Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial
Identifieur interne : 006192 ( Ncbi/Merge ); précédent : 006191; suivant : 006193Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial
Auteurs : Abbas Javadzadeh Bolouri ; Atessa Pakfetrat ; Arghavan Tonkaboni ; Seyed Amir Aledavood ; Mohsen Fathi Najafi ; Zahra Delavarian ; Mohammad Taghi Shakeri ; Azade MohtashamiSource :
- Iranian Journal of Cancer Prevention [ 2008-2398 ] ; 2015.
Abstract
Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients.
Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer.
In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading.
We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05).
This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis.
Url:
DOI: 10.17795/ijcp-4019
PubMed: 26634113
PubMed Central: 4667229
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<author><name sortKey="Pakfetrat, Atessa" sort="Pakfetrat, Atessa" uniqKey="Pakfetrat A" first="Atessa" last="Pakfetrat">Atessa Pakfetrat</name>
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<author><name sortKey="Tonkaboni, Arghavan" sort="Tonkaboni, Arghavan" uniqKey="Tonkaboni A" first="Arghavan" last="Tonkaboni">Arghavan Tonkaboni</name>
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<author><name sortKey="Aledavood, Seyed Amir" sort="Aledavood, Seyed Amir" uniqKey="Aledavood S" first="Seyed Amir" last="Aledavood">Seyed Amir Aledavood</name>
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<author><name sortKey="Fathi Najafi, Mohsen" sort="Fathi Najafi, Mohsen" uniqKey="Fathi Najafi M" first="Mohsen" last="Fathi Najafi">Mohsen Fathi Najafi</name>
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<author><name sortKey="Shakeri, Mohammad Taghi" sort="Shakeri, Mohammad Taghi" uniqKey="Shakeri M" first="Mohammad Taghi" last="Shakeri">Mohammad Taghi Shakeri</name>
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<author><name sortKey="Mohtashami, Azade" sort="Mohtashami, Azade" uniqKey="Mohtashami A" first="Azade" last="Mohtashami">Azade Mohtashami</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial</title>
<author><name sortKey="Javadzadeh Bolouri, Abbas" sort="Javadzadeh Bolouri, Abbas" uniqKey="Javadzadeh Bolouri A" first="Abbas" last="Javadzadeh Bolouri">Abbas Javadzadeh Bolouri</name>
<affiliation><nlm:aff id="aff1">Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Pakfetrat, Atessa" sort="Pakfetrat, Atessa" uniqKey="Pakfetrat A" first="Atessa" last="Pakfetrat">Atessa Pakfetrat</name>
<affiliation><nlm:aff id="aff1">Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Tonkaboni, Arghavan" sort="Tonkaboni, Arghavan" uniqKey="Tonkaboni A" first="Arghavan" last="Tonkaboni">Arghavan Tonkaboni</name>
<affiliation><nlm:aff id="aff2">Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Aledavood, Seyed Amir" sort="Aledavood, Seyed Amir" uniqKey="Aledavood S" first="Seyed Amir" last="Aledavood">Seyed Amir Aledavood</name>
<affiliation><nlm:aff id="aff3">Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fathi Najafi, Mohsen" sort="Fathi Najafi, Mohsen" uniqKey="Fathi Najafi M" first="Mohsen" last="Fathi Najafi">Mohsen Fathi Najafi</name>
<affiliation><nlm:aff id="aff4">Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Delavarian, Zahra" sort="Delavarian, Zahra" uniqKey="Delavarian Z" first="Zahra" last="Delavarian">Zahra Delavarian</name>
<affiliation><nlm:aff id="aff5">Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shakeri, Mohammad Taghi" sort="Shakeri, Mohammad Taghi" uniqKey="Shakeri M" first="Mohammad Taghi" last="Shakeri">Mohammad Taghi Shakeri</name>
<affiliation><nlm:aff id="aff6">Department of Community Med and Public Health, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Mohtashami, Azade" sort="Mohtashami, Azade" uniqKey="Mohtashami A" first="Azade" last="Mohtashami">Azade Mohtashami</name>
<affiliation><nlm:aff id="aff3">Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran</nlm:aff>
<wicri:noCountry code="subfield">IR Iran</wicri:noCountry>
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<series><title level="j">Iranian Journal of Cancer Prevention</title>
<idno type="ISSN">2008-2398</idno>
<idno type="eISSN">2008-2401</idno>
<imprint><date when="2015">2015</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Background:</title>
<p>Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients.</p>
</sec>
<sec><title>Objectives:</title>
<p>Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer.</p>
</sec>
<sec><title>Patients and Methods:</title>
<p>In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading.</p>
</sec>
<sec><title>Results:</title>
<p>We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05).</p>
</sec>
<sec><title>Conclusions:</title>
<p>This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Little, Jw" uniqKey="Little J">JW Little</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stewart, Bw" uniqKey="Stewart B">BW Stewart</name>
</author>
<author><name sortKey="Kleihues, P" uniqKey="Kleihues P">P Kleihues</name>
</author>
<author><name sortKey="International Agency For Research On Cancer" uniqKey="International Agency For Research On Cancer">International Agency for Research on Cancer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Silveira, A" uniqKey="Silveira A">A Silveira</name>
</author>
<author><name sortKey="Goncalves, J" uniqKey="Goncalves J">J Gonçalves</name>
</author>
<author><name sortKey="Sequeira, T" uniqKey="Sequeira T">T Sequeira</name>
</author>
<author><name sortKey="Ribeiro, C" uniqKey="Ribeiro C">C Ribeiro</name>
</author>
<author><name sortKey="Lopes, C" uniqKey="Lopes C">C Lopes</name>
</author>
<author><name sortKey="Monteiro, E" uniqKey="Monteiro E">E Monteiro</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petersen, Pe" uniqKey="Petersen P">PE Petersen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scully, C" uniqKey="Scully C">C Scully</name>
</author>
<author><name sortKey="Epstein, Jb" uniqKey="Epstein J">JB Epstein</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vissink, A" uniqKey="Vissink A">A Vissink</name>
</author>
<author><name sortKey="Burlage, Fr" uniqKey="Burlage F">FR Burlage</name>
</author>
<author><name sortKey="Spijkervet, Fkl" uniqKey="Spijkervet F">FKL Spijkervet</name>
</author>
<author><name sortKey="Jansma, J" uniqKey="Jansma J">J Jansma</name>
</author>
<author><name sortKey="Coppes, Rp" uniqKey="Coppes R">RP Coppes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Suemaru, K" uniqKey="Suemaru K">K Suemaru</name>
</author>
<author><name sortKey="Cui, R" uniqKey="Cui R">R Cui</name>
</author>
<author><name sortKey="Li, B" uniqKey="Li B">B Li</name>
</author>
<author><name sortKey="Watanabe, S" uniqKey="Watanabe S">S Watanabe</name>
</author>
<author><name sortKey="Okihara, K" uniqKey="Okihara K">K Okihara</name>
</author>
<author><name sortKey="Hashimoto, K" uniqKey="Hashimoto K">K Hashimoto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berger, Am" uniqKey="Berger A">AM Berger</name>
</author>
<author><name sortKey="Fall Dickson Jane, M" uniqKey="Fall Dickson Jane M">M Fall-Dickson Jane</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Burket, Lw" uniqKey="Burket L">LW Burket</name>
</author>
<author><name sortKey="Greenberg, Ms" uniqKey="Greenberg M">MS Greenberg</name>
</author>
<author><name sortKey="Glick, M" uniqKey="Glick M">M Glick</name>
</author>
<author><name sortKey="Ship, Ja" uniqKey="Ship J">JA Ship</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Vera Llonch, M" uniqKey="Vera Llonch M">M Vera-Llonch</name>
</author>
<author><name sortKey="Oster, G" uniqKey="Oster G">G Oster</name>
</author>
<author><name sortKey="Hagiwara, M" uniqKey="Hagiwara M">M Hagiwara</name>
</author>
<author><name sortKey="Sonis, S" uniqKey="Sonis S">S Sonis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hall, Ej" uniqKey="Hall E">EJ Hall</name>
</author>
<author><name sortKey="Giaccia, Aj" uniqKey="Giaccia A">AJ Giaccia</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Farrell, Cl" uniqKey="Farrell C">CL Farrell</name>
</author>
<author><name sortKey="Bready, Jv" uniqKey="Bready J">JV Bready</name>
</author>
<author><name sortKey="Rex, Kl" uniqKey="Rex K">KL Rex</name>
</author>
<author><name sortKey="Chen, Jn" uniqKey="Chen J">JN Chen</name>
</author>
<author><name sortKey="Dipalma, Cr" uniqKey="Dipalma C">CR DiPalma</name>
</author>
<author><name sortKey="Whitcomb, Kl" uniqKey="Whitcomb K">KL Whitcomb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Khalil, Ml" uniqKey="Khalil M">ML Khalil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kukreja, B" uniqKey="Kukreja B">B Kukreja</name>
</author>
<author><name sortKey="Dodwad, V" uniqKey="Dodwad V">V Dodwad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Scheller, S" uniqKey="Scheller S">S Scheller</name>
</author>
<author><name sortKey="Gazda, G" uniqKey="Gazda G">G Gazda</name>
</author>
<author><name sortKey="Krol, W" uniqKey="Krol W">W Krol</name>
</author>
<author><name sortKey="Czuba, Z" uniqKey="Czuba Z">Z Czuba</name>
</author>
<author><name sortKey="Zajusz, A" uniqKey="Zajusz A">A Zajusz</name>
</author>
<author><name sortKey="Gabrys, J" uniqKey="Gabrys J">J Gabrys</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Orsolic, N" uniqKey="Orsolic N">N Orsolic</name>
</author>
<author><name sortKey="Benkovic, V" uniqKey="Benkovic V">V Benkovic</name>
</author>
<author><name sortKey="Horvat Knezevic, A" uniqKey="Horvat Knezevic A">A Horvat-Knezevic</name>
</author>
<author><name sortKey="Kopjar, N" uniqKey="Kopjar N">N Kopjar</name>
</author>
<author><name sortKey="Kosalec, I" uniqKey="Kosalec I">I Kosalec</name>
</author>
<author><name sortKey="Bakmaz, M" uniqKey="Bakmaz M">M Bakmaz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="You, Wc" uniqKey="You W">WC You</name>
</author>
<author><name sortKey="Hsieh, Cc" uniqKey="Hsieh C">CC Hsieh</name>
</author>
<author><name sortKey="Huang, Jt" uniqKey="Huang J">JT Huang</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lee, Sh" uniqKey="Lee S">SH Lee</name>
</author>
<author><name sortKey="Kim, Th" uniqKey="Kim T">TH Kim</name>
</author>
<author><name sortKey="Kim, Jy" uniqKey="Kim J">JY Kim</name>
</author>
<author><name sortKey="Park, Sy" uniqKey="Park S">SY Park</name>
</author>
<author><name sortKey="Pyo, Hr" uniqKey="Pyo H">HR Pyo</name>
</author>
<author><name sortKey="Shin, Kh" uniqKey="Shin K">KH Shin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benderli Cihan, Y" uniqKey="Benderli Cihan Y">Y Benderli Cihan</name>
</author>
<author><name sortKey="Deniz, K" uniqKey="Deniz K">K Deniz</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ghassemi, L" uniqKey="Ghassemi L">L Ghassemi</name>
</author>
<author><name sortKey="Zabihi, E" uniqKey="Zabihi E">E Zabihi</name>
</author>
<author><name sortKey="Mahdavi, R" uniqKey="Mahdavi R">R Mahdavi</name>
</author>
<author><name sortKey="Seyedmajidi, M" uniqKey="Seyedmajidi M">M Seyedmajidi</name>
</author>
<author><name sortKey="Akram, S" uniqKey="Akram S">S Akram</name>
</author>
<author><name sortKey="Motallebnejad, M" uniqKey="Motallebnejad M">M Motallebnejad</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Olaitan, Pb" uniqKey="Olaitan P">PB Olaitan</name>
</author>
<author><name sortKey="Adeleke, Oe" uniqKey="Adeleke O">OE Adeleke</name>
</author>
<author><name sortKey="Ola, Io" uniqKey="Ola I">IO Ola</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benkovic, V" uniqKey="Benkovic V">V Benkovic</name>
</author>
<author><name sortKey="Orsolic, N" uniqKey="Orsolic N">N Orsolic</name>
</author>
<author><name sortKey="Knezevic, Ah" uniqKey="Knezevic A">AH Knezevic</name>
</author>
<author><name sortKey="Ramic, S" uniqKey="Ramic S">S Ramic</name>
</author>
<author><name sortKey="Dikic, D" uniqKey="Dikic D">D Dikic</name>
</author>
<author><name sortKey="Basic, I" uniqKey="Basic I">I Basic</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benkovic, V" uniqKey="Benkovic V">V Benkovic</name>
</author>
<author><name sortKey="Knezevic, Ah" uniqKey="Knezevic A">AH Knezevic</name>
</author>
<author><name sortKey="Dikic, D" uniqKey="Dikic D">D Dikic</name>
</author>
<author><name sortKey="Lisicic, D" uniqKey="Lisicic D">D Lisicic</name>
</author>
<author><name sortKey="Orsolic, N" uniqKey="Orsolic N">N Orsolic</name>
</author>
<author><name sortKey="Basic, I" uniqKey="Basic I">I Basic</name>
</author>
</analytic>
</biblStruct>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Iran J Cancer Prev</journal-id>
<journal-id journal-id-type="iso-abbrev">Iran J Cancer Prev</journal-id>
<journal-id journal-id-type="doi">10.17795/ijcp</journal-id>
<journal-id journal-id-type="publisher-id">Shahid Beheshti University of Medical Sciences</journal-id>
<journal-title-group><journal-title>Iranian Journal of Cancer Prevention</journal-title>
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<issn pub-type="ppub">2008-2398</issn>
<issn pub-type="epub">2008-2401</issn>
<publisher><publisher-name>Shahid Beheshti University of Medical Sciences</publisher-name>
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<article-meta><article-id pub-id-type="pmid">26634113</article-id>
<article-id pub-id-type="pmc">4667229</article-id>
<article-id pub-id-type="doi">10.17795/ijcp-4019</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
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<title-group><article-title>Preventing and Therapeutic Effect of Propolis in Radiotherapy Induced Mucositis of Head and Neck Cancers: A Triple-Blind, Randomized, Placebo-Controlled Trial</article-title>
</title-group>
<contrib-group><contrib id="idp190976" contrib-type="author"><name><surname>Javadzadeh Bolouri</surname>
<given-names>Abbas</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
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<contrib id="idp193856" contrib-type="author"><name><surname>Pakfetrat</surname>
<given-names>Atessa</given-names>
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<xref ref-type="aff" rid="aff1">1</xref>
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<contrib id="idp194656" contrib-type="author"><name><surname>Tonkaboni</surname>
<given-names>Arghavan</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="corresp" rid="idp122080">*</xref>
</contrib>
<contrib id="idp195296" contrib-type="author"><name><surname>Aledavood</surname>
<given-names>Seyed Amir</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib id="idp195936" contrib-type="author"><name><surname>Fathi Najafi</surname>
<given-names>Mohsen</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib id="idp196576" contrib-type="author"><name><surname>Delavarian</surname>
<given-names>Zahra</given-names>
</name>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib id="idp197216" contrib-type="author"><name><surname>Shakeri</surname>
<given-names>Mohammad Taghi</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib id="idp197856" contrib-type="author"><name><surname>Mohtashami</surname>
<given-names>Azade</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Department of Oral Medicine, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran</aff>
<aff id="aff2"><label>2</label>
Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran</aff>
<aff id="aff3"><label>3</label>
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran</aff>
<aff id="aff4"><label>4</label>
Department of Veterinary Research and Biotechnology, Razi Vaccine and Serum Research Institute, Mashhad, IR Iran</aff>
<aff id="aff5"><label>5</label>
Department of Oral Medicine, Oral and Maxillofacial Diseases Research Center, Faculty of Dentistry, Mashhad University of Medical Sciences, Mashhad, IR Iran</aff>
<aff id="aff6"><label>6</label>
Department of Community Med and Public Health, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, IR Iran</aff>
<author-notes><corresp id="idp122080"><label>*</label>
Corresponding author: Arghavan Tonkaboni, Department of Oral Medicine, School of Dentistry, Tehran University of Medical Sciences, Tehran, IR Iran. Tel: +98-9123802173; +98-2155851141, Fax: +98-2166525925, E-mail: <email>a.tonkaboni@yahoo.com</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>27</day>
<month>10</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2015</year>
</pub-date>
<volume>8</volume>
<issue>5</issue>
<elocation-id>e4019</elocation-id>
<history><date date-type="received"><day>07</day>
<month>9</month>
<year>2015</year>
</date>
<date date-type="accepted"><day>22</day>
<month>9</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015, Iranian Journal of Cancer Prevention.</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>
) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited.</license-p>
</license>
</permissions>
<abstract><sec><title>Background:</title>
<p>Mucositis is one of the acute complications of radiotherapy which can ulcerate oral mucosa and cause severe pain and discomfort which can affect oral normal function. Propolis is a natural source of flavenoid which has antiulcer, antibacterial, antifungal, healing and anti-inflammatory effects. Using such an affordable compound without any bad smell or taste that has reasonable price can help the radiotherapy undergoing patients.</p>
</sec>
<sec><title>Objectives:</title>
<p>Our goal is assessing the preventing and therapeutic effect of propolis in radiotherapy induced mucositis in patients with head and neck cancer.</p>
</sec>
<sec><title>Patients and Methods:</title>
<p>In a randomized triple blind clinical trial, 20 patient were selected randomly to swish and swallow 15 ml of water based extract of propolis mouth wash 3 times a day in the case group (n = 10) and 15 ml placebo mouth wash in control group (n = 10). we use NIC-CTC scale for determining mucositis grading.</p>
</sec>
<sec><title>Results:</title>
<p>We use T-test, Man-Whitney, Chi-square, and Friedman as analyzing tests. Case group had significantly (P < 0.05) lower grade of mucositis in all of the follow-ups, but xerostomia is not significantly different in two groups (P > 0.05).</p>
</sec>
<sec><title>Conclusions:</title>
<p>This is a pilot study which shows water based extract of propolis efficiently prevents and heals radiotherapy induced mucositis.</p>
</sec>
</abstract>
<kwd-group kwd-group-type="author"><kwd>Cancer</kwd>
<kwd>Mouthwashes</kwd>
<kwd>Mucositis</kwd>
<kwd>Propolis</kwd>
<kwd>Radiotherapy</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Aledavood, Seyed Amir" sort="Aledavood, Seyed Amir" uniqKey="Aledavood S" first="Seyed Amir" last="Aledavood">Seyed Amir Aledavood</name>
<name sortKey="Delavarian, Zahra" sort="Delavarian, Zahra" uniqKey="Delavarian Z" first="Zahra" last="Delavarian">Zahra Delavarian</name>
<name sortKey="Fathi Najafi, Mohsen" sort="Fathi Najafi, Mohsen" uniqKey="Fathi Najafi M" first="Mohsen" last="Fathi Najafi">Mohsen Fathi Najafi</name>
<name sortKey="Javadzadeh Bolouri, Abbas" sort="Javadzadeh Bolouri, Abbas" uniqKey="Javadzadeh Bolouri A" first="Abbas" last="Javadzadeh Bolouri">Abbas Javadzadeh Bolouri</name>
<name sortKey="Mohtashami, Azade" sort="Mohtashami, Azade" uniqKey="Mohtashami A" first="Azade" last="Mohtashami">Azade Mohtashami</name>
<name sortKey="Pakfetrat, Atessa" sort="Pakfetrat, Atessa" uniqKey="Pakfetrat A" first="Atessa" last="Pakfetrat">Atessa Pakfetrat</name>
<name sortKey="Shakeri, Mohammad Taghi" sort="Shakeri, Mohammad Taghi" uniqKey="Shakeri M" first="Mohammad Taghi" last="Shakeri">Mohammad Taghi Shakeri</name>
<name sortKey="Tonkaboni, Arghavan" sort="Tonkaboni, Arghavan" uniqKey="Tonkaboni A" first="Arghavan" last="Tonkaboni">Arghavan Tonkaboni</name>
</noCountry>
</tree>
</affiliations>
</record>
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