First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells
Identifieur interne : 006302 ( Ncbi/Merge ); précédent : 006301; suivant : 006303First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells
Auteurs : Wataru Katagiri [Japon] ; Masashi Osugi [Japon] ; Takamasa Kawai [Japon] ; Hideharu Hibi [Japon]Source :
- Head & Face Medicine [ 1746-160X ] ; 2016.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Biopsie, Cellules cultivées, Femelle, Humains, Implants dentaires, Lambeaux chirurgicaux, Membrane artificielle, Mâchoire partiellement édentée (), Mâchoire partiellement édentée (anatomopathologie), Mâle, Parodontite (), Pose d'implant dentaire endo-osseux (), Processus alvéolaire (anatomopathologie), Radiographie panoramique, Reconstruction de crête alvéolaire (), Régénération osseuse, Régénération tissulaire guidée (), Résultat thérapeutique, Structures d'échafaudage tissulaires, Sujet âgé, Sélection de patients, Test ELISA, Tomodensitométrie.
- MESH :
- anatomopathologie : Mâchoire partiellement édentée, Processus alvéolaire.
- Adulte d'âge moyen, Biopsie, Cellules cultivées, Femelle, Humains, Implants dentaires, Lambeaux chirurgicaux, Membrane artificielle, Mâchoire partiellement édentée, Mâle, Parodontite, Pose d'implant dentaire endo-osseux, Radiographie panoramique, Reconstruction de crête alvéolaire, Régénération osseuse, Régénération tissulaire guidée, Résultat thérapeutique, Structures d'échafaudage tissulaires, Sujet âgé, Sélection de patients, Test ELISA, Tomodensitométrie.
English descriptors
- KwdEn :
- Aged, Alveolar Process (pathology), Alveolar Ridge Augmentation (methods), Biopsy, Bone Regeneration, Cells, Cultured, Dental Implantation, Endosseous (methods), Dental Implants, Enzyme-Linked Immunosorbent Assay, Female, Guided Tissue Regeneration (methods), Humans, Jaw, Edentulous, Partially (pathology), Jaw, Edentulous, Partially (surgery), Male, Membranes, Artificial, Middle Aged, Patient Selection, Periodontitis (complications), Radiography, Panoramic, Surgical Flaps, Tissue Scaffolds, Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- chemical : Dental Implants, Membranes, Artificial.
- complications : Periodontitis.
- methods : Alveolar Ridge Augmentation, Dental Implantation, Endosseous, Guided Tissue Regeneration.
- pathology : Alveolar Process, Jaw, Edentulous, Partially.
- surgery : Jaw, Edentulous, Partially.
- Aged, Biopsy, Bone Regeneration, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Patient Selection, Radiography, Panoramic, Surgical Flaps, Tissue Scaffolds, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.
The protocol of this clinical study was approved by the ethics committee of Nagoya University Hospital. MSC-CM was prepared from conditioned medium from commercially available human bone marrow-derived MSCs. Patients were treated with beta-tricalcuim phosphate (β-TCP) or an atelocollagen sponge soaked with MSC-CM. Clinical and radiographic assessments were performed during the follow-up period. Histological assessments were also performed in some cases. Clinical and histological data from patients who underwent the SFE procedure without MSC-CM were also used retrospectively as reference controls.
MSC-CM contained several cytokines such as insulin-like growth factor-1, vascular endothelial growth factor, transforming growth factor-β1, and hepatocyte growth factor in relatively low amounts. No systemic or local complications were reported throughout the study. Radiographic evaluation revealed early bone formation in all cases. Histological evaluation also supported the radiographic findings. Furthermore, infiltration of inflammatory cells was scarce throughout the specimens.
MSC-CM was used safely and with less inflammatory signs and appears to have great osteogenic potential for regenerative medicine of bone. This is the first in-human clinical study of alveolar bone regeneration using MSC-CM.
