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ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

Identifieur interne : 003845 ( Ncbi/Curation ); précédent : 003844; suivant : 003846

ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

Auteurs : Xiaojie Ji [États-Unis] ; Smruti Pushalkar [États-Unis] ; Yihong Li [États-Unis] ; Robert Glickman [États-Unis] ; Kenneth Fleisher [États-Unis] ; Deepak Saxena [États-Unis]

Source :

Oral diseases [ 1354-523X ] ; 2011.

RBID : PMC:3232327

Abstract

OBJECTIVE

Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues.

MATERIALS AND METHODS

The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0 to 2 were enrolled in this study and patient groups were divided into an antibiotic cohort (n=10) treated with systemic antibiotic and a non-antibiotic cohort (n=10) with no prior antibiotic therapy.

RESULTS

The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum Firmicutes with bacterial species, Streptococcus intermedius, Lactobacillus gasseri, Mogibacterium timidum and Solobacterium moorei whereas patients without antibiotics had greater amounts of Parvimonas micra, and S. anginosus. Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes.

CONCLUSION

This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232327

DOI: 10.1111/j.1601-0825.2011.01848.x
PubMed: 21883710
PubMed Central: 3232327

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Le document en format XML

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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVE</title>
<p id="P1">Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues.</p>
</sec>
<sec sec-type="materials|methods" id="S2"><title>MATERIALS AND METHODS</title>
<p id="P2">The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0 to 2 were enrolled in this study and patient groups were divided into an antibiotic cohort (n=10) treated with systemic antibiotic and a non-antibiotic cohort (n=10) with no prior antibiotic therapy.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum <italic>Firmicutes</italic>
 with bacterial species, <italic>Streptococcus intermedius, Lactobacillus gasseri</italic>
, <italic>Mogibacterium timidum</italic>
 and <italic>Solobacterium moorei</italic>
 whereas patients without antibiotics had greater amounts of <italic>Parvimonas micra</italic>
, and <italic>S. anginosus.</italic>
 Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes.</p>
</sec>
<sec id="S4"><title>CONCLUSION</title>
<p id="P4">This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions.</p>
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ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

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Abstract

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