Scoring irradiation mucositis in head and neck cancer patients
Identifieur interne : 001775 ( Istex/Corpus ); précédent : 001774; suivant : 001776Scoring irradiation mucositis in head and neck cancer patients
Auteurs : F. K. L. Spijkervet ; H. K. F. Van Saene ; A. K. Panders ; A. Vermey ; D. M. MehtaSource :
- Journal of Oral Pathology & Medicine [ 0904-2512 ] ; 1989-03.
English descriptors
- KwdEn :
- Alimentation loss, Buccal mucosa, Candidiasis, Conventional irradiation protocol, Dent assoc, Discoloration, Distinguishable areas, Edentulous patients, Erythema, First week, Fourth week, Generalized symptoms, Hickey score, Highest mucositis score, Highest mueositis score, Intraobserver agreement, Irradiation mucositis, Irradiation protocol, Irradiation therapy, Local mucositis signs, Mouth floor, Mucositis, Mucositis score, Mucositis signs, Mueositis, Mueositis score, Nasogastric tube feedings, Neck cancer, Neck cancer patients, Oral candidiasis, Oral cavity, Oral complications, Oral hygienist, Oral mucosa, Oral mucositis, Oral pathol, Oral surg, Oral tissues, Ordinal scale, Particular area, Prosthet dent, Pseudomembranes, Radiotherapy, Several subareas, Steep slope, Study patients, Therapeutic irradiation, Third week, Weight loss, White discoloration.
- Teeft :
- Alimentation loss, Buccal mucosa, Candidiasis, Conventional irradiation protocol, Dent assoc, Discoloration, Distinguishable areas, Edentulous patients, Erythema, First week, Fourth week, Generalized symptoms, Hickey score, Highest mucositis score, Highest mueositis score, Intraobserver agreement, Irradiation mucositis, Irradiation protocol, Irradiation therapy, Local mucositis signs, Mouth floor, Mucositis, Mucositis score, Mucositis signs, Mueositis, Mueositis score, Nasogastric tube feedings, Neck cancer, Neck cancer patients, Oral candidiasis, Oral cavity, Oral complications, Oral hygienist, Oral mucosa, Oral mucositis, Oral pathol, Oral surg, Oral tissues, Ordinal scale, Particular area, Prosthet dent, Pseudomembranes, Radiotherapy, Several subareas, Steep slope, Study patients, Therapeutic irradiation, Third week, Weight loss, White discoloration.
Abstract
Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.
Url:
DOI: 10.1111/j.1600-0714.1989.tb00756.x
Links to Exploration step
ISTEX:309C0739800CA555C04DE6D7531855168DDCA0E7Le document en format XML
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Van Saene</name><affiliation><mods:affiliation>Department of Medical Microbiology, University of Liverpool, England.</mods:affiliation></affiliation></author><author><name sortKey="Panders, A K" sort="Panders, A K" uniqKey="Panders A" first="A. K." last="Panders">A. K. Panders</name><affiliation><mods:affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Vermey, A" sort="Vermey, A" uniqKey="Vermey A" first="A." last="Vermey">A. Vermey</name><affiliation><mods:affiliation>Department of Surgery Oncology Division, University Hospital Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Mehta, D M" sort="Mehta, D M" uniqKey="Mehta D" first="D. M." last="Mehta">D. M. 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Spijkervet</name><affiliation><mods:affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: F. K. L. Spijkervet, Department of Oral & Maxillofacial Surgery, University Hospital, A. Deusinglaan 1, 9713 Av Groningen, The Netherlands.</mods:affiliation></affiliation></author><author><name sortKey="Van Saene, H K F" sort="Van Saene, H K F" uniqKey="Van Saene H" first="H. K. F." last="Van Saene">H. K. F. Van Saene</name><affiliation><mods:affiliation>Department of Medical Microbiology, University of Liverpool, England.</mods:affiliation></affiliation></author><author><name sortKey="Panders, A K" sort="Panders, A K" uniqKey="Panders A" first="A. K." last="Panders">A. K. Panders</name><affiliation><mods:affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Vermey, A" sort="Vermey, A" uniqKey="Vermey A" first="A." last="Vermey">A. Vermey</name><affiliation><mods:affiliation>Department of Surgery Oncology Division, University Hospital Groningen, The Netherlands</mods:affiliation></affiliation></author><author><name sortKey="Mehta, D M" sort="Mehta, D M" uniqKey="Mehta D" first="D. M." last="Mehta">D. M. Mehta</name><affiliation><mods:affiliation>Department of Radiotherapy, University Hospital Groningen, The Netherlands</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Oral Pathology & Medicine</title><title level="j" type="alt">JOURNAL ORAL PATHOLOGY MEDICINE</title><idno