alpha-Defensin levels in whole saliva of totally edentulous subjects.
Identifieur interne : 002557 ( Ncbi/Curation ); précédent : 002556; suivant : 002558alpha-Defensin levels in whole saliva of totally edentulous subjects.
Auteurs : C. Fanali [Italie] ; R. Inzitari ; T. Cabras ; E. Pisano ; M. Castagnola ; R. Celletti ; A. Manni ; I. MessanaSource :
- International journal of immunopathology and pharmacology [ 0394-6320 ]
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : alpha-Defensins.
- metabolism : Mouth, Edentulous, Saliva.
- Adult, Aged, Case-Control Studies, Chromatography, High Pressure Liquid, Humans, Middle Aged.
Abstract
Salivary levels of alpha-defensins 1-4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II). Whole saliva was treated with trifluoroacetic acid and the acidic soluble fraction analyzed by High Performance Liquid Chromatography-Mass Spectrometry. The area of the extracted ion current peaks was used for peptide quantification. Levels of alpha-defensins1-4, but not of histatins, were significantly lower in totally edentulous patients with respect to both Control group I and Control group II. The two control groups did not show significant differences. The reduced level of oral alpha-defensins, which are mainly of crevicular origin, is most likely due to the absence of the gingival sulcus in the edentulous subjects. The near absence of alpha- defensins might be in part responsible for the higher vulnerability of the oral cavity to oral pathogen infections observed in totally edentulous patients.
DOI: 10.1177/039463200802100409
PubMed: 19144270
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001F68
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :001F68
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001F68
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002557
Links to Exploration step
pubmed:19144270Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">alpha-Defensin levels in whole saliva of totally edentulous subjects.</title><author><name sortKey="Fanali, C" sort="Fanali, C" uniqKey="Fanali C" first="C" last="Fanali">C. Fanali</name><affiliation wicri:level="3"><nlm:affiliation>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma, Italia.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Inzitari, R" sort="Inzitari, R" uniqKey="Inzitari R" first="R" last="Inzitari">R. Inzitari</name></author><author><name sortKey="Cabras, T" sort="Cabras, T" uniqKey="Cabras T" first="T" last="Cabras">T. Cabras</name></author><author><name sortKey="Pisano, E" sort="Pisano, E" uniqKey="Pisano E" first="E" last="Pisano">E. Pisano</name></author><author><name sortKey="Castagnola, M" sort="Castagnola, M" uniqKey="Castagnola M" first="M" last="Castagnola">M. Castagnola</name></author><author><name sortKey="Celletti, R" sort="Celletti, R" uniqKey="Celletti R" first="R" last="Celletti">R. Celletti</name></author><author><name sortKey="Manni, A" sort="Manni, A" uniqKey="Manni A" first="A" last="Manni">A. Manni</name></author><author><name sortKey="Messana, I" sort="Messana, I" uniqKey="Messana I" first="I" last="Messana">I. Messana</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2008 Oct-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:19144270</idno><idno type="pmid">19144270</idno><idno type="doi">10.1177/039463200802100409</idno><idno type="wicri:Area/PubMed/Corpus">001F68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001F68</idno><idno type="wicri:Area/PubMed/Curation">001F68</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001F68</idno><idno type="wicri:Area/PubMed/Checkpoint">001F68</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001F68</idno><idno type="wicri:Area/Ncbi/Merge">002557</idno><idno type="wicri:Area/Ncbi/Curation">002557</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">alpha-Defensin levels in whole saliva of totally edentulous subjects.</title><author><name sortKey="Fanali, C" sort="Fanali, C" uniqKey="Fanali C" first="C" last="Fanali">C. Fanali</name><affiliation wicri:level="3"><nlm:affiliation>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma, Italia.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Inzitari, R" sort="Inzitari, R" uniqKey="Inzitari R" first="R" last="Inzitari">R. Inzitari</name></author><author><name sortKey="Cabras, T" sort="Cabras, T" uniqKey="Cabras T" first="T" last="Cabras">T. Cabras</name></author><author><name sortKey="Pisano, E" sort="Pisano, E" uniqKey="Pisano E" first="E" last="Pisano">E. Pisano</name></author><author><name sortKey="Castagnola, M" sort="Castagnola, M" uniqKey="Castagnola M" first="M" last="Castagnola">M. Castagnola</name></author><author><name sortKey="Celletti, R" sort="Celletti, R" uniqKey="Celletti R" first="R" last="Celletti">R. Celletti</name></author><author><name sortKey="Manni, A" sort="Manni, A" uniqKey="Manni A" first="A" last="Manni">A. Manni</name></author><author><name sortKey="Messana, I" sort="Messana, I" uniqKey="Messana I" first="I" last="Messana">I. Messana</name></author></analytic><series><title level="j">International journal of immunopathology and pharmacology</title><idno type="ISSN">0394-6320</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Chromatography, High Pressure Liquid</term><term>Humans</term><term>Middle Aged</term><term>Mouth, Edentulous (metabolism)</term><term>Saliva (metabolism)</term><term>alpha-Defensins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Bouche édentée (métabolisme)</term><term>Chromatographie en phase liquide à haute performance</term><term>Défensines-alpha (métabolisme)</term><term>Humains</term><term>Salive (métabolisme)</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>alpha-Defensins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mouth, Edentulous</term><term>Saliva</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Bouche édentée</term><term>Défensines-alpha</term><term>Salive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Chromatography, High Pressure Liquid</term><term>Humans</term><term>Middle Aged</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Chromatographie en phase liquide à haute performance</term><term>Humains</term><term>Sujet âgé</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Salivary levels of alpha-defensins 1-4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II). Whole saliva was treated with trifluoroacetic acid and the acidic soluble fraction analyzed by High Performance Liquid Chromatography-Mass Spectrometry. The area of the extracted ion current peaks was used for peptide quantification. Levels of alpha-defensins1-4, but not of histatins, were significantly lower in totally edentulous patients with respect to both Control group I and Control group II. The two control groups did not show significant differences. The reduced level of oral alpha-defensins, which are mainly of crevicular origin, is most likely due to the absence of the gingival sulcus in the edentulous subjects. The near absence of alpha- defensins might be in part responsible for the higher vulnerability of the oral cavity to oral pathogen infections observed in totally edentulous patients.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002557 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002557 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:19144270
|texte= alpha-Defensin levels in whole saliva of totally edentulous subjects.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:19144270" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |