Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study
Identifieur interne : 006059 ( Ncbi/Merge ); précédent : 006058; suivant : 006060Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study
Auteurs : Nam-Ho Kim [Corée du Sud] ; So-Hyoun Lee [Corée du Sud] ; Jae-Jun Ryu [Corée du Sud] ; Kyung-Hee Choi [Corée du Sud] ; Jung-Bo Huh [Corée du Sud]Source :
- BioMed Research International [ 2314-6133 ] ; 2015.
Abstract
This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design.
Url:
DOI: 10.1155/2015/459393
PubMed: 26504807
PubMed Central: 4609358
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study</title><author><name sortKey="Kim, Nam Ho" sort="Kim, Nam Ho" uniqKey="Kim N" first="Nam-Ho" last="Kim">Nam-Ho Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705</wicri:regionArea><wicri:noRegion>Seongbuk-gu 136-705</wicri:noRegion></affiliation></author><author><name sortKey="Lee, So Hyoun" sort="Lee, So Hyoun" uniqKey="Lee S" first="So-Hyoun" last="Lee">So-Hyoun Lee</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870</wicri:regionArea><wicri:noRegion>Yangsan 676-870</wicri:noRegion></affiliation></author><author><name sortKey="Ryu, Jae Jun" sort="Ryu, Jae Jun" uniqKey="Ryu J" first="Jae-Jun" last="Ryu">Jae-Jun Ryu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705</wicri:regionArea><wicri:noRegion>Seongbuk-gu 136-705</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Kyung Hee" sort="Choi, Kyung Hee" uniqKey="Choi K" first="Kyung-Hee" last="Choi">Kyung-Hee Choi</name><affiliation wicri:level="1"><nlm:aff id="I3">Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801</wicri:regionArea><wicri:noRegion>Busan 617-801</wicri:noRegion></affiliation></author><author><name sortKey="Huh, Jung Bo" sort="Huh, Jung Bo" uniqKey="Huh J" first="Jung-Bo" last="Huh">Jung-Bo Huh</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870</wicri:regionArea><wicri:noRegion>Yangsan 676-870</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26504807</idno><idno type="pmc">4609358</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609358</idno><idno type="RBID">PMC:4609358</idno><idno type="doi">10.1155/2015/459393</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002905</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002905</idno><idno type="wicri:Area/Pmc/Curation">002905</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002905</idno><idno type="wicri:Area/Pmc/Checkpoint">000E34</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000E34</idno><idno type="wicri:Area/Ncbi/Merge">006059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study</title><author><name sortKey="Kim, Nam Ho" sort="Kim, Nam Ho" uniqKey="Kim N" first="Nam-Ho" last="Kim">Nam-Ho Kim</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705</wicri:regionArea><wicri:noRegion>Seongbuk-gu 136-705</wicri:noRegion></affiliation></author><author><name sortKey="Lee, So Hyoun" sort="Lee, So Hyoun" uniqKey="Lee S" first="So-Hyoun" last="Lee">So-Hyoun Lee</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870</wicri:regionArea><wicri:noRegion>Yangsan 676-870</wicri:noRegion></affiliation></author><author><name sortKey="Ryu, Jae Jun" sort="Ryu, Jae Jun" uniqKey="Ryu J" first="Jae-Jun" last="Ryu">Jae-Jun Ryu</name><affiliation wicri:level="1"><nlm:aff id="I1">Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705</wicri:regionArea><wicri:noRegion>Seongbuk-gu 136-705</wicri:noRegion></affiliation></author><author><name sortKey="Choi, Kyung Hee" sort="Choi, Kyung Hee" uniqKey="Choi K" first="Kyung-Hee" last="Choi">Kyung-Hee Choi</name><affiliation wicri:level="1"><nlm:aff id="I3">Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801</wicri:regionArea><wicri:noRegion>Busan 617-801</wicri:noRegion></affiliation></author><author><name sortKey="Huh, Jung Bo" sort="Huh, Jung Bo" uniqKey="Huh J" first="Jung-Bo" last="Huh">Jung-Bo Huh</name><affiliation wicri:level="1"><nlm:aff id="I2">Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea</nlm:aff><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870</wicri:regionArea><wicri:noRegion>Yangsan 676-870</wicri:noRegion></affiliation></author></analytic><series><title level="j">BioMed Research International</title><idno type="ISSN">2314-6133</idno><idno type="eISSN">2314-6141</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design. <italic>Methods</italic>. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1 mg/mL). After assessment of surface characteristics and rhBMP-2 releasing profile, the experimental groups and untreated control groups (<italic>n</italic> = 6 in each group, two animals in each group) were placed in split-mouth designed animal models with buccal open defect. At 8 weeks after implant placement, implant stability quotients (ISQ) values were recorded and vertical bone height (VBH, mm), bone-to-implant contact ratio (BIC, %), and bone volume (BV, %) in the upper 3 mm defect areas were measured. <italic>Results</italic>. The ISQ values were highest in the 1.0 group. Mean values of VBH (mm), BIC (%), and BV (%) were greater in the 0.5 mg/mL and 1.0 mg/mL groups than those in 0.1 and control groups in buccal defect areas. <italic>Conclusion</italic>. In the open defect area surrounding the SLA implant, coating with 0.5 and 1.0 mg/mL concentrations of rhBMP-2 was more effective, compared with untreated group, in promoting bone regeneration and osseointegration.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Albrektsson, T" uniqKey="Albrektsson T">T. Albrektsson</name></author><author><name sortKey="Br Nemark, P I" uniqKey="Br Nemark P">P.-I. Brånemark</name></author><author><name sortKey="Hansson, H A" uniqKey="Hansson H">H.-A. Hansson</name></author><author><name sortKey="Lindstrom, J" uniqKey="Lindstrom J">J. Lindström</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Le Guehennec, L" uniqKey="Le Guehennec L">L. Le Guéhennec</name></author><author><name sortKey="Soueidan, A" uniqKey="Soueidan A">A. Soueidan</name></author><author><name sortKey="Layrolle, P" uniqKey="Layrolle P">P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Res Int</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Res Int</journal-id><journal-id journal-id-type="publisher-id">BMRI</journal-id><journal-title-group><journal-title>BioMed Research International</journal-title></journal-title-group><issn pub-type="ppub">2314-6133</issn><issn pub-type="epub">2314-6141</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26504807</article-id><article-id pub-id-type="pmc">4609358</article-id><article-id pub-id-type="doi">10.1155/2015/459393</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Effects of rhBMP-2 on Sandblasted and Acid Etched Titanium Implant Surfaces on Bone Regeneration and Osseointegration: Spilt-Mouth Designed Pilot Study</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Nam-Ho</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>So-Hyoun</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ryu</surname><given-names>Jae-Jun</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Choi</surname><given-names>Kyung-Hee</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Huh</surname><given-names>Jung-Bo</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Department of Dentistry, College of Medicine, Korea University, Anam-Dong 5-Ga, Seongbuk-gu 136-705, Republic of Korea</aff><aff id="I2"><sup>2</sup>Department of Prosthodontics, Dental Research Institute, Biomedical Research Institute, School of Dentistry, Pusan National University, Yangsan 676-870, Republic of Korea</aff><aff id="I3"><sup>3</sup>Research Development Institute, Cowellmedi Co., Ltd., Busan 617-801, Republic of Korea</aff><author-notes><corresp id="cor1">*Jung-Bo Huh: <email>huhjb@pusan.ac.kr</email></corresp><fn fn-type="other"><p>Academic Editor: Giuseppe Cama</p></fn></author-notes><pub-date pub-type="ppub"><year>2015</year></pub-date><pub-date pub-type="epub"><day>4</day><month>10</month><year>2015</year></pub-date><volume>2015</volume><elocation-id>459393</elocation-id><history><date date-type="received"><day>21</day><month>5</month><year>2015</year></date><date date-type="rev-recd"><day>14</day><month>7</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2015 Nam-Ho Kim et al.</copyright-statement><copyright-year>2015</copyright-year><license xlink:href="https://creativecommons.org/licenses/by/3.0/"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>This study was conducted to evaluate effects of rhBMP-2 applied at different concentrations to sandblasted and acid etched (SLA) implants on osseointegration and bone regeneration in a bone defect of beagle dogs as pilot study using split-mouth design. <italic>Methods</italic>. For experimental groups, SLA implants were coated with different concentrations of rhBMP-2 (0.1, 0.5, and 1 mg/mL). After assessment of surface characteristics and rhBMP-2 releasing profile, the experimental groups and untreated control groups (<italic>n</italic> = 6 in each group, two animals in each group) were placed in split-mouth designed animal models with buccal open defect. At 8 weeks after implant placement, implant stability quotients (ISQ) values were recorded and vertical bone height (VBH, mm), bone-to-implant contact ratio (BIC, %), and bone volume (BV, %) in the upper 3 mm defect areas were measured. <italic>Results</italic>. The ISQ values were highest in the 1.0 group. Mean values of VBH (mm), BIC (%), and BV (%) were greater in the 0.5 mg/mL and 1.0 mg/mL groups than those in 0.1 and control groups in buccal defect areas. <italic>Conclusion</italic>. In the open defect area surrounding the SLA implant, coating with 0.5 and 1.0 mg/mL concentrations of rhBMP-2 was more effective, compared with untreated group, in promoting bone regeneration and osseointegration.</p></abstract></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Experimental implant design and schematic diagram of the buccal open defect and mesial, distal, and lingual 1 mm defect models. Twenty-four implants (7.0 mm long and 3.5 mm in diameter; Cowellmedi Co., Busan, Korea) were made of pure titanium and were designed with a straight section on their upper 3 mm and broad threads on their lower 4 mm. A 5.5 mm diameter cover screw mounted on the implant.</p></caption><graphic xlink:href="BMRI2015-459393.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Surgical procedures. (a) Alveolar bone was flattened. (b) 5.5 mm width peri-implant defects were created using a trephine bur (Dentech, Tokyo). (c) The implant was placed within its prepared site, and peri-implant defect areas were covered using a 5.5 mm diameter cover screw.</p></caption><graphic xlink:href="BMRI2015-459393.002"></graphic></fig><fig id="fig3" orientation="portrait" position="float"><label>Figure 3</label><caption><p>SEM images of each group. (a, e) The control group, (b, f) the 0.1 group, (c, g) the 0.5 group, and (d, h) the 1.0 group. Asterisk: freeze dried rhBMP-2: (a, b, c, d) ×1000, (e, f, g, h) ×5000.</p></caption><graphic xlink:href="BMRI2015-459393.003"></graphic></fig><fig id="fig4" orientation="portrait" position="float"><label>Figure 4</label><caption><p>Release kinetics of rhBMP-2 in the three experimental groups. The 1.0 group showed a slower release tendency than the other groups, but all groups showed an initial burst release pattern.</p></caption><graphic xlink:href="BMRI2015-459393.004"></graphic></fig><fig id="fig5" orientation="portrait" position="float"><label>Figure 5</label><caption><p>Fluorescent images obtained using a confocal laser microscope. In the 0.5 and 1.0 groups, massive bone remodeling was also observed in the early stage, and this was maintained in the late stage.</p></caption><graphic xlink:href="BMRI2015-459393.005"></graphic></fig><fig id="fig6" orientation="portrait" position="float"><label>Figure 6</label><caption><p>Images of histological specimens of each group obtained at 8 weeks: control group (a, b, and c), 0.1 group (d, e, and f), 0.5 group (g, h, and i), and 1.0 group (j, k, and l). Buccal side (a, d, g, and j). Lingual side (c, f, i, and l). F: fibrous tissue; NB: newly formed bone; OB: old bone (central original magnification ×12.5, left and right sides: ×40 original magnification).</p></caption><graphic xlink:href="BMRI2015-459393.006"></graphic></fig><fig id="fig7" orientation="portrait" position="float"><label>Figure 7</label><caption><p>Parameters measured in histologic specimens: vertical bone height in the buccal open defect and lingual peri-implant defect areas (VBH, mm), bone-to-implant contact ratio for the upper 3 mm straight implant portions in buccal and lingual defect areas (BIC, red line, %), and bone volume in the buccal and lingual defect area (BV in yellow box, %).</p></caption><graphic xlink:href="BMRI2015-459393.007"></graphic></fig><table-wrap id="tab1" orientation="portrait" position="float"><label>Table 1</label><caption><p>Implant stability quotient (ISQ) values at 8 weeks after implantation.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Group</th><th align="center" rowspan="1" colspan="1">At surgery</th><th align="center" rowspan="1" colspan="1">At 8 weeks</th><th align="center" rowspan="1" colspan="1">ISQ change</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Control</td><td align="center" rowspan="1" colspan="1">46.83 ± 3.97</td><td align="center" rowspan="1" colspan="1">60.17 ± 3.25</td><td align="center" rowspan="1" colspan="1">13.33 ± 5.43</td></tr><tr><td align="left" rowspan="1" colspan="1">0.1</td><td align="center" rowspan="1" colspan="1">48.00 ± 4.00</td><td align="center" rowspan="1" colspan="1">64.83 ± 3.19</td><td align="center" rowspan="1" colspan="1">16.83 ± 4.67</td></tr><tr><td align="left" rowspan="1" colspan="1">0.5</td><td align="center" rowspan="1" colspan="1">49.83 ± 5.95</td><td align="center" rowspan="1" colspan="1">71.67 ± 6.15</td><td align="center" rowspan="1" colspan="1">19.83 ± 9.56</td></tr><tr><td align="left" rowspan="1" colspan="1">1.0</td><td align="center" rowspan="1" colspan="1">52.67 ± 7.61</td><td align="center" rowspan="1" colspan="1">72.00 ± 2.68</td><td align="center" rowspan="1" colspan="1">18.17 ± 6.94</td></tr></tbody></table><table-wrap-foot><fn><p>At surgery: ISQ value at surgery.</p></fn><fn><p>At week 8: ISQ value 8 weeks after implantation.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tab2" orientation="portrait" position="float"><label>Table 2</label><caption><p>Means (±SDs) of VBH (mm), BIC (%), and BV (%) of the upper 3 mm straight portion of implant in buccal and lingual defect areas at 8 weeks after implantation.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1">Group</th><th align="center" colspan="2" rowspan="1">VBH (mm)</th><th align="center" colspan="2" rowspan="1">BIC (%)</th><th align="center" colspan="2" rowspan="1">BV (%)</th></tr><tr><th align="center" rowspan="1" colspan="1">Buccal</th><th align="center" rowspan="1" colspan="1">Lingual</th><th align="center" rowspan="1" colspan="1">Buccal</th><th align="center" rowspan="1" colspan="1">Lingual</th><th align="center" rowspan="1" colspan="1">Buccal</th><th align="center" rowspan="1" colspan="1">Lingual</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Control</td><td align="center" rowspan="1" colspan="1">−0.02 ± 0.62</td><td align="center" rowspan="1" colspan="1">2.43 ± 0.29</td><td align="center" rowspan="1" colspan="1">0.67 ± 1.15</td><td align="center" rowspan="1" colspan="1">23.37 ± 7.08</td><td align="center" rowspan="1" colspan="1">2.77 ± 3.71</td><td align="center" rowspan="1" colspan="1">46.50 ± 11.36</td></tr><tr><td align="left" rowspan="1" colspan="1">0.1</td><td align="center" rowspan="1" colspan="1">0.71 ± 0.62 </td><td align="center" rowspan="1" colspan="1">2.70 ± 0.34</td><td align="center" rowspan="1" colspan="1">10.24 ± 10.99</td><td align="center" rowspan="1" colspan="1">26.50 ± 10.97</td><td align="center" rowspan="1" colspan="1">13.30 ± 11.24</td><td align="center" rowspan="1" colspan="1">60.50 ± 14.60</td></tr><tr><td align="left" rowspan="1" colspan="1">0.5</td><td align="center" rowspan="1" colspan="1">1.88 ± 0.52</td><td align="center" rowspan="1" colspan="1">2.80 ± 0.23</td><td align="center" rowspan="1" colspan="1">24.47 ± 6.63</td><td align="center" rowspan="1" colspan="1">35.45 ± 7.16</td><td align="center" rowspan="1" colspan="1">33.67 ± 5.24</td><td align="center" rowspan="1" colspan="1">66.17 ± 13.00</td></tr><tr><td align="left" rowspan="1" colspan="1">1.0</td><td align="center" rowspan="1" colspan="1">2.06 ± 0.60</td><td align="center" rowspan="1" colspan="1">2.88 ± 0.16</td><td align="center" rowspan="1" colspan="1">18.42 ± 8.65</td><td align="center" rowspan="1" colspan="1">33.43 ± 11.39</td><td align="center" rowspan="1" colspan="1">35.67 ± 8.80</td><td align="center" rowspan="1" colspan="1">65.00 ± 15.76</td></tr></tbody></table><table-wrap-foot><fn><p>VBH: vertical bone height (mm); BIC: bone-to-implant contact in the defect area (%); BV: bone volume in defect area. </p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Corée du Sud</li></country></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Kim, Nam Ho" sort="Kim, Nam Ho" uniqKey="Kim N" first="Nam-Ho" last="Kim">Nam-Ho Kim</name></noRegion><name sortKey="Choi, Kyung Hee" sort="Choi, Kyung Hee" uniqKey="Choi K" first="Kyung-Hee" last="Choi">Kyung-Hee Choi</name><name sortKey="Huh, Jung Bo" sort="Huh, Jung Bo" uniqKey="Huh J" first="Jung-Bo" last="Huh">Jung-Bo Huh</name><name sortKey="Lee, So Hyoun" sort="Lee, So Hyoun" uniqKey="Lee S" first="So-Hyoun" last="Lee">So-Hyoun Lee</name><name sortKey="Ryu, Jae Jun" sort="Ryu, Jae Jun" uniqKey="Ryu J" first="Jae-Jun" last="Ryu">Jae-Jun Ryu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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