High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
Identifieur interne : 007127 ( Ncbi/Merge ); précédent : 007126; suivant : 007128High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
Auteurs : Jinpan Liu [République populaire de Chine] ; Ronghui Li [République populaire de Chine] ; Tongjun Liu [République populaire de Chine] ; Xiaohui Rausch-Fan [Autriche] ; Mingguo Wang [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.
Url:
DOI: 10.1038/s41598-017-06937-y
PubMed: 28765610
PubMed Central: 5539157
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China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author><author><name sortKey="Li, Ronghui" sort="Li, Ronghui" uniqKey="Li R" first="Ronghui" last="Li">Ronghui Li</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Tongjun" sort="Liu, Tongjun" uniqKey="Liu T" first="Tongjun" last="Liu">Tongjun Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author><author><name sortKey="Rausch Fan, Xiaohui" sort="Rausch Fan, Xiaohui" uniqKey="Rausch Fan X" first="Xiaohui" last="Rausch-Fan">Xiaohui Rausch-Fan</name><affiliation wicri:level="3"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9259 8492</institution-id><institution-id institution-id-type="GRID">grid.22937.3d</institution-id><institution>Division of Conservative Dentistry and Periodontology,</institution><institution>School of Dentistry, Medical University of Vienna,</institution></institution-wrap>Sensengasse 2a, 1090 Vienna, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Sensengasse 2a, 1090 Vienna</wicri:regionArea><placeName><region type="land" nuts="2">Vienne (Autriche)</region><settlement type="city">Vienne (Autriche)</settlement></placeName></affiliation></author><author><name sortKey="Wang, Mingguo" sort="Wang, Mingguo" uniqKey="Wang M" first="Mingguo" last="Wang">Mingguo Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</nlm:aff><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Jinan</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Kuula, H" uniqKey="Kuula H">H Kuula</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author><author><name sortKey="Meyle, J" uniqKey="Meyle J">J Meyle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abrahamsson, I" uniqKey="Abrahamsson I">I Abrahamsson</name></author><author><name sortKey="Berglundh, T" uniqKey="Berglundh T">T Berglundh</name></author><author><name sortKey="Lindhe, J" uniqKey="Lindhe J">J Lindhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liskmann, S" uniqKey="Liskmann S">S Liskmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lotze, Mt" uniqKey="Lotze M">MT Lotze</name></author><author><name sortKey="Tracey, Kj" uniqKey="Tracey K">KJ Tracey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Youn, Jh" uniqKey="Youn J">JH Youn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ivanov, S" uniqKey="Ivanov S">S Ivanov</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Js" uniqKey="Park J">JS Park</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Abdulahad, Da" uniqKey="Abdulahad D">DA Abdulahad</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Diener, Kr" uniqKey="Diener K">KR Diener</name></author><author><name sortKey="Al Dasooqi, N" uniqKey="Al Dasooqi N">N Al-Dasooqi</name></author><author><name sortKey="Lousberg, El" uniqKey="Lousberg E">EL Lousberg</name></author><author><name sortKey="Hayball, Jd" uniqKey="Hayball J">JD Hayball</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Garcia Arnandis, I" uniqKey="Garcia Arnandis I">I Garcia-Arnandis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nogueira, Av" uniqKey="Nogueira A">AV Nogueira</name></author><author><name sortKey="De Souza, Ja" uniqKey="De Souza J">JA de Souza</name></author><author><name sortKey="De Molon, Rs" uniqKey="De Molon R">RS de Molon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Taniguchi, N" uniqKey="Taniguchi N">N Taniguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morimoto, Y" uniqKey="Morimoto Y">Y Morimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fonseca, Fj" uniqKey="Fonseca F">FJ Fonseca</name></author><author><name sortKey="Moraes Junior, M" uniqKey="Moraes Junior M">M Moraes Junior</name></author><author><name sortKey="Lourenco, Ej" uniqKey="Lourenco E">EJ Lourenco</name></author><author><name sortKey="Teles Dde, M" uniqKey="Teles Dde M">M Teles Dde</name></author><author><name sortKey="Figueredo, Cm" uniqKey="Figueredo C">CM Figueredo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Petkovic, Ab" uniqKey="Petkovic A">AB Petkovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gustafsson, A" uniqKey="Gustafsson A">A Gustafsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Page, Rc" uniqKey="Page R">RC Page</name></author><author><name sortKey="Offenbacher, S" uniqKey="Offenbacher S">S Offenbacher</name></author><author><name sortKey="Schroeder, He" uniqKey="Schroeder H">HE Schroeder</name></author><author><name sortKey="Seymour, Gj" uniqKey="Seymour G">GJ Seymour</name></author><author><name sortKey="Kornman, Ks" uniqKey="Kornman K">KS Kornman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Uitto, Vj" uniqKey="Uitto V">VJ Uitto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bhardwaj, S" uniqKey="Bhardwaj S">S Bhardwaj</name></author><author><name sortKey="Prabhuji, Ml" uniqKey="Prabhuji M">ML Prabhuji</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luo, L" uniqKey="Luo L">L Luo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Feghali, K" uniqKey="Feghali K">K Feghali</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ito, Y" uniqKey="Ito Y">Y Ito</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sha, Y" uniqKey="Sha Y">Y Sha</name></author><author><name sortKey="Zmijewski, J" uniqKey="Zmijewski J">J Zmijewski</name></author><author><name sortKey="Xu, Z" uniqKey="Xu Z">Z Xu</name></author><author><name sortKey="Abraham, E" uniqKey="Abraham E">E Abraham</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hayakawa, K" uniqKey="Hayakawa K">K Hayakawa</name></author><author><name sortKey="Arai, K" uniqKey="Arai K">K Arai</name></author><author><name sortKey="Lo, Eh" uniqKey="Lo E">EH Lo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ueno, H" uniqKey="Ueno H">H Ueno</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Czura, Cj" uniqKey="Czura C">CJ Czura</name></author><author><name sortKey="Tracey, Kj" uniqKey="Tracey K">KJ Tracey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ek, M" uniqKey="Ek M">M Ek</name></author><author><name sortKey="Popovic, K" uniqKey="Popovic K">K Popovic</name></author><author><name sortKey="Harris, He" uniqKey="Harris H">HE Harris</name></author><author><name sortKey="Naucler, Cs" uniqKey="Naucler C">CS Naucler</name></author><author><name sortKey="Wahren Herlenius, M" uniqKey="Wahren Herlenius M">M Wahren-Herlenius</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gemmell, E" uniqKey="Gemmell E">E Gemmell</name></author><author><name sortKey="Carter, Cl" uniqKey="Carter C">CL Carter</name></author><author><name sortKey="Seymour, Gj" uniqKey="Seymour G">GJ Seymour</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hasegawa, N" uniqKey="Hasegawa N">N Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Agnello, D" uniqKey="Agnello D">D Agnello</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Yang, H" uniqKey="Yang H">H Yang</name></author><author><name sortKey="Tracey, Kj" uniqKey="Tracey K">KJ Tracey</name></author><author><name sortKey="Ghezzi, P" uniqKey="Ghezzi P">P Ghezzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, Jh" uniqKey="Liu J">JH Liu</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Sci Rep</journal-id><journal-id journal-id-type="iso-abbrev">Sci Rep</journal-id><journal-title-group><journal-title>Scientific Reports</journal-title></journal-title-group><issn pub-type="epub">2045-2322</issn><publisher><publisher-name>Nature Publishing Group UK</publisher-name><publisher-loc>London</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28765610</article-id><article-id pub-id-type="pmc">5539157</article-id><article-id pub-id-type="publisher-id">6937</article-id><article-id pub-id-type="doi">10.1038/s41598-017-06937-y</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Jinpan</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Li</surname><given-names>Ronghui</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Tongjun</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rausch-Fan</surname><given-names>Xiaohui</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname><given-names>Mingguo</given-names></name><address><email>2563309609@qq.com</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><aff id="Aff1"><label>1</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1761 1174</institution-id><institution-id institution-id-type="GRID">grid.27255.37</institution-id><institution>Department of Stomatology, Jinan Central Hospital,</institution><institution>Shandong University,</institution></institution-wrap>Jinan, 250013 P.R. China</aff><aff id="Aff2"><label>2</label><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9259 8492</institution-id><institution-id institution-id-type="GRID">grid.22937.3d</institution-id><institution>Division of Conservative Dentistry and Periodontology,</institution><institution>School of Dentistry, Medical University of Vienna,</institution></institution-wrap>Sensengasse 2a, 1090 Vienna, Austria</aff></contrib-group><pub-date pub-type="epub"><day>1</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2017</year></pub-date><pub-date pub-type="collection"><year>2017</year></pub-date><volume>7</volume><elocation-id>7027</elocation-id><history><date date-type="received"><day>27</day><month>3</month><year>2017</year></date><date date-type="accepted"><day>21</day><month>6</month><year>2017</year></date></history><permissions><copyright-statement>© The Author(s) 2017</copyright-statement><license license-type="OpenAccess"><license-p><bold>Open Access</bold> This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><abstract id="Abs1"><p id="Par1">Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2017</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Autriche</li><li>République populaire de Chine</li></country><region><li>Vienne (Autriche)</li></region><settlement><li>Vienne (Autriche)</li></settlement></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Jinpan" sort="Liu, Jinpan" uniqKey="Liu J" first="Jinpan" last="Liu">Jinpan Liu</name></noRegion><name sortKey="Li, Ronghui" sort="Li, Ronghui" uniqKey="Li R" first="Ronghui" last="Li">Ronghui Li</name><name sortKey="Liu, Tongjun" sort="Liu, Tongjun" uniqKey="Liu T" first="Tongjun" last="Liu">Tongjun Liu</name><name sortKey="Wang, Mingguo" sort="Wang, Mingguo" uniqKey="Wang M" first="Mingguo" last="Wang">Mingguo Wang</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Rausch Fan, Xiaohui" sort="Rausch Fan, Xiaohui" uniqKey="Rausch Fan X" first="Xiaohui" last="Rausch-Fan">Xiaohui Rausch-Fan</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5539157
|texte= High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:28765610" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |