Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.
Identifieur interne : 001848 ( Ncbi/Merge ); précédent : 001847; suivant : 001849Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.
Auteurs : Yen-Teen Chen [Taïwan] ; Hsiao-Pei Tu ; Yu-Tang Chin ; E-Chin Shen ; Cheng-Yang Chiang ; Ching-Hwa Gau ; Earl FuSource :
- Journal of periodontology [ 0022-3492 ] ; 2005.
Descripteurs français
- KwdFr :
- ARN messager (analyse), Animaux, Bouche édentée (anatomopathologie), Ciclosporine (effets indésirables), Croissance exagérée de la gencive (), Facteur de croissance IGF-I (), Facteur de croissance endothéliale vasculaire de type A (), Facteur de croissance transformant bêta (), Facteur de croissance transformant bêta-1, Gencive (), Gencive (anatomopathologie), Immunohistochimie, Mâle, Protéines proto-oncogènes c-sis (), Rat Sprague-Dawley, Rats, Réaction de polymérisation en chaîne, Régulation positive ().
- MESH :
- analyse : ARN messager.
- anatomopathologie : Bouche édentée, Gencive.
- effets indésirables : Ciclosporine.
- Animaux, Croissance exagérée de la gencive, Facteur de croissance IGF-I, Facteur de croissance endothéliale vasculaire de type A, Facteur de croissance transformant bêta, Facteur de croissance transformant bêta-1, Gencive, Immunohistochimie, Mâle, Protéines proto-oncogènes c-sis, Rat Sprague-Dawley, Rats, Réaction de polymérisation en chaîne, Régulation positive.
English descriptors
- KwdEn :
- Animals, Cyclosporine (adverse effects), Gingiva (drug effects), Gingiva (pathology), Gingival Overgrowth (chemically induced), Immunohistochemistry, Insulin-Like Growth Factor I (drug effects), Male, Mouth, Edentulous (pathology), Polymerase Chain Reaction, Proto-Oncogene Proteins c-sis (drug effects), RNA, Messenger (analysis), Rats, Rats, Sprague-Dawley, Transforming Growth Factor beta (drug effects), Transforming Growth Factor beta1, Up-Regulation (drug effects), Vascular Endothelial Growth Factor A (drug effects).
- MESH :
- chemical , adverse effects : Cyclosporine.
- chemical , analysis : RNA, Messenger.
- chemically induced : Gingival Overgrowth.
- drug effects : Gingiva, Insulin-Like Growth Factor I, Proto-Oncogene Proteins c-sis, Transforming Growth Factor beta, Up-Regulation, Vascular Endothelial Growth Factor A.
- pathology : Gingiva, Mouth, Edentulous.
- Animals, Immunohistochemistry, Male, Polymerase Chain Reaction, Rats, Rats, Sprague-Dawley, Transforming Growth Factor beta1.
Abstract
To examine the effects of cyclosporin A (CsA) on the expression of growth factors in induced gingival overgrowth with limited contributing factors arising from local inflammation caused by bacterial plaque, this study of gingival overgrowth was designed on the edentulous ridge of rats.
DOI: 10.1902/jop.2005.76.12.2267
PubMed: 16332239
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pubmed:16332239Le document en format XML
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<term>Cyclosporine (adverse effects)</term>
<term>Gingiva (drug effects)</term>
<term>Gingiva (pathology)</term>
<term>Gingival Overgrowth (chemically induced)</term>
<term>Immunohistochemistry</term>
<term>Insulin-Like Growth Factor I (drug effects)</term>
<term>Male</term>
<term>Mouth, Edentulous (pathology)</term>
<term>Polymerase Chain Reaction</term>
<term>Proto-Oncogene Proteins c-sis (drug effects)</term>
<term>RNA, Messenger (analysis)</term>
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<term>Rats, Sprague-Dawley</term>
<term>Transforming Growth Factor beta (drug effects)</term>
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<term>Croissance exagérée de la gencive ()</term>
<term>Facteur de croissance IGF-I ()</term>
<term>Facteur de croissance endothéliale vasculaire de type A ()</term>
<term>Facteur de croissance transformant bêta ()</term>
<term>Facteur de croissance transformant bêta-1</term>
<term>Gencive ()</term>
<term>Gencive (anatomopathologie)</term>
<term>Immunohistochimie</term>
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<term>Gencive</term>
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<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gingiva</term>
<term>Insulin-Like Growth Factor I</term>
<term>Proto-Oncogene Proteins c-sis</term>
<term>Transforming Growth Factor beta</term>
<term>Up-Regulation</term>
<term>Vascular Endothelial Growth Factor A</term>
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<term>Mouth, Edentulous</term>
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<term>Polymerase Chain Reaction</term>
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<term>Transforming Growth Factor beta1</term>
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<term>Croissance exagérée de la gencive</term>
<term>Facteur de croissance IGF-I</term>
<term>Facteur de croissance endothéliale vasculaire de type A</term>
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<front><div type="abstract" xml:lang="en">To examine the effects of cyclosporin A (CsA) on the expression of growth factors in induced gingival overgrowth with limited contributing factors arising from local inflammation caused by bacterial plaque, this study of gingival overgrowth was designed on the edentulous ridge of rats.</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16332239</PMID>
<DateCompleted><Year>2006</Year>
<Month>03</Month>
<Day>23</Day>
</DateCompleted>
<DateRevised><Year>2013</Year>
<Month>11</Month>
<Day>21</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3492</ISSN>
<JournalIssue CitedMedium="Print"><Volume>76</Volume>
<Issue>12</Issue>
<PubDate><Year>2005</Year>
<Month>Dec</Month>
</PubDate>
</JournalIssue>
<Title>Journal of periodontology</Title>
<ISOAbbreviation>J. Periodontol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.</ArticleTitle>
<Pagination><MedlinePgn>2267-75</MedlinePgn>
</Pagination>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To examine the effects of cyclosporin A (CsA) on the expression of growth factors in induced gingival overgrowth with limited contributing factors arising from local inflammation caused by bacterial plaque, this study of gingival overgrowth was designed on the edentulous ridge of rats.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">After a 3-week healing period following maxillary molar extractions, 16 five-week-old male Sprague-Dawley rats were assigned to CsA and control groups. Animals in the CsA group were fed 30 mg/kg CsA daily, whereas the control rats received a mineral oil vehicle instead. After 4 weeks, all animals were sacrificed, and the morphology of edentulous ridges was recorded by dental impression. The gingivae on the left-hand side were dissected and stored for mRNA analysis, whereas the gingivae on the right-hand side were fixed in 4% paraformaldehyde for immunohistochemistry (IHC) analysis of transforming growth factor-beta1 (TGF-beta1), platelet-derived growth factor beta (PDGF-beta), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The edentulous gingivae were enlarged and the body weights were reduced in the CsA-treated animals compared to controls. The mRNA expressions of TGF-beta1, IGF-1, and VEGF were higher in the gingivae of the CsA group than in the control group. In addition, a greater mRNA expression (7.21-fold) of VEGF was demonstrated in the CsA group than in the control group by real-time polymerase chain reaction (PCR). The percentages of cells staining positive for TGF-beta1 and VEGF were significantly greater in the CsA rats than in the control rats.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Greater mRNA expression and positive staining for TGF-beta1 and VEGF were observed in the edentulous gingivae of rats that received CsA. Therefore, CsA may upregulate TGF-beta1 and VEGF gene expression and protein secretion in CsA-induced gingival overgrowth.</AbstractText>
</Abstract>
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<name sortKey="Fu, Earl" sort="Fu, Earl" uniqKey="Fu E" first="Earl" last="Fu">Earl Fu</name>
<name sortKey="Gau, Ching Hwa" sort="Gau, Ching Hwa" uniqKey="Gau C" first="Ching-Hwa" last="Gau">Ching-Hwa Gau</name>
<name sortKey="Shen, E Chin" sort="Shen, E Chin" uniqKey="Shen E" first="E-Chin" last="Shen">E-Chin Shen</name>
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