Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.
Identifieur interne : 004758 ( Ncbi/Merge ); précédent : 004757; suivant : 004759Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.
Auteurs : Sotiria Davidopoulou [Grèce] ; Eudoxia Diza ; Dimitra Sakellari ; George Menexes ; Sotirios KalfasSource :
- Archives of oral biology [ 1879-1506 ] ; 2013.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Bouche édentée (métabolisme), Facteurs sexuels, Famille multigénique, Femelle, Humains, Jeune adulte, Mâle, Parodonte (métabolisme), Parodontite chronique (métabolisme), Peptides antimicrobiens cationiques (analyse), Protéines et peptides salivaires (analyse), Salive (), Sujet âgé, Sujet âgé de 80 ans ou plus.
- MESH :
- analyse : Peptides antimicrobiens cationiques, Protéines et peptides salivaires.
- métabolisme : Bouche édentée, Parodonte, Parodontite chronique.
- Adolescent, Adulte, Adulte d'âge moyen, Facteurs sexuels, Famille multigénique, Femelle, Humains, Jeune adulte, Mâle, Salive, Sujet âgé, Sujet âgé de 80 ans ou plus.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Antimicrobial Cationic Peptides (analysis), Chronic Periodontitis (metabolism), Female, Humans, Male, Middle Aged, Mouth, Edentulous (metabolism), Multigene Family, Periodontium (metabolism), Saliva (chemistry), Salivary Proteins and Peptides (analysis), Sex Factors, Young Adult.
- MESH :
- chemical , analysis : Antimicrobial Cationic Peptides, Salivary Proteins and Peptides.
- chemistry : Saliva.
- metabolism : Chronic Periodontitis, Mouth, Edentulous, Periodontium.
- Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Multigene Family, Sex Factors, Young Adult.
Abstract
The antimicrobial peptide LL-37, a component of innate immunity, has an important role in maintaining oral health. This study aimed to investigate the concentration of free LL-37 in whole saliva of periodontally healthy, edentulous and chronic periodontitis subjects.
DOI: 10.1016/j.archoralbio.2013.01.003
PubMed: 23778112
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pubmed:23778112Le document en format XML
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Diza</name></author><author><name sortKey="Sakellari, Dimitra" sort="Sakellari, Dimitra" uniqKey="Sakellari D" first="Dimitra" last="Sakellari">Dimitra Sakellari</name></author><author><name sortKey="Menexes, George" sort="Menexes, George" uniqKey="Menexes G" first="George" last="Menexes">George Menexes</name></author><author><name sortKey="Kalfas, Sotirios" sort="Kalfas, Sotirios" uniqKey="Kalfas S" first="Sotirios" last="Kalfas">Sotirios Kalfas</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23778112</idno><idno type="pmid">23778112</idno><idno type="doi">10.1016/j.archoralbio.2013.01.003</idno><idno type="wicri:Area/PubMed/Corpus">000B82</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B82</idno><idno type="wicri:Area/PubMed/Curation">000B82</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B82</idno><idno 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Thessaloniki</wicri:noRegion></affiliation></author><author><name sortKey="Diza, Eudoxia" sort="Diza, Eudoxia" uniqKey="Diza E" first="Eudoxia" last="Diza">Eudoxia Diza</name></author><author><name sortKey="Sakellari, Dimitra" sort="Sakellari, Dimitra" uniqKey="Sakellari D" first="Dimitra" last="Sakellari">Dimitra Sakellari</name></author><author><name sortKey="Menexes, George" sort="Menexes, George" uniqKey="Menexes G" first="George" last="Menexes">George Menexes</name></author><author><name sortKey="Kalfas, Sotirios" sort="Kalfas, Sotirios" uniqKey="Kalfas S" first="Sotirios" last="Kalfas">Sotirios Kalfas</name></author></analytic><series><title level="j">Archives of oral biology</title><idno type="eISSN">1879-1506</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antimicrobial Cationic Peptides (analysis)</term><term>Chronic Periodontitis (metabolism)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Mouth, Edentulous (metabolism)</term><term>Multigene Family</term><term>Periodontium (metabolism)</term><term>Saliva (chemistry)</term><term>Salivary Proteins and Peptides (analysis)</term><term>Sex Factors</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bouche édentée (métabolisme)</term><term>Facteurs sexuels</term><term>Famille multigénique</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Parodonte (métabolisme)</term><term>Parodontite chronique (métabolisme)</term><term>Peptides antimicrobiens cationiques (analyse)</term><term>Protéines et peptides salivaires (analyse)</term><term>Salive ()</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Antimicrobial