Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats.
Identifieur interne : 001973 ( Ncbi/Curation ); précédent : 001972; suivant : 001974Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats.
Auteurs : Hsiao-Pei Tu [République populaire de Chine] ; Yen-Teen Chen ; Yi-Shing Shieh ; Yu-Tang Chin ; Ren-Yeong Huang ; Shih-Fang Yang ; Ching-Hwa Gau ; Earl FuSource :
- Journal of periodontology [ 0022-3492 ] ; 2006.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Animaux, Antigène nucléaire de prolifération cellulaire (métabolisme), Bouche édentée (métabolisme), Cadhérines (métabolisme), Ciclosporine (effets indésirables), Ciclosporine (pharmacologie), Cycline D1 (métabolisme), Expression des gènes (), Gencive (), Gencive (métabolisme), Hyperplasie gingivale (), Hyperplasie gingivale (métabolisme), Immunosuppresseurs (effets indésirables), Immunosuppresseurs (pharmacologie), Mâle, Rats, Régulation négative, bêta-Caténine (métabolisme), Épithélium (), Épithélium (métabolisme).
- MESH :
- effets indésirables : Ciclosporine, Immunosuppresseurs.
- métabolisme : ARN messager, Antigène nucléaire de prolifération cellulaire, Bouche édentée, Cadhérines, Cycline D1, Gencive, Hyperplasie gingivale, bêta-Caténine, Épithélium.
- pharmacologie : Ciclosporine, Immunosuppresseurs.
- Animaux, Expression des gènes, Gencive, Hyperplasie gingivale, Mâle, Rats, Régulation négative, Épithélium.
English descriptors
- KwdEn :
- Animals, Cadherins (metabolism), Cyclin D1 (metabolism), Cyclosporine (adverse effects), Cyclosporine (pharmacology), Down-Regulation, Epithelium (drug effects), Epithelium (metabolism), Gene Expression (drug effects), Gingiva (drug effects), Gingiva (metabolism), Gingival Hyperplasia (chemically induced), Gingival Hyperplasia (metabolism), Immunosuppressive Agents (adverse effects), Immunosuppressive Agents (pharmacology), Male, Mouth, Edentulous (metabolism), Proliferating Cell Nuclear Antigen (metabolism), RNA, Messenger (metabolism), Rats, beta Catenin (metabolism).
- MESH :
- chemical , adverse effects : Cyclosporine, Immunosuppressive Agents.
- chemical , metabolism : Cadherins, Cyclin D1, Proliferating Cell Nuclear Antigen, RNA, Messenger, beta Catenin.
- chemical , pharmacology : Cyclosporine, Immunosuppressive Agents.
- chemically induced : Gingival Hyperplasia.
- drug effects : Epithelium, Gene Expression, Gingiva.
- metabolism : Epithelium, Gingiva, Gingival Hyperplasia, Mouth, Edentulous.
- Animals, Down-Regulation, Male, Rats.
Abstract
To examine the role of E-cadherin in epithelial hyperplasia of cyclosporin A (CsA)-induced gingival enlargement, mRNA and protein levels of E-cadherin, beta-catenin, proliferating cell nuclear antigen (PCNA), and Cyclin D1 were examined in the edentulous gingiva of rats following CsA treatment.
DOI: 10.1902/jop.2006.050316
PubMed: 16671876
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pubmed:16671876Le document en format XML
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xml:lang="fr"><term>Ciclosporine</term><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelium</term><term>Gingiva</term><term>Gingival Hyperplasia</term><term>Mouth, Edentulous</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Antigène nucléaire de prolifération cellulaire</term><term>Bouche édentée</term><term>Cadhérines</term><term>Cycline D1</term><term>Gencive</term><term>Hyperplasie gingivale</term><term>bêta-Caténine</term><term>Épithélium</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Ciclosporine</term><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Down-Regulation</term><term>Male</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Expression des gènes</term><term>Gencive</term><term>Hyperplasie 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