Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression
Identifieur interne : 009E87 ( Ncbi/Merge ); précédent : 009E86; suivant : 009E88Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression
Auteurs : Johann Lechner [Allemagne] ; Sabine Schuett [Allemagne] ; Volker Von Baehr [Allemagne]Source :
- Clinical, Cosmetic and Investigational Dentistry [ 1179-1357 ] ; 2017.
Abstract
Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecrosis in the jawbone” (AIOJ). To shed light on the clinical details of this condition, osteolytic jawbone samples of 24 patients with different systemic immunological diseases were examined using four steps: presurgical dental X-ray, postsurgical histology, polymerase chain reaction DNA analysis (PCR DNA) of bacteria, and RANTES/CCL5 (R/C) expression. These four steps showed that neither X-ray nor histology delivered unambiguous results with respect to inflammatory processes; furthermore, the PCR results did not show evidence of any microbial load within the jaw samples. However, there is a striking, coherent overexpression of chemokine R/C in the AIOJ samples. This study proved the aseptic existence of “silent inflammation” within the jawbone. The ICD-10 (AIOJ) definition, which is hard to interpret, can now be substantiated with clinical evidence, while the cytokine expressions described in this report can explain the systemic immunological effects observed within the group of examined patients.
Url:
DOI: 10.2147/CCIDE.S149545
PubMed: NONE
PubMed Central: 5687454
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002A92
- to stream Pmc, to step Curation: 002A92
- to stream Pmc, to step Checkpoint: 000318
Links to Exploration step
PMC:5687454Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression</title><author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name><affiliation wicri:level="3"><nlm:aff id="af1-ccide-9-099">Clinic for Integrative Dentistry, Munich</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>Clinic for Integrative Dentistry</wicri:orgArea></affiliation></author><author><name sortKey="Schuett, Sabine" sort="Schuett, Sabine" uniqKey="Schuett S" first="Sabine" last="Schuett">Sabine Schuett</name><affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name><affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">5687454</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5687454</idno><idno type="RBID">PMC:5687454</idno><idno type="doi">10.2147/CCIDE.S149545</idno><idno type="pmid">NONE</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002A92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002A92</idno><idno type="wicri:Area/Pmc/Curation">002A92</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002A92</idno><idno type="wicri:Area/Pmc/Checkpoint">000318</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000318</idno><idno type="wicri:Area/Ncbi/Merge">009E87</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression</title><author><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name><affiliation wicri:level="3"><nlm:aff id="af1-ccide-9-099">Clinic for Integrative Dentistry, Munich</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>Clinic for Integrative Dentistry</wicri:orgArea></affiliation></author><author><name sortKey="Schuett, Sabine" sort="Schuett, Sabine" uniqKey="Schuett S" first="Sabine" last="Schuett">Sabine Schuett</name><affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author><author><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name><affiliation wicri:level="3"><nlm:aff id="af2-ccide-9-099">Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin</wicri:regionArea><placeName><region type="land" nuts="3">Berlin</region><settlement type="city">Berlin</settlement></placeName></affiliation></author></analytic><series><title level="j">Clinical, Cosmetic and Investigational Dentistry</title><idno type="eISSN">1179-1357</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecrosis in the jawbone” (AIOJ). To shed light on the clinical details of this condition, osteolytic jawbone samples of 24 patients with different systemic immunological diseases were examined using four steps: presurgical dental X-ray, postsurgical histology, polymerase chain reaction DNA analysis (PCR DNA) of bacteria, and RANTES/CCL5 (R/C) expression. These four steps showed that neither X-ray nor histology delivered unambiguous results with respect to inflammatory processes; furthermore, the PCR results did not show evidence of any microbial load within the jaw samples. However, there is a striking, coherent overexpression of chemokine R/C in the AIOJ samples. This study proved the aseptic existence of “silent inflammation” within the jawbone. The ICD-10 (AIOJ) definition, which is hard to interpret, can now be substantiated with clinical evidence, while the cytokine expressions described in this report can explain the systemic immunological effects observed within the group of examined patients.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Townsend, Mj" uniqKey="Townsend M">MJ Townsend</name></author><author><name sortKey="Mckenzie, An" uniqKey="Mckenzie A">AN McKenzie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lechner, J" uniqKey="Lechner J">J Lechner</name></author><author><name sortKey="Von Baehr, V" uniqKey="Von Baehr V">V von Baehr</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lechner, J" uniqKey="Lechner J">J Lechner</name></author><author><name sortKey="Von Baehr, V" uniqKey="Von Baehr V">V von Baehr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ono, K" uniqKey="Ono K">K Ono</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mankin, Hj" uniqKey="Mankin H">HJ Mankin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ratner, Ej" uniqKey="Ratner E">EJ Ratner</name></author><author><name sortKey="Langer, B" uniqKey="Langer B">B Langer</name></author><author><name sortKey="Evins, Ml" uniqKey="Evins M">ML Evins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Graff Radford, Sb" uniqKey="Graff Radford S">SB Graff-Radford</name></author><author><name sortKey="Simmons, M" uniqKey="Simmons M">M Simmons</name></author><author><name sortKey="Fox, L" uniqKey="Fox L">L Fox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author><author><name sortKey="Roberts, Am" uniqKey="Roberts A">AM Roberts</name></author><author><name sortKey="Person, P" uniqKey="Person P">P Person</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lechner, J" uniqKey="Lechner J">J Lechner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stulnig, T" uniqKey="Stulnig T">T Stulnig</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, Sf" uniqKey="Schwartz S">SF Schwartz</name></author><author><name sortKey="Foster, Jk" uniqKey="Foster J">JK Foster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ardran, Cm" uniqKey="Ardran C">CM Ardran</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Patel, S" uniqKey="Patel S">S Patel</name></author><author><name sortKey="Dawood, A" uniqKey="Dawood A">A Dawood</name></author><author><name sortKey="Mannocci, F" uniqKey="Mannocci F">F Mannocci</name></author><author><name sortKey="Wilson, R" uniqKey="Wilson R">R Wilson</name></author><author><name sortKey="Pitt Ford, T" uniqKey="Pitt Ford T">T Pitt Ford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Segall, Ro" uniqKey="Segall R">RO Segall</name></author><author><name sortKey="Del Rio, Ce" uniqKey="Del Rio C">CE Del Rio</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author><author><name sortKey="Roberts, A" uniqKey="Roberts A">A Roberts</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Levy, Ja" uniqKey="Levy J">JA Levy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Luettichau, I" uniqKey="Von Luettichau I">I von Luettichau</name></author><author><name sortKey="Nelson, Pj" uniqKey="Nelson P">PJ Nelson</name></author><author><name sortKey="Pattison, Jm" uniqKey="Pattison J">JM Pattison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stearns, Sc" uniqKey="Stearns S">SC Stearns</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tilg, H" uniqKey="Tilg H">H Tilg</name></author><author><name sortKey="Moschen, Ra" uniqKey="Moschen R">RA Moschen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Appay, V" uniqKey="Appay V">V Appay</name></author><author><name sortKey="Rowland Jones, Sl" uniqKey="Rowland Jones S">SL Rowland-Jones</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bolin, Lm" uniqKey="Bolin L">LM Bolin</name></author><author><name sortKey="Murray, R" uniqKey="Murray R">R Murray</name></author><author><name sortKey="Lukacs, Nw" uniqKey="Lukacs N">NW Lukacs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, M" uniqKey="Fischer M">M Fischer</name></author><author><name sortKey="Juremalm, M" uniqKey="Juremalm M">M Juremalm</name></author><author><name sortKey="Olsson, N" uniqKey="Olsson N">N Olsson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rathanaswami, P" uniqKey="Rathanaswami P">P Rathanaswami</name></author><author><name sortKey="Hachicha, M" uniqKey="Hachicha M">M Hachicha</name></author><author><name sortKey="Sadick, M" uniqKey="Sadick M">M Sadick</name></author><author><name sortKey="Schall, Tj" uniqKey="Schall T">TJ Schall</name></author><author><name sortKey="Mccoll, Sr" uniqKey="Mccoll S">SR McColl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author><author><name sortKey="Margolis, M" uniqKey="Margolis M">M Margolis</name></author><author><name sortKey="Shankland, W" uniqKey="Shankland W">W Shankland</name></author><author><name sortKey="Imbeau, J" uniqKey="Imbeau J">J Imbeau</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Nawas, B" uniqKey="Al Nawas B">B Al-Nawas</name></author><author><name sortKey="Klein, Mo" uniqKey="Klein M">MO Klein</name></author><author><name sortKey="Gotz, H" uniqKey="Gotz H">H Götz</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Cosmet Investig Dent</journal-id><journal-id journal-id-type="iso-abbrev">Clin Cosmet Investig Dent</journal-id><journal-id journal-id-type="publisher-id">Clinical, Cosmetic and Investigational Dentistry</journal-id><journal-title-group><journal-title>Clinical, Cosmetic and Investigational Dentistry</journal-title></journal-title-group><issn pub-type="epub">1179-1357</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">5687454</article-id><article-id pub-id-type="doi">10.2147/CCIDE.S149545</article-id><article-id pub-id-type="publisher-id">ccide-9-099</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lechner</surname><given-names>Johann</given-names></name><xref ref-type="aff" rid="af1-ccide-9-099">1</xref><xref ref-type="corresp" rid="c1-ccide-9-099"></xref></contrib><contrib contrib-type="author"><name><surname>Schuett</surname><given-names>Sabine</given-names></name><xref ref-type="aff" rid="af2-ccide-9-099">2</xref></contrib><contrib contrib-type="author"><name><surname>von Baehr</surname><given-names>Volker</given-names></name><xref ref-type="aff" rid="af2-ccide-9-099">2</xref></contrib></contrib-group><aff id="af1-ccide-9-099"><label>1</label>Clinic for Integrative Dentistry, Munich</aff><aff id="af2-ccide-9-099"><label>2</label>Department of Immunology and Allergology, Institute for Medical Diagnostics in MVZ GbR, Berlin, Germany</aff><author-notes><corresp id="c1-ccide-9-099">Correspondence: Johann Lechner, Clinic for Integrative Dentistry, Gruenwalder Str. 10A, 81547 Munich, Germany, Tel +49 89 697 00 55, Fax +49 89 692 58 30, Email <email>drlechner@aol.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>09</day><month>11</month><year>2017</year></pub-date><volume>9</volume><fpage>99</fpage><lpage>109</lpage><permissions><copyright-statement>© 2017 Lechner et al. This work is published and licensed by Dove Medical Press Limited</copyright-statement><copyright-year>2017</copyright-year><license><license-p>The full terms of this license are available at <ext-link ext-link-type="uri" xlink:href="https://www.dovepress.com/terms.php">https://www.dovepress.com/terms.php</ext-link> and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.</license-p></license></permissions><abstract><p>Of the definitions listed in the International Statistical Classification of Diseases and Related Health Problems, tenth revision (ICD-10), two disease descriptions can be found together: “idiopathic aseptic bone necrosis” and “avascular bone necrosis.” The relevant literature on both the conditions abbreviates both as “aseptic ischemic osteonecrosis in the jawbone” (AIOJ). To shed light on the clinical details of this condition, osteolytic jawbone samples of 24 patients with different systemic immunological diseases were examined using four steps: presurgical dental X-ray, postsurgical histology, polymerase chain reaction DNA analysis (PCR DNA) of bacteria, and RANTES/CCL5 (R/C) expression. These four steps showed that neither X-ray nor histology delivered unambiguous results with respect to inflammatory processes; furthermore, the PCR results did not show evidence of any microbial load within the jaw samples. However, there is a striking, coherent overexpression of chemokine R/C in the AIOJ samples. This study proved the aseptic existence of “silent inflammation” within the jawbone. The ICD-10 (AIOJ) definition, which is hard to interpret, can now be substantiated with clinical evidence, while the cytokine expressions described in this report can explain the systemic immunological effects observed within the group of examined patients.</p></abstract><kwd-group><title>Keywords</title><kwd>jawbone</kwd><kwd>osteonecrosis</kwd><kwd>RANTES</kwd><kwd>CCL5</kwd><kwd>silent inflammation</kwd><kwd>aseptic inflammation</kwd><kwd>PCR</kwd><kwd>ICD-10</kwd></kwd-group></article-meta></front><floats-group><fig id="f1-ccide-9-099" position="float"><label>Figure 1</label><caption><p>(<bold>A</bold>) Morphology of fatty degenerative osteonecrosis in the jawbone. (<bold>B</bold>) Red circle indicates FDOJ area.</p><p><bold>Abbreviation:</bold> FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></caption><graphic xlink:href="ccide-9-099Fig1"></graphic></fig><fig id="f2-ccide-9-099" position="float"><label>Figure 2</label><caption><p>Pathohistological structure of typical fatty degenerative osteonecrosis in the jawbone tissue (200 fold).</p></caption><graphic xlink:href="ccide-9-099Fig2"></graphic></fig><fig id="f3-ccide-9-099" position="float"><label>Figure 3</label><caption><p>Paper sticks serving as a pooled sample within a fatty degenerative osteonecrosis in the jawbone lump.