Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats.
Identifieur interne : 001973 ( Ncbi/Merge ); précédent : 001972; suivant : 001974Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats.
Auteurs : Hsiao-Pei Tu [République populaire de Chine] ; Yen-Teen Chen ; Yi-Shing Shieh ; Yu-Tang Chin ; Ren-Yeong Huang ; Shih-Fang Yang ; Ching-Hwa Gau ; Earl FuSource :
- Journal of periodontology [ 0022-3492 ] ; 2006.
Descripteurs français
- KwdFr :
- ARN messager (métabolisme), Animaux, Antigène nucléaire de prolifération cellulaire (métabolisme), Bouche édentée (métabolisme), Cadhérines (métabolisme), Ciclosporine (effets indésirables), Ciclosporine (pharmacologie), Cycline D1 (métabolisme), Expression des gènes (), Gencive (), Gencive (métabolisme), Hyperplasie gingivale (), Hyperplasie gingivale (métabolisme), Immunosuppresseurs (effets indésirables), Immunosuppresseurs (pharmacologie), Mâle, Rats, Régulation négative, bêta-Caténine (métabolisme), Épithélium (), Épithélium (métabolisme).
- MESH :
- effets indésirables : Ciclosporine, Immunosuppresseurs.
- métabolisme : ARN messager, Antigène nucléaire de prolifération cellulaire, Bouche édentée, Cadhérines, Cycline D1, Gencive, Hyperplasie gingivale, bêta-Caténine, Épithélium.
- pharmacologie : Ciclosporine, Immunosuppresseurs.
- Animaux, Expression des gènes, Gencive, Hyperplasie gingivale, Mâle, Rats, Régulation négative, Épithélium.
English descriptors
- KwdEn :
- Animals, Cadherins (metabolism), Cyclin D1 (metabolism), Cyclosporine (adverse effects), Cyclosporine (pharmacology), Down-Regulation, Epithelium (drug effects), Epithelium (metabolism), Gene Expression (drug effects), Gingiva (drug effects), Gingiva (metabolism), Gingival Hyperplasia (chemically induced), Gingival Hyperplasia (metabolism), Immunosuppressive Agents (adverse effects), Immunosuppressive Agents (pharmacology), Male, Mouth, Edentulous (metabolism), Proliferating Cell Nuclear Antigen (metabolism), RNA, Messenger (metabolism), Rats, beta Catenin (metabolism).
- MESH :
- chemical , adverse effects : Cyclosporine, Immunosuppressive Agents.
- chemical , metabolism : Cadherins, Cyclin D1, Proliferating Cell Nuclear Antigen, RNA, Messenger, beta Catenin.
- chemical , pharmacology : Cyclosporine, Immunosuppressive Agents.
- chemically induced : Gingival Hyperplasia.
- drug effects : Epithelium, Gene Expression, Gingiva.
- metabolism : Epithelium, Gingiva, Gingival Hyperplasia, Mouth, Edentulous.
- Animals, Down-Regulation, Male, Rats.
Abstract
To examine the role of E-cadherin in epithelial hyperplasia of cyclosporin A (CsA)-induced gingival enlargement, mRNA and protein levels of E-cadherin, beta-catenin, proliferating cell nuclear antigen (PCNA), and Cyclin D1 were examined in the edentulous gingiva of rats following CsA treatment.
DOI: 10.1902/jop.2006.050316
PubMed: 16671876
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pubmed:16671876Le document en format XML
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Biology, National Yang-Ming University, Taipei, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yen Teen" sort="Chen, Yen Teen" uniqKey="Chen Y" first="Yen-Teen" last="Chen">Yen-Teen Chen</name></author><author><name sortKey="Shieh, Yi Shing" sort="Shieh, Yi Shing" uniqKey="Shieh Y" first="Yi-Shing" last="Shieh">Yi-Shing Shieh</name></author><author><name sortKey="Chin, Yu Tang" sort="Chin, Yu Tang" uniqKey="Chin Y" first="Yu-Tang" last="Chin">Yu-Tang Chin</name></author><author><name sortKey="Huang, Ren Yeong" sort="Huang, Ren Yeong" uniqKey="Huang R" first="Ren-Yeong" last="Huang">Ren-Yeong Huang</name></author><author><name sortKey="Yang, Shih Fang" sort="Yang, Shih Fang" uniqKey="Yang S" first="Shih-Fang" last="Yang">Shih-Fang Yang</name></author><author><name sortKey="Gau, Ching Hwa" sort="Gau, Ching Hwa" uniqKey="Gau C" first="Ching-Hwa" last="Gau">Ching-Hwa Gau</name></author><author><name sortKey="Fu, Earl" sort="Fu, Earl" uniqKey="Fu E" first="Earl" last="Fu">Earl Fu</name></author></analytic><series><title level="j">Journal of periodontology</title><idno type="ISSN">0022-3492</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cadherins (metabolism)</term><term>Cyclin D1 (metabolism)</term><term>Cyclosporine (adverse effects)</term><term>Cyclosporine (pharmacology)</term><term>Down-Regulation</term><term>Epithelium (drug effects)</term><term>Epithelium (metabolism)</term><term>Gene Expression (drug effects)</term><term>Gingiva (drug effects)</term><term>Gingiva (metabolism)</term><term>Gingival Hyperplasia (chemically induced)</term><term>Gingival Hyperplasia (metabolism)</term><term>Immunosuppressive Agents (adverse effects)</term><term>Immunosuppressive Agents (pharmacology)</term><term>Male</term><term>Mouth, Edentulous (metabolism)</term><term>Proliferating Cell Nuclear Antigen (metabolism)</term><term>RNA, Messenger (metabolism)</term><term>Rats</term><term>beta Catenin (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN messager (métabolisme)</term><term>Animaux</term><term>Antigène nucléaire de prolifération cellulaire (métabolisme)</term><term>Bouche édentée (métabolisme)</term><term>Cadhérines (métabolisme)</term><term>Ciclosporine (effets indésirables)</term><term>Ciclosporine (pharmacologie)</term><term>Cycline D1 (métabolisme)</term><term>Expression des gènes ()</term><term>Gencive ()</term><term>Gencive (métabolisme)</term><term>Hyperplasie gingivale ()</term><term>Hyperplasie gingivale (métabolisme)</term><term>Immunosuppresseurs (effets indésirables)</term><term>Immunosuppresseurs (pharmacologie)</term><term>Mâle</term><term>Rats</term><term>Régulation négative</term><term>bêta-Caténine (métabolisme)</term><term>Épithélium ()</term><term>Épithélium (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Cyclosporine</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cadherins</term><term>Cyclin D1</term><term>Proliferating Cell Nuclear Antigen</term><term>RNA, Messenger</term><term>beta Catenin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Cyclosporine</term><term>Immunosuppressive Agents</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Gingival Hyperplasia</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Epithelium</term><term>Gene Expression</term><term>Gingiva</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Ciclosporine</term><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Epithelium</term><term>Gingiva</term><term>Gingival Hyperplasia</term><term>Mouth, Edentulous</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>ARN messager</term><term>Antigène nucléaire de prolifération cellulaire</term><term>Bouche édentée</term><term>Cadhérines</term><term>Cycline D1</term><term>Gencive</term><term>Hyperplasie gingivale</term><term>bêta-Caténine</term><term>Épithélium</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Ciclosporine</term><term>Immunosuppresseurs</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Down-Regulation</term><term>Male</term><term>Rats</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Expression des gènes</term><term>Gencive</term><term>Hyperplasie gingivale</term><term>Mâle</term><term>Rats</term><term>Régulation négative</term><term>Épithélium</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">To examine the role of E-cadherin in epithelial hyperplasia of cyclosporin A (CsA)-induced gingival enlargement, mRNA and protein levels of E-cadherin, beta-catenin, proliferating cell nuclear antigen (PCNA), and Cyclin D1 were examined in the edentulous gingiva of rats following CsA treatment.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">16671876</PMID><DateCompleted><Year>2006</Year><Month>07</Month><Day>19</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0022-3492</ISSN><JournalIssue CitedMedium="Print"><Volume>77</Volume><Issue>5</Issue><PubDate><Year>2006</Year><Month>May</Month></PubDate></JournalIssue><Title>Journal of periodontology</Title><ISOAbbreviation>J. Periodontol.</ISOAbbreviation></Journal><ArticleTitle>Cyclosporin-induced downregulation of the expression of E-cadherin during proliferation of edentulous gingival epithelium in rats.</ArticleTitle><Pagination><MedlinePgn>832-9</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">To examine the role of E-cadherin in epithelial hyperplasia of cyclosporin A (CsA)-induced gingival enlargement, mRNA and protein levels of E-cadherin, beta-catenin, proliferating cell nuclear antigen (PCNA), and Cyclin D1 were examined in the edentulous gingiva of rats following CsA treatment.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Three weeks after the extraction of all maxillary molars, 20 male Sprague-Dawley rats were assigned to a CsA-fed group (30 mg/kg daily) or a control group. Five rats per group were sacrificed at weeks 1 and 4. Edentulous ridge specimens were taken, and the expression levels of E-cadherin, beta-catenin, Cyclin D1, and PCNA mRNAs were estimated by reverse transcription-polymerase chain reaction (RT-PCR). Tissue specimens of the week 4 groups were examined using immunohistochemical (IHC) staining for proteins.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">The mRNA expression of E-cadherin was significantly weaker in the CsA-treated group than the control group at both times. Using IHC staining, a weaker level of membrane-bonded E-cadherin was also observed in the gingival epithelial cells in the CsA group than in controls. By contrast, significantly stronger beta-catenin and Cyclin D1 mRNA expressions and protein levels were found in CsA-treated rats than controls by RT-PCR and immunohistochemistry at week 4, whereas PCNA production was stronger at both times.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">CsA treatment reduced the production of E-cadherin but increased the production of beta-catenin, Cyclin D1, and PCNA. Thus, CsA may downregulate E-cadherin gene expression, leading to the epithelial cell proliferation of gingival overgrowth.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tu</LastName><ForeName>Hsiao-Pei</ForeName><Initials>HP</Initials><AffiliationInfo><Affiliation>Institute of Oral Biology, National Yang-Ming University, Taipei, Taiwan, Republic of China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Yen-Teen</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Shieh</LastName><ForeName>Yi-Shing</ForeName><Initials>YS</Initials></Author><Author ValidYN="Y"><LastName>Chin</LastName><ForeName>Yu-Tang</ForeName><Initials>YT</Initials></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Ren-Yeong</ForeName><Initials>RY</Initials></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Shih-Fang</ForeName><Initials>SF</Initials></Author><Author ValidYN="Y"><LastName>Gau</LastName><ForeName>Ching-Hwa</ForeName><Initials>CH</Initials></Author><Author ValidYN="Y"><LastName>Fu</LastName><ForeName>Earl</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Periodontol</MedlineTA><NlmUniqueID>8000345</NlmUniqueID><ISSNLinking>0022-3492</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015820">Cadherins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007166">Immunosuppressive Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018809">Proliferating Cell Nuclear Antigen</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D012333">RNA, Messenger</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051176">beta Catenin</NameOfSubstance></Chemical><Chemical><RegistryNumber>136601-57-5</RegistryNumber><NameOfSubstance UI="D019938">Cyclin D1</NameOfSubstance></Chemical><Chemical><RegistryNumber>83HN0GTJ6D</RegistryNumber><NameOfSubstance UI="D016572">Cyclosporine</NameOfSubstance></Chemical></ChemicalList><CitationSubset>D</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015820" MajorTopicYN="N">Cadherins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D019938" MajorTopicYN="N">Cyclin D1</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016572" MajorTopicYN="N">Cyclosporine</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015536" MajorTopicYN="N">Down-Regulation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004848" MajorTopicYN="N">Epithelium</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005881" MajorTopicYN="N">Gingiva</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005885" MajorTopicYN="N">Gingival Hyperplasia</DescriptorName><QualifierName UI="Q000139" MajorTopicYN="N">chemically induced</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007166" MajorTopicYN="N">Immunosuppressive Agents</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009066" MajorTopicYN="N">Mouth, Edentulous</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018809" MajorTopicYN="N">Proliferating Cell Nuclear Antigen</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012333" MajorTopicYN="N">RNA, Messenger</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051176" MajorTopicYN="N">beta Catenin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>5</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2006</Year><Month>7</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>5</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">16671876</ArticleId><ArticleId IdType="doi">10.1902/jop.2006.050316</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><noCountry><name sortKey="Chen, Yen Teen" sort="Chen, Yen Teen" uniqKey="Chen Y" first="Yen-Teen" last="Chen">Yen-Teen Chen</name><name sortKey="Chin, Yu Tang" sort="Chin, Yu Tang" uniqKey="Chin Y" first="Yu-Tang" last="Chin">Yu-Tang Chin</name><name sortKey="Fu, Earl" sort="Fu, Earl" uniqKey="Fu E" first="Earl" last="Fu">Earl Fu</name><name sortKey="Gau, Ching Hwa" sort="Gau, Ching Hwa" uniqKey="Gau C" first="Ching-Hwa" last="Gau">Ching-Hwa Gau</name><name sortKey="Huang, Ren Yeong" sort="Huang, Ren Yeong" uniqKey="Huang R" first="Ren-Yeong" last="Huang">Ren-Yeong Huang</name><name sortKey="Shieh, Yi Shing" sort="Shieh, Yi Shing" uniqKey="Shieh Y" first="Yi-Shing" last="Shieh">Yi-Shing Shieh</name><name sortKey="Yang, Shih Fang" sort="Yang, Shih Fang" uniqKey="Yang S" first="Shih-Fang" last="Yang">Shih-Fang Yang</name></noCountry><country name="République populaire de Chine"><noRegion><name sortKey="Tu, Hsiao Pei" sort="Tu, Hsiao Pei" uniqKey="Tu H" first="Hsiao-Pei" last="Tu">Hsiao-Pei Tu</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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