Antibodies to periodontal pathogens are associated with coronary heart disease
Identifieur interne : 000578 ( PascalFrancis/Corpus ); précédent : 000577; suivant : 000579Antibodies to periodontal pathogens are associated with coronary heart disease
Auteurs : Pirkko J. Pussinen ; Pekka Jousilahti ; Georg Alfthan ; Timo Palosuo ; Sirkka Asikainen ; Veikko SalomaaSource :
- Arteriosclerosis, thrombosis, and vascular biology [ 1079-5642 ] ; 2003.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 04-0019041 INIST |
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ET : | Antibodies to periodontal pathogens are associated with coronary heart disease |
AU : | PUSSINEN (Pirkko J.); JOUSILAHTI (Pekka); ALFTHAN (Georg); PALOSUO (Timo); ASIKAINEN (Sirkka); SALOMAA (Veikko) |
AF : | Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital/Finlande (1 aut., 5 aut.); Department of Epidemiology and Health Promotion, KTL-National Public Health Institute/Helsinki/Finlande (2 aut., 6 aut.); Department of Health and Functional Ability, KTL-National Public Health Institute/Helsinki/Finlande (3 aut., 4 aut.); Umeå University/Suède (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Arteriosclerosis, thrombosis, and vascular biology; ISSN 1079-5642; Coden ATVBFA; Etats-Unis; Da. 2003; Vol. 23; No. 7; Pp. 1250-1254; Bibl. 15 ref. |
LA : | Anglais |
EA : | Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD. |
CC : | 002B12A03 |
FD : | Cardiopathie coronaire; Homme; Anticorps; Parodontite; Sérologie; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Bactériose; Association morbide; Physiopathologie; Pathogénie |
FG : | Pasteurellaceae; Bactérie; Bacteroidaceae; Infection; Appareil circulatoire pathologie; Stomatologie; Parodontopathie |
ED : | Coronary heart disease; Human; Antibody; Periodontitis; Serology; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Bacteriosis; Concomitant disease; Pathophysiology; Pathogenesis |
EG : | Pasteurellaceae; Bacteria; Bacteroidaceae; Infection; Cardiovascular disease; Stomatology; Periodontal disease |
SD : | Cardiopatía coronaria; Hombre; Anticuerpo; Parodontitis; Serología; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Bacteriosis; Asociación morbosa; Fisiopatología; Patogenia |
LO : | INIST-19104.354000119956370190 |
ID : | 04-0019041 |
Links to Exploration step
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<term>Concomitant disease</term>
<term>Coronary heart disease</term>
<term>Human</term>
<term>Pathogenesis</term>
<term>Pathophysiology</term>
<term>Periodontitis</term>
<term>Porphyromonas gingivalis</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Cardiopathie coronaire</term>
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<front><div type="abstract" xml:lang="en">Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.</div>
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</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Bacteroidaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Bacteroidaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Bacteroidaceae</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Appareil circulatoire pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Stomatologie</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Stomatology</s0>
<s5>45</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Estomatología</s0>
<s5>45</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Parodontopathie</s0>
<s5>46</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Periodontal disease</s0>
<s5>46</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Parodontopatía</s0>
<s5>46</s5>
</fC07>
<fN21><s1>012</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
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<server><NO>PASCAL 04-0019041 INIST</NO>
<ET>Antibodies to periodontal pathogens are associated with coronary heart disease</ET>
<AU>PUSSINEN (Pirkko J.); JOUSILAHTI (Pekka); ALFTHAN (Georg); PALOSUO (Timo); ASIKAINEN (Sirkka); SALOMAA (Veikko)</AU>
<AF>Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital/Finlande (1 aut., 5 aut.); Department of Epidemiology and Health Promotion, KTL-National Public Health Institute/Helsinki/Finlande (2 aut., 6 aut.); Department of Health and Functional Ability, KTL-National Public Health Institute/Helsinki/Finlande (3 aut., 4 aut.); Umeå University/Suède (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Arteriosclerosis, thrombosis, and vascular biology; ISSN 1079-5642; Coden ATVBFA; Etats-Unis; Da. 2003; Vol. 23; No. 7; Pp. 1250-1254; Bibl. 15 ref.</SO>
<LA>Anglais</LA>
<EA>Objective-We analyzed the association of coronary heart disease (CHD) and serology of periodontitis in a random sample (n=1163) of men (aged 45 to 74 years) by determining serum IgG-antibodies to Actinobacillus actinomvcetemcomitans and Porphyromonas gingivalis. Methods and Results-CHD (n=159) was more prevalent among edentulous than dentate subjects (19.8% and 12.1%, P=0.003). In the dentate population, CHD was more common among subjects seropositive for P. gingivalis compared with those seronegative (14.0% and 9.7%, P=0.029). Accordingly, CHD was more prevalent in subjects with a high combined antibody response than those with a low response (17.4% and 11.1%, P=0.026). When adjusted for age and several CHD risk factors, the subjects with a high combined antibody response had an odds ratio of 1.5 (95% CI, 0.95 to 2.50, P=0.077) for prevalent CHD. In a linear regression model, the combined antibody response was directly associated with prevalent CHD (P=0.046) and inversely with serum HDL cholesterol concentration (P=0.050). Conclusions-In conclusion, edentulousness and serum antibodies to major periodontal pathogens were associated with CHD. This suggests that periodontal infection or response of the host against the infection may play a role in the pathogenesis of CHD.</EA>
<CC>002B12A03</CC>
<FD>Cardiopathie coronaire; Homme; Anticorps; Parodontite; Sérologie; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Bactériose; Association morbide; Physiopathologie; Pathogénie</FD>
<FG>Pasteurellaceae; Bactérie; Bacteroidaceae; Infection; Appareil circulatoire pathologie; Stomatologie; Parodontopathie</FG>
<ED>Coronary heart disease; Human; Antibody; Periodontitis; Serology; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Bacteriosis; Concomitant disease; Pathophysiology; Pathogenesis</ED>
<EG>Pasteurellaceae; Bacteria; Bacteroidaceae; Infection; Cardiovascular disease; Stomatology; Periodontal disease</EG>
<SD>Cardiopatía coronaria; Hombre; Anticuerpo; Parodontitis; Serología; Actinobacillus actinomycetemcomitans; Porphyromonas gingivalis; Bacteriosis; Asociación morbosa; Fisiopatología; Patogenia</SD>
<LO>INIST-19104.354000119956370190</LO>
<ID>04-0019041</ID>
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</inist>
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