Url:
DOI: 10.1186/s13005-016-0101-5
PubMed: 26772731
PubMed Central: 4714459
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<term>Alveolar Ridge Augmentation (methods)</term>
<term>Biopsy</term>
<term>Bone Regeneration</term>
<term>Cells, Cultured</term>
<term>Dental Implantation, Endosseous (methods)</term>
<term>Dental Implants</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Guided Tissue Regeneration (methods)</term>
<term>Humans</term>
<term>Jaw, Edentulous, Partially (pathology)</term>
<term>Jaw, Edentulous, Partially (surgery)</term>
<term>Male</term>
<term>Membranes, Artificial</term>
<term>Middle Aged</term>
<term>Patient Selection</term>
<term>Periodontitis (complications)</term>
<term>Radiography, Panoramic</term>
<term>Surgical Flaps</term>
<term>Tissue Scaffolds</term>
<term>Tomography, X-Ray Computed</term>
<term>Treatment Outcome</term>
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<term>Biopsie</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Lambeaux chirurgicaux</term>
<term>Membrane artificielle</term>
<term>Mâchoire partiellement édentée ()</term>
<term>Mâchoire partiellement édentée (anatomopathologie)</term>
<term>Mâle</term>
<term>Parodontite ()</term>
<term>Pose d'implant dentaire endo-osseux ()</term>
<term>Processus alvéolaire (anatomopathologie)</term>
<term>Radiographie panoramique</term>
<term>Reconstruction de crête alvéolaire ()</term>
<term>Régénération osseuse</term>
<term>Régénération tissulaire guidée ()</term>
<term>Résultat thérapeutique</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Sujet âgé</term>
<term>Sélection de patients</term>
<term>Test ELISA</term>
<term>Tomodensitométrie</term>
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<term>Membranes, Artificial</term>
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<term>Processus alvéolaire</term>
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<term>Dental Implantation, Endosseous</term>
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<term>Jaw, Edentulous, Partially</term>
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<term>Biopsy</term>
<term>Bone Regeneration</term>
<term>Cells, Cultured</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Selection</term>
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<term>Surgical Flaps</term>
<term>Tissue Scaffolds</term>
<term>Tomography, X-Ray Computed</term>
<term>Treatment Outcome</term>
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<term>Biopsie</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Lambeaux chirurgicaux</term>
<term>Membrane artificielle</term>
<term>Mâchoire partiellement édentée</term>
<term>Mâle</term>
<term>Parodontite</term>
<term>Pose d'implant dentaire endo-osseux</term>
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<term>Structures d'échafaudage tissulaires</term>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.</p>
</sec>
<sec><title>Methods</title>
<p>The protocol of this clinical study was approved by the ethics committee of Nagoya University Hospital. MSC-CM was prepared from conditioned medium from commercially available human bone marrow-derived MSCs. Patients were treated with beta-tricalcuim phosphate (β-TCP) or an atelocollagen sponge soaked with MSC-CM. Clinical and radiographic assessments were performed during the follow-up period. Histological assessments were also performed in some cases. Clinical and histological data from patients who underwent the SFE procedure without MSC-CM were also used retrospectively as reference controls.</p>
</sec>
<sec><title>Results</title>
<p>MSC-CM contained several cytokines such as insulin-like growth factor-1, vascular endothelial growth factor, transforming growth factor-β1, and hepatocyte growth factor in relatively low amounts. No systemic or local complications were reported throughout the study. Radiographic evaluation revealed early bone formation in all cases. Histological evaluation also supported the radiographic findings. Furthermore, infiltration of inflammatory cells was scarce throughout the specimens.</p>
</sec>
<sec><title>Conclusions</title>
<p>MSC-CM was used safely and with less inflammatory signs and appears to have great osteogenic potential for regenerative medicine of bone. This is the first in-human clinical study of alveolar bone regeneration using MSC-CM.</p>
</sec>
</div>
</front>
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<double pmid="26772731"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells</title>
<author><name sortKey="Katagiri, Wataru" sort="Katagiri, Wataru" uniqKey="Katagiri W" first="Wataru" last="Katagiri">Wataru Katagiri</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osugi, Masashi" sort="Osugi, Masashi" uniqKey="Osugi M" first="Masashi" last="Osugi">Masashi Osugi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kawai, Takamasa" sort="Kawai, Takamasa" uniqKey="Kawai T" first="Takamasa" last="Kawai">Takamasa Kawai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hibi, Hideharu" sort="Hibi, Hideharu" uniqKey="Hibi H" first="Hideharu" last="Hibi">Hideharu Hibi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
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<idno type="pmid">26772731</idno>
<idno type="pmc">4714459</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4714459</idno>
<idno type="RBID">PMC:4714459</idno>
<idno type="doi">10.1186/s13005-016-0101-5</idno>
<date when="2016">2016</date>
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<idno type="wicri:Area/Pmc/Checkpoint">000687</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000687</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells</title>
<author><name sortKey="Katagiri, Wataru" sort="Katagiri, Wataru" uniqKey="Katagiri W" first="Wataru" last="Katagiri">Wataru Katagiri</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Osugi, Masashi" sort="Osugi, Masashi" uniqKey="Osugi M" first="Masashi" last="Osugi">Masashi Osugi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kawai, Takamasa" sort="Kawai, Takamasa" uniqKey="Kawai T" first="Takamasa" last="Kawai">Takamasa Kawai</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hibi, Hideharu" sort="Hibi, Hideharu" uniqKey="Hibi H" first="Hideharu" last="Hibi">Hideharu Hibi</name>
<affiliation wicri:level="1"><nlm:aff id="Aff1">Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550 Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya</wicri:regionArea>
