EdenteV2, PascalFrancis, Corpus, bibRecord, 000523

Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats

Identifieur interne : 000523 ( PascalFrancis/Corpus ); précédent : 000522; suivant : 000524

Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats

Auteurs : A. Takahashi ; T. Saito ; H. Mayanagi ; J. Kamei ; K. Onodera

Source :

Methods and findings in experimental and clinical pharmacology [ 0379-0355 ] ; 2004.

RBID : Pascal:05-0121247

Descripteurs français

Pascal (Inist)
- Anticonvulsivant, Phénytoïne, Zonisamide, Dentine, Densité minérale osseuse, Rat, Animal, Epilepsie, Technologie pharmaceutique.

English descriptors

KwdEn :
- Animal, Anticonvulsant, Bone mineral density, Dentin, Epilepsy, Pharmaceutical technology, Phenytoin, Rat, Zonisamide.

Abstract

This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Methods find. exp. clin. pharmacol.`
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A11	`01`	`1`		`@1 TAKAHASHI (A.)`
A11	`02`	`1`		`@1 SAITO (T.)`
A11	`03`	`1`		`@1 MAYANAGI (H.)`
A11	`04`	`1`		`@1 KAMEI (J.)`
A11	`05`	`1`		`@1 ONODERA (K.)`
A14	`01`			`@1 Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital @2 Sendai @3 JPN @Z 1 aut. @Z 2 aut. @Z 3 aut.`
A14	`02`			`@1 Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University @2 Tokyo @3 JPN @Z 4 aut.`
A14	`03`			`@1 Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry @2 Okayama @3 JPN @Z 5 aut.`
A20				`@1 769-773`
A21				`@1 2004`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 18217 @5 354000127001680030`
A44				`@0 0000 @1 © 2005 INIST-CNRS. All rights reserved.`
A45				`@0 16 ref.`
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C01	`01`		`ENG`	@0 This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.
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C03	`01`	`X`	`SPA`	`@0 Anticonvulsivante @5 11`
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C03	`02`	`X`	`ENG`	`@0 Phenytoin @2 NK @2 FR @5 12`
C03	`02`	`X`	`SPA`	`@0 Fenitoína @2 NK @2 FR @5 12`
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C03	`05`	`X`	`ENG`	`@0 Bone mineral density @5 16`
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C03	`08`	`X`	`FRE`	`@0 Epilepsie @5 19`
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C03	`09`	`X`	`FRE`	`@0 Technologie pharmaceutique @5 20`
C03	`09`	`X`	`ENG`	`@0 Pharmaceutical technology @5 20`
C03	`09`	`X`	`SPA`	`@0 Tecnología farmacéutica @5 20`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
C07	`03`	`X`	`FRE`	`@0 Vertebrata @2 NS`
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C07	`03`	`X`	`SPA`	`@0 Vertebrata @2 NS`
C07	`04`	`X`	`FRE`	`@0 Sulfonamide @5 61`
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N21				`@1 080`
N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 05-0121247 INIST
ET :	Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
AU :	TAKAHASHI (A.); SAITO (T.); MAYANAGI (H.); KAMEI (J.); ONODERA (K.)
AF :	Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital/Sendai/Japon (1 aut., 2 aut., 3 aut.); Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University/Tokyo/Japon (4 aut.); Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry/Okayama/Japon (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Methods and findings in experimental and clinical pharmacology; ISSN 0379-0355; Espagne; Da. 2004; Vol. 26; No. 10; Pp. 769-773; Bibl. 16 ref.
LA :	Anglais
EA :	This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.
CC :	002B02A03
FD :	Anticonvulsivant; Phénytoïne; Zonisamide; Dentine; Densité minérale osseuse; Rat; Animal; Epilepsie; Technologie pharmaceutique
FG :	Rodentia; Mammalia; Vertebrata; Sulfonamide; Encéphale pathologie; Système nerveux central pathologie; Système nerveux pathologie
ED :	Anticonvulsant; Phenytoin; Zonisamide; Dentin; Bone mineral density; Rat; Animal; Epilepsy; Pharmaceutical technology
EG :	Rodentia; Mammalia; Vertebrata; Sulfonamide; Cerebral disorder; Central nervous system disease; Nervous system diseases
SD :	Anticonvulsivante; Fenitoína; Zonisamida; Dentina; Masa mineral ósea; Rata; Animal; Epilepsia; Tecnología farmacéutica
LO :	INIST-18217.354000127001680030
ID :	05-0121247

Links to Exploration step

Pascal:05-0121247

Le document en format XML

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<front><div type="abstract" xml:lang="en">This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.</div>
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<fC01 i1="01" l="ENG"><s0>This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.</s0>
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<s5>12</s5>
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<fC03 i1="03" i2="X" l="FRE"><s0>Zonisamide</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Zonisamide</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Zonisamida</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>14</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Dentine</s0>
<s5>15</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Dentin</s0>
<s5>15</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Dentina</s0>
<s5>15</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Densité minérale osseuse</s0>
<s5>16</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Bone mineral density</s0>
<s5>16</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Masa mineral ósea</s0>
<s5>16</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Rat</s0>
<s5>17</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Rat</s0>
<s5>17</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Rata</s0>
<s5>17</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Animal</s0>
<s5>18</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Epilepsie</s0>
<s5>19</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Epilepsy</s0>
<s5>19</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Epilepsia</s0>
<s5>19</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Technologie pharmaceutique</s0>
<s5>20</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Pharmaceutical technology</s0>
<s5>20</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Tecnología farmacéutica</s0>
<s5>20</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Sulfonamide</s0>
<s5>61</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Sulfonamide</s0>
<s5>61</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sulfonamida</s0>
<s5>61</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
<s5>62</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>62</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>62</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>63</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>63</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>63</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Système nerveux pathologie</s0>
<s5>64</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>64</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>64</s5>
</fC07>
<fN21><s1>080</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 05-0121247 INIST</NO>
<ET>Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats</ET>
<AU>TAKAHASHI (A.); SAITO (T.); MAYANAGI (H.); KAMEI (J.); ONODERA (K.)</AU>
<AF>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital/Sendai/Japon (1 aut., 2 aut., 3 aut.); Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University/Tokyo/Japon (4 aut.); Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry/Okayama/Japon (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Methods and findings in experimental and clinical pharmacology; ISSN 0379-0355; Espagne; Da. 2004; Vol. 26; No. 10; Pp. 769-773; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.</EA>
<CC>002B02A03</CC>
<FD>Anticonvulsivant; Phénytoïne; Zonisamide; Dentine; Densité minérale osseuse; Rat; Animal; Epilepsie; Technologie pharmaceutique</FD>
<FG>Rodentia; Mammalia; Vertebrata; Sulfonamide; Encéphale pathologie; Système nerveux central pathologie; Système nerveux pathologie</FG>
<ED>Anticonvulsant; Phenytoin; Zonisamide; Dentin; Bone mineral density; Rat; Animal; Epilepsy; Pharmaceutical technology</ED>
<EG>Rodentia; Mammalia; Vertebrata; Sulfonamide; Cerebral disorder; Central nervous system disease; Nervous system diseases</EG>
<SD>Anticonvulsivante; Fenitoína; Zonisamida; Dentina; Masa mineral ósea; Rata; Animal; Epilepsia; Tecnología farmacéutica</SD>
<LO>INIST-18217.354000127001680030</LO>
<ID>05-0121247</ID>
</server>
</inist>
</record>

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Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats

Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats

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