type="ISSN">0904-2512</idno><idno type="eISSN">1600-0714</idno><imprint><biblScope unit="vol">18</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="171">171</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-03">1989-03</date></imprint><idno type="ISSN">0904-2512</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0904-2512</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alimentation loss</term><term>Buccal mucosa</term><term>Candidiasis</term><term>Conventional irradiation protocol</term><term>Dent assoc</term><term>Discoloration</term><term>Distinguishable areas</term><term>Edentulous patients</term><term>Erythema</term><term>First week</term><term>Fourth week</term><term>Generalized symptoms</term><term>Hickey score</term><term>Highest mucositis score</term><term>Highest mueositis score</term><term>Intraobserver agreement</term><term>Irradiation mucositis</term><term>Irradiation protocol</term><term>Irradiation therapy</term><term>Local mucositis signs</term><term>Mouth floor</term><term>Mucositis</term><term>Mucositis score</term><term>Mucositis signs</term><term>Mueositis</term><term>Mueositis score</term><term>Nasogastric tube feedings</term><term>Neck cancer</term><term>Neck cancer patients</term><term>Oral candidiasis</term><term>Oral cavity</term><term>Oral complications</term><term>Oral hygienist</term><term>Oral mucosa</term><term>Oral mucositis</term><term>Oral pathol</term><term>Oral surg</term><term>Oral tissues</term><term>Ordinal scale</term><term>Particular area</term><term>Prosthet dent</term><term>Pseudomembranes</term><term>Radiotherapy</term><term>Several subareas</term><term>Steep slope</term><term>Study patients</term><term>Therapeutic irradiation</term><term>Third week</term><term>Weight loss</term><term>White discoloration</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alimentation loss</term><term>Buccal mucosa</term><term>Candidiasis</term><term>Conventional irradiation protocol</term><term>Dent assoc</term><term>Discoloration</term><term>Distinguishable areas</term><term>Edentulous patients</term><term>Erythema</term><term>First week</term><term>Fourth week</term><term>Generalized symptoms</term><term>Hickey score</term><term>Highest mucositis score</term><term>Highest mueositis score</term><term>Intraobserver agreement</term><term>Irradiation mucositis</term><term>Irradiation protocol</term><term>Irradiation therapy</term><term>Local mucositis signs</term><term>Mouth floor</term><term>Mucositis</term><term>Mucositis score</term><term>Mucositis signs</term><term>Mueositis</term><term>Mueositis score</term><term>Nasogastric tube feedings</term><term>Neck cancer</term><term>Neck cancer patients</term><term>Oral candidiasis</term><term>Oral cavity</term><term>Oral complications</term><term>Oral hygienist</term><term>Oral mucosa</term><term>Oral mucositis</term><term>Oral pathol</term><term>Oral surg</term><term>Oral tissues</term><term>Ordinal scale</term><term>Particular area</term><term>Prosthet dent</term><term>Pseudomembranes</term><term>Radiotherapy</term><term>Several subareas</term><term>Steep slope</term><term>Study patients</term><term>Therapeutic irradiation</term><term>Third week</term><term>Weight loss</term><term>White discoloration</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>mucositis</json:string><json:string>erythema</json:string><json:string>pseudomembranes</json:string><json:string>mueositis</json:string><json:string>mucositis score</json:string><json:string>oral candidiasis</json:string><json:string>candidiasis</json:string><json:string>radiotherapy</json:string><json:string>irradiation mucositis</json:string><json:string>discoloration</json:string><json:string>oral cavity</json:string><json:string>local mucositis signs</json:string><json:string>white discoloration</json:string><json:string>generalized symptoms</json:string><json:string>neck cancer</json:string><json:string>oral mucositis</json:string><json:string>conventional irradiation protocol</json:string><json:string>dent assoc</json:string><json:string>oral surg</json:string><json:string>mueositis score</json:string><json:string>nasogastric tube feedings</json:string><json:string>highest mucositis score</json:string><json:string>particular area</json:string><json:string>prosthet dent</json:string><json:string>oral pathol</json:string><json:string>study patients</json:string><json:string>mucositis signs</json:string><json:string>oral mucosa</json:string><json:string>mouth floor</json:string><json:string>several subareas</json:string><json:string>irradiation therapy</json:string><json:string>ordinal scale</json:string><json:string>fourth week</json:string><json:string>edentulous patients</json:string><json:string>oral hygienist</json:string><json:string>first week</json:string><json:string>irradiation protocol</json:string><json:string>intraobserver agreement</json:string><json:string>buccal mucosa</json:string><json:string>distinguishable areas</json:string><json:string>highest mueositis score</json:string><json:string>weight loss</json:string><json:string>steep slope</json:string><json:string>hickey score</json:string><json:string>alimentation loss</json:string><json:string>oral complications</json:string><json:string>oral tissues</json:string><json:string>therapeutic irradiation</json:string><json:string>neck cancer patients</json:string><json:string>third week</json:string></teeft></keywords><author><json:item><name>F. K. L. Spijkervet</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</json:string><json:string>Correspondence address: F. K. L. Spijkervet, Department of Oral & Maxillofacial Surgery, University Hospital, A. Deusinglaan 1, 9713 Av Groningen, The Netherlands.</json:string></affiliations></json:item><json:item><name>H. K. F. van Saene</name><affiliations><json:string>Department of Medical Microbiology, University of Liverpool, England.</json:string></affiliations></json:item><json:item><name>A. K. Panders</name><affiliations><json:string>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>A. Vermey</name><affiliations><json:string>Department of Surgery Oncology Division, University Hospital Groningen, The Netherlands</json:string></affiliations></json:item><json:item><name>D. M. Mehta</name><affiliations><json:string>Department of Radiotherapy, University Hospital Groningen, The Netherlands</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>cancer, head and neck</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>irradiation mucositis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>mouth, diseases</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>scoring system</value></json:item></subject><articleId><json:string>JOP167</json:string></articleId><arkIstex>ark:/67375/WNG-FR14NXJ3-D</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>205</abstractWordCount><abstractCharCount>1405</abstractCharCount><keywordCount>4</keywordCount><score>7.665</score><pdfWordCount>3205</pdfWordCount><pdfCharCount>20805</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>768 x 1070 pts</pdfPageSize></qualityIndicators><title>Scoring irradiation mucositis in head and neck cancer patients</title><pmid><json:string>2760855</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Oral Pathology & Medicine</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1600-0714</json:string></doi><issn><json:string>0904-2512</json:string></issn><eissn><json:string>1600-0714</json:string></eissn><publisherId><json:string>JOP</json:string></publisherId><volume>18</volume><issue>3</issue><pages><first>167</first><last>171</last><total>5</total></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1989</json:string></date><geogName></geogName><orgName><json:string>Anonymous.</json:string><json:string>University of Liverpool</json:string><json:string>Department of Oral</json:string></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>K. L. Spijkervet</json:string><json:string>F. K. L. Spijkervef</json:string><json:string>J. Oral</json:string><json:string>D. M. Mehta</json:string><json:string>A. K. Panders</json:string><json:string>A. Vermey</json:string><json:string>A. Deusinglaan</json:string></persName><placeName><json:string>Netherlands</json:string></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-FR14NXJ3-D</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - pathology</json:string><json:string>2 - dentistry, oral surgery & medicine</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - dentistry</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Periodontics</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Biochemistry, Genetics and Molecular Biology</json:string><json:string>3 - Cancer Research</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Otorhinolaryngology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Dentistry</json:string><json:string>3 - Oral Surgery</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Pathology and Forensic Medicine</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1989</publicationDate><copyrightDate>1989</