alpha-Defensin levels in whole saliva of totally edentulous subjects.
Identifieur interne : 002557 ( Ncbi/Merge ); précédent : 002556; suivant : 002558alpha-Defensin levels in whole saliva of totally edentulous subjects.
Auteurs : C. Fanali [Italie] ; R. Inzitari ; T. Cabras ; E. Pisano ; M. Castagnola ; R. Celletti ; A. Manni ; I. MessanaSource :
- International journal of immunopathology and pharmacology [ 0394-6320 ]
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : alpha-Defensins.
- metabolism : Mouth, Edentulous, Saliva.
- Adult, Aged, Case-Control Studies, Chromatography, High Pressure Liquid, Humans, Middle Aged.
Abstract
Salivary levels of alpha-defensins 1-4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II). Whole saliva was treated with trifluoroacetic acid and the acidic soluble fraction analyzed by High Performance Liquid Chromatography-Mass Spectrometry. The area of the extracted ion current peaks was used for peptide quantification. Levels of alpha-defensins1-4, but not of histatins, were significantly lower in totally edentulous patients with respect to both Control group I and Control group II. The two control groups did not show significant differences. The reduced level of oral alpha-defensins, which are mainly of crevicular origin, is most likely due to the absence of the gingival sulcus in the edentulous subjects. The near absence of alpha- defensins might be in part responsible for the higher vulnerability of the oral cavity to oral pathogen infections observed in totally edentulous patients.
DOI: 10.1177/039463200802100409
PubMed: 19144270
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Fanali</name><affiliation wicri:level="3"><nlm:affiliation>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma, Italia.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Inzitari, R" sort="Inzitari, R" uniqKey="Inzitari R" first="R" last="Inzitari">R. Inzitari</name></author><author><name sortKey="Cabras, T" sort="Cabras, T" uniqKey="Cabras T" first="T" last="Cabras">T. Cabras</name></author><author><name sortKey="Pisano, E" sort="Pisano, E" uniqKey="Pisano E" first="E" last="Pisano">E. Pisano</name></author><author><name sortKey="Castagnola, M" sort="Castagnola, M" uniqKey="Castagnola M" first="M" last="Castagnola">M. Castagnola</name></author><author><name sortKey="Celletti, R" sort="Celletti, R" uniqKey="Celletti R" first="R" last="Celletti">R. Celletti</name></author><author><name sortKey="Manni, A" sort="Manni, A" uniqKey="Manni A" first="A" last="Manni">A. Manni</name></author><author><name sortKey="Messana, I" sort="Messana, I" uniqKey="Messana I" first="I" last="Messana">I. 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Whole saliva was treated with trifluoroacetic acid and the acidic soluble fraction analyzed by High Performance Liquid Chromatography-Mass Spectrometry. The area of the extracted ion current peaks was used for peptide quantification. Levels of alpha-defensins1-4, but not of histatins, were significantly lower in totally edentulous patients with respect to both Control group I and Control group II. The two control groups did not show significant differences. The reduced level of oral alpha-defensins, which are mainly of crevicular origin, is most likely due to the absence of the gingival sulcus in the edentulous subjects. The near absence of alpha- defensins might be in part responsible for the higher vulnerability of the oral cavity to oral pathogen infections observed in totally edentulous patients.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19144270</PMID><DateCompleted><Year>2009</Year><Month>03</Month><Day>30</Day></DateCompleted><DateRevised><Year>2017</Year><Month>02</Month><Day>14</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0394-6320</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>4</Issue><PubDate><MedlineDate>2008 Oct-Dec</MedlineDate></PubDate></JournalIssue><Title>International journal of immunopathology and pharmacology</Title><ISOAbbreviation>Int J Immunopathol Pharmacol</ISOAbbreviation></Journal><ArticleTitle>alpha-Defensin levels in whole saliva of totally edentulous subjects.</ArticleTitle><Pagination><MedlinePgn>845-9</MedlinePgn></Pagination><Abstract><AbstractText>Salivary levels of alpha-defensins 1-4 and histatins 1, 3 and 5 were determined in 11 totally edentulous patients, 11 younger healthy adults with normal gingival mucosa (Control group I) and 8 subjects, age-matched with edentulous patients, having a minimum of 25 teeth (Control group II). Whole saliva was treated with trifluoroacetic acid and the acidic soluble fraction analyzed by High Performance Liquid Chromatography-Mass Spectrometry. The area of the extracted ion current peaks was used for peptide quantification. Levels of alpha-defensins1-4, but not of histatins, were significantly lower in totally edentulous patients with respect to both Control group I and Control group II. The two control groups did not show significant differences. The reduced level of oral alpha-defensins, which are mainly of crevicular origin, is most likely due to the absence of the gingival sulcus in the edentulous subjects. The near absence of alpha- defensins might be in part responsible for the higher vulnerability of the oral cavity to oral pathogen infections observed in totally edentulous patients.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Fanali</LastName><ForeName>C</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Istituto di Biochimica e Biochimica Clinica, Università Cattolica and Istituto Scientifico Internazionale (ISI) per la Ricerca sulla Fertilità e l'Infertilità Umana - Paolo VI, Roma, Italia.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Inzitari</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Cabras</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Pisano</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Castagnola</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Celletti</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Manni</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Messana</LastName><ForeName>I</ForeName><Initials>I</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Int J Immunopathol Pharmacol</MedlineTA><NlmUniqueID>8911335</NlmUniqueID><ISSNLinking>0394-6320</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D023084">alpha-Defensins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002851" MajorTopicYN="N">Chromatography, High Pressure Liquid</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D023084" MajorTopicYN="N">alpha-Defensins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>1</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>1</Month><Day>16</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>3</Month><Day>31</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">19144270</ArticleId><ArticleId IdType="pii">9</ArticleId><ArticleId IdType="doi">10.1177/039463200802100409</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><noCountry><name sortKey="Cabras, T" sort="Cabras, T" uniqKey="Cabras T" first="T" last="Cabras">T. Cabras</name><name sortKey="Castagnola, M" sort="Castagnola, M" uniqKey="Castagnola M" first="M" last="Castagnola">M. Castagnola</name><name sortKey="Celletti, R" sort="Celletti, R" uniqKey="Celletti R" first="R" last="Celletti">R. Celletti</name><name sortKey="Inzitari, R" sort="Inzitari, R" uniqKey="Inzitari R" first="R" last="Inzitari">R. Inzitari</name><name sortKey="Manni, A" sort="Manni, A" uniqKey="Manni A" first="A" last="Manni">A. Manni</name><name sortKey="Messana, I" sort="Messana, I" uniqKey="Messana I" first="I" last="Messana">I. Messana</name><name sortKey="Pisano, E" sort="Pisano, E" uniqKey="Pisano E" first="E" last="Pisano">E. Pisano</name></noCountry><country name="Italie"><region name="Latium"><name sortKey="Fanali, C" sort="Fanali, C" uniqKey="Fanali C" first="C" last="Fanali">C. Fanali</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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