Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.
Identifieur interne : 002874 ( PubMed/Corpus ); précédent : 002873; suivant : 002875Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.
Auteurs : Yen-Teen Chen ; Hsiao-Pei Tu ; Yu-Tang Chin ; E-Chin Shen ; Cheng-Yang Chiang ; Ching-Hwa Gau ; Earl FuSource :
- Journal of periodontology [ 0022-3492 ] ; 2005.
English descriptors
- KwdEn :
- Animals, Cyclosporine (adverse effects), Gingiva (drug effects), Gingiva (pathology), Gingival Overgrowth (chemically induced), Immunohistochemistry, Insulin-Like Growth Factor I (drug effects), Male, Mouth, Edentulous (pathology), Polymerase Chain Reaction, Proto-Oncogene Proteins c-sis (drug effects), RNA, Messenger (analysis), Rats, Rats, Sprague-Dawley, Transforming Growth Factor beta (drug effects), Transforming Growth Factor beta1, Up-Regulation (drug effects), Vascular Endothelial Growth Factor A (drug effects).
- MESH :
- chemical , adverse effects : Cyclosporine.
- chemical , analysis : RNA, Messenger.
- chemically induced : Gingival Overgrowth.
- drug effects : Gingiva, Insulin-Like Growth Factor I, Proto-Oncogene Proteins c-sis, Transforming Growth Factor beta, Up-Regulation, Vascular Endothelial Growth Factor A.
- pathology : Gingiva, Mouth, Edentulous.
- Animals, Immunohistochemistry, Male, Polymerase Chain Reaction, Rats, Rats, Sprague-Dawley, Transforming Growth Factor beta1.
Abstract
To examine the effects of cyclosporin A (CsA) on the expression of growth factors in induced gingival overgrowth with limited contributing factors arising from local inflammation caused by bacterial plaque, this study of gingival overgrowth was designed on the edentulous ridge of rats.
DOI: 10.1902/jop.2005.76.12.2267
PubMed: 16332239
Links to Exploration step
pubmed:16332239Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.</title><author><name sortKey="Chen, Yen Teen" sort="Chen, Yen Teen" uniqKey="Chen Y" first="Yen-Teen" last="Chen">Yen-Teen Chen</name><affiliation><nlm:affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, Hsiao Pei" sort="Tu, Hsiao Pei" uniqKey="Tu H" first="Hsiao-Pei" last="Tu">Hsiao-Pei Tu</name></author><author><name sortKey="Chin, Yu Tang" sort="Chin, Yu Tang" uniqKey="Chin Y" first="Yu-Tang" last="Chin">Yu-Tang Chin</name></author><author><name sortKey="Shen, E Chin" sort="Shen, E Chin" uniqKey="Shen E" first="E-Chin" last="Shen">E-Chin Shen</name></author><author><name sortKey="Chiang, Cheng Yang" sort="Chiang, Cheng Yang" uniqKey="Chiang C" first="Cheng-Yang" last="Chiang">Cheng-Yang Chiang</name></author><author><name sortKey="Gau, Ching Hwa" sort="Gau, Ching Hwa" uniqKey="Gau C" first="Ching-Hwa" last="Gau">Ching-Hwa Gau</name></author><author><name sortKey="Fu, Earl" sort="Fu, Earl" uniqKey="Fu E" first="Earl" last="Fu">Earl Fu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="RBID">pubmed:16332239</idno><idno type="pmid">16332239</idno><idno type="doi">10.1902/jop.2005.76.12.2267</idno><idno type="wicri:Area/PubMed/Corpus">002874</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002874</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.</title><author><name sortKey="Chen, Yen Teen" sort="Chen, Yen Teen" uniqKey="Chen Y" first="Yen-Teen" last="Chen">Yen-Teen Chen</name><affiliation><nlm:affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.</nlm:affiliation></affiliation></author><author><name sortKey="Tu, Hsiao Pei" sort="Tu, Hsiao Pei" uniqKey="Tu H" first="Hsiao-Pei" last="Tu">Hsiao-Pei Tu</name></author><author><name sortKey="Chin, Yu Tang" sort="Chin, Yu Tang" uniqKey="Chin Y" first="Yu-Tang" last="Chin">Yu-Tang Chin</name></author><author><name sortKey="Shen, E Chin" sort="Shen, E Chin" uniqKey="Shen E" first="E-Chin" last="Shen">E-Chin Shen</name></author><author><name sortKey="Chiang, Cheng Yang" sort="Chiang, Cheng Yang" uniqKey="Chiang C" first="Cheng-Yang" last="Chiang">Cheng-Yang Chiang</name></author><author><name sortKey="Gau, Ching Hwa" sort="Gau, Ching Hwa" uniqKey="Gau C" first="Ching-Hwa" last="Gau">Ching-Hwa Gau</name></author><author><name sortKey="Fu, Earl" sort="Fu, Earl" uniqKey="Fu E" first="Earl" last="Fu">Earl Fu</name></author></analytic><series><title level="j">Journal of periodontology</title><idno type="ISSN">0022-3492</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cyclosporine (adverse effects)</term><term>Gingiva (drug effects)</term><term>Gingiva (pathology)</term><term>Gingival Overgrowth (chemically induced)</term><term>Immunohistochemistry</term><term>Insulin-Like Growth Factor I (drug effects)</term><term>Male</term><term>Mouth, Edentulous (pathology)</term><term>Polymerase Chain Reaction</term><term>Proto-Oncogene Proteins c-sis (drug effects)</term><term>RNA, Messenger (analysis)</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Transforming Growth Factor beta (drug effects)</term><term>Transforming Growth Factor beta1</term><term>Up-Regulation (drug effects)</term><term>Vascular Endothelial Growth Factor A (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Cyclosporine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>RNA, Messenger</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Gingival Overgrowth</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gingiva</term><term>Insulin-Like Growth Factor I</term><term>Proto-Oncogene Proteins c-sis</term><term>Transforming Growth Factor beta</term><term>Up-Regulation</term><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Gingiva</term><term>Mouth, Edentulous</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Immunohistochemistry</term><term>Male</term><term>Polymerase Chain Reaction</term><term>Rats</term><term>Rats, Sprague-Dawley</term><term>Transforming Growth Factor beta1</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the effects of cyclosporin A (CsA) on the expression of growth factors in induced gingival overgrowth with limited contributing factors arising from local inflammation caused by bacterial plaque, this study of gingival overgrowth was designed on the edentulous ridge of rats.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16332239</PMID><DateCompleted><Year>2006</Year><Month>03</Month><Day>23</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3492</ISSN><JournalIssue CitedMedium="Print"><Volume>76</Volume><Issue>12</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of periodontology</Title><ISOAbbreviation>J. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Upregulation of transforming growth factor-beta1 and vascular endothelial growth factor gene and protein expression in cyclosporin-induced overgrown edentulous gingiva in rats.</ArticleTitle><Pagination><MedlinePgn>2267-75</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To examine the effects of cyclosporin A (CsA) on the expression of growth factors in induced gingival overgrowth with limited contributing factors arising from local inflammation caused by bacterial plaque, this study of gingival overgrowth was designed on the edentulous ridge of rats.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">After a 3-week healing period following maxillary molar extractions, 16 five-week-old male Sprague-Dawley rats were assigned to CsA and control groups. Animals in the CsA group were fed 30 mg/kg CsA daily, whereas the control rats received a mineral oil vehicle instead. After 4 weeks, all animals were sacrificed, and the morphology of edentulous ridges was recorded by dental impression. The gingivae on the left-hand side were dissected and stored for mRNA analysis, whereas the gingivae on the right-hand side were fixed in 4% paraformaldehyde for immunohistochemistry (IHC) analysis of transforming growth factor-beta1 (TGF-beta1), platelet-derived growth factor beta (PDGF-beta), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The edentulous gingivae were enlarged and the body weights were reduced in the CsA-treated animals compared to controls. The mRNA expressions of TGF-beta1, IGF-1, and VEGF were higher in the gingivae of the CsA group than in the control group. In addition, a greater mRNA expression (7.21-fold) of VEGF was demonstrated in the CsA group than in the control group by real-time polymerase chain reaction (PCR). The percentages of cells staining positive for TGF-beta1 and VEGF were significantly greater in the CsA rats than in the control rats.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Greater mRNA expression and positive staining for TGF-beta1 and VEGF were observed in the edentulous gingivae of rats that received CsA. Therefore, CsA may upregulate TGF-beta1 and VEGF gene expression and protein secretion in CsA-induced gingival overgrowth.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yen-Teen</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>Hsiao-Pei</ForeName><Initials>HP</Initials></Author><Author ValidYN="Y"><LastName>Chin</LastName><ForeName>Yu-Tang</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Shen</LastName><ForeName>E-Chin</ForeName><Initials>EC</Initials></Author><Author ValidYN="Y"><LastName>Chiang</LastName><ForeName>Cheng-Yang</ForeName><Initials>CY</Initials></Author><Author ValidYN="Y"><LastName>Gau</LastName><ForeName>Ching-Hwa</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Earl</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontol</MedlineTA><NlmUniqueID>8000345</NlmUniqueID><ISSNLinking>0022-3492</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D020574">Proto-Oncogene Proteins c-sis</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C508962">Tgfb1 protein, rat</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D016212">Transforming Growth Factor beta</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D053773">Transforming Growth Factor beta1</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D042461">Vascular Endothelial Growth Factor A</NameOfSubstance></Chemical><Chemical><RegistryNumber>67763-96-6</RegistryNumber><NameOfSubstance UI="D007334">Insulin-Like Growth Factor I</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019214" MajorTopicYN="N">Gingival Overgrowth</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="Y">chemically induced</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007334" MajorTopicYN="N">Insulin-Like Growth Factor I</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016133" MajorTopicYN="N">Polymerase Chain Reaction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020574" MajorTopicYN="N">Proto-Oncogene Proteins c-sis</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="N">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017207" MajorTopicYN="N">Rats, Sprague-Dawley</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016212" MajorTopicYN="N">Transforming Growth Factor beta</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D053773" MajorTopicYN="N">Transforming Growth Factor beta1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015854" MajorTopicYN="N">Up-Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>12</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>3</Month><Day>24</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate 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