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RANK-Ligand inhibitor associated osteonecrosis of the jaw

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RANK-Ligand inhibitor associated osteonecrosis of the jaw

Auteurs : Ashkan Rashad [Allemagne] ; Ralf Smeets [Allemagne] ; Max Heiland [Allemagne]

Source :

GMS Interdisciplinary Plastic and Reconstructive Surgery DGPW [ 2193-8091 ] ; 2013.

RBID : PMC:4582495

Abstract

Osteonecrosis of the jaw may be caused by many different triggers. One of them is described to be the drug or medication related osteonecrosis of the jaw. Since many years bisphosphonates induced the dreaded diagnosis. Recently a drug named denosumab is reported to show similar effects on the jaw. In this case report we present a RANK-Ligand inhibitor associated osteonecrosis of the lower jaw and discuss the lights and shadows of this newly introduced drug.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4582495

DOI: 10.3205/iprs000037
PubMed: 26504708
PubMed Central: 4582495

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<front><div type="abstract" xml:lang="en"><p>Osteonecrosis of the jaw may be caused by many different triggers. One of them is described to be the drug or medication related osteonecrosis of the jaw. Since many years bisphosphonates induced the dreaded diagnosis. Recently a drug named denosumab is reported to show similar effects on the jaw. In this case report we present a RANK-Ligand inhibitor associated osteonecrosis of the lower jaw and discuss the lights and shadows of this newly introduced drug.</p>
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<pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">GMS Interdiscip Plast Reconstr Surg DGPW</journal-id>
<journal-id journal-id-type="iso-abbrev">GMS Interdiscip Plast Reconstr Surg DGPW</journal-id>
<journal-id journal-id-type="publisher-id">GMS Interdiscip Plast Reconstr Surg DGPW</journal-id>
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<issn pub-type="epub">2193-8091</issn>
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<article-id pub-id-type="doi">10.3205/iprs000037</article-id>
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<article-id pub-id-type="other">urn:nbn:de:0183-iprs0000374</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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</article-categories>
<title-group><article-title>RANK-Ligand inhibitor associated osteonecrosis of the jaw</article-title>
<trans-title-group xml:lang="de"><trans-title>RANK-Ligand Inhibitor-assoziierte Osteonekrose des Kiefers</trans-title>
</trans-title-group>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Rashad</surname>
<given-names>Ashkan</given-names>
</name>
<xref ref-type="corresp" rid="COR1">*</xref>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Smeets</surname>
<given-names>Ralf</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Heiland</surname>
<given-names>Max</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</aff>
<author-notes><corresp id="COR1">*To whom correspondence should be addressed: Ashkan Rashad, Department of Oral and Maxillofacial Surgery, University Medical Center Hamburg-Eppendorf, Martinistraße 52, D-20246 Hamburg, Germany, Tel.: +49-177/856-2393, Fax: +49-40/7410-55467, E-mail: <email>a.rashad@uke.de</email>
</corresp>
</author-notes>
<pub-date pub-type="epub"><day>19</day>
<month>11</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="collection"><year>2013</year>
</pub-date>
<volume>2</volume>
<elocation-id>Doc17</elocation-id>
<permissions><copyright-statement>Copyright © 2013 Rashad et al.</copyright-statement>
<copyright-year>2013</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/">http://creativecommons.org/licenses/by-nc-nd/3.0/</ext-link>
). You are free to copy, distribute and transmit the work, provided the original author and source are credited.</license-p>
</license>
</permissions>
<self-uri xlink:type="simple" xlink:href="http://www.egms.de/en/journals/iprs/2013-2/iprs000037.shtml">This article is available from http://www.egms.de/en/journals/iprs/2013-2/iprs000037.shtml</self-uri>
<abstract><p>Osteonecrosis of the jaw may be caused by many different triggers. One of them is described to be the drug or medication related osteonecrosis of the jaw. Since many years bisphosphonates induced the dreaded diagnosis. Recently a drug named denosumab is reported to show similar effects on the jaw. In this case report we present a RANK-Ligand inhibitor associated osteonecrosis of the lower jaw and discuss the lights and shadows of this newly introduced drug.</p>
</abstract>
<trans-abstract xml:lang="de"><title>Zusammenfassung</title>
<p>Die Osteonekrose des Kiefers kann durch verschiedene Auslöser verursacht sein. Einer dieser Auslöser wird als die Medikamenten-assoziierte Osteonekrose des Kiefers beschrieben. Seit mehreren Jahren induzieren Bisphosphonate die gefürchtete Diagnose. Kürzlich wurden ähnliche Auswirkungen durch Gabe des Arzneimittels Denosumab beobachtet. Anhand des Fallberichtes präsentieren wir eine RANK-Ligand Inhibitor assoziierte Osteonekrose des Unterkiefers und erörtern die Licht- und Schattenseiten des neuartigen Medikaments. </p>
</trans-abstract>
<kwd-group><kwd>RANK-Ligand inhibitor</kwd>
<kwd>denosumab</kwd>
<kwd>osteonecrosis</kwd>
<kwd>jaw</kwd>
<kwd>bisphosphonates</kwd>
</kwd-group>
</article-meta>
</front>
<floats-group><fig id="F1" position="float"><label>Figure 1</label>
<caption><title>Intraoral illustration of lower jaw with absence of any dehiscence</title>
</caption>
<graphic xlink:href="IPRS-02-17-g-001"></graphic>
</fig>
<fig id="F2" position="float"><label>Figure 2</label>
<caption><title>Panoramic view reveals edentulous site after extraction and disturbed presentation of mainly anterior part of the mandible</title>
</caption>
<graphic xlink:href="IPRS-02-17-g-002"></graphic>
</fig>
<fig id="F3" position="float"><label>Figure 3</label>
<caption><title>Panoramic pre-extraction view with remaining anterior teeth 10 months ago</title>
</caption>
<graphic xlink:href="IPRS-02-17-g-003"></graphic>
</fig>
<fig id="F4" position="float"><label>Figure 4</label>
<caption><title>Finally CT scan showed up whole extent of osteonecrosis</title>
</caption>
<graphic xlink:href="IPRS-02-17-g-004"></graphic>
</fig>
</floats-group>
</pmc>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Hambourg</li>
</region>
<settlement><li>Hambourg</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Hambourg"><name sortKey="Rashad, Ashkan" sort="Rashad, Ashkan" uniqKey="Rashad A" first="Ashkan" last="Rashad">Ashkan Rashad</name>
</region>
<name sortKey="Heiland, Max" sort="Heiland, Max" uniqKey="Heiland M" first="Max" last="Heiland">Max Heiland</name>
<name sortKey="Smeets, Ralf" sort="Smeets, Ralf" uniqKey="Smeets R" first="Ralf" last="Smeets">Ralf Smeets</name>
</country>
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</record>

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RANK-Ligand inhibitor associated osteonecrosis of the jaw

RANK-Ligand inhibitor associated osteonecrosis of the jaw

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