Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
Identifieur interne : 000F52 ( Pmc/Checkpoint ); précédent : 000F51; suivant : 000F53Clinical significance of interleukin-1 genotype in smoking patients as a predictor of peri-implantitis: A case-control study
Auteurs : Cristina García-Delaney [Espagne] ; Maria-Ángeles Sánchez-Garcés [Espagne] ; Rui Figueiredo [Espagne] ; Alba Sánchez-Torres [Espagne] ; Cosme Gay-Escoda [Espagne]Source :
- Medicina Oral, Patología Oral y Cirugía Bucal [ 1698-4447 ] ; 2015.
Abstract
Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.
A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.
The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (
IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.
Url:
DOI: 10.4317/medoral.20655
PubMed: 26449434
PubMed Central: 4670255
Affiliations:
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.</p>
</sec>
<sec><title>Material and Methods</title>
<p>A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.</p>
</sec>
<sec><title>Results</title>
<p>The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (<italic>p</italic>
=0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.</p>
</sec>
<sec><title>Conclusions</title>
<p>IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.</p>
<p><bold>Key words:</bold>
Peri-implantitis, interleukin-1 genotype positive, case-control study, smoking.</p>
</sec>
</div>
</front>
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<biblStruct><analytic><author><name sortKey="Feloutzis, A" uniqKey="Feloutzis A">A Feloutzis</name>
</author>
<author><name sortKey="Lang, Np" uniqKey="Lang N">NP Lang</name>
</author>
<author><name sortKey="Tonetti, Ms" uniqKey="Tonetti M">MS Tonetti</name>
</author>
<author><name sortKey="Burgin, W" uniqKey="Burgin W">W Bürgin</name>
</author>
<author><name sortKey="Br Gger, U" uniqKey="Br Gger U">U Brägger</name>
</author>
<author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gruica, B" uniqKey="Gruica B">B Gruica</name>
</author>
<author><name sortKey="Wang, Hy" uniqKey="Wang H">HY Wang</name>
</author>
<author><name sortKey="Lang, N" uniqKey="Lang N">N Lang</name>
</author>
<author><name sortKey="Buser, D" uniqKey="Buser D">D Buser</name>
</author>
</analytic>
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</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Med Oral Patol Oral Cir Bucal</journal-id>
<journal-id journal-id-type="iso-abbrev">Med Oral Patol Oral Cir Bucal</journal-id>
<journal-id journal-id-type="publisher-id">Medicina Oral S.L.</journal-id>
<journal-title-group><journal-title>Medicina Oral, Patología Oral y Cirugía Bucal</journal-title>
</journal-title-group>
<issn pub-type="ppub">1698-4447</issn>
<issn pub-type="epub">1698-6946</issn>
<publisher><publisher-name>Medicina Oral S.L.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">26449434</article-id>
<article-id pub-id-type="pmc">4670255</article-id>
<article-id pub-id-type="publisher-id">20655</article-id>
<article-id pub-id-type="doi">10.4317/medoral.20655</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research</subject>
<subj-group><subject>Oral Surgery</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Clinical significance of interleukin-1 genotype in smoking patients
as a predictor of peri-implantitis: A case-control study</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>García-Delaney</surname>
<given-names>Cristina</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sánchez-Garcés</surname>
<given-names>Maria-Ángeles</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Figueiredo</surname>
<given-names>Rui</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sánchez-Torres</surname>
<given-names>Alba</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gay-Escoda</surname>
<given-names>Cosme</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
DDS. Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</aff>
<aff id="A2"><label>2</label>
MD, DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</aff>
<aff id="A3"><label>3</label>
DDS, MS, PhD, Associate Professor of Oral Surgery. Master’s Degree Program in Oral Surgery and Implantology, School of Dentistry, University of Barcelona, Barcelona. Researcher of the IDIBELL Institute, Barcelona, Spain</aff>
<aff id="A4"><label>4</label>
DDS. Fellow of the Master of Oral Surgery and Orofacial Implantology. School of Dentistry of the University of Barcelona, Spain</aff>
<aff id="A5"><label>5</label>
MD, DDS, MS, PhD, Chairman and Professor of Oral and Maxillofacial Surgery, School of Dentistry, Barcelona. Director of the Master`s Degree Program in Oral Surgery and Implantology (EHFRE International University/FUCSO). Coordinator/Researcher of the IDIBELL Institute. Head of the Oral Surgery, Implantology and Maxillofacial Surgery Department of the Teknon Medical Center, Barcelona, Spain</aff>
<author-notes><corresp> Faculty of Dentistry. Campus de Bellvitge
University of Barcelona
C/ Feixa Llarga, s/n
Pavelló Govern, 2ª planta, Despatx 2.9
08907 L’Hospitalet de Llobregat
Barcelona Spain
, E-mail: <email>rui@ruibf.com </email>
</corresp>
<fn id="FN1" fn-type="conflict"><p><bold>Conflict of interest statement:</bold>
The authors have declared that no conflict of interest exist.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>11</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>9</day>
<month>10</month>
<year>2015</year>
</pub-date>
<volume>20</volume>
<issue>6</issue>
<fpage>e737</fpage>
<lpage>e743</lpage>
<history><date date-type="accepted"><day>21</day>
<month>5</month>
<year>2015</year>
</date>
<date date-type="received"><day>5</day>
<month>2</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright: © 2015 Medicina Oral S.L.</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/2.5/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background</title>
<p>Interleukin-1 (IL-1) is a proinflammatory cytokine that plays an important role in the pathogenesis of periodontitis, and so it might be useful to detect high-risk cases of peri-implantitis. It has been reported that IL-1 polymorphisms and smoking habit have a synergic effect, increasing the incidence of peri-implantitis. The aim of the present study was to evaluate the relationship between IL-1 gene polymorphisms and peri-implantitis in smoking patients.</p>
</sec>
<sec><title>Material and Methods</title>
<p>A case-control study was performed in 27 patients with peri-implantitis and 27 patients with healthy implants. All patients included were smokers. IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C were identified by polymerase chain reaction (PCR) amplification in order to establish a relation between these variables and the presence of peri-implantitis. A bivariate analysis was performed and odds-ratio (OR) were calculated.</p>
</sec>
<sec><title>Results</title>
<p>The incidence of peri-implantitis was significantly higher in patients with previous history of periodontitis (<italic>p</italic>
=0.024; OR=10.9). Both groups were similar regarding IL-1A-C889T, IL-1B+C3953T and IL-1RN+T2018C genotypes. No increased risk in heavy smokers with IL-1 polymorphism was found.</p>
</sec>
<sec><title>Conclusions</title>
<p>IL-1 genotypes do not seem to be good predictors of peri-implantitis in the great majority of smoking patients. Furthermore, no synergic effect was found between IL-1 genotypes and heavy smokers. Patients with a previous history of periodontitis were more prone to peri-implantitis.</p>
<p><bold>Key words:</bold>
Peri-implantitis, interleukin-1 genotype positive, case-control study, smoking.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Espagne</li>
</country>
<region><li>Catalogne</li>
</region>
<settlement><li>Barcelone</li>
</settlement>
</list>
<tree><country name="Espagne"><noRegion><name sortKey="Garcia Delaney, Cristina" sort="Garcia Delaney, Cristina" uniqKey="Garcia Delaney C" first="Cristina" last="García-Delaney">Cristina García-Delaney</name>
</noRegion>
<name sortKey="Figueiredo, Rui" sort="Figueiredo, Rui" uniqKey="Figueiredo R" first="Rui" last="Figueiredo">Rui Figueiredo</name>
<name sortKey="Gay Escoda, Cosme" sort="Gay Escoda, Cosme" uniqKey="Gay Escoda C" first="Cosme" last="Gay-Escoda">Cosme Gay-Escoda</name>
<name sortKey="Sanchez Garces, Maria Ngeles" sort="Sanchez Garces, Maria Ngeles" uniqKey="Sanchez Garces M" first="Maria-Ángeles" last="Sánchez-Garcés">Maria-Ángeles Sánchez-Garcés</name>
<name sortKey="Sanchez Torres, Alba" sort="Sanchez Torres, Alba" uniqKey="Sanchez Torres A" first="Alba" last="Sánchez-Torres">Alba Sánchez-Torres</name>
</country>
</tree>
</affiliations>
</record>
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