Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes
Identifieur interne : 000437 ( PascalFrancis/Corpus ); précédent : 000436; suivant : 000438Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes
Auteurs : Wendy A. Shultis ; E. Jennifer Weil ; Helen C. Looker ; Jeffrey M. Curtis ; Marc Shlossman ; Robert J. Genco ; William C. Knowler ; Robert G. NelsonSource :
- Diabetes care [ 0149-5992 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
OBJECTIVE - The purpose of this study was to investigate the effect of periodontitis on development of overt nephropathy, defined as macroalbuminuria, and end-stage renal disease (ESRD) in type 2 diabetes. RESEARCH DESIGN AND METHODS - Individuals residing in the Gila River Indian Community aged ≥25 years with type 2 diabetes, one or more periodontal examination, estimated glomerular filtration rate ≥60 ml/min per 1.73 m2, and no macroalbuminuria (urinary albumin-to-creatinine ratio ≥300 mg/g) were identified. Periodontitis was classified as none/ mild, moderate, severe, or edentulous using number of teeth and alveolar bone score. Subjects were followed to development of macroalbuminuria or ESRD, defined as onset of renal replacement therapy or death attributed to diabetic nephropathy. RESULTS - Of the 529 individuals, 107 (20%) had none/mild periodontitis, 200 (38%) had moderate periodontitis, 117 (22%) had severe periodontitis, and 105 (20%) were edentulous at baseline. During follow-up of up to 22 years, 193 individuals developed macroalbuminuria and 68 developed ESRD. Age- and sex-adjusted incidence of macroalbuminuria and ESRD increased with severity of periodontitis. After adjustment for age, sex, diabetes duration, BMI, and smoking in a proportional hazards model, the incidences of macroalbuminuria were 2.0, 2.1, and 2.6 times as high in individuals with moderate or severe periodontitis or those who were edentulous, respectively, compared with those with none/mild periodontitis (P =0.01). Incidences of ESRD in individuals with moderate or severe periodontitis or in those who were edentulous were 2.3, 3.5, and 4.9 times as high, respectively, compared with those with none/mild periodontitis (P = 0.02). CONCLUSIONS - Periodontitis predicts development of overt nephropathy and ESRD in individuals with type 2 diabetes. Whether treatment of periodontitis will reduce the risk of diabetic kidney disease remains to be determined.
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Format Inist (serveur)
NO : | PASCAL 07-0230055 INIST |
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ET : | Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes |
AU : | SHULTIS (Wendy A.); WEIL (E. Jennifer); LOOKER (Helen C.); CURTIS (Jeffrey M.); SHLOSSMAN (Marc); GENCO (Robert J.); KNOWLER (William C.); NELSON (Robert G.) |
AF : | Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health/Phoenix, Arizona/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 7 aut., 8 aut.); Department of Oral Biology, State University of New York at Buffalo/Buffalo, New York/Etats-Unis (5 aut., 6 aut.); Arizona School of Dentistry and Oral Health/Mesa, Arizona/Etats-Unis (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Diabetes care; ISSN 0149-5992; Coden DICAD2; Etats-Unis; Da. 2007; Vol. 30; No. 2; Pp. 306-311; Bibl. 37 ref. |
LA : | Anglais |
EA : | OBJECTIVE - The purpose of this study was to investigate the effect of periodontitis on development of overt nephropathy, defined as macroalbuminuria, and end-stage renal disease (ESRD) in type 2 diabetes. RESEARCH DESIGN AND METHODS - Individuals residing in the Gila River Indian Community aged ≥25 years with type 2 diabetes, one or more periodontal examination, estimated glomerular filtration rate ≥60 ml/min per 1.73 m2, and no macroalbuminuria (urinary albumin-to-creatinine ratio ≥300 mg/g) were identified. Periodontitis was classified as none/ mild, moderate, severe, or edentulous using number of teeth and alveolar bone score. Subjects were followed to development of macroalbuminuria or ESRD, defined as onset of renal replacement therapy or death attributed to diabetic nephropathy. RESULTS - Of the 529 individuals, 107 (20%) had none/mild periodontitis, 200 (38%) had moderate periodontitis, 117 (22%) had severe periodontitis, and 105 (20%) were edentulous at baseline. During follow-up of up to 22 years, 193 individuals developed macroalbuminuria and 68 developed ESRD. Age- and sex-adjusted incidence of macroalbuminuria and ESRD increased with severity of periodontitis. After adjustment for age, sex, diabetes duration, BMI, and smoking in a proportional hazards model, the incidences of macroalbuminuria were 2.0, 2.1, and 2.6 times as high in individuals with moderate or severe periodontitis or those who were edentulous, respectively, compared with those with none/mild periodontitis (P =0.01). Incidences of ESRD in individuals with moderate or severe periodontitis or in those who were edentulous were 2.3, 3.5, and 4.9 times as high, respectively, compared with those with none/mild periodontitis (P = 0.02). CONCLUSIONS - Periodontitis predicts development of overt nephropathy and ESRD in individuals with type 2 diabetes. Whether treatment of periodontitis will reduce the risk of diabetic kidney disease remains to be determined. |
CC : | 002B21E01A; 002B10C02 |
FD : | Parodontite; Homme; Néphropathie; Insuffisance rénale; Diabète type 2 |
FG : | Stomatologie; Parodontopathie; Appareil urinaire pathologie; Rein pathologie; Endocrinopathie; Métabolisme pathologie |
ED : | Periodontitis; Human; Nephropathy; Renal failure; Type 2 diabetes |
EG : | Stomatology; Periodontal disease; Urinary system disease; Kidney disease; Endocrinopathy; Metabolic diseases |
SD : | Parodontitis; Hombre; Nefropatía; Insuficiencia renal; Diabetes de tipo 2 |
LO : | INIST-18054.354000143320930180 |
ID : | 07-0230055 |
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Pascal:07-0230055Le document en format XML
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<series><title level="j" type="main">Diabetes care</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term>
<term>Nephropathy</term>
<term>Periodontitis</term>
<term>Renal failure</term>
<term>Type 2 diabetes</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Parodontite</term>
<term>Homme</term>
<term>Néphropathie</term>
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<front><div type="abstract" xml:lang="en">OBJECTIVE - The purpose of this study was to investigate the effect of periodontitis on development of overt nephropathy, defined as macroalbuminuria, and end-stage renal disease (ESRD) in type 2 diabetes. RESEARCH DESIGN AND METHODS - Individuals residing in the Gila River Indian Community aged ≥25 years with type 2 diabetes, one or more periodontal examination, estimated glomerular filtration rate ≥60 ml/min per 1.73 m<sup>2</sup>
, and no macroalbuminuria (urinary albumin-to-creatinine ratio ≥300 mg/g) were identified. Periodontitis was classified as none/ mild, moderate, severe, or edentulous using number of teeth and alveolar bone score. Subjects were followed to development of macroalbuminuria or ESRD, defined as onset of renal replacement therapy or death attributed to diabetic nephropathy. RESULTS - Of the 529 individuals, 107 (20%) had none/mild periodontitis, 200 (38%) had moderate periodontitis, 117 (22%) had severe periodontitis, and 105 (20%) were edentulous at baseline. During follow-up of up to 22 years, 193 individuals developed macroalbuminuria and 68 developed ESRD. Age- and sex-adjusted incidence of macroalbuminuria and ESRD increased with severity of periodontitis. After adjustment for age, sex, diabetes duration, BMI, and smoking in a proportional hazards model, the incidences of macroalbuminuria were 2.0, 2.1, and 2.6 times as high in individuals with moderate or severe periodontitis or those who were edentulous, respectively, compared with those with none/mild periodontitis (P =0.01). Incidences of ESRD in individuals with moderate or severe periodontitis or in those who were edentulous were 2.3, 3.5, and 4.9 times as high, respectively, compared with those with none/mild periodontitis (P = 0.02). CONCLUSIONS - Periodontitis predicts development of overt nephropathy and ESRD in individuals with type 2 diabetes. Whether treatment of periodontitis will reduce the risk of diabetic kidney disease remains to be determined.</div>
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<fA14 i1="01"><s1>Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health</s1>
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<fA14 i1="02"><s1>Department of Oral Biology, State University of New York at Buffalo</s1>
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<sZ>6 aut.</sZ>
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<s2>Mesa, Arizona</s2>
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<fC01 i1="01" l="ENG"><s0>OBJECTIVE - The purpose of this study was to investigate the effect of periodontitis on development of overt nephropathy, defined as macroalbuminuria, and end-stage renal disease (ESRD) in type 2 diabetes. RESEARCH DESIGN AND METHODS - Individuals residing in the Gila River Indian Community aged ≥25 years with type 2 diabetes, one or more periodontal examination, estimated glomerular filtration rate ≥60 ml/min per 1.73 m<sup>2</sup>
, and no macroalbuminuria (urinary albumin-to-creatinine ratio ≥300 mg/g) were identified. Periodontitis was classified as none/ mild, moderate, severe, or edentulous using number of teeth and alveolar bone score. Subjects were followed to development of macroalbuminuria or ESRD, defined as onset of renal replacement therapy or death attributed to diabetic nephropathy. RESULTS - Of the 529 individuals, 107 (20%) had none/mild periodontitis, 200 (38%) had moderate periodontitis, 117 (22%) had severe periodontitis, and 105 (20%) were edentulous at baseline. During follow-up of up to 22 years, 193 individuals developed macroalbuminuria and 68 developed ESRD. Age- and sex-adjusted incidence of macroalbuminuria and ESRD increased with severity of periodontitis. After adjustment for age, sex, diabetes duration, BMI, and smoking in a proportional hazards model, the incidences of macroalbuminuria were 2.0, 2.1, and 2.6 times as high in individuals with moderate or severe periodontitis or those who were edentulous, respectively, compared with those with none/mild periodontitis (P =0.01). Incidences of ESRD in individuals with moderate or severe periodontitis or in those who were edentulous were 2.3, 3.5, and 4.9 times as high, respectively, compared with those with none/mild periodontitis (P = 0.02). CONCLUSIONS - Periodontitis predicts development of overt nephropathy and ESRD in individuals with type 2 diabetes. Whether treatment of periodontitis will reduce the risk of diabetic kidney disease remains to be determined.</s0>
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</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Human</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Néphropathie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Nephropathy</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Nefropatía</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Insuffisance rénale</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Renal failure</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Insuficiencia renal</s0>
<s5>07</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Diabète type 2</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Type 2 diabetes</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Diabetes de tipo 2</s0>
<s2>NM</s2>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Stomatologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Stomatology</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Estomatología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Parodontopathie</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Periodontal disease</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Parodontopatía</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Appareil urinaire pathologie</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Urinary system disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Aparato urinario patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Rein pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Kidney disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Riñón patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Endocrinopathie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Endocrinopathy</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Endocrinopatía</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Métabolisme pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Metabolic diseases</s0>
<s5>42</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Metabolismo patología</s0>
<s5>42</s5>
</fC07>
<fN21><s1>155</s1>
</fN21>
</pA>
</standard>
<server><NO>PASCAL 07-0230055 INIST</NO>
<ET>Effect of periodontitis on overt nephropathy and end-stage renal disease in type 2 diabetes</ET>
<AU>SHULTIS (Wendy A.); WEIL (E. Jennifer); LOOKER (Helen C.); CURTIS (Jeffrey M.); SHLOSSMAN (Marc); GENCO (Robert J.); KNOWLER (William C.); NELSON (Robert G.)</AU>
<AF>Diabetes Epidemiology and Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health/Phoenix, Arizona/Etats-Unis (1 aut., 2 aut., 3 aut., 4 aut., 7 aut., 8 aut.); Department of Oral Biology, State University of New York at Buffalo/Buffalo, New York/Etats-Unis (5 aut., 6 aut.); Arizona School of Dentistry and Oral Health/Mesa, Arizona/Etats-Unis (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Diabetes care; ISSN 0149-5992; Coden DICAD2; Etats-Unis; Da. 2007; Vol. 30; No. 2; Pp. 306-311; Bibl. 37 ref.</SO>
<LA>Anglais</LA>
<EA>OBJECTIVE - The purpose of this study was to investigate the effect of periodontitis on development of overt nephropathy, defined as macroalbuminuria, and end-stage renal disease (ESRD) in type 2 diabetes. RESEARCH DESIGN AND METHODS - Individuals residing in the Gila River Indian Community aged ≥25 years with type 2 diabetes, one or more periodontal examination, estimated glomerular filtration rate ≥60 ml/min per 1.73 m<sup>2</sup>
, and no macroalbuminuria (urinary albumin-to-creatinine ratio ≥300 mg/g) were identified. Periodontitis was classified as none/ mild, moderate, severe, or edentulous using number of teeth and alveolar bone score. Subjects were followed to development of macroalbuminuria or ESRD, defined as onset of renal replacement therapy or death attributed to diabetic nephropathy. RESULTS - Of the 529 individuals, 107 (20%) had none/mild periodontitis, 200 (38%) had moderate periodontitis, 117 (22%) had severe periodontitis, and 105 (20%) were edentulous at baseline. During follow-up of up to 22 years, 193 individuals developed macroalbuminuria and 68 developed ESRD. Age- and sex-adjusted incidence of macroalbuminuria and ESRD increased with severity of periodontitis. After adjustment for age, sex, diabetes duration, BMI, and smoking in a proportional hazards model, the incidences of macroalbuminuria were 2.0, 2.1, and 2.6 times as high in individuals with moderate or severe periodontitis or those who were edentulous, respectively, compared with those with none/mild periodontitis (P =0.01). Incidences of ESRD in individuals with moderate or severe periodontitis or in those who were edentulous were 2.3, 3.5, and 4.9 times as high, respectively, compared with those with none/mild periodontitis (P = 0.02). CONCLUSIONS - Periodontitis predicts development of overt nephropathy and ESRD in individuals with type 2 diabetes. Whether treatment of periodontitis will reduce the risk of diabetic kidney disease remains to be determined.</EA>
<CC>002B21E01A; 002B10C02</CC>
<FD>Parodontite; Homme; Néphropathie; Insuffisance rénale; Diabète type 2</FD>
<FG>Stomatologie; Parodontopathie; Appareil urinaire pathologie; Rein pathologie; Endocrinopathie; Métabolisme pathologie</FG>
<ED>Periodontitis; Human; Nephropathy; Renal failure; Type 2 diabetes</ED>
<EG>Stomatology; Periodontal disease; Urinary system disease; Kidney disease; Endocrinopathy; Metabolic diseases</EG>
<SD>Parodontitis; Hombre; Nefropatía; Insuficiencia renal; Diabetes de tipo 2</SD>
<LO>INIST-18054.354000143320930180</LO>
<ID>07-0230055</ID>
</server>
</inist>
</record>
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