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ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

Identifieur interne : 002161 ( Pmc/Corpus ); précédent : 002160; suivant : 002162

ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

Auteurs : Xiaojie Ji ; Smruti Pushalkar ; Yihong Li ; Robert Glickman ; Kenneth Fleisher ; Deepak Saxena

Source :

Oral diseases [ 1354-523X ] ; 2011.

RBID : PMC:3232327

Abstract

OBJECTIVE

Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues.

MATERIALS AND METHODS

The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0 to 2 were enrolled in this study and patient groups were divided into an antibiotic cohort (n=10) treated with systemic antibiotic and a non-antibiotic cohort (n=10) with no prior antibiotic therapy.

RESULTS

The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum Firmicutes with bacterial species, Streptococcus intermedius, Lactobacillus gasseri, Mogibacterium timidum and Solobacterium moorei whereas patients without antibiotics had greater amounts of Parvimonas micra, and S. anginosus. Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes.

CONCLUSION

This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3232327

DOI: 10.1111/j.1601-0825.2011.01848.x
PubMed: 21883710
PubMed Central: 3232327

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PMC:3232327

Le document en format XML

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<author><name sortKey="Ji, Xiaojie" sort="Ji, Xiaojie" uniqKey="Ji X" first="Xiaojie" last="Ji">Xiaojie Ji</name>
<affiliation><nlm:aff id="A1">Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, NY 11201, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Pushalkar, Smruti" sort="Pushalkar, Smruti" uniqKey="Pushalkar S" first="Smruti" last="Pushalkar">Smruti Pushalkar</name>
<affiliation><nlm:aff id="A2">Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Yihong" sort="Li, Yihong" uniqKey="Li Y" first="Yihong" last="Li">Yihong Li</name>
<affiliation><nlm:aff id="A2">Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glickman, Robert" sort="Glickman, Robert" uniqKey="Glickman R" first="Robert" last="Glickman">Robert Glickman</name>
<affiliation><nlm:aff id="A3">Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fleisher, Kenneth" sort="Fleisher, Kenneth" uniqKey="Fleisher K" first="Kenneth" last="Fleisher">Kenneth Fleisher</name>
<affiliation><nlm:aff id="A3">Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saxena, Deepak" sort="Saxena, Deepak" uniqKey="Saxena D" first="Deepak" last="Saxena">Deepak Saxena</name>
<affiliation><nlm:aff id="A2">Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
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<author><name sortKey="Ji, Xiaojie" sort="Ji, Xiaojie" uniqKey="Ji X" first="Xiaojie" last="Ji">Xiaojie Ji</name>
<affiliation><nlm:aff id="A1">Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, NY 11201, USA</nlm:aff>
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<author><name sortKey="Pushalkar, Smruti" sort="Pushalkar, Smruti" uniqKey="Pushalkar S" first="Smruti" last="Pushalkar">Smruti Pushalkar</name>
<affiliation><nlm:aff id="A2">Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Yihong" sort="Li, Yihong" uniqKey="Li Y" first="Yihong" last="Li">Yihong Li</name>
<affiliation><nlm:aff id="A2">Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Glickman, Robert" sort="Glickman, Robert" uniqKey="Glickman R" first="Robert" last="Glickman">Robert Glickman</name>
<affiliation><nlm:aff id="A3">Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Fleisher, Kenneth" sort="Fleisher, Kenneth" uniqKey="Fleisher K" first="Kenneth" last="Fleisher">Kenneth Fleisher</name>
<affiliation><nlm:aff id="A3">Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Saxena, Deepak" sort="Saxena, Deepak" uniqKey="Saxena D" first="Deepak" last="Saxena">Deepak Saxena</name>
<affiliation><nlm:aff id="A2">Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</nlm:aff>
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<series><title level="j">Oral diseases</title>
<idno type="ISSN">1354-523X</idno>
<idno type="eISSN">1601-0825</idno>
<imprint><date when="2011">2011</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>OBJECTIVE</title>
<p id="P1">Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues.</p>
</sec>
<sec sec-type="materials|methods" id="S2"><title>MATERIALS AND METHODS</title>
<p id="P2">The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0 to 2 were enrolled in this study and patient groups were divided into an antibiotic cohort (n=10) treated with systemic antibiotic and a non-antibiotic cohort (n=10) with no prior antibiotic therapy.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum <italic>Firmicutes</italic>
 with bacterial species, <italic>Streptococcus intermedius, Lactobacillus gasseri</italic>
, <italic>Mogibacterium timidum</italic>
 and <italic>Solobacterium moorei</italic>
 whereas patients without antibiotics had greater amounts of <italic>Parvimonas micra</italic>
