Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
Identifieur interne : 000523 ( PascalFrancis/Corpus ); précédent : 000522; suivant : 000524Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats
Auteurs : A. Takahashi ; T. Saito ; H. Mayanagi ; J. Kamei ; K. OnoderaSource :
- Methods and findings in experimental and clinical pharmacology [ 0379-0355 ] ; 2004.
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English descriptors
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Abstract
This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.
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Format Inist (serveur)
NO : | PASCAL 05-0121247 INIST |
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ET : | Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats |
AU : | TAKAHASHI (A.); SAITO (T.); MAYANAGI (H.); KAMEI (J.); ONODERA (K.) |
AF : | Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital/Sendai/Japon (1 aut., 2 aut., 3 aut.); Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University/Tokyo/Japon (4 aut.); Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry/Okayama/Japon (5 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Methods and findings in experimental and clinical pharmacology; ISSN 0379-0355; Espagne; Da. 2004; Vol. 26; No. 10; Pp. 769-773; Bibl. 16 ref. |
LA : | Anglais |
EA : | This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth. |
CC : | 002B02A03 |
FD : | Anticonvulsivant; Phénytoïne; Zonisamide; Dentine; Densité minérale osseuse; Rat; Animal; Epilepsie; Technologie pharmaceutique |
FG : | Rodentia; Mammalia; Vertebrata; Sulfonamide; Encéphale pathologie; Système nerveux central pathologie; Système nerveux pathologie |
ED : | Anticonvulsant; Phenytoin; Zonisamide; Dentin; Bone mineral density; Rat; Animal; Epilepsy; Pharmaceutical technology |
EG : | Rodentia; Mammalia; Vertebrata; Sulfonamide; Cerebral disorder; Central nervous system disease; Nervous system diseases |
SD : | Anticonvulsivante; Fenitoína; Zonisamida; Dentina; Masa mineral ósea; Rata; Animal; Epilepsia; Tecnología farmacéutica |
LO : | INIST-18217.354000127001680030 |
ID : | 05-0121247 |
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Pascal:05-0121247Le document en format XML
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<server><NO>PASCAL 05-0121247 INIST</NO>
<ET>Effects of the antiepileptics phenytoin and zonisamide on dentin formation and bone mineral density of the mandible in growing rats</ET>
<AU>TAKAHASHI (A.); SAITO (T.); MAYANAGI (H.); KAMEI (J.); ONODERA (K.)</AU>
<AF>Clinics of Dentistry for the Disabled, Tohoku University Dental Hospital/Sendai/Japon (1 aut., 2 aut., 3 aut.); Department of Pathophysiology, School of Pharmacy and Pharmaceutical Sciences, Hoshi University/Tokyo/Japon (4 aut.); Department of Dental Pharmacology, Okayama University Graduate School of Medicine and Dentistry/Okayama/Japon (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Methods and findings in experimental and clinical pharmacology; ISSN 0379-0355; Espagne; Da. 2004; Vol. 26; No. 10; Pp. 769-773; Bibl. 16 ref.</SO>
<LA>Anglais</LA>
<EA>This study was undertaken to examine the effects of the antiepileptics phenytoin and zonisamide on changes in the mineral density of the incisor and bone mineral density (BMD) of the mandibular head, and on the rate of dentin formation using histomorphometric measurements. After repeated administration of phenytoin or zonisamide to male grooving rats, the mineral density of the lower incisors and mandibular head were determined by analyzing microradiographs and dentin formation rates were determined by histomorphometric measurements. Results showed a significant decrease in the mean values of BMD of the mandibular head and lower incisors in groups treated with phenytoin or zonisamide compared with the vehicle-treated group (p < 0.05). The percent rates of decrease in mineral density of the incisors for phenytoin and zonisamide were 6.8% and 4.0%, respectively. Phenytoin and zonisamide significantly reduced the dentin formation rate for the mesial and distal areas compared with the vehicle-treated group. Thus, epileptic children who are treated over a long period with antiepileptics, especially at primary school age, should ensure good oral hygiene so as not to suffer bone loss, edentulism or gingival overgrowth.</EA>
<CC>002B02A03</CC>
<FD>Anticonvulsivant; Phénytoïne; Zonisamide; Dentine; Densité minérale osseuse; Rat; Animal; Epilepsie; Technologie pharmaceutique</FD>
<FG>Rodentia; Mammalia; Vertebrata; Sulfonamide; Encéphale pathologie; Système nerveux central pathologie; Système nerveux pathologie</FG>
<ED>Anticonvulsant; Phenytoin; Zonisamide; Dentin; Bone mineral density; Rat; Animal; Epilepsy; Pharmaceutical technology</ED>
<EG>Rodentia; Mammalia; Vertebrata; Sulfonamide; Cerebral disorder; Central nervous system disease; Nervous system diseases</EG>
<SD>Anticonvulsivante; Fenitoína; Zonisamida; Dentina; Masa mineral ósea; Rata; Animal; Epilepsia; Tecnología farmacéutica</SD>
<LO>INIST-18217.354000127001680030</LO>
<ID>05-0121247</ID>
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