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Candida albicans susceptibility to lactoperoxidase-generated hypoiodite

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Candida albicans susceptibility to lactoperoxidase-generated hypoiodite

Auteurs : Mohamed Ahariz [Belgique] ; Philippe Courtois [Belgique]

Source :

Clinical, Cosmetic and Investigational Dentistry [ 1179-1357 ] ; 2010.

RBID : PMC:3645462

Abstract

In vivo, lactoperoxidase produces hypothiocyanite (OSCN⁻) from thiocyanate (SCN⁻) in the presence of hydrogen peroxide (H₂O₂); in vitro, iodide (I⁻) can be oxidized into hypoiodite (OI⁻) by this enzyme. The aim of this study was to compare in vitro the anti-Candida effect of iodide versus thiocyanate used as lactoperoxidase substrate to prevent Candida biofilms development. Candida albicans ATCC 10231 susceptibility upon both peroxidase systems was tested in three different experimental designs: (i) in a liquid culture medium, (ii) in an interface model between solid culture medium and gel containing the enzymic systems, (iii) in a biofilm model onto titanium and acrylic resin. Yeast growth in liquid medium was monitored by turbidimetry at 600 nm. Material-adherent yeast biomass was evaluated by the tetrazolium salt MTT method. The iodide-peroxidase system has been shown to inhibit Candida biofilm formation at lower substrate concentrations (~200 fold less H₂O₂ donor) and for longer incubation periods than the thiocyanate-peroxidase system. In conclusion, efficiency of lactoperoxidase-generated OI⁻ to prevent C. albicans biofilm development allows refining iodine antifungal use in ex vivo conditions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3645462

PubMed: 23662084
PubMed Central: 3645462

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 susceptibility to lactoperoxidase-generated hypoiodite</title>
<author><name sortKey="Ahariz, Mohamed" sort="Ahariz, Mohamed" uniqKey="Ahariz M" first="Mohamed" last="Ahariz">Mohamed Ahariz</name>
<affiliation wicri:level="4"><nlm:aff id="af1-ccide-2-069">Laboratory of Experimental Hormonology, Université Libre de Bruxelles, Brussels, Belgium</nlm:aff>
<country xml:lang="fr">Belgique</country>
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<author><name sortKey="Courtois, Philippe" sort="Courtois, Philippe" uniqKey="Courtois P" first="Philippe" last="Courtois">Philippe Courtois</name>
<affiliation wicri:level="4"><nlm:aff id="af2-ccide-2-069">Laboratory of Experimental Hormonology, Université Libre de Bruxelles, Brussels, Belgium and UER de Biologie Médicale, Haute Ecole Francisco Ferrer, Brussels, Belgium</nlm:aff>
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 susceptibility to lactoperoxidase-generated hypoiodite</title>
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<affiliation wicri:level="4"><nlm:aff id="af1-ccide-2-069">Laboratory of Experimental Hormonology, Université Libre de Bruxelles, Brussels, Belgium</nlm:aff>
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<affiliation wicri:level="4"><nlm:aff id="af2-ccide-2-069">Laboratory of Experimental Hormonology, Université Libre de Bruxelles, Brussels, Belgium and UER de Biologie Médicale, Haute Ecole Francisco Ferrer, Brussels, Belgium</nlm:aff>
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<front><div type="abstract" xml:lang="en"><p><italic>In vivo</italic>
, lactoperoxidase produces hypothiocyanite (OSCN<sup>−</sup>
) from thiocyanate (SCN<sup>−</sup>
) in the presence of hydrogen peroxide (H<sub>2</sub>
O<sub>2</sub>
); <italic>in vitro</italic>
, iodide (I<sup>−</sup>
) can be oxidized into hypoiodite (OI<sup>−</sup>
) by this enzyme. The aim of this study was to compare <italic>in vitro</italic>
 the anti-<italic>Candida</italic>
 effect of iodide <italic>versus</italic>
 thiocyanate used as lactoperoxidase substrate to prevent <italic>Candida</italic>
 biofilms development. <italic>Candida albicans</italic>
 ATCC 10231 susceptibility upon both peroxidase systems was tested in three different experimental designs: (i) in a liquid culture medium, (ii) in an interface model between solid culture medium and gel containing the enzymic systems, (iii) in a biofilm model onto titanium and acrylic resin. Yeast growth in liquid medium was monitored by turbidimetry at 600 nm. Material-adherent yeast biomass was evaluated by the tetrazolium salt MTT method. The iodide-peroxidase system has been shown to inhibit <italic>Candida</italic>
 biofilm formation at lower substrate concentrations (~200 fold less H<sub>2</sub>
O<sub>2</sub>
 donor) and for longer incubation periods than the thiocyanate-peroxidase system. In conclusion, efficiency of lactoperoxidase-generated OI<sup>−</sup>
 to prevent <italic>C. albicans</italic>
 biofilm development allows refining iodine antifungal use in <italic>ex vivo</italic>
 conditions.</p>
</div>
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Candida albicans susceptibility to lactoperoxidase-generated hypoiodite

Candida albicans susceptibility to lactoperoxidase-generated hypoiodite

Source :

Abstract

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