><given-names>Mazen</given-names></name><xref rid="FN2" ref-type="author-notes">†</xref></contrib><contrib contrib-type="author"><name><surname>Schmidt</surname><given-names>Marcella</given-names></name><xref ref-type="aff" rid="A2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Giordano</surname><given-names>Russell A.</given-names></name><xref ref-type="aff" rid="A3">§</xref></contrib><contrib contrib-type="author"><name><surname>Ashman</surname><given-names>Arthur</given-names></name><xref ref-type="aff" rid="A4">||</xref></contrib><contrib contrib-type="author"><name><surname>Diekwisch</surname><given-names>Thomas G.</given-names></name><xref ref-type="aff" rid="A2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Van Dyke</surname><given-names>Thomas</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib></contrib-group><aff id="A1"><label>*</label>Department of Periodontology, The Forsyth Institute, Cambridge, MA</aff><aff id="A2"><label>‡</label>Brodie Laboratory for Craniofacial Genetics, Department of Oral Biology, College of Dentistry, University of Illinois at Chicago, Chicago, IL</aff><aff id="A3"><label>§</label>Department of Restorative Sciences/Biomaterials, Boston University</aff><aff id="A4"><label>||</label>Department of Periodontology and Implant Dentistry, College of Dentistry, New York University, New York, NY</aff><author-notes><corresp id="FN1">Correspondence: Dr. Hatice Hasturk, Department of Periodontology, The Forsyth Institute, 245 First St., Suite 1757; Cambridge, MA 02142. <email>hhasturk@forsyth.org</email></corresp><fn id="FN2" fn-type="present-address"><label>†</label><p>Currently, private practice, New Bedford, MA; previously, Department of Periodontology and Oral Biology, Boston University School of Dental Medicine, Boston, MA.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>3</day><month>11</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>22</day><month>2</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>9</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>11</month><year>2015</year></pub-date><volume>82</volume><issue>9</issue><fpage>1339</fpage><lpage>1352</lpage><pmc-comment>elocation-id from pubmed: 10.1902/jop.2011.100617</pmc-comment>
<abstract><sec id="S1"><title>Background</title><p id="P1">The present study is designed as a proof-of-concept study to evaluate light/chemical hardening technology and a newly formulated polymethylmethacrylate, polyhydroxyethylmethacrylate, and calcium hydroxide (PPCH) plus polyanhydride (PA) (PPCH-PA) composite graft material as a bone substitute compared to positive and negative controls in a minipig model.</p></sec><sec id="S2"><title>Methods</title><p id="P2">PPCH-PA (composite graft); PPCH alone (positive control), PA alone (positive control), and no graft (negative control) were compared. Four mandibular premolar teeth per quadrant were extracted; a total of 48 implants were placed into sockets in three minipigs. Abutments were placed protruding into the oral cavity 4 mm in height for immediate loading. Crestal areas and intrabony spaces were filled with PPCH-PA, PPCH, or PA using a three-phase delivery system in which all graft materials were hardened by a light cure. In the negative control group, implant sites were left untreated. At 12 weeks, block sections containing implants were obtained. Evaluations included periodontal probing, pullout-force load, and stability measurements to determine implant stability, radiographs to examine bone levels, and scanning electron microscopy (SEM)–energy-dispersed spectroscopy to determine bone-to-implant contact.</p></sec><sec id="S3"><title>Results</title><p id="P3">Probing measurements did not reveal any pathologic pocket formation or bone loss. Radiographs revealed that immediate implant placement and loading resulted in bone at or slightly apical to the first thread of the implant in all groups at 12 weeks. Stability test values showed a relative clinical stability for all implants (range: −7 to +1); however, implants augmented with PPCH-PA exhibited a statistically significantly greater stability compared to all other groups (<italic>P</italic> <0.05). The newly formed bone in PPCH-PA–treated sites was well organized with less marrow spaces and well-distributed osteocytes. SEM revealed a tighter implant–socket interface in the PPCH-PA group compared to other groups with reduced microfissures and implant–bone interface fractures during pullout testing, whereas implants treated with PA or no graft showed ≈10-μm microfissures between the implant and bone with fractures of the intrathread bone.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The newly formulated chemically hardened graft material PPCH-PA was useful in immediate implant placement after tooth extraction and resulted in greater stability and a well-organized implant–bone interface with immediate loading, especially in those areas where cancellous bone was present. The results of this proof-of-concept study warranted further research investigating different healing times and longer durations.</p></sec></abstract><kwd-group><kwd>Alveolar ridge augmentation</kwd><kwd>bone replacement material</kwd><kwd>dental implants</kwd><kwd>models</kwd><kwd>animal</kwd><kwd>tooth extraction</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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