Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws
Identifieur interne : 003247 ( Pmc/Curation ); précédent : 003246; suivant : 003248Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws
Auteurs : Monir Moradzadeh Khiavi ; Amir Ala Aghbali ; Monireh Halimi ; Maryam Kouhsoltani ; Hamed HamishehkarSource :
- Journal of Oral and Maxillofacial Pathology : JOMFP [ 0973-029X ] ; 2013.
Abstract
The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.
Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.
There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (
The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.
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DOI: 10.4103/0973-029X.125197
PubMed: 24574652
PubMed Central: 3927335
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws</title><author><name sortKey="Khiavi, Monir Moradzadeh" sort="Khiavi, Monir Moradzadeh" uniqKey="Khiavi M" first="Monir Moradzadeh" last="Khiavi">Monir Moradzadeh Khiavi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aghbali, Amir Ala" sort="Aghbali, Amir Ala" uniqKey="Aghbali A" first="Amir Ala" last="Aghbali">Amir Ala Aghbali</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Halimi, Monireh" sort="Halimi, Monireh" uniqKey="Halimi M" first="Monireh" last="Halimi">Monireh Halimi</name><affiliation><nlm:aff id="aff3"><italic>Department of Pathology, Imam Reza Hospital, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Kouhsoltani, Maryam" sort="Kouhsoltani, Maryam" uniqKey="Kouhsoltani M" first="Maryam" last="Kouhsoltani">Maryam Kouhsoltani</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Hamishehkar, Hamed" sort="Hamishehkar, Hamed" uniqKey="Hamishehkar H" first="Hamed" last="Hamishehkar">Hamed Hamishehkar</name><affiliation><nlm:aff id="aff4"><italic>Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24574652</idno><idno type="pmc">3927335</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3927335</idno><idno type="RBID">PMC:3927335</idno><idno type="doi">10.4103/0973-029X.125197</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">003247</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003247</idno><idno type="wicri:Area/Pmc/Curation">003247</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003247</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws</title><author><name sortKey="Khiavi, Monir Moradzadeh" sort="Khiavi, Monir Moradzadeh" uniqKey="Khiavi M" first="Monir Moradzadeh" last="Khiavi">Monir Moradzadeh Khiavi</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Aghbali, Amir Ala" sort="Aghbali, Amir Ala" uniqKey="Aghbali A" first="Amir Ala" last="Aghbali">Amir Ala Aghbali</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Halimi, Monireh" sort="Halimi, Monireh" uniqKey="Halimi M" first="Monireh" last="Halimi">Monireh Halimi</name><affiliation><nlm:aff id="aff3"><italic>Department of Pathology, Imam Reza Hospital, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Kouhsoltani, Maryam" sort="Kouhsoltani, Maryam" uniqKey="Kouhsoltani M" first="Maryam" last="Kouhsoltani">Maryam Kouhsoltani</name><affiliation><nlm:aff id="aff2"><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></nlm:aff></affiliation></author><author><name sortKey="Hamishehkar, Hamed" sort="Hamishehkar, Hamed" uniqKey="Hamishehkar H" first="Hamed" last="Hamishehkar">Hamed Hamishehkar</name><affiliation><nlm:aff id="aff4"><italic>Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Oral and Maxillofacial Pathology : JOMFP</title><idno type="ISSN">0973-029X</idno><idno type="eISSN">1998-393X</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Aim and Objective:</title><p>The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.</p></sec><sec id="st3"><title>Results:</title><p>There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (<italic>P</italic> < 0.001; <italic>r</italic> = 0.87 and 0.75, respectively).</p></sec><sec id="st4"><title>Conclusion:</title><p>The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Neville, Bw" uniqKey="Neville B">BW Neville</name></author><author><name sortKey="Damm, Dd" uniqKey="Damm D">DD Damm</name></author><author><name sortKey="Allen, Cm" uniqKey="Allen C">CM Allen</name></author><author><name sortKey="Bouquot, Je" uniqKey="Bouquot J">JE Bouquot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kruse Losler, B" uniqKey="Kruse Losler B">B Kruse-Losler</name></author><author><name sortKey="Diallo, R" uniqKey="Diallo R">R Diallo</name></author><author><name sortKey="Gaertner, C" uniqKey="Gaertner C">C Gaertner</name></author><author><name sortKey="Mischke, Kl" uniqKey="Mischke K">KL Mischke</name></author><author><name sortKey="Joos, U" uniqKey="Joos U">U 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J">JC Tiffee</name></author><author><name sortKey="Aufdemorte, Tb" uniqKey="Aufdemorte T">TB Aufdemorte</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Maxillofac Pathol</journal-id><journal-id journal-id-type="iso-abbrev">J Oral Maxillofac Pathol</journal-id><journal-id journal-id-type="publisher-id">JOMFP</journal-id><journal-title-group><journal-title>Journal of Oral and Maxillofacial Pathology : JOMFP</journal-title></journal-title-group><issn pub-type="ppub">0973-029X</issn><issn pub-type="epub">1998-393X</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24574652</article-id><article-id pub-id-type="pmc">3927335</article-id><article-id pub-id-type="publisher-id">JOMFP-17-358</article-id><article-id pub-id-type="doi">10.4103/0973-029X.125197</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Immunohistochemical expression of Src protein in peripheral and central giant cell granulomas of the jaws</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Khiavi</surname><given-names>Monir Moradzadeh</given-names></name><xref ref-type="aff" rid="aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Aghbali</surname><given-names>Amir Ala</given-names></name><xref ref-type="aff" rid="aff2">1</xref></contrib><contrib contrib-type="author"><name><surname>Halimi</surname><given-names>Monireh</given-names></name><xref ref-type="aff" rid="aff3">2</xref></contrib><contrib contrib-type="author"><name><surname>Kouhsoltani</surname><given-names>Maryam</given-names></name><xref ref-type="aff" rid="aff2">1</xref><xref ref-type="corresp" rid="cor1"></xref></contrib><contrib contrib-type="author"><name><surname>Hamishehkar</surname><given-names>Hamed</given-names></name><xref ref-type="aff" rid="aff4">3</xref></contrib></contrib-group><aff id="aff1"><italic>Department of Oral Pathology, Faculty of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran</italic></aff><aff id="aff2"><label>1</label><italic>Department of Oral Pathology, Faculty of Dentistry, Tabriz, Iran</italic></aff><aff id="aff3"><label>2</label><italic>Department of Pathology, Imam Reza Hospital, Tabriz, Iran</italic></aff><aff id="aff4"><label>3</label><italic>Department of Pharmaceutical Technology Laboratory, Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran</italic></aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold><italic>Asst. Prof. Maryam Kouhsoltani, Faculty of Dentisry, Tabriz University of Medical Sciences, Golgasht Street, Tabriz, Iran. E-mail: <email xlink:href="mkoohsoltani@yahoo.com">mkoohsoltani@yahoo.com</email></italic></corresp></author-notes><pub-date pub-type="ppub"><season>Sep-Dec</season><year>2013</year></pub-date><volume>17</volume><issue>3</issue><fpage>358</fpage><lpage>362</lpage><permissions><copyright-statement>Copyright: © Journal of Oral and Maxillofacial Pathology</copyright-statement><copyright-year>2013</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Aim and Objective:</title><p>The aim of this study was to investigate the expression of Src protein (an osteoclastic factor) in peripheral and central giant cell granulomas (PGCG and CGCGs) of the jaws and the relationship between the expression of this protein and the clinical behavior of these two lesions.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>Thirty cases of PGCG and 30 cases of CGCG were immunohistochemically stained with Src. A staining-intensity-distribution (SID) score (proportion of stained cells × staining intensity) was used to evaluate immunoreactivity of the protein. Data were analyzed using statistical package for social sciences (SPSS) 17.0.</p></sec><sec id="st3"><title>Results:</title><p>There were no significant differences in the Src expression and the SID score between PGCG and CGCG. Furthermore, Spearman's rank correlation coefficient showed that there was a significant correlation between Src expression and SID score within both PGCG and CGCG (<italic>P</italic> < 0.001; <italic>r</italic> = 0.87 and 0.75, respectively).</p></sec><sec id="st4"><title>Conclusion:</title><p>The findings of this study suggest that the multinucleated giant cells share some similarities with osteoclasts and Src protein can be used as a new therapeutic target to inhibit osteoclastic activity. In addition, differences in immunoreactivity of this osteoclastic protein do not reflect different clinical behaviors of PGCG and CGCG.</p></sec></abstract><kwd-group><kwd>Central giant cell granuloma</kwd><kwd>immunohistochemistry</kwd><kwd>peripheral giant cell granuloma</kwd><kwd>Src</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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