<wicri:noRegion>Nagoya</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Head & Face Medicine</title>
<idno type="eISSN">1746-160X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<front><div type="abstract" xml:lang="en"><sec><title>Background</title>
<p>Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.</p>
</sec>
<sec><title>Methods</title>
<p>The protocol of this clinical study was approved by the ethics committee of Nagoya University Hospital. MSC-CM was prepared from conditioned medium from commercially available human bone marrow-derived MSCs. Patients were treated with beta-tricalcuim phosphate (β-TCP) or an atelocollagen sponge soaked with MSC-CM. Clinical and radiographic assessments were performed during the follow-up period. Histological assessments were also performed in some cases. Clinical and histological data from patients who underwent the SFE procedure without MSC-CM were also used retrospectively as reference controls.</p>
</sec>
<sec><title>Results</title>
<p>MSC-CM contained several cytokines such as insulin-like growth factor-1, vascular endothelial growth factor, transforming growth factor-β1, and hepatocyte growth factor in relatively low amounts. No systemic or local complications were reported throughout the study. Radiographic evaluation revealed early bone formation in all cases. Histological evaluation also supported the radiographic findings. Furthermore, infiltration of inflammatory cells was scarce throughout the specimens.</p>
</sec>
<sec><title>Conclusions</title>
<p>MSC-CM was used safely and with less inflammatory signs and appears to have great osteogenic potential for regenerative medicine of bone. This is the first in-human clinical study of alveolar bone regeneration using MSC-CM.</p>
</sec>
</div>
</front>
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<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan. w-kat@med.nagoya-u.ac.jp.</nlm:affiliation>
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</author>
<author><name sortKey="Osugi, Masashi" sort="Osugi, Masashi" uniqKey="Osugi M" first="Masashi" last="Osugi">Masashi Osugi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550</wicri:regionArea>
<wicri:noRegion>466-8550</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kawai, Takamasa" sort="Kawai, Takamasa" uniqKey="Kawai T" first="Takamasa" last="Kawai">Takamasa Kawai</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550</wicri:regionArea>
<wicri:noRegion>466-8550</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hibi, Hideharu" sort="Hibi, Hideharu" uniqKey="Hibi H" first="Hideharu" last="Hibi">Hideharu Hibi</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550</wicri:regionArea>
<wicri:noRegion>466-8550</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Head & face medicine</title>
<idno type="eISSN">1746-160X</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Alveolar Process (pathology)</term>
<term>Alveolar Ridge Augmentation (methods)</term>
<term>Biopsy</term>
<term>Bone Regeneration</term>
<term>Cells, Cultured</term>
<term>Dental Implantation, Endosseous (methods)</term>
<term>Dental Implants</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Guided Tissue Regeneration (methods)</term>
<term>Humans</term>
<term>Jaw, Edentulous, Partially (pathology)</term>
<term>Jaw, Edentulous, Partially (surgery)</term>
<term>Male</term>
<term>Membranes, Artificial</term>
<term>Middle Aged</term>
<term>Patient Selection</term>
<term>Periodontitis (complications)</term>
<term>Radiography, Panoramic</term>
<term>Surgical Flaps</term>
<term>Tissue Scaffolds</term>
<term>Tomography, X-Ray Computed</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Lambeaux chirurgicaux</term>
<term>Membrane artificielle</term>
<term>Mâchoire partiellement édentée ()</term>
<term>Mâchoire partiellement édentée (anatomopathologie)</term>
<term>Mâle</term>
<term>Parodontite ()</term>
<term>Pose d'implant dentaire endo-osseux ()</term>
<term>Processus alvéolaire (anatomopathologie)</term>
<term>Radiographie panoramique</term>
<term>Reconstruction de crête alvéolaire ()</term>
<term>Régénération osseuse</term>
<term>Régénération tissulaire guidée ()</term>
<term>Résultat thérapeutique</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Sujet âgé</term>
<term>Sélection de patients</term>
<term>Test ELISA</term>
<term>Tomodensitométrie</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term>
<term>Membranes, Artificial</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Mâchoire partiellement édentée</term>
<term>Processus alvéolaire</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Periodontitis</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Alveolar Ridge Augmentation</term>
<term>Dental Implantation, Endosseous</term>
<term>Guided Tissue Regeneration</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Process</term>
<term>Jaw, Edentulous, Partially</term>
</keywords>
<keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous, Partially</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Biopsy</term>
<term>Bone Regeneration</term>
<term>Cells, Cultured</term>
<term>Enzyme-Linked Immunosorbent Assay</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Selection</term>
<term>Radiography, Panoramic</term>
<term>Surgical Flaps</term>
<term>Tissue Scaffolds</term>
<term>Tomography, X-Ray Computed</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Biopsie</term>
<term>Cellules cultivées</term>
<term>Femelle</term>
<term>Humains</term>
<term>Implants dentaires</term>
<term>Lambeaux chirurgicaux</term>
<term>Membrane artificielle</term>
<term>Mâchoire partiellement édentée</term>
<term>Mâle</term>
<term>Parodontite</term>
<term>Pose d'implant dentaire endo-osseux</term>
<term>Radiographie panoramique</term>
<term>Reconstruction de crête alvéolaire</term>
<term>Régénération osseuse</term>
<term>Régénération tissulaire guidée</term>
<term>Résultat thérapeutique</term>
<term>Structures d'échafaudage tissulaires</term>
<term>Sujet âgé</term>
<term>Sélection de patients</term>
<term>Test ELISA</term>
<term>Tomodensitométrie</term>
</keywords>
</textClass>
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<front><div type="abstract" xml:lang="en">Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.</div>
</front>
</TEI>
</pubmed>
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