Cationic Peptides</term><term>Salivary Proteins and Peptides</term></keywords><keywords scheme="MESH" qualifier="analyse" xml:lang="fr"><term>Peptides antimicrobiens cationiques</term><term>Protéines et peptides salivaires</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Chronic Periodontitis</term><term>Mouth, Edentulous</term><term>Periodontium</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bouche édentée</term><term>Parodonte</term><term>Parodontite chronique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Multigene Family</term><term>Sex Factors</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs sexuels</term><term>Famille multigénique</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Salive</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The antimicrobial peptide LL-37, a component of innate immunity, has an important role in maintaining oral health. This study aimed to investigate the concentration of free LL-37 in whole saliva of periodontally healthy, edentulous and chronic periodontitis subjects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23778112</PMID><DateCompleted><Year>2014</Year><Month>02</Month><Day>20</Day></DateCompleted><DateRevised><Year>2013</Year><Month>06</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1506</ISSN><JournalIssue CitedMedium="Internet"><Volume>58</Volume><Issue>8</Issue><PubDate><Year>2013</Year><Month>Aug</Month></PubDate></JournalIssue><Title>Archives of oral biology</Title><ISOAbbreviation>Arch. Oral Biol.</ISOAbbreviation></Journal><ArticleTitle>Salivary concentration of free LL-37 in edentulism, chronic periodontitis and healthy periodontium.</ArticleTitle><Pagination><MedlinePgn>930-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.archoralbio.2013.01.003</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0003-9969(13)00008-3</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The antimicrobial peptide LL-37, a component of innate immunity, has an important role in maintaining oral health. This study aimed to investigate the concentration of free LL-37 in whole saliva of periodontally healthy, edentulous and chronic periodontitis subjects.</AbstractText><AbstractText Label="DESIGN" NlmCategory="METHODS">Unstimulated whole saliva was sampled from 154 subjects (76 periodontally healthy, 20 edentulous, and 58 subjects with chronic periodontitis). All participants were in good general health. The salivary LL-37 was determined by ELISA.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The median salivary concentrations of free LL-37 were 30.5, 22.5, and 1.8ng/ml for the healthy, the chronic periodontitis and the edentulous group, respectively. The differences in concentration between the edentulous and the others were statistically significant (Mann-Whitney test, p<0.001). In the healthy subjects, women displayed significantly higher peptide concentrations compared to men (Mann-Whitney test, p<0.05). The intra-subject variation in LL-37 concentration was wider for the healthy (range 0.75-285ng/ml) and chronic periodontitis patients (range 1-207ng/ml) than for the edentulous subjects (range 0.15-4.4ng/ml).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The present findings show that edentulism correlates with a substantial decrease in salivary levels of free LL-37, thus indicating the considerable contribution of the gingival tissues in the secretion of the peptide in the oral environment.</AbstractText><CopyrightInformation>Copyright © 2013 Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Davidopoulou</LastName><ForeName>Sotiria</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>School of Dentistry, Department of Preventive Dentistry, Periodontology and Implant Biology, Aristotle University of Thessaloniki, Greece. sotiria@davidopoulou.gr</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Diza</LastName><ForeName>Eudoxia</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Sakellari</LastName><ForeName>Dimitra</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Menexes</LastName><ForeName>George</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Kalfas</LastName><ForeName>Sotirios</ForeName><Initials>S</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType 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UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D023181" MajorTopicYN="N">Antimicrobial Cationic Peptides</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D055113" MajorTopicYN="N">Chronic Periodontitis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" 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