Scoring irradiation mucositis in head and neck cancer patients
Identifieur interne : 00C435 ( Main/Merge ); précédent : 00C434; suivant : 00C436Scoring irradiation mucositis in head and neck cancer patients
Auteurs : F. K. L. Spijkervet [Pays-Bas] ; H. K. F. Van Saene [Royaume-Uni] ; A. K. Panders [Pays-Bas] ; A. Vermey [Pays-Bas] ; D. M. Mehta [Pays-Bas]Source :
- Journal of Oral Pathology & Medicine [ 0904-2512 ] ; 1989-03.
English descriptors
- KwdEn :
- Alimentation loss, Buccal mucosa, Candidiasis, Conventional irradiation protocol, Dent assoc, Discoloration, Distinguishable areas, Edentulous patients, Erythema, First week, Fourth week, Generalized symptoms, Hickey score, Highest mucositis score, Highest mueositis score, Intraobserver agreement, Irradiation mucositis, Irradiation protocol, Irradiation therapy, Local mucositis signs, Mouth floor, Mucositis, Mucositis score, Mucositis signs, Mueositis, Mueositis score, Nasogastric tube feedings, Neck cancer, Neck cancer patients, Oral candidiasis, Oral cavity, Oral complications, Oral hygienist, Oral mucosa, Oral mucositis, Oral pathol, Oral surg, Oral tissues, Ordinal scale, Particular area, Prosthet dent, Pseudomembranes, Radiotherapy, Several subareas, Steep slope, Study patients, Therapeutic irradiation, Third week, Weight loss, White discoloration.
- Teeft :
- Alimentation loss, Buccal mucosa, Candidiasis, Conventional irradiation protocol, Dent assoc, Discoloration, Distinguishable areas, Edentulous patients, Erythema, First week, Fourth week, Generalized symptoms, Hickey score, Highest mucositis score, Highest mueositis score, Intraobserver agreement, Irradiation mucositis, Irradiation protocol, Irradiation therapy, Local mucositis signs, Mouth floor, Mucositis, Mucositis score, Mucositis signs, Mueositis, Mueositis score, Nasogastric tube feedings, Neck cancer, Neck cancer patients, Oral candidiasis, Oral cavity, Oral complications, Oral hygienist, Oral mucosa, Oral mucositis, Oral pathol, Oral surg, Oral tissues, Ordinal scale, Particular area, Prosthet dent, Pseudomembranes, Radiotherapy, Several subareas, Steep slope, Study patients, Therapeutic irradiation, Third week, Weight loss, White discoloration.
Abstract
Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.
Url:
DOI: 10.1111/j.1600-0714.1989.tb00756.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001775
- to stream Istex, to step Curation: 001775
- to stream Istex, to step Checkpoint: 005857
Links to Exploration step
ISTEX:309C0739800CA555C04DE6D7531855168DDCA0E7Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Scoring irradiation mucositis in head and neck cancer patients</title>
<author><name sortKey="Spijkervet, F K L" sort="Spijkervet, F K L" uniqKey="Spijkervet F" first="F. K. L." last="Spijkervet">F. K. L. Spijkervet</name>
</author>
<author><name sortKey="Van Saene, H K F" sort="Van Saene, H K F" uniqKey="Van Saene H" first="H. K. F." last="Van Saene">H. K. F. Van Saene</name>
</author>
<author><name sortKey="Panders, A K" sort="Panders, A K" uniqKey="Panders A" first="A. K." last="Panders">A. K. Panders</name>
</author>
<author><name sortKey="Vermey, A" sort="Vermey, A" uniqKey="Vermey A" first="A." last="Vermey">A. Vermey</name>
</author>
<author><name sortKey="Mehta, D M" sort="Mehta, D M" uniqKey="Mehta D" first="D. M." last="Mehta">D. M. Mehta</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:309C0739800CA555C04DE6D7531855168DDCA0E7</idno>
<date when="1989" year="1989">1989</date>
<idno type="doi">10.1111/j.1600-0714.1989.tb00756.x</idno>
<idno type="url">https://api.istex.fr/document/309C0739800CA555C04DE6D7531855168DDCA0E7/fulltext/pdf</idno>
<idno type="wicri:Area/Istex/Corpus">001775</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001775</idno>
<idno type="wicri:Area/Istex/Curation">001775</idno>
<idno type="wicri:Area/Istex/Checkpoint">005857</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">005857</idno>
<idno type="wicri:doubleKey">0904-2512:1989:Spijkervet F:scoring:irradiation:mucositis</idno>
<idno type="wicri:Area/Main/Merge">00C435</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">Scoring irradiation mucositis in head and neck cancer patients</title>
<author><name sortKey="Spijkervet, F K L" sort="Spijkervet, F K L" uniqKey="Spijkervet F" first="F. K. L." last="Spijkervet">F. K. L. Spijkervet</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, University Hospital Groningen</wicri:regionArea>
<wicri:noRegion>University Hospital Groningen</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Correspondence address: F. K. L. Spijkervet, Department of Oral & Maxillofacial Surgery, University Hospital, A. Deusinglaan 1, 9713 Av Groningen</wicri:regionArea>
<wicri:noRegion>9713 Av Groningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Saene, H K F" sort="Van Saene, H K F" uniqKey="Van Saene H" first="H. K. F." last="Van Saene">H. K. F. Van Saene</name>
<affiliation wicri:level="2"><country>Royaume-Uni</country>
<placeName><region type="country">Angleterre</region>
</placeName>
<wicri:cityArea>Department of Medical Microbiology, University of Liverpool</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Panders, A K" sort="Panders, A K" uniqKey="Panders A" first="A. K." last="Panders">A. K. Panders</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Oral and Maxillofacial Surgery, University Hospital Groningen</wicri:regionArea>
<wicri:noRegion>University Hospital Groningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Vermey, A" sort="Vermey, A" uniqKey="Vermey A" first="A." last="Vermey">A. Vermey</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Surgery Oncology Division, University Hospital Groningen</wicri:regionArea>
<wicri:noRegion>University Hospital Groningen</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mehta, D M" sort="Mehta, D M" uniqKey="Mehta D" first="D. M." last="Mehta">D. M. Mehta</name>
<affiliation wicri:level="1"><country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiotherapy, University Hospital Groningen</wicri:regionArea>
<wicri:noRegion>University Hospital Groningen</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Journal of Oral Pathology & Medicine</title>
<title level="j" type="alt">JOURNAL ORAL PATHOLOGY MEDICINE</title>
<idno type="ISSN">0904-2512</idno>
<idno type="eISSN">1600-0714</idno>
<imprint><biblScope unit="vol">18</biblScope>
<biblScope unit="issue">3</biblScope>
<biblScope unit="page" from="167">167</biblScope>
<biblScope unit="page" to="171">171</biblScope>
<biblScope unit="page-count">5</biblScope>
<publisher>Blackwell Publishing Ltd</publisher>
<pubPlace>Oxford, UK</pubPlace>
<date type="published" when="1989-03">1989-03</date>
</imprint>
<idno type="ISSN">0904-2512</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0904-2512</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alimentation loss</term>
<term>Buccal mucosa</term>
<term>Candidiasis</term>
<term>Conventional irradiation protocol</term>
<term>Dent assoc</term>
<term>Discoloration</term>
<term>Distinguishable areas</term>
<term>Edentulous patients</term>
<term>Erythema</term>
<term>First week</term>
<term>Fourth week</term>
<term>Generalized symptoms</term>
<term>Hickey score</term>
<term>Highest mucositis score</term>
<term>Highest mueositis score</term>
<term>Intraobserver agreement</term>
<term>Irradiation mucositis</term>
<term>Irradiation protocol</term>
<term>Irradiation therapy</term>
<term>Local mucositis signs</term>
<term>Mouth floor</term>
<term>Mucositis</term>
<term>Mucositis score</term>
<term>Mucositis signs</term>
<term>Mueositis</term>
<term>Mueositis score</term>
<term>Nasogastric tube feedings</term>
<term>Neck cancer</term>
<term>Neck cancer patients</term>
<term>Oral candidiasis</term>
<term>Oral cavity</term>
<term>Oral complications</term>
<term>Oral hygienist</term>
<term>Oral mucosa</term>
<term>Oral mucositis</term>
<term>Oral pathol</term>
<term>Oral surg</term>
<term>Oral tissues</term>
<term>Ordinal scale</term>
<term>Particular area</term>
<term>Prosthet dent</term>
<term>Pseudomembranes</term>
<term>Radiotherapy</term>
<term>Several subareas</term>
<term>Steep slope</term>
<term>Study patients</term>
<term>Therapeutic irradiation</term>
<term>Third week</term>
<term>Weight loss</term>
<term>White discoloration</term>
</keywords>
<keywords scheme="Teeft" xml:lang="en"><term>Alimentation loss</term>
<term>Buccal mucosa</term>
<term>Candidiasis</term>
<term>Conventional irradiation protocol</term>
<term>Dent assoc</term>
<term>Discoloration</term>
<term>Distinguishable areas</term>
<term>Edentulous patients</term>
<term>Erythema</term>
<term>First week</term>
<term>Fourth week</term>
<term>Generalized symptoms</term>
<term>Hickey score</term>
<term>Highest mucositis score</term>
<term>Highest mueositis score</term>
<term>Intraobserver agreement</term>
<term>Irradiation mucositis</term>
<term>Irradiation protocol</term>
<term>Irradiation therapy</term>
<term>Local mucositis signs</term>
<term>Mouth floor</term>
<term>Mucositis</term>
<term>Mucositis score</term>
<term>Mucositis signs</term>
<term>Mueositis</term>
<term>Mueositis score</term>
<term>Nasogastric tube feedings</term>
<term>Neck cancer</term>
<term>Neck cancer patients</term>
<term>Oral candidiasis</term>
<term>Oral cavity</term>
<term>Oral complications</term>
<term>Oral hygienist</term>
<term>Oral mucosa</term>
<term>Oral mucositis</term>
<term>Oral pathol</term>
<term>Oral surg</term>
<term>Oral tissues</term>
<term>Ordinal scale</term>
<term>Particular area</term>
<term>Prosthet dent</term>
<term>Pseudomembranes</term>
<term>Radiotherapy</term>
<term>Several subareas</term>
<term>Steep slope</term>
<term>Study patients</term>
<term>Therapeutic irradiation</term>
<term>Third week</term>
<term>Weight loss</term>
<term>White discoloration</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 00C435 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 00C435 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Main |étape= Merge |type= RBID |clé= ISTEX:309C0739800CA555C04DE6D7531855168DDCA0E7 |texte= Scoring irradiation mucositis in head and neck cancer patients }}
![]() | This area was generated with Dilib version V0.6.32. | ![]() |