Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws
Identifieur interne : 004E73 ( Ncbi/Checkpoint ); précédent : 004E72; suivant : 004E74Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws
Auteurs : Monir Moradzadeh Khiavi ; Amir Ala Aghbali ; Monireh Halimi ; Maryam Kouhsoltani ; Hamed HamishehkarSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2013.
Abstract
The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.
Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.
There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (
The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.
Url:
DOI: 10.4103/0973-029X.125197
PubMed: 24574652
PubMed Central: 3927335
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 003247
- to stream Pmc, to step Curation: 003247
- to stream Pmc, to step Checkpoint: 001974
- to stream Ncbi, to step Merge: 004E73
- to stream Ncbi, to step Curation: 004E73
Links to Exploration step
PMC:3927335Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws</title><author><name sortKey="Khiavi, Monir Moradzadeh" sort="Khiavi, Monir Moradzadeh" uniqKey="Khiavi M" first="Monir Moradzadeh" last="Khiavi">Monir Moradzadeh Khiavi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aghbali, Amir Ala" sort="Aghbali, Amir Ala" uniqKey="Aghbali A" first="Amir Ala" last="Aghbali">Amir Ala Aghbali</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Halimi, Monireh" sort="Halimi, Monireh" uniqKey="Halimi M" first="Monireh" last="Halimi">Monireh Halimi</name><affiliation><nlm:aff id="aff3"><italic>Department of Pathology, Imam Reza Hospital, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Kouhsoltani, Maryam" sort="Kouhsoltani, Maryam" uniqKey="Kouhsoltani M" first="Maryam" last="Kouhsoltani">Maryam Kouhsoltani</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Hamishehkar, Hamed" sort="Hamishehkar, Hamed" uniqKey="Hamishehkar H" first="Hamed" last="Hamishehkar">Hamed Hamishehkar</name><affiliation><nlm:aff id="aff4"><italic>Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24574652</idno><idno type="pmc">3927335</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927335</idno><idno type="RBID">PMC:3927335</idno><idno type="doi">10.4103/0973-029X.125197</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003247</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003247</idno><idno type="wicri:Area/Pmc/Curation">003247</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003247</idno><idno type="wicri:Area/Pmc/Checkpoint">001974</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001974</idno><idno type="wicri:Area/Ncbi/Merge">004E73</idno><idno type="wicri:Area/Ncbi/Curation">004E73</idno><idno type="wicri:Area/Ncbi/Checkpoint">004E73</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws</title><author><name sortKey="Khiavi, Monir Moradzadeh" sort="Khiavi, Monir Moradzadeh" uniqKey="Khiavi M" first="Monir Moradzadeh" last="Khiavi">Monir Moradzadeh Khiavi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aghbali, Amir Ala" sort="Aghbali, Amir Ala" uniqKey="Aghbali A" first="Amir Ala" last="Aghbali">Amir Ala Aghbali</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Halimi, Monireh" sort="Halimi, Monireh" uniqKey="Halimi M" first="Monireh" last="Halimi">Monireh Halimi</name><affiliation><nlm:aff id="aff3"><italic>Department of Pathology, Imam Reza Hospital, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Kouhsoltani, Maryam" sort="Kouhsoltani, Maryam" uniqKey="Kouhsoltani M" first="Maryam" last="Kouhsoltani">Maryam Kouhsoltani</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Hamishehkar, Hamed" sort="Hamishehkar, Hamed" uniqKey="Hamishehkar H" first="Hamed" last="Hamishehkar">Hamed Hamishehkar</name><affiliation><nlm:aff id="aff4"><italic>Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aim and Objective:</title><p>The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.</p></sec><sec id="st3"><title>Results:</title><p>There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (<italic>P</italic> < 0.001; <italic>r</italic> = 0.87 and 0.75, respectively).