High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
Identifieur interne : 000D67 ( Pmc/Curation ); précédent : 000D66; suivant : 000D68High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease
Auteurs : Jinpan Liu [République populaire de Chine] ; Ronghui Li [République populaire de Chine] ; Tongjun Liu [République populaire de Chine] ; Xiaohui Rausch-Fan [Autriche] ; Mingguo Wang [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Abstract
Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.
Url:
DOI: 10.1038/s41598-017-06937-y
PubMed: 28765610
PubMed Central: 5539157
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<front><div type="abstract" xml:lang="en"><p id="Par1">Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.</p>
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<title-group><article-title>High Mobility Group Box 1 Protein Level as a Novel Biomarker for the Development of Peri-Implant Disease</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Jinpan</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Ronghui</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Liu</surname>
<given-names>Tongjun</given-names>
</name>
<xref ref-type="aff" rid="Aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rausch-Fan</surname>
<given-names>Xiaohui</given-names>
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<xref ref-type="aff" rid="Aff2">2</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Wang</surname>
<given-names>Mingguo</given-names>
</name>
<address><email>2563309609@qq.com</email>
</address>
<xref ref-type="aff" rid="Aff1">1</xref>
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<aff id="Aff1"><label>1</label>
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<institution-id institution-id-type="GRID">grid.27255.37</institution-id>
<institution>Department of Stomatology, Jinan Central Hospital,</institution>
<institution>Shandong University,</institution>
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Jinan, 250013 P.R. China</aff>
<aff id="Aff2"><label>2</label>
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Sensengasse 2a, 1090 Vienna, Austria</aff>
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<pub-date pub-type="epub"><day>1</day>
<month>8</month>
<year>2017</year>
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<month>8</month>
<year>2017</year>
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<volume>7</volume>
<elocation-id>7027</elocation-id>
<history><date date-type="received"><day>27</day>
<month>3</month>
<year>2017</year>
</date>
<date date-type="accepted"><day>21</day>
<month>6</month>
<year>2017</year>
</date>
</history>
<permissions><copyright-statement>© The Author(s) 2017</copyright-statement>
<license license-type="OpenAccess"><license-p><bold>Open Access</bold>
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<abstract id="Abs1"><p id="Par1">Peri-implant disease is a chronic inflammation of the soft and hard tissues around a dental implant, resulting from bacterial infection. Recent evidence indicates that some pro-inflammatory cytokines and chemokines released by immunocytes are substantially responsible for the progress and consequence of inflammation. High mobility group box 1 (HMGB1) is released into the extracellular matrix and acts as a key pro-inflammatory factor during injury, necrosis and inflammation. A higher concentration of HMGB1 has been found in gingival crevicular fluid from inflammatory gingival tissue than from healthy sites. HMGB1 mRNA and protein are overexpressed in murine periodontal ligament fibroblasts stimulated with lipopolysaccharide (LPS) and IL-1β. Thus, this study sought to assess HMGB1 expression in peri-implant crevicular fluid (PICF) at each stage of peri-implant disease and to investigate the correlation between HMGB1 and peri-implant disease progress. The results demonstrated that the HMGB1 expression level in PICF is indicative of the progress of peri-implant disease and hence may be a useful diagnostic and prognostic biomarker for peri-implant tissue.</p>
</abstract>
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