</p><p><bold>Abbreviation:</bold> FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></caption><graphic xlink:href="ccide-9-099Fig3"></graphic></fig><fig id="f4-ccide-9-099" position="float"><label>Figure 4</label><caption><p>(<bold>A</bold>) Measuring the OPG radiodensity of an FDOJ area in the lower jawbone, right-sided region =48/49. (<bold>B</bold>) Morphology of the extracted FDOJ area, which is compared in size with a ceramic ball mill (Φ=0.6 mm).</p><p><bold>Abbreviations:</bold> ÒPG, orthopantomogram; XrDn, X-ray density; FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></caption><graphic xlink:href="ccide-9-099Fig4"></graphic></fig><fig id="f5-ccide-9-099" position="float"><label>Figure 5</label><caption><p>Histological characteristics of the 24 FDOJ samples, of which only 12% showed “Inflammation-inactive cells.”</p><p><bold>Abbreviation:</bold> FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></caption><graphic xlink:href="ccide-9-099Fig5"></graphic></fig><fig id="f6-ccide-9-099" position="float"><label>Figure 6</label><caption><p>Comparison of RANTES/CCL5 expression in 19 normal jawbone samples (blue column) and 24 FDOJ samples in four groups of ISD patients (red columns).</p><p><bold>Abbreviations:</bold> FDOJ, fatty degenerative osteonecrosis in the jawbone; ISD, immunological systemic disease.</p></caption><graphic xlink:href="ccide-9-099Fig6"></graphic></fig><fig id="f7-ccide-9-099" position="float"><label>Figure 7</label><caption><p>Correlation between radiodensity and RANTES levels in FDOJ. The red lines indicate the mean values of FDOJ collective; the green lines are equivalent to values associated with a normal jawbone. Red dots indicate values out of statistical significant.</p><p><bold>Abbreviations:</bold> XrDn, X-ray density; FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></caption><graphic xlink:href="ccide-9-099Fig7"></graphic></fig><fig id="f8-ccide-9-099" position="float"><label>Figure 8</label><caption><p>Comparison of RANTES/CCL5 expression and OPG X-ray density among the various samples collected between those with FDOJ and the normal results associated with a normal jawbone.</p><p><bold>Abbreviations:</bold> OPG, orthopantomogram; XrDn, X-ray density; FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></caption><graphic xlink:href="ccide-9-099Fig8"></graphic></fig><table-wrap id="t1-ccide-9-099" position="float"><label>Table 1</label><caption><p>PCR DNA analysis of 24 FDOJ regions</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Nr</th><th valign="top" align="left" rowspan="1" colspan="1">Re glo</th><th valign="top" align="left" rowspan="1" colspan="1">A a</th><th valign="top" align="left" rowspan="1" colspan="1">P g</th><th valign="top" align="left" rowspan="1" colspan="1">T f</th><th valign="top" align="left" rowspan="1" colspan="1">T d</th><th valign="top" align="left" rowspan="1" colspan="1">P i</th><th valign="top" align="left" rowspan="1" colspan="1">P m</th><th valign="top" align="left" rowspan="1" colspan="1">F s</th><th valign="top" align="left" rowspan="1" colspan="1">F n</th><th valign="top" align="left" rowspan="1" colspan="1">C r</th><th valign="top" align="left" rowspan="1" colspan="1">E n</th><th valign="top" align="left" rowspan="1" colspan="1">E C</th><th valign="top" align="left" rowspan="1" colspan="1">C g</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">1</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">++</td><td valign="top" align="left" rowspan="1" colspan="1">++</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">17</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">45/45</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">6</td><td valign="top" align="left" rowspan="1" colspan="1">37</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">7</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">8</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">9</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">10</td><td valign="top" align="left" rowspan="1" colspan="1">38/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">++</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">11</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">12</td><td valign="top" align="left" rowspan="1" colspan="1">16</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">13</td><td valign="top" align="left" rowspan="1" colspan="1">28/29</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">14</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">15</td><td valign="top" align="left" rowspan="1" colspan="1">18</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">16</td><td valign="top" align="left" rowspan="1" colspan="1">36</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">17</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">18</td><td valign="top" align="left" rowspan="1" colspan="1">28/29</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">19</td><td valign="top" align="left" rowspan="1" colspan="1">24</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">20</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">21</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">22</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">23</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">24</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-ccide-9-099"><p><bold>Notes:</bold> Very high-degree pathogenic: <italic>Aggregatibacter actinomycetemcomitans</italic> (A a), <italic>Porphyromonas gingivalis</italic> (P g), <italic>Tannerella forsythia</italic> (T f), and <italic>Treponema denticola</italic> (T d). High-degree pathogenic: <italic>Prevotella intermedia</italic> (P i), <italic>Parvimonas micra</italic> (P m), <italic>Fusobacterium</italic> spp. (F s), <italic>Fusobacterium nucleatum</italic> (F n), <italic>Campylobatcer rectus</italic>/<italic>showae</italic> (C r), and <italic>Eubacterium nodatum</italic> (E n). Moderately pathogenic: <italic>Eikenella corrodens</italic> (E c) and <italic>Capnocytophaga gingiva</italic> (C g). + = moderate, ++ = strong, +++ = severe.</p></fn><fn id="tfn2-ccide-9-099"><p><bold>Abbreviations:</bold> PCR DNA, polymerase chain reaction DNA analysis; FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-ccide-9-099" position="float"><label>Table 2</label><caption><p>Statistical results of periodontal pathogenic marker germs present in the FDOJ samples</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">A a</th><th valign="top" align="left" rowspan="1" colspan="1">P g</th><th valign="top" align="left" rowspan="1" colspan="1">T f</th><th valign="top" align="left" rowspan="1" colspan="1">T d</th><th valign="top" align="left" rowspan="1" colspan="1">P i</th><th valign="top" align="left" rowspan="1" colspan="1">P m</th><th valign="top" align="left" rowspan="1" colspan="1">F s</th><th valign="top" align="left" rowspan="1" colspan="1">F n</th><th valign="top" align="left" rowspan="1" colspan="1">C r</th><th valign="top" align="left" rowspan="1" colspan="1">E n</th><th valign="top" align="left" rowspan="1" colspan="1">E c</th><th valign="top" align="left" rowspan="1" colspan="1">C g</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">4%</td><td valign="top" align="left" rowspan="1" colspan="1">16%</td><td valign="top" align="left" rowspan="1" colspan="1">20%</td><td valign="top" align="left" rowspan="1" colspan="1">12%</td><td valign="top" align="left" rowspan="1" colspan="1">4%</td><td valign="top" align="left" rowspan="1" colspan="1">4%</td><td valign="top" align="left" rowspan="1" colspan="1">12%</td><td valign="top" align="left" rowspan="1" colspan="1">0%</td><td valign="top" align="left" rowspan="1" colspan="1">16%</td><td valign="top" align="left" rowspan="1" colspan="1">0%</td><td valign="top" align="left" rowspan="1" colspan="1">4%</td><td valign="top" align="left" rowspan="1" colspan="1">4%</td></tr></tbody></table><table-wrap-foot><fn id="tfn3-ccide-9-099"><p><bold>Notes:</bold> Very high-degree pathogenic: <italic>Aggregatibacter actinomycetemcomitans</italic> (A a), <italic>Porphyromonas gingivalis</italic> (P g), <italic>Tannerella forsythia</italic> (T f), and <italic>Treponema denticola</italic> (T d). Highdegree pathogenic: <italic>Prevotella intermedia</italic> (P i), <italic>Parvimonas micra</italic> (P m), <italic>Fusobacterium spp</italic>. (F s), <italic>Fusobacterium nucleatum</italic> (F n), <italic>Campylobatcer rectus/showae</italic> (C r), and <italic>Eubacterium nodatum</italic> (E n). Moderately pathogenic: <italic>Eikenella corrodens</italic> (E c) and <italic>Capnocytophaga gingiva</italic> (C g).</p></fn><fn id="tfn4-ccide-9-099"><p><bold>Abbreviation:</bold> FDOJ, fatty degenerative osteonecrosis in the jawbone.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t3-ccide-9-099" position="float"><label>Table 3</label><caption><p>Overview and juxtaposition of the results obtained from 24 FDOJ samples from presurgical OPG radiodensity, intrasurgical R/C expression, histology, and PCR bacterial analysis of fatty degenerative necrotized medulla areas.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1">Patient</th><th valign="top" align="left" rowspan="1" colspan="1">Area JB</th><th valign="top" align="left" rowspan="1" colspan="1">X-ray density</th><th valign="top" align="left" rowspan="1" colspan="1">RANTES (pg/mL)</th><th valign="top" align="left" rowspan="1" colspan="1">Histo inflammat-cells (inactive)</th><th valign="top" align="left" rowspan="1" colspan="1">Histo ischam/fibros/Troph/Necr Ad (grad)</th><th valign="top" align="left" rowspan="1" colspan="1">PCR bacteria (summary positive)</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">1</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">126</td><td valign="top" align="left" rowspan="1" colspan="1">176</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">10</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">152</td><td valign="top" align="left" rowspan="1" colspan="1">1172</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">1</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">156</td><td valign="top" align="left" rowspan="1" colspan="1">1537</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">2</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">17</td><td valign="top" align="left" rowspan="1" colspan="1">142</td><td valign="top" align="left" rowspan="1" colspan="1">4035</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">5</td><td valign="top" align="left" rowspan="1" colspan="1">45/46</td><td valign="top" align="left" rowspan="1" colspan="1">90</td><td valign="top" align="left" rowspan="1" colspan="1">4262</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">6</td><td valign="top" align="left" rowspan="1" colspan="1">37</td><td valign="top" align="left" rowspan="1" colspan="1">178</td><td valign="top" align="left" rowspan="1" colspan="1">2575</td><td valign="top" align="left" rowspan="1" colspan="1">Inactive</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">7</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">159</td><td valign="top" align="left" rowspan="1" colspan="1">518</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">1</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">8</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">169</td><td valign="top" align="left" rowspan="1" colspan="1">2087</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">9</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">122</td><td valign="top" align="left" rowspan="1" colspan="1">677</td><td valign="top" align="left" rowspan="1" colspan="1">Inactive</td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">10</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">159</td><td valign="top" align="left" rowspan="1" colspan="1">2000</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">1</td><td valign="top" align="left" rowspan="1" colspan="1">8</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">11</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">146</td><td valign="top" align="left" rowspan="1" colspan="1">2162</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">1</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">12</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">169</td><td valign="top" align="left" rowspan="1" colspan="1">2917</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">f3</td><td valign="top" align="left" rowspan="1" colspan="1">28/29</td><td valign="top" align="left" rowspan="1" colspan="1">81</td><td valign="top" align="left" rowspan="1" colspan="1">5352</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">14</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">147</td><td valign="top" align="left" rowspan="1" colspan="1">17000</td><td valign="top" align="left" rowspan="1" colspan="1">Inactive</td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">15</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">132</td><td valign="top" align="left" rowspan="1" colspan="1">4185</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">16</td><td valign="top" align="left" rowspan="1" colspan="1">36</td><td valign="top" align="left" rowspan="1" colspan="1">115</td><td valign="top" align="left" rowspan="1" colspan="1">7036</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">17</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">122</td><td valign="top" align="left" rowspan="1" colspan="1">10915</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">18</td><td valign="top" align="left" rowspan="1" colspan="1">28/29</td><td valign="top" align="left" rowspan="1" colspan="1">138</td><td valign="top" align="left" rowspan="1" colspan="1">3122</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">19</td><td valign="top" align="left" rowspan="1" colspan="1">24</td><td valign="top" align="left" rowspan="1" colspan="1">101</td><td valign="top" align="left" rowspan="1" colspan="1">3200</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">20</td><td valign="top" align="left" rowspan="1" colspan="1">18/19</td><td valign="top" align="left" rowspan="1" colspan="1">121</td><td valign="top" align="left" rowspan="1" colspan="1">5600</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">21</td><td valign="top" align="left" rowspan="1" colspan="1">38/39</td><td valign="top" align="left" rowspan="1" colspan="1">146</td><td valign="top" align="left" rowspan="1" colspan="1">2437</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">22</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">189</td><td valign="top" align="left" rowspan="1" colspan="1">6950</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">23</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">192</td><td valign="top" align="left" rowspan="1" colspan="1">9000</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">4</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">24</td><td valign="top" align="left" rowspan="1" colspan="1">48/49</td><td valign="top" align="left" rowspan="1" colspan="1">124</td><td valign="top" align="left" rowspan="1" colspan="1">2125</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">3</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Median</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">140</td><td valign="top" align="left" rowspan="1" colspan="1">4210</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">2.6</td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Normal</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1">125</td><td valign="top" align="left" rowspan="1" colspan="1">149.9</td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td><td valign="top" align="left" rowspan="1" colspan="1"></td></tr></tbody></table><table-wrap-foot><fn id="tfn5-ccide-9-099"><p><bold>Abbreviations:</bold> OPG, orthopantomogram; FDOJ, fatty degenerative osteonecrosis in the jawbone; R/C, RANTES/CCL5; PCR, polymerase chain reaction; JB, jawbone; Histo, histology; ischam, ischemia; fibros, fibrosis; troph, trophic dysfunction; Necr Ad, necrotic adipocytes; grad, grading.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t4-ccide-9-099" position="float"><label>Table 4</label><caption><p>Overview of four inflammatory types in the jawbone</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"></th><th valign="top" align="left" rowspan="1" colspan="1">Apical/intra-dental pulpitis/abscess</th><th valign="top" align="left" rowspan="1" colspan="1">Periodontal periodontitis</th><th valign="top" align="left" rowspan="1" colspan="1">Intra-osseous acute osteomyelitis</th><th valign="top" align="left" rowspan="1" colspan="1">Intra-osseous “silent” FDOJ</th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Visibility on X-ray</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Bacteria</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">++</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Pain</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Histology – inflammation</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">++</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td><td valign="top" align="left" rowspan="1" colspan="1">0</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Trophism/ischemia</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">0</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Cytokines</td><td valign="top" align="left" rowspan="1" colspan="1">IL-1, TNF-a</td><td valign="top" align="left" rowspan="1" colspan="1">IL-6/TNF-a</td><td valign="top" align="left" rowspan="1" colspan="1">IL-6/TNF-a</td><td valign="top" align="left" rowspan="1" colspan="1">RANTES/CCL5</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Systemic impact</td><td valign="top" align="left" rowspan="1" colspan="1">Pain/sepsis</td><td valign="top" align="left" rowspan="1" colspan="1">+</td><td valign="top" align="left" rowspan="1" colspan="1">Septic</td><td valign="top" align="left" rowspan="1" colspan="1">+++</td></tr></tbody></table><table-wrap-foot><fn id="tfn6-ccide-9-099"><p><bold>Note:</bold> + = moderate, ++ = strong, +++ = severe.</p></fn><fn id="tfn7-ccide-9-099"><p><bold>Abbreviations:</bold> FDOJ, fatty degenerative osteonecrosis in the jawbone; IL, interleukin; TNF, tumor necrosis factor.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>Berlin</li><li>District de Haute-Bavière</li></region><settlement><li>Berlin</li><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Lechner, Johann" sort="Lechner, Johann" uniqKey="Lechner J" first="Johann" last="Lechner">Johann Lechner</name></region><name sortKey="Schuett, Sabine" sort="Schuett, Sabine" uniqKey="Schuett S" first="Sabine" last="Schuett">Sabine Schuett</name><name sortKey="Von Baehr, Volker" sort="Von Baehr, Volker" uniqKey="Von Baehr V" first="Volker" last="Von Baehr">Volker Von Baehr</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 009E87 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 009E87 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= PMC:5687454
|texte= Aseptic-avascular osteonecrosis: local “silent inflammation” in the jawbone and RANTES/CCL5 overexpression
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:NONE" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |