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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Gene Expression Dynamics During Bone Healing and Osseointegration</title><author><name sortKey="Lin, Zhao" sort="Lin, Zhao" uniqKey="Lin Z" first="Zhao" last="Lin">Zhao Lin</name><affiliation><nlm:aff id="A1">Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA; previously, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI</nlm:aff></affiliation></author><author><name sortKey="Rios, Hector F" sort="Rios, Hector F" uniqKey="Rios H" first="Hector F." last="Rios">Hector F. Rios</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Volk, Sarah L" sort="Volk, Sarah L" uniqKey="Volk S" first="Sarah L." last="Volk">Sarah L. Volk</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Sugai, James V" sort="Sugai, James V" uniqKey="Sugai J" first="James V." last="Sugai">James V. Sugai</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Jin, Qiming" sort="Jin, Qiming" uniqKey="Jin Q" first="Qiming" last="Jin">Qiming Jin</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Giannobile, William V" sort="Giannobile, William V" uniqKey="Giannobile W" first="William V." last="Giannobile">William V. Giannobile</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biomedical Engineering, College of Engineering, University of Michigan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21142982</idno><idno type="pmc">3399909</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3399909</idno><idno type="RBID">PMC:3399909</idno><idno type="doi">10.1902/jop.2010.100577</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">002697</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002697</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Gene Expression Dynamics During Bone Healing and Osseointegration</title><author><name sortKey="Lin, Zhao" sort="Lin, Zhao" uniqKey="Lin Z" first="Zhao" last="Lin">Zhao Lin</name><affiliation><nlm:aff id="A1">Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA; previously, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI</nlm:aff></affiliation></author><author><name sortKey="Rios, Hector F" sort="Rios, Hector F" uniqKey="Rios H" first="Hector F." last="Rios">Hector F. Rios</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Volk, Sarah L" sort="Volk, Sarah L" uniqKey="Volk S" first="Sarah L." last="Volk">Sarah L. Volk</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Sugai, James V" sort="Sugai, James V" uniqKey="Sugai J" first="James V." last="Sugai">James V. Sugai</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Jin, Qiming" sort="Jin, Qiming" uniqKey="Jin Q" first="Qiming" last="Jin">Qiming Jin</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation></author><author><name sortKey="Giannobile, William V" sort="Giannobile, William V" uniqKey="Giannobile W" first="William V." last="Giannobile">William V. Giannobile</name><affiliation><nlm:aff id="A2">Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</nlm:aff></affiliation><affiliation><nlm:aff id="A3">Department of Biomedical Engineering, College of Engineering, University of Michigan</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Periodontology</title><idno type="ISSN">0022-3492</idno><idno type="eISSN">1943-3670</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">Understanding the molecular features of bone repair and osseointegration may aid in the development of therapeutics to improve implant outcomes. The purpose of this investigation is to determine the gene expression dynamics during alveolar bone repair and implant osseointegration.</p></sec><sec id="S2"><title>Methods</title><p id="P2">An implant osseointegration preclinical animal model was used whereby maxillary defects were created at the time of oral implant placement, while a tooth extraction socket healing model was established on the contralateral side of each animal. The surrounding tissues in the zone of the healing defects were harvested during regeneration for temporal evaluation using histology, immunohistochemistry, laser capture microdissection, and quantitative reverse transcription–polymerase chain reaction for the identification of a panel of 17 putative genes associated with wound repair.</p></sec><sec id="S3"><title>Results</title><p id="P3">In both models, three distinct expression patterns were displayed: 1) genes that are slowly increased during the healing process, such as bone morphogenetic protein 4, runt-related transcription factor 2, and osteocalcin; 2) genes that are upregulated at the early stage of healing and then downregulated at later stages, such as interleukin and chemokine (C-X-C motif) ligands 2 and 5; and 3) genes that are constitutively expressed over time, such as scleraxis. Although some similarities between osseointegration and tooth extraction socket were seen, distinct features developed and triggered a characteristic coordinated expression and orchestration of transcription factors, growth factors, extracellular matrix molecules, and chemokines.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Characterization of these events contributes to a better understanding of cooperative molecular dynamics in alveolar bone healing, and highlights potential pathways that could be further explored for the enhancement of osseous regenerative strategies.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8000345</journal-id><journal-id journal-id-type="pubmed-jr-id">5144</journal-id><journal-id journal-id-type="nlm-ta">J Periodontol</journal-id><journal-id journal-id-type="iso-abbrev">J. Periodontol.</journal-id><journal-title-group><journal-title>Journal of Periodontology</journal-title></journal-title-group><issn pub-type="ppub">0022-3492</issn><issn pub-type="epub">1943-3670</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21142982</article-id><article-id pub-id-type="pmc">3399909</article-id><article-id pub-id-type="doi">10.1902/jop.2010.100577</article-id><article-id pub-id-type="manuscript">NIHMS301652</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Gene Expression Dynamics During Bone Healing and Osseointegration</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lin</surname><given-names>Zhao</given-names></name><xref ref-type="aff" rid="A1">*</xref></contrib><contrib contrib-type="author"><name><surname>Rios</surname><given-names>Hector F.</given-names></name><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Volk</surname><given-names>Sarah L.</given-names></name><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Sugai</surname><given-names>James V.</given-names></name><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Jin</surname><given-names>Qiming</given-names></name><xref ref-type="aff" rid="A2">†</xref></contrib><contrib contrib-type="author"><name><surname>Giannobile</surname><given-names>William V.</given-names></name><xref ref-type="aff" rid="A2">†</xref><xref ref-type="aff" rid="A3">‡</xref></contrib></contrib-group><aff id="A1"><label>*</label>Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA; previously, Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, MI</aff><aff id="A2"><label>†</label>Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan</aff><aff id="A3"><label>‡</label>Department of Biomedical Engineering, College of Engineering, University of Michigan</aff><author-notes><corresp id="FN1">Correspondence: Dr. William V. Giannobile, Michigan Center for Oral Health Research, University of Michigan School of Dentistry, 1011 N. University Ave., Ann Arbor, MI 48109–1078. Fax: 734/763-5503;: <email>william.giannobile@umich.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>9</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>18</day><month>7</month><year>2012</year></pub-date><volume>82</volume><issue>7</issue><fpage>1007</fpage><lpage>1017</lpage><abstract><sec id="S1"><title>Background</title><p id="P1">Understanding the molecular features of bone repair and osseointegration may aid in the development of therapeutics to improve implant outcomes. The purpose of this investigation is to determine the gene expression dynamics during alveolar bone repair and implant osseointegration.</p></sec><sec id="S2"><title>Methods</title><p id="P2">An implant osseointegration preclinical animal model was used whereby maxillary defects were created at the time of oral implant placement, while a tooth extraction socket healing model was established on the contralateral side of each animal. The surrounding tissues in the zone of the healing defects were harvested during regeneration for temporal evaluation using histology, immunohistochemistry, laser capture microdissection, and quantitative reverse transcription–polymerase chain reaction for the identification of a panel of 17 putative genes associated with wound repair.</p></sec><sec id="S3"><title>Results</title><p id="P3">In both models, three distinct expression patterns were displayed: 1) genes that are slowly increased during the healing process, such as bone morphogenetic protein 4, runt-related transcription factor 2, and osteocalcin; 2) genes that are upregulated at the early stage of healing and then downregulated at later stages, such as interleukin and chemokine (C-X-C motif) ligands 2 and 5; and 3) genes that are constitutively expressed over time, such as scleraxis. Although some similarities between osseointegration and tooth extraction socket were seen, distinct features developed and triggered a characteristic coordinated expression and orchestration of transcription factors, growth factors, extracellular matrix molecules, and chemokines.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">Characterization of these events contributes to a better understanding of cooperative molecular dynamics in alveolar bone healing, and highlights potential pathways that could be further explored for the enhancement of osseous regenerative strategies.</p></sec></abstract><funding-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>R01 DE013397 || DE</award-id></award-group><award-group><funding-source country="United States">National Institute of Dental and Craniofacial Research : NIDCR</funding-source><award-id>K23 DE019872-02 || DE</award-id></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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