</p></sec><sec id="st4"><title>Conclusion:</title><p>The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Neville, Bw" uniqKey="Neville B">BW Neville</name></author><author><name sortKey="Damm, Dd" uniqKey="Damm D">DD Damm</name></author><author><name sortKey="Allen, Cm" uniqKey="Allen C">CM Allen</name></author><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruse Losler, B" uniqKey="Kruse Losler B">B Kruse-Losler</name></author><author><name sortKey="Diallo, R" uniqKey="Diallo R">R Diallo</name></author><author><name sortKey="Gaertner, C" uniqKey="Gaertner C">C Gaertner</name></author><author><name sortKey="Mischke, Kl" uniqKey="Mischke K">KL Mischke</name></author><author><name sortKey="Joos, U" uniqKey="Joos U">U Joos</name></author><author><name sortKey="Kleinheinz, J" uniqKey="Kleinheinz J">J Kleinheinz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Torabinia, N" uniqKey="Torabinia N">N Torabinia</name></author><author><name sortKey="Razavi, Sm" uniqKey="Razavi S">SM Razavi</name></author><author><name sortKey="Shokrolahi, Z" uniqKey="Shokrolahi Z">Z Shokrolahi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Regezi, Ja" uniqKey="Regezi J">JA Regezi</name></author><author><name sortKey="Sciubba, Jj" uniqKey="Sciubba J">JJ Sciubba</name></author><author><name sortKey="Jordan, Rc" uniqKey="Jordan R">RC Jordan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fl Rez Moreno, Ga" uniqKey="Fl Rez Moreno G">GA Flórez-Moreno</name></author><author><name sortKey="Henao Ruiz, M" uniqKey="Henao Ruiz M">M Henao-Ruiz</name></author><author><name sortKey="Santa Saenz, Dm" uniqKey="Santa Saenz D">DM Santa-Sáenz</name></author><author><name sortKey="Casta Eda Pelaez, Da" uniqKey="Casta Eda Pelaez D">DA Castañeda-Peláez</name></author><author><name sortKey="Tob N Arroyave, Si" uniqKey="Tob N Arroyave S">SI Tobón-Arroyave</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giansanti, Js" uniqKey="Giansanti J">JS Giansanti</name></author><author><name sortKey="Waldron, Ca" uniqKey="Waldron C">CA Waldron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pandolfi, Pj" uniqKey="Pandolfi P">PJ Pandolfi</name></author><author><name sortKey="Felefli, S" uniqKey="Felefli S">S Felefli</name></author><author><name sortKey="Flaitz, Cm" uniqKey="Flaitz C">CM Flaitz</name></author><author><name sortKey="Johnson, Jv" uniqKey="Johnson J">JV Johnson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Whitaker, Sb" uniqKey="Whitaker S">SB Whitaker</name></author><author><name sortKey="Waldron, Ca" uniqKey="Waldron C">CA Waldron</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vered, M" uniqKey="Vered M">M Vered</name></author><author><name sortKey="Nasrallah, W" uniqKey="Nasrallah W">W Nasrallah</name></author><author><name sortKey="Buchner, A" uniqKey="Buchner A">A Buchner</name></author><author><name sortKey="Dayan, D" uniqKey="Dayan D">D Dayan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tob N Arroyave, Si" uniqKey="Tob N Arroyave S">SI Tobón-Arroyave</name></author><author><name sortKey="Franco Gonzalez, Lm" uniqKey="Franco Gonzalez L">LM Franco-González</name></author><author><name sortKey="Isaza Guzman, Dm" uniqKey="Isaza Guzman D">DM Isaza-Guzmán</name></author><author><name sortKey="Florez Moreno, Ga" uniqKey="Florez Moreno G">GA Florez-Moreno</name></author><author><name sortKey="Bravo Va Squez, T" uniqKey="Bravo Va Squez T">T Bravo-Va´squez</name></author><author><name sortKey="Castan Eda Pela Ez, Da" uniqKey="Castan Eda Pela Ez D">DA Castan˜eda-Pela´ez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, B" uniqKey="Liu B">B Liu</name></author><author><name sortKey="Yu, Sf" uniqKey="Yu S">SF Yu</name></author><author><name sortKey="Li, Tj" uniqKey="Li T">TJ Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Roux, S" uniqKey="Roux S">S Roux</name></author><author><name sortKey="Amazit, L" uniqKey="Amazit L">L Amazit</name></author><author><name sortKey="Meduri, G" uniqKey="Meduri G">G Meduri</name></author><author><name sortKey="Guiochon Mantel, A" uniqKey="Guiochon Mantel A">A Guiochon-Mantel</name></author><author><name sortKey="Milgrom, E" uniqKey="Milgrom E">E Milgrom</name></author><author><name sortKey="Mariette, X" uniqKey="Mariette X">X Mariette</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, C" uniqKey="Wang C">C Wang</name></author><author><name sortKey="Song, Y" uniqKey="Song Y">Y Song</name></author><author><name sortKey="Peng, B" uniqKey="Peng B">B Peng</name></author><author><name sortKey="Fan, M" uniqKey="Fan M">M Fan</name></author><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Zhu, S" uniqKey="Zhu S">S Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xing, L" uniqKey="Xing L">L Xing</name></author><author><name sortKey="Venegas, Am" uniqKey="Venegas A">AM Venegas</name></author><author><name sortKey="Chen, A" uniqKey="Chen A">A Chen</name></author><author><name sortKey="Garrett Beal, L" uniqKey="Garrett Beal L">L Garrett-Beal</name></author><author><name sortKey="Boyce, Bf" uniqKey="Boyce B">BF Boyce</name></author><author><name sortKey="Varmus, He" uniqKey="Varmus H">HE Varmus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Suda, T" uniqKey="Suda T">T Suda</name></author><author><name sortKey="Takahashi, N" uniqKey="Takahashi N">N Takahashi</name></author><author><name sortKey="Udagawa, N" uniqKey="Udagawa N">N Udagawa</name></author><author><name sortKey="Jimi, E" uniqKey="Jimi E">E Jimi</name></author><author><name sortKey="Gillespie, Mt" uniqKey="Gillespie M">MT Gillespie</name></author><author><name sortKey="Martin, Tj" uniqKey="Martin T">TJ Martin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tob N Arroyave, Si" uniqKey="Tob N Arroyave S">SI Tobón-Arroyave</name></author><author><name sortKey="Mideros Simarra, Sm" uniqKey="Mideros Simarra S">SM Mideros-Simarra</name></author><author><name sortKey="Casta O Ramirez, Lm" uniqKey="Casta O Ramirez L">LM Castaño-Ramírez</name></author><author><name sortKey="Fl Rez Moreno, Ga" uniqKey="Fl Rez Moreno G">GA Flórez-Moreno</name></author><author><name sortKey="Isaza Guzman, Dm" uniqKey="Isaza Guzman D">DM Isaza-Guzmán</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J Li</name></author><author><name sortKey="Sarosi, I" uniqKey="Sarosi I">I Sarosi</name></author><author><name sortKey="Yan, Xq" uniqKey="Yan X">XQ Yan</name></author><author><name sortKey="Morony, S" uniqKey="Morony S">S Morony</name></author><author><name sortKey="Capparelli, C" uniqKey="Capparelli C">C Capparelli</name></author><author><name sortKey="Tan, H" uniqKey="Tan H">H Tan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lim, L" uniqKey="Lim L">L Lim</name></author><author><name sortKey="Gibbins, Jr" uniqKey="Gibbins J">JR Gibbins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Souza, Pea" uniqKey="Souza P">PEA Souza</name></author><author><name sortKey="Mesquita, Ra" uniqKey="Mesquita R">RA Mesquita</name></author><author><name sortKey="Gomez, Rs" uniqKey="Gomez R">RS Gomez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tiffee, Jc" uniqKey="Tiffee J">JC Tiffee</name></author><author><name sortKey="Aufdemorte, Tb" uniqKey="Aufdemorte T">TB Aufdemorte</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Aghbali, Amir Ala" sort="Aghbali, Amir Ala" uniqKey="Aghbali A" first="Amir Ala" last="Aghbali">Amir Ala Aghbali</name><name sortKey="Halimi, Monireh" sort="Halimi, Monireh" uniqKey="Halimi M" first="Monireh" last="Halimi">Monireh Halimi</name><name sortKey="Hamishehkar, Hamed" sort="Hamishehkar, Hamed" uniqKey="Hamishehkar H" first="Hamed" last="Hamishehkar">Hamed Hamishehkar</name><name sortKey="Khiavi, Monir Moradzadeh" sort="Khiavi, Monir Moradzadeh" uniqKey="Khiavi M" first="Monir Moradzadeh" last="Khiavi">Monir Moradzadeh Khiavi</name><name sortKey="Kouhsoltani, Maryam" sort="Kouhsoltani, Maryam" uniqKey="Kouhsoltani M" first="Maryam" last="Kouhsoltani">Maryam Kouhsoltani</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Ncbi/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004E73 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd -nk 004E73 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Ncbi
|étape= Checkpoint
|type= RBID
|clé= PMC:3927335
|texte= Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Checkpoint/RBID.i -Sk "pubmed:24574652" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |