Genetic Networks in Osseointegration
Identifieur interne : 004A71 ( Ncbi/Curation ); précédent : 004A70; suivant : 004A72Genetic Networks in Osseointegration
Auteurs : I. NishimuraSource :
- Journal of Dental Research [ 0022-0345 ] ; 2013.
Abstract
Osseointegration-based dental implants have become a well-accepted treatment modality for complete and partial edentulism. The success of this treatment largely depends on the stable integration and maintenance of implant fixtures in alveolar bone; however, the molecular and cellular mechanisms regulating this unique tissue reaction have not yet been fully uncovered. Radiographic and histologic observations suggest the sustained retention of peri-implant bone without an apparent susceptibility to catabolic bone remodeling; therefore, implant-induced bone formation continues to be intensively investigated. Increasing numbers of whole-genome transcriptome studies suggest complex molecular pathways that may play putative roles in osseointegration. This review highlights genetic networks related to bone quality, the transient chondrogenic phase, the vitamin D axis, and the peripheral circadian rhythm to elute the regulatory mechanisms underlying the establishment and maintenance of osseointegration.
Url:
DOI: 10.1177/0022034513504928
PubMed: 24158334
PubMed Central: 3827622
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