EdenteV2, PascalFrancis, Corpus, bibRecord, 000268

Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species

Identifieur interne : 000268 ( PascalFrancis/Corpus ); précédent : 000267; suivant : 000269

Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species

Auteurs : Stephane Bonneau ; Laurence Maynard ; Krzysztof Tomczuk ; Dawid Kok ; Hyone-Myong Eun

Source :

Parasitology research : (1987) [ 0932-0113 ] ; 2009.

RBID : Pascal:09-0377380

Descripteurs français

Pascal (Inist)
- Anthelminthique, Ivermectine, Praziquantel, Cheval, Parasite.

English descriptors

KwdEn :
- Anthelmintic, Horse, Ivermectin, Parasite, Praziquantel.

Abstract

In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

A01	`01`	`1`		`@0 0932-0113`
A02	`01`			`@0 PARREZ`
A03		`1`		`@0 Parasitol. res. : (1987)`
A05				`@2 105`
A06				`@2 3`
A08	`01`	`1`	`ENG`	`@1 Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species`
A11	`01`	`1`		`@1 BONNEAU (Stephane)`
A11	`02`	`1`		`@1 MAYNARD (Laurence)`
A11	`03`	`1`		`@1 TOMCZUK (Krzysztof)`
A11	`04`	`1`		`@1 KOK (Dawid)`
A11	`05`	`1`		`@1 EUN (Hyone-Myong)`
A14	`01`			`@1 R&D Department, Virbac S.A., B.P. 27 @2 06511 Carros @3 FRA @Z 1 aut. @Z 2 aut. @Z 5 aut.`
A14	`02`			`@1 Department of parasitology and invasive disease, Veterinary faculty, Agricultural University of Lublin @2 Lublin @3 POL @Z 3 aut.`
A14	`03`			`@1 ClinVet International, Universitas @2 9321 Bloemfontein @3 ZAF @Z 4 aut.`
A20				`@1 817-823`
A21				`@1 2009`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 5859 @5 354000187589960280`
A44				`@0 0000 @1 © 2009 INIST-CNRS. All rights reserved.`
A45				`@0 1/2 p.`
A47	`01`	`1`		`@0 09-0377380`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Parasitology research : (1987)`
A66	`01`			`@0 DEU`
C01	`01`		`ENG`	@0 In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
C02	`01`	`X`		`@0 002A12A01`
C03	`01`	`X`	`FRE`	`@0 Anthelminthique @5 01`
C03	`01`	`X`	`ENG`	`@0 Anthelmintic @5 01`
C03	`01`	`X`	`SPA`	`@0 Antihelmíntico @5 01`
C03	`02`	`X`	`FRE`	`@0 Ivermectine @2 NK @2 FR @2 FF @5 02`
C03	`02`	`X`	`ENG`	`@0 Ivermectin @2 NK @2 FR @2 FF @5 02`
C03	`02`	`X`	`SPA`	`@0 Ivermectina @2 NK @2 FR @2 FF @5 02`
C03	`03`	`X`	`FRE`	`@0 Praziquantel @2 NK @2 FR @5 03`
C03	`03`	`X`	`ENG`	`@0 Praziquantel @2 NK @2 FR @5 03`
C03	`03`	`X`	`SPA`	`@0 Prazicuantel @2 NK @2 FR @5 03`
C03	`04`	`X`	`FRE`	`@0 Cheval @5 04`
C03	`04`	`X`	`ENG`	`@0 Horse @5 04`
C03	`04`	`X`	`SPA`	`@0 Caballo @5 04`
C03	`05`	`X`	`FRE`	`@0 Parasite @5 05`
C03	`05`	`X`	`ENG`	`@0 Parasite @5 05`
C03	`05`	`X`	`SPA`	`@0 Parásito @5 05`
C07	`01`	`X`	`FRE`	`@0 Perissodactyla @2 NS`
C07	`01`	`X`	`ENG`	`@0 Perissodactyla @2 NS`
C07	`01`	`X`	`SPA`	`@0 Perissodactyla @2 NS`
C07	`02`	`X`	`FRE`	`@0 Ungulata @2 NS`
C07	`02`	`X`	`ENG`	`@0 Ungulata @2 NS`
C07	`02`	`X`	`SPA`	`@0 Ungulata @2 NS`
C07	`03`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`04`	`X`	`FRE`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`ENG`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`SPA`	`@0 Vertebrata @2 NS`
N21				`@1 271`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 09-0377380 INIST
ET :	Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species
AU :	BONNEAU (Stephane); MAYNARD (Laurence); TOMCZUK (Krzysztof); KOK (Dawid); EUN (Hyone-Myong)
AF :	R&D Department, Virbac S.A., B.P. 27/06511 Carros/France (1 aut., 2 aut., 5 aut.); Department of parasitology and invasive disease, Veterinary faculty, Agricultural University of Lublin/Lublin/Pologne (3 aut.); ClinVet International, Universitas/9321 Bloemfontein/Afrique du Sud (4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Parasitology research : (1987); ISSN 0932-0113; Coden PARREZ; Allemagne; Da. 2009; Vol. 105; No. 3; Pp. 817-823; Bibl. 1/2 p.
LA :	Anglais
EA :	In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
CC :	002A12A01
FD :	Anthelminthique; Ivermectine; Praziquantel; Cheval; Parasite
FG :	Perissodactyla; Ungulata; Mammalia; Vertebrata
ED :	Anthelmintic; Ivermectin; Praziquantel; Horse; Parasite
EG :	Perissodactyla; Ungulata; Mammalia; Vertebrata
SD :	Antihelmíntico; Ivermectina; Prazicuantel; Caballo; Parásito
LO :	INIST-5859.354000187589960280
ID :	09-0377380

Links to Exploration step

Pascal:09-0377380

Le document en format XML

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<author><name sortKey="Eun, Hyone Myong" sort="Eun, Hyone Myong" uniqKey="Eun H" first="Hyone-Myong" last="Eun">Hyone-Myong Eun</name>
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<front><div type="abstract" xml:lang="en">In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.</div>
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<fC01 i1="01" l="ENG"><s0>In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.</s0>
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<fC03 i1="04" i2="X" l="ENG"><s0>Horse</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Caballo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Parasite</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Parasite</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Parásito</s0>
<s5>05</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Perissodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Perissodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Perissodactyla</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Ungulata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>271</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 09-0377380 INIST</NO>
<ET>Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species</ET>
<AU>BONNEAU (Stephane); MAYNARD (Laurence); TOMCZUK (Krzysztof); KOK (Dawid); EUN (Hyone-Myong)</AU>
<AF>R&D Department, Virbac S.A., B.P. 27/06511 Carros/France (1 aut., 2 aut., 5 aut.); Department of parasitology and invasive disease, Veterinary faculty, Agricultural University of Lublin/Lublin/Pologne (3 aut.); ClinVet International, Universitas/9321 Bloemfontein/Afrique du Sud (4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Parasitology research : (1987); ISSN 0932-0113; Coden PARREZ; Allemagne; Da. 2009; Vol. 105; No. 3; Pp. 817-823; Bibl. 1/2 p.</SO>
<LA>Anglais</LA>
<EA>In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n=6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.</EA>
<CC>002A12A01</CC>
<FD>Anthelminthique; Ivermectine; Praziquantel; Cheval; Parasite</FD>
<FG>Perissodactyla; Ungulata; Mammalia; Vertebrata</FG>
<ED>Anthelmintic; Ivermectin; Praziquantel; Horse; Parasite</ED>
<EG>Perissodactyla; Ungulata; Mammalia; Vertebrata</EG>
<SD>Antihelmíntico; Ivermectina; Prazicuantel; Caballo; Parásito</SD>
<LO>INIST-5859.354000187589960280</LO>
<ID>09-0377380</ID>
</server>
</inist>
</record>

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Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species

Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species

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