Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression
Identifieur interne : 009E87 ( Ncbi/Checkpoint ); précédent : 009E86; suivant : 009E88Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression
Auteurs : Johann Lechner [Allemagne] ; Sabine Schuett [Allemagne] ; Volker Von Baehr [Allemagne]Source :
- Clinical, Cosmetic and Investigational Dentistry [ 1179-1357 ] ; 2017.
Abstract
Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecrosis in the jawbone” (AIOJ). To shed light on the clinical details of this condition, osteolytic jawbone samples of 24 patients with different systemic immunological diseases were examined using four steps: presurgical dental X-ray, postsurgical histology, polymerase chain reaction DNA analysis (PCR DNA) of bacteria, and RANTES/CCL5 (R/C) expression. These four steps showed that neither X-ray nor histology delivered unambiguous results with respect to inflammatory processes; furthermore, the PCR results did not show evidence of any microbial load within the jaw samples. However, there is a striking, coherent overexpression of chemokine R/C in the AIOJ samples. This study proved the aseptic existence of “silent inflammation” within the jawbone. The ICD-10 (AIOJ) definition, which is hard to interpret, can now be substantiated with clinical evidence, while the cytokine expressions described in this report can explain the systemic immunological effects observed within the group of examined patients.
Url:
DOI: 10.2147/CCIDE.S149545
PubMed: NONE
PubMed Central: 5687454
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002A92
- to stream Pmc, to step Curation: 002A92
- to stream Pmc, to step Checkpoint: 000318
- to stream Ncbi, to step Merge: 009E87
- to stream Ncbi, to step Curation: 009E87
Links to Exploration step
PMC:5687454Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression</title>
<author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
<affiliation wicri:level="3"><nlm:aff id="af1-ccide-9-099">Clinic for Integrative Dentistry, Munich</nlm:aff>
<country>Allemagne</country>
<placeName><settlement type="city">Munich</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
</placeName>
<wicri:orgArea>Clinic for Integrative Dentistry</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Schuett, Sabine" sort="Schuett, Sabine" uniqKey="Schuett S" first="Sabine" last="Schuett">Sabine Schuett</name>
<affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
<affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmc">5687454</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687454</idno>
<idno type="RBID">PMC:5687454</idno>
<idno type="doi">10.2147/CCIDE.S149545</idno>
<idno type="pmid">NONE</idno>
<date when="2017">2017</date>
<idno type="wicri:Area/Pmc/Corpus">002A92</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A92</idno>
<idno type="wicri:Area/Pmc/Curation">002A92</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A92</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000318</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000318</idno>
<idno type="wicri:Area/Ncbi/Merge">009E87</idno>
<idno type="wicri:Area/Ncbi/Curation">009E87</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">009E87</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression</title>
<author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
<affiliation wicri:level="3"><nlm:aff id="af1-ccide-9-099">Clinic for Integrative Dentistry, Munich</nlm:aff>
<country>Allemagne</country>
<placeName><settlement type="city">Munich</settlement>
<region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
</placeName>
<wicri:orgArea>Clinic for Integrative Dentistry</wicri:orgArea>
</affiliation>
</author>
<author><name sortKey="Schuett, Sabine" sort="Schuett, Sabine" uniqKey="Schuett S" first="Sabine" last="Schuett">Sabine Schuett</name>
<affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
<affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea>
<placeName><region type="land" nuts="3">Berlin</region>
<settlement type="city">Berlin</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Clinical, Cosmetic and Investigational Dentistry</title>
<idno type="eISSN">1179-1357</idno>
<imprint><date when="2017">2017</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecrosis in the jawbone” (AIOJ). To shed light on the clinical details of this condition, osteolytic jawbone samples of 24 patients with different systemic immunological diseases were examined using four steps: presurgical dental X-ray, postsurgical histology, polymerase chain reaction DNA analysis (PCR DNA) of bacteria, and RANTES/CCL5 (R/C) expression. These four steps showed that neither X-ray nor histology delivered unambiguous results with respect to inflammatory processes; furthermore, the PCR results did not show evidence of any microbial load within the jaw samples. However, there is a striking, coherent overexpression of chemokine R/C in the AIOJ samples. This study proved the aseptic existence of “silent inflammation” within the jawbone. The ICD-10 (AIOJ) definition, which is hard to interpret, can now be substantiated with clinical evidence, while the cytokine expressions described in this report can explain the systemic immunological effects observed within the group of examined patients.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Townsend, Mj" uniqKey="Townsend M">MJ Townsend</name>
</author>
<author><name sortKey="Mckenzie, An" uniqKey="Mckenzie A">AN McKenzie</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lechner, J" uniqKey="Lechner J">J Lechner</name>
</author>
<author><name sortKey="Von Baehr, V" uniqKey="Von Baehr V">V von Baehr</name>
</author>
</analytic>
</biblStruct>
<biblStruct></biblStruct>
<biblStruct><analytic><author><name sortKey="Lechner, J" uniqKey="Lechner J">J Lechner</name>
</author>
<author><name sortKey="Von Baehr, V" uniqKey="Von Baehr V">V von Baehr</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ono, K" uniqKey="Ono K">K Ono</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mankin, Hj" uniqKey="Mankin H">HJ Mankin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ratner, Ej" uniqKey="Ratner E">EJ Ratner</name>
</author>
<author><name sortKey="Langer, B" uniqKey="Langer B">B Langer</name>
</author>
<author><name sortKey="Evins, Ml" uniqKey="Evins M">ML Evins</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Graff Radford, Sb" uniqKey="Graff Radford S">SB Graff-Radford</name>
</author>
<author><name sortKey="Simmons, M" uniqKey="Simmons M">M Simmons</name>
</author>
<author><name sortKey="Fox, L" uniqKey="Fox L">L Fox</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name>
</author>
<author><name sortKey="Roberts, Am" uniqKey="Roberts A">AM Roberts</name>
</author>
<author><name sortKey="Person, P" uniqKey="Person P">P Person</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lechner, J" uniqKey="Lechner J">J Lechner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stulnig, T" uniqKey="Stulnig T">T Stulnig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schwartz, Sf" uniqKey="Schwartz S">SF Schwartz</name>
</author>
<author><name sortKey="Foster, Jk" uniqKey="Foster J">JK Foster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ardran, Cm" uniqKey="Ardran C">CM Ardran</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name>
</author>
<author><name sortKey="Dawood, A" uniqKey="Dawood A">A Dawood</name>
</author>
<author><name sortKey="Mannocci, F" uniqKey="Mannocci F">F Mannocci</name>
</author>
<author><name sortKey="Wilson, R" uniqKey="Wilson R">R Wilson</name>
</author>
<author><name sortKey="Pitt Ford, T" uniqKey="Pitt Ford T">T Pitt Ford</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Segall, Ro" uniqKey="Segall R">RO Segall</name>
</author>
<author><name sortKey="Del Rio, Ce" uniqKey="Del Rio C">CE Del Rio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name>
</author>
<author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Levy, Ja" uniqKey="Levy J">JA Levy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Von Luettichau, I" uniqKey="Von Luettichau I">I von Luettichau</name>
</author>
<author><name sortKey="Nelson, Pj" uniqKey="Nelson P">PJ Nelson</name>
</author>
<author><name sortKey="Pattison, Jm" uniqKey="Pattison J">JM Pattison</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Stearns, Sc" uniqKey="Stearns S">SC Stearns</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Tilg, H" uniqKey="Tilg H">H Tilg</name>
</author>
<author><name sortKey="Moschen, Ra" uniqKey="Moschen R">RA Moschen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Appay, V" uniqKey="Appay V">V Appay</name>
</author>
<author><name sortKey="Rowland Jones, Sl" uniqKey="Rowland Jones S">SL Rowland-Jones</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bolin, Lm" uniqKey="Bolin L">LM Bolin</name>
</author>
<author><name sortKey="Murray, R" uniqKey="Murray R">R Murray</name>
</author>
<author><name sortKey="Lukacs, Nw" uniqKey="Lukacs N">NW Lukacs</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name>
</author>
<author><name sortKey="Juremalm, M" uniqKey="Juremalm M">M Juremalm</name>
</author>
<author><name sortKey="Olsson, N" uniqKey="Olsson N">N Olsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rathanaswami, P" uniqKey="Rathanaswami P">P Rathanaswami</name>
</author>
<author><name sortKey="Hachicha, M" uniqKey="Hachicha M">M Hachicha</name>
</author>
<author><name sortKey="Sadick, M" uniqKey="Sadick M">M Sadick</name>
</author>
<author><name sortKey="Schall, Tj" uniqKey="Schall T">TJ Schall</name>
</author>
<author><name sortKey="Mccoll, Sr" uniqKey="Mccoll S">SR McColl</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name>
</author>
<author><name sortKey="Margolis, M" uniqKey="Margolis M">M Margolis</name>
</author>
<author><name sortKey="Shankland, W" uniqKey="Shankland W">W Shankland</name>
</author>
<author><name sortKey="Imbeau, J" uniqKey="Imbeau J">J Imbeau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Al Nawas, B" uniqKey="Al Nawas B">B Al-Nawas</name>
</author>
<author><name sortKey="Klein, Mo" uniqKey="Klein M">MO Klein</name>
</author>
<author><name sortKey="Gotz, H" uniqKey="Gotz H">H Götz</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<affiliations><list><country><li>Allemagne</li>
</country>
<region><li>Bavière</li>
<li>Berlin</li>
<li>District de Haute-Bavière</li>
</region>
<settlement><li>Berlin</li>
<li>Munich</li>
</settlement>
</list>
<tree><country name="Allemagne"><region name="Bavière"><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name>
</region>
<name sortKey="Schuett, Sabine" sort="Schuett, Sabine" uniqKey="Schuett S" first="Sabine" last="Schuett">Sabine Schuett</name>
<name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009E87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 009E87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Ncbi |étape= Checkpoint |type= RBID |clé= PMC:5687454 |texte= Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:NONE" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
This area was generated with Dilib version V0.6.32. |