, and <italic>S. anginosus.</italic>
 Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes.</p>
</sec>
<sec id="S4"><title>CONCLUSION</title>
<p id="P4">This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="en"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
  <front><journal-meta><journal-id journal-id-type="nlm-journal-id">9508565</journal-id>
<journal-id journal-id-type="pubmed-jr-id">8783</journal-id>
<journal-id journal-id-type="nlm-ta">Oral Dis</journal-id>
<journal-title-group><journal-title>Oral diseases</journal-title>
</journal-title-group>
<issn pub-type="ppub">1354-523X</issn>
<issn pub-type="epub">1601-0825</issn>
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<article-meta><article-id pub-id-type="pmid">21883710</article-id>
<article-id pub-id-type="pmc">3232327</article-id>
<article-id pub-id-type="doi">10.1111/j.1601-0825.2011.01848.x</article-id>
<article-id pub-id-type="manuscript">NIHMS316263</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Ji</surname>
<given-names>Xiaojie</given-names>
</name>
<xref rid="A1" ref-type="aff">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Pushalkar</surname>
<given-names>Smruti</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Yihong</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Glickman</surname>
<given-names>Robert</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fleisher</surname>
<given-names>Kenneth</given-names>
</name>
<xref rid="A3" ref-type="aff">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Saxena</surname>
<given-names>Deepak</given-names>
</name>
<xref rid="A2" ref-type="aff">2</xref>
<xref rid="FN1" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Chemical and Biological Sciences, Polytechnic Institute of New York University, NY 11201, USA</aff>
<aff id="A2"><label>2</label>
Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, New York, NY 10010, USA</aff>
<aff id="A3"><label>3</label>
Department of Oral and Maxillofacial Surgery, New York University College of Dentistry, New York, NY 10010, USA</aff>
<author-notes><corresp id="FN1"><label>*</label>
Corresponding Author: Deepak Saxena, Ph.D, Department of Basic Science and Craniofacial Biology, New York University College of Dentistry, 345 East 24<sup>th</sup>
 Street, 921-B, New York, NY 10010-4086, Phone: +1 212 998 9256, Fax: +1 212 995 4087, <email>ds100@nyu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>16</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="epub"><day>29</day>
<month>8</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>1</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>1</day>
<month>1</month>
<year>2013</year>
</pub-date>
<volume>18</volume>
<issue>1</issue>
<fpage>85</fpage>
<lpage>95</lpage>
<abstract><sec id="S1"><title>OBJECTIVE</title>
<p id="P1">Oral infection is considered to play a critical role in the pathogenesis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) and antibiotic therapy has become a mainstay of BRONJ therapy. This study was aimed to investigate the effect of antibiotics on bacterial diversity in BRONJ tissues.</p>
</sec>
<sec sec-type="materials|methods" id="S2"><title>MATERIALS AND METHODS</title>
<p id="P2">The bacterial profile from soft tissues associated with the BRONJ lesion was determined using 16S rRNA-based denaturing gradient gel electrophoresis (DGGE) and sequencing. Twenty BRONJ subjects classified as stage 0 to 2 were enrolled in this study and patient groups were divided into an antibiotic cohort (n=10) treated with systemic antibiotic and a non-antibiotic cohort (n=10) with no prior antibiotic therapy.</p>
</sec>
<sec id="S3"><title>RESULTS</title>
<p id="P3">The DGGE fingerprints indicated no significant differences in bacterial diversity of BRONJ tissue samples. Patients on antibiotics had higher relative abundance of phylum <italic>Firmicutes</italic>
 with bacterial species, <italic>Streptococcus intermedius, Lactobacillus gasseri</italic>
, <italic>Mogibacterium timidum</italic>
 and <italic>Solobacterium moorei</italic>
 whereas patients without antibiotics had greater amounts of <italic>Parvimonas micra</italic>
, and <italic>S. anginosus.</italic>
 Thirty percent of bacterial populations were uncultured (yet-to be cultured) phylotypes.</p>
</sec>
<sec id="S4"><title>CONCLUSION</title>
<p id="P4">This study using limited sample size indicated that oral antibiotic therapy may have a limited efficacy on the bacterial population associated with BRONJ lesions.</p>
</sec>
</abstract>
<kwd-group><kwd>BRONJ</kwd>
<kwd>antibiotics</kwd>
<kwd>DGGE</kwd>
<kwd>microbial diversity</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

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ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

ANTIBIOTIC EFFECTS ON BACTERIAL PROFILE IN OSTEONECROSIS OF THE JAW

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Abstract

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