Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
Identifieur interne : 000548 ( PascalFrancis/Checkpoint ); précédent : 000547; suivant : 000549Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
Auteurs : A. Takahashi [Japon] ; T. Saito [Japon] ; H. Mayanagi [Japon] ; J. Kamei [Japon] ; K. Onodera [Japon]Source :
- Methods and findings in experimental and clinical pharmacology [ 0379-0355 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:05-0121247Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats</title><author><name sortKey="Takahashi, A" sort="Takahashi, A" uniqKey="Takahashi A" first="A." last="Takahashi">A. Takahashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T." last="Saito">T. Saito</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Mayanagi, H" sort="Mayanagi, H" uniqKey="Mayanagi H" first="H." last="Mayanagi">H. Mayanagi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Kamei, J" sort="Kamei, J" uniqKey="Kamei J" first="J." last="Kamei">J. Kamei</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>4 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Onodera, K" sort="Onodera, K" uniqKey="Onodera K" first="K." last="Onodera">K. Onodera</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry</s1><s2>Okayama</s2><s3>JPN</s3><sZ>5 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Okayama</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">05-0121247</idno><date when="2004">2004</date><idno type="stanalyst">PASCAL 05-0121247 INIST</idno><idno type="RBID">Pascal:05-0121247</idno><idno type="wicri:Area/PascalFrancis/Corpus">000523</idno><idno type="wicri:Area/PascalFrancis/Curation">000180</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000548</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000548</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats</title><author><name sortKey="Takahashi, A" sort="Takahashi, A" uniqKey="Takahashi A" first="A." last="Takahashi">A. Takahashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T." last="Saito">T. Saito</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Mayanagi, H" sort="Mayanagi, H" uniqKey="Mayanagi H" first="H." last="Mayanagi">H. Mayanagi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Sendai</wicri:noRegion></affiliation></author><author><name sortKey="Kamei, J" sort="Kamei, J" uniqKey="Kamei J" first="J." last="Kamei">J. Kamei</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>4 aut.</sZ></inist:fA14><country>Japon</country><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Onodera, K" sort="Onodera, K" uniqKey="Onodera K" first="K." last="Onodera">K. Onodera</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry</s1><s2>Okayama</s2><s3>JPN</s3><sZ>5 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Okayama</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Methods and findings in experimental and clinical pharmacology</title><title level="j" type="abbreviated">Methods find. exp. clin. pharmacol.</title><idno type="ISSN">0379-0355</idno><imprint><date when="2004">2004</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Methods and findings in experimental and clinical pharmacology</title><title level="j" type="abbreviated">Methods find. exp. clin. pharmacol.</title><idno type="ISSN">0379-0355</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal</term><term>Anticonvulsant</term><term>Bone mineral density</term><term>Dentin</term><term>Epilepsy</term><term>Pharmaceutical technology</term><term>Phenytoin</term><term>Rat</term><term>Zonisamide</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anticonvulsivant</term><term>Phénytoïne</term><term>Zonisamide</term><term>Dentine</term><term>Densité minérale osseuse</term><term>Rat</term><term>Animal</term><term>Epilepsie</term><term>Technologie pharmaceutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0379-0355</s0></fA01><fA03 i2="1"><s0>Methods find. exp. clin. pharmacol.</s0></fA03><fA05><s2>26</s2></fA05><fA06><s2>10</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats</s1></fA08><fA11 i1="01" i2="1"><s1>TAKAHASHI (A.)</s1></fA11><fA11 i1="02" i2="1"><s1>SAITO (T.)</s1></fA11><fA11 i1="03" i2="1"><s1>MAYANAGI (H.)</s1></fA11><fA11 i1="04" i2="1"><s1>KAMEI (J.)</s1></fA11><fA11 i1="05" i2="1"><s1>ONODERA (K.)</s1></fA11><fA14 i1="01"><s1>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital</s1><s2>Sendai</s2><s3>JPN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University</s1><s2>Tokyo</s2><s3>JPN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry</s1><s2>Okayama</s2><s3>JPN</s3><sZ>5 aut.</sZ></fA14><fA20><s1>769-773</s1></fA20><fA21><s1>2004</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>18217</s2><s5>354000127001680030</s5></fA43><fA44><s0>0000</s0><s1>© 2005 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>16 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>05-0121247</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Methods and findings in experimental and clinical pharmacology</s0></fA64><fA66 i1="01"><s0>ESP</s0></fA66><fC01 i1="01" l="ENG"><s0>This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.</s0></fC01><fC02 i1="01" i2="X"><s0>002B02A03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Anticonvulsivant</s0><s5>11</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Anticonvulsant</s0><s5>11</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Anticonvulsivante</s0><s5>11</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Phénytoïne</s0><s2>NK</s2><s2>FR</s2><s5>12</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Phenytoin</s0><s2>NK</s2><s2>FR</s2><s5>12</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Fenitoína</s0><s2>NK</s2><s2>FR</s2><s5>12</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Zonisamide</s0><s2>NK</s2><s2>FR</s2><s5>14</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Zonisamide</s0><s2>NK</s2><s2>FR</s2><s5>14</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Zonisamida</s0><s2>NK</s2><s2>FR</s2><s5>14</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Dentine</s0><s5>15</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dentin</s0><s5>15</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Dentina</s0><s5>15</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Densité minérale osseuse</s0><s5>16</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Bone mineral density</s0><s5>16</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Masa mineral ósea</s0><s5>16</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Rat</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Rat</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Rata</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Animal</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Animal</s0><s5>18</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Animal</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Epilepsie</s0><s5>19</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Epilepsy</s0><s5>19</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Epilepsia</s0><s5>19</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Technologie pharmaceutique</s0><s5>20</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>Pharmaceutical technology</s0><s5>20</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Tecnología farmacéutica</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Sulfonamide</s0><s5>61</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Sulfonamide</s0><s5>61</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sulfonamida</s0><s5>61</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>62</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>62</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>62</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>63</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>63</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>63</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>64</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>64</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>64</s5></fC07><fN21><s1>080</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><noRegion><name sortKey="Takahashi, A" sort="Takahashi, A" uniqKey="Takahashi A" first="A." last="Takahashi">A. Takahashi</name></noRegion><name sortKey="Kamei, J" sort="Kamei, J" uniqKey="Kamei J" first="J." last="Kamei">J. Kamei</name><name sortKey="Mayanagi, H" sort="Mayanagi, H" uniqKey="Mayanagi H" first="H." last="Mayanagi">H. Mayanagi</name><name sortKey="Onodera, K" sort="Onodera, K" uniqKey="Onodera K" first="K." last="Onodera">K. Onodera</name><name sortKey="Saito, T" sort="Saito, T" uniqKey="Saito T" first="T." last="Saito">T. Saito</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000548 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000548 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:05-0121247
|texte= Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
}}
| This area was generated with Dilib version V0.6.32. |  |