First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells.
Identifieur interne : 000242 ( PubMed/Corpus ); précédent : 000241; suivant : 000243First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells.
Auteurs : Wataru Katagiri ; Masashi Osugi ; Takamasa Kawai ; Hideharu HibiSource :
- Head & face medicine [ 1746-160X ] ; 2016.
English descriptors
- KwdEn :
- Aged, Alveolar Process (pathology), Alveolar Ridge Augmentation (methods), Biopsy, Bone Regeneration, Cells, Cultured, Dental Implantation, Endosseous (methods), Dental Implants, Enzyme-Linked Immunosorbent Assay, Female, Guided Tissue Regeneration (methods), Humans, Jaw, Edentulous, Partially (pathology), Jaw, Edentulous, Partially (surgery), Male, Membranes, Artificial, Middle Aged, Patient Selection, Periodontitis (complications), Radiography, Panoramic, Surgical Flaps, Tissue Scaffolds, Tomography, X-Ray Computed, Treatment Outcome.
- MESH :
- chemical : Dental Implants, Membranes, Artificial.
- complications : Periodontitis.
- methods : Alveolar Ridge Augmentation, Dental Implantation, Endosseous, Guided Tissue Regeneration.
- pathology : Alveolar Process, Jaw, Edentulous, Partially.
- surgery : Jaw, Edentulous, Partially.
- Aged, Biopsy, Bone Regeneration, Cells, Cultured, Enzyme-Linked Immunosorbent Assay, Female, Humans, Male, Middle Aged, Patient Selection, Radiography, Panoramic, Surgical Flaps, Tissue Scaffolds, Tomography, X-Ray Computed, Treatment Outcome.
Abstract
Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.
DOI: 10.1186/s13005-016-0101-5
PubMed: 26772731
Links to Exploration step
pubmed:26772731Le document en format XML
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uniqKey="Kawai T" first="Takamasa" last="Kawai">Takamasa Kawai</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hibi, Hideharu" sort="Hibi, Hideharu" uniqKey="Hibi H" first="Hideharu" last="Hibi">Hideharu Hibi</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:26772731</idno><idno type="pmid">26772731</idno><idno type="doi">10.1186/s13005-016-0101-5</idno><idno type="wicri:Area/PubMed/Corpus">000242</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000242</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells.</title><author><name sortKey="Katagiri, Wataru" sort="Katagiri, Wataru" uniqKey="Katagiri W" first="Wataru" last="Katagiri">Wataru Katagiri</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan. w-kat@med.nagoya-u.ac.jp.</nlm:affiliation></affiliation></author><author><name sortKey="Osugi, Masashi" sort="Osugi, Masashi" uniqKey="Osugi M" first="Masashi" last="Osugi">Masashi Osugi</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kawai, Takamasa" sort="Kawai, Takamasa" uniqKey="Kawai T" first="Takamasa" last="Kawai">Takamasa Kawai</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hibi, Hideharu" sort="Hibi, Hideharu" uniqKey="Hibi H" first="Hideharu" last="Hibi">Hideharu Hibi</name><affiliation><nlm:affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Head & face medicine</title><idno type="eISSN">1746-160X</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Alveolar Process (pathology)</term><term>Alveolar Ridge Augmentation (methods)</term><term>Biopsy</term><term>Bone Regeneration</term><term>Cells, Cultured</term><term>Dental Implantation, Endosseous (methods)</term><term>Dental Implants</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Guided Tissue Regeneration (methods)</term><term>Humans</term><term>Jaw, Edentulous, Partially (pathology)</term><term>Jaw, Edentulous, Partially (surgery)</term><term>Male</term><term>Membranes, Artificial</term><term>Middle Aged</term><term>Patient Selection</term><term>Periodontitis (complications)</term><term>Radiography, Panoramic</term><term>Surgical Flaps</term><term>Tissue Scaffolds</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Dental Implants</term><term>Membranes, Artificial</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Periodontitis</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Alveolar Ridge Augmentation</term><term>Dental Implantation, Endosseous</term><term>Guided Tissue Regeneration</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Alveolar Process</term><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous, Partially</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Biopsy</term><term>Bone Regeneration</term><term>Cells, Cultured</term><term>Enzyme-Linked Immunosorbent Assay</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Patient Selection</term><term>Radiography, Panoramic</term><term>Surgical Flaps</term><term>Tissue Scaffolds</term><term>Tomography, X-Ray Computed</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26772731</PMID><DateCompleted><Year>2016</Year><Month>10</Month><Day>10</Day></DateCompleted><DateRevised><Year>2017</Year><Month>09</Month><Day>24</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1746-160X</ISSN><JournalIssue CitedMedium="Internet"><Volume>12</Volume><PubDate><Year>2016</Year><Month>Jan</Month><Day>15</Day></PubDate></JournalIssue><Title>Head & face medicine</Title><ISOAbbreviation>Head Face Med</ISOAbbreviation></Journal><ArticleTitle>First-in-human study and clinical case reports of the alveolar bone regeneration with the secretome from human mesenchymal stem cells.</ArticleTitle><Pagination><MedlinePgn>5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13005-016-0101-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Secreted growth factors and cytokines in the conditioned medium from bone marrow-derived mesenchymal stem cells (MSC-CM) have several effects on cell behavior. Our previous studies revealed that MSC-CM enhances bone regeneration by increasing cell mobilization, angiogenesis, and osteogenesis in vitro and in vivo. This clinical study was undertaken to evaluate the safety and use of MSC-CM for alveolar bone regeneration in eight patients who were diagnosed as needing bone augmentation prior to dental implant placement.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The protocol of this clinical study was approved by the ethics committee of Nagoya University Hospital. MSC-CM was prepared from conditioned medium from commercially available human bone marrow-derived MSCs. Patients were treated with beta-tricalcium phosphate (β-TCP) or an atelocollagen sponge soaked with MSC-CM. Clinical and radiographic assessments were performed during the follow-up period. Histological assessments were also performed in some cases. Clinical and histological data from patients who underwent the SFE procedure without MSC-CM were also used retrospectively as reference controls.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">MSC-CM contained several cytokines such as insulin-like growth factor-1, vascular endothelial growth factor, transforming growth factor-β1, and hepatocyte growth factor in relatively low amounts. No systemic or local complications were reported throughout the study. Radiographic evaluation revealed early bone formation in all cases. Histological evaluation also supported the radiographic findings. Furthermore, infiltration of inflammatory cells was scarce throughout the specimens.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">MSC-CM was used safely and with less inflammatory signs and appears to have great osteogenic potential for regenerative medicine of bone. This is the first in-human clinical study of alveolar bone regeneration using MSC-CM.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Katagiri</LastName><ForeName>Wataru</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan. w-kat@med.nagoya-u.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Osugi</LastName><ForeName>Masashi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kawai</LastName><ForeName>Takamasa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hibi</LastName><ForeName>Hideharu</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, 466-8550, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>01</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Head Face Med</MedlineTA><NlmUniqueID>101245792</NlmUniqueID><ISSNLinking>1746-160X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental Implants</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008567">Membranes, Artificial</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="Cites"><RefSource>Int J Oral Maxillofac Implants. 2013 Jul-Aug;28(4):1009-16</RefSource><PMID Version="1">23869359</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Bone Miner Res. 2010 Nov;25(11):2447-59</RefSource><PMID Version="1">20499340</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Oral Maxillofac Surg. 2008 Apr;66(4):616-24</RefSource><PMID Version="1">18355584</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Bone. 1998 Sep;23(3):223-31</RefSource><PMID Version="1">9737344</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Tissue Eng Part A. 2008 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MajorTopicYN="N">Alveolar Ridge Augmentation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001706" MajorTopicYN="N">Biopsy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001861" MajorTopicYN="Y">Bone Regeneration</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003758" MajorTopicYN="N">Dental Implantation, Endosseous</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="Y">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004797" MajorTopicYN="N">Enzyme-Linked Immunosorbent Assay</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D048091" MajorTopicYN="N">Guided Tissue Regeneration</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007576" MajorTopicYN="N">Jaw, Edentulous, Partially</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008567" MajorTopicYN="N">Membranes, Artificial</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018579" MajorTopicYN="N">Patient Selection</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010518" MajorTopicYN="N">Periodontitis</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011862" MajorTopicYN="N">Radiography, Panoramic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013524" MajorTopicYN="N">Surgical Flaps</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054457" MajorTopicYN="N">Tissue Scaffolds</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014057" MajorTopicYN="N">Tomography, X-Ray Computed</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4714459</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>06</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>01</Month><Day>12</Day></PubMedPubDate><PubMedPubDate 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