EdenteV2, PascalFrancis, Curation, bibRecord, 000125

Antibodies to periodontal pathogens are associated with coronary heart disease

Identifieur interne : 000125 ( PascalFrancis/Curation ); précédent : 000124; suivant : 000126

Antibodies to periodontal pathogens are associated with coronary heart disease

Auteurs : Pirkko J. Pussinen [Finlande] ; Pekka Jousilahti [Finlande] ; Georg Alfthan [Finlande] ; Timo Palosuo [Finlande] ; Sirkka Asikainen [Finlande, Suède] ; Veikko Salomaa [Finlande]

Source :

Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2003.

RBID : Pascal:04-0019041

Descripteurs français

Pascal (Inist)
- Cardiopathie coronaire, Homme, Anticorps, Parodontite, Sérologie, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Bactériose, Association morbide, Physiopathologie, Pathogénie.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Actinobacillus actinomycetemcomitans, Antibody, Bacteriosis, Concomitant disease, Coronary heart disease, Human, Pathogenesis, Pathophysiology, Periodontitis, Porphyromonas gingivalis, Serology.

Abstract

Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.

A01	`01`	`1`		`@0 1079-5642`
A02	`01`			`@0 ATVBFA`
A03		`1`		`@0 Arterioscler. thromb. vasc. biol.`
A05				`@2 23`
A06				`@2 7`
A08	`01`	`1`	`ENG`	`@1 Antibodies to periodontal pathogens are associated with coronary heart disease`
A11	`01`	`1`		`@1 PUSSINEN (Pirkko J.)`
A11	`02`	`1`		`@1 JOUSILAHTI (Pekka)`
A11	`03`	`1`		`@1 ALFTHAN (Georg)`
A11	`04`	`1`		`@1 PALOSUO (Timo)`
A11	`05`	`1`		`@1 ASIKAINEN (Sirkka)`
A11	`06`	`1`		`@1 SALOMAA (Veikko)`
A14	`01`			`@1 Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital @3 FIN @Z 1 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Epidemiology and Health Promotion, KTL-National Public Health Institute @2 Helsinki @3 FIN @Z 2 aut. @Z 6 aut.`
A14	`03`			`@1 Department of Health and Functional Ability, KTL-National Public Health Institute @2 Helsinki @3 FIN @Z 3 aut. @Z 4 aut.`
A14	`04`			`@1 Umeå University @3 SWE @Z 5 aut.`
A20				`@1 1250-1254`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 19104 @5 354000119956370190`
A44				`@0 0000 @1 © 2004 INIST-CNRS. All rights reserved.`
A45				`@0 15 ref.`
A47	`01`	`1`		`@0 04-0019041`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Arteriosclerosis, thrombosis, and vascular biology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.
C02	`01`	`X`		`@0 002B12A03`
C03	`01`	`X`	`FRE`	`@0 Cardiopathie coronaire @5 01`
C03	`01`	`X`	`ENG`	`@0 Coronary heart disease @5 01`
C03	`01`	`X`	`SPA`	`@0 Cardiopatía coronaria @5 01`
C03	`02`	`X`	`FRE`	`@0 Homme @5 02`
C03	`02`	`X`	`ENG`	`@0 Human @5 02`
C03	`02`	`X`	`SPA`	`@0 Hombre @5 02`
C03	`03`	`X`	`FRE`	`@0 Anticorps @5 03`
C03	`03`	`X`	`ENG`	`@0 Antibody @5 03`
C03	`03`	`X`	`SPA`	`@0 Anticuerpo @5 03`
C03	`04`	`X`	`FRE`	`@0 Parodontite @5 04`
C03	`04`	`X`	`ENG`	`@0 Periodontitis @5 04`
C03	`04`	`X`	`SPA`	`@0 Parodontitis @5 04`
C03	`05`	`X`	`FRE`	`@0 Sérologie @5 05`
C03	`05`	`X`	`ENG`	`@0 Serology @5 05`
C03	`05`	`X`	`SPA`	`@0 Serología @5 05`
C03	`06`	`X`	`FRE`	`@0 Actinobacillus actinomycetemcomitans @2 NS @5 06`
C03	`06`	`X`	`ENG`	`@0 Actinobacillus actinomycetemcomitans @2 NS @5 06`
C03	`06`	`X`	`SPA`	`@0 Actinobacillus actinomycetemcomitans @2 NS @5 06`
C03	`07`	`X`	`FRE`	`@0 Porphyromonas gingivalis @2 NS @5 07`
C03	`07`	`X`	`ENG`	`@0 Porphyromonas gingivalis @2 NS @5 07`
C03	`07`	`X`	`SPA`	`@0 Porphyromonas gingivalis @2 NS @5 07`
C03	`08`	`X`	`FRE`	`@0 Bactériose @2 NM @5 08`
C03	`08`	`X`	`ENG`	`@0 Bacteriosis @2 NM @5 08`
C03	`08`	`X`	`SPA`	`@0 Bacteriosis @2 NM @5 08`
C03	`09`	`X`	`FRE`	`@0 Association morbide @5 09`
C03	`09`	`X`	`ENG`	`@0 Concomitant disease @5 09`
C03	`09`	`X`	`SPA`	`@0 Asociación morbosa @5 09`
C03	`10`	`X`	`FRE`	`@0 Physiopathologie @5 10`
C03	`10`	`X`	`ENG`	`@0 Pathophysiology @5 10`
C03	`10`	`X`	`SPA`	`@0 Fisiopatología @5 10`
C03	`11`	`X`	`FRE`	`@0 Pathogénie @5 11`
C03	`11`	`X`	`ENG`	`@0 Pathogenesis @5 11`
C03	`11`	`X`	`SPA`	`@0 Patogenia @5 11`
C07	`01`	`X`	`FRE`	`@0 Pasteurellaceae @2 NS`
C07	`01`	`X`	`ENG`	`@0 Pasteurellaceae @2 NS`
C07	`01`	`X`	`SPA`	`@0 Pasteurellaceae @2 NS`
C07	`02`	`X`	`FRE`	`@0 Bactérie`
C07	`02`	`X`	`ENG`	`@0 Bacteria`
C07	`02`	`X`	`SPA`	`@0 Bacteria`
C07	`03`	`X`	`FRE`	`@0 Bacteroidaceae @2 NS`
C07	`03`	`X`	`ENG`	`@0 Bacteroidaceae @2 NS`
C07	`03`	`X`	`SPA`	`@0 Bacteroidaceae @2 NS`
C07	`04`	`X`	`FRE`	`@0 Infection @2 NM`
C07	`04`	`X`	`ENG`	`@0 Infection @2 NM`
C07	`04`	`X`	`SPA`	`@0 Infección @2 NM`
C07	`05`	`X`	`FRE`	`@0 Appareil circulatoire pathologie @5 37`
C07	`05`	`X`	`ENG`	`@0 Cardiovascular disease @5 37`
C07	`05`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 37`
C07	`06`	`X`	`FRE`	`@0 Stomatologie @5 45`
C07	`06`	`X`	`ENG`	`@0 Stomatology @5 45`
C07	`06`	`X`	`SPA`	`@0 Estomatología @5 45`
C07	`07`	`X`	`FRE`	`@0 Parodontopathie @5 46`
C07	`07`	`X`	`ENG`	`@0 Periodontal disease @5 46`
C07	`07`	`X`	`SPA`	`@0 Parodontopatía @5 46`
N21				`@1 012`
N82				`@1 PSI`

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000578

Links to Exploration step

Pascal:04-0019041

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Antibodies to periodontal pathogens are associated with coronary heart disease</title>
<author><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Epidemiology and Health Promotion, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Alfthan, Georg" sort="Alfthan, Georg" uniqKey="Alfthan G" first="Georg" last="Alfthan">Georg Alfthan</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Health and Functional Ability, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Palosuo, Timo" sort="Palosuo, Timo" uniqKey="Palosuo T" first="Timo" last="Palosuo">Timo Palosuo</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Health and Functional Ability, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Asikainen, Sirkka" sort="Asikainen, Sirkka" uniqKey="Asikainen S" first="Sirkka" last="Asikainen">Sirkka Asikainen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Umeå University</s1>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Epidemiology and Health Promotion, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">04-0019041</idno>
<date when="2003">2003</date>
<idno type="stanalyst">PASCAL 04-0019041 INIST</idno>
<idno type="RBID">Pascal:04-0019041</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000578</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000125</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Antibodies to periodontal pathogens are associated with coronary heart disease</title>
<author><name sortKey="Pussinen, Pirkko J" sort="Pussinen, Pirkko J" uniqKey="Pussinen P" first="Pirkko J." last="Pussinen">Pirkko J. Pussinen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Jousilahti, Pekka" sort="Jousilahti, Pekka" uniqKey="Jousilahti P" first="Pekka" last="Jousilahti">Pekka Jousilahti</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Epidemiology and Health Promotion, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Alfthan, Georg" sort="Alfthan, Georg" uniqKey="Alfthan G" first="Georg" last="Alfthan">Georg Alfthan</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Health and Functional Ability, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Palosuo, Timo" sort="Palosuo, Timo" uniqKey="Palosuo T" first="Timo" last="Palosuo">Timo Palosuo</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Health and Functional Ability, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
<author><name sortKey="Asikainen, Sirkka" sort="Asikainen, Sirkka" uniqKey="Asikainen S" first="Sirkka" last="Asikainen">Sirkka Asikainen</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Umeå University</s1>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Suède</country>
</affiliation>
</author>
<author><name sortKey="Salomaa, Veikko" sort="Salomaa, Veikko" uniqKey="Salomaa V" first="Veikko" last="Salomaa">Veikko Salomaa</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Epidemiology and Health Promotion, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Arteriosclerosis, thrombosis, and vascular biology</title>
<title level="j" type="abbreviated">Arterioscler. thromb. vasc. biol.</title>
<idno type="ISSN">1079-5642</idno>
<imprint><date when="2003">2003</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Arteriosclerosis, thrombosis, and vascular biology</title>
<title level="j" type="abbreviated">Arterioscler. thromb. vasc. biol.</title>
<idno type="ISSN">1079-5642</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actinobacillus actinomycetemcomitans</term>
<term>Antibody</term>
<term>Bacteriosis</term>
<term>Concomitant disease</term>
<term>Coronary heart disease</term>
<term>Human</term>
<term>Pathogenesis</term>
<term>Pathophysiology</term>
<term>Periodontitis</term>
<term>Porphyromonas gingivalis</term>
<term>Serology</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term>
<term>Homme</term>
<term>Anticorps</term>
<term>Parodontite</term>
<term>Sérologie</term>
<term>Actinobacillus actinomycetemcomitans</term>
<term>Porphyromonas gingivalis</term>
<term>Bactériose</term>
<term>Association morbide</term>
<term>Physiopathologie</term>
<term>Pathogénie</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.</div>
</front>
</TEI>
<inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>1079-5642</s0>
</fA01>
<fA02 i1="01"><s0>ATVBFA</s0>
</fA02>
<fA03 i2="1"><s0>Arterioscler. thromb. vasc. biol.</s0>
</fA03>
<fA05><s2>23</s2>
</fA05>
<fA06><s2>7</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG"><s1>Antibodies to periodontal pathogens are associated with coronary heart disease</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>PUSSINEN (Pirkko J.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>JOUSILAHTI (Pekka)</s1>
</fA11>
<fA11 i1="03" i2="1"><s1>ALFTHAN (Georg)</s1>
</fA11>
<fA11 i1="04" i2="1"><s1>PALOSUO (Timo)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>ASIKAINEN (Sirkka)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>SALOMAA (Veikko)</s1>
</fA11>
<fA14 i1="01"><s1>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital</s1>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Epidemiology and Health Promotion, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Health and Functional Ability, KTL-National Public Health Institute</s1>
<s2>Helsinki</s2>
<s3>FIN</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Umeå University</s1>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA20><s1>1250-1254</s1>
</fA20>
<fA21><s1>2003</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>19104</s2>
<s5>354000119956370190</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>15 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0019041</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Arteriosclerosis, thrombosis, and vascular biology</s0>
</fA64>
<fA66 i1="01"><s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B12A03</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Cardiopathie coronaire</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Coronary heart disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Cardiopatía coronaria</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Human</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Anticorps</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Antibody</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Anticuerpo</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Parodontite</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Periodontitis</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Parodontitis</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Sérologie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Serology</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Serología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Actinobacillus actinomycetemcomitans</s0>
<s2>NS</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Actinobacillus actinomycetemcomitans</s0>
<s2>NS</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Actinobacillus actinomycetemcomitans</s0>
<s2>NS</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Porphyromonas gingivalis</s0>
<s2>NS</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Porphyromonas gingivalis</s0>
<s2>NS</s2>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Porphyromonas gingivalis</s0>
<s2>NS</s2>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Bactériose</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Bacteriosis</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Bacteriosis</s0>
<s2>NM</s2>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Association morbide</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Concomitant disease</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Asociación morbosa</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Physiopathologie</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Pathophysiology</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Fisiopatología</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Pathogénie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Pathogenesis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Patogenia</s0>
<s5>11</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Pasteurellaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Pasteurellaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Pasteurellaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Bactérie</s0>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Bacteria</s0>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Bacteria</s0>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Bacteroidaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Bacteroidaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Bacteroidaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Stomatologie</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Stomatology</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Estomatología</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Parodontopathie</s0>
<s5>46</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Periodontal disease</s0>
<s5>46</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Parodontopatía</s0>
<s5>46</s5>
</fC07>
<fN21><s1>012</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/PascalFrancis/Curation

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000125 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Curation/biblio.hfd -nk 000125 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Santé
   |area=    EdenteV2
   |flux=    PascalFrancis
   |étape=   Curation
   |type=    RBID
   |clé=     Pascal:04-0019041
   |texte=   Antibodies to periodontal pathogens are associated with coronary heart disease
}}

This area was generated with Dilib version V0.6.32.
Data generation: Thu Nov 30 15:26:48 2017. Site generation: Tue Mar 8 16:36:20 2022

	Serveur d'exploration sur le patient édenté
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur le patient édenté

Antibodies to periodontal pathogens are associated with coronary heart disease

Antibodies to periodontal pathogens are associated with coronary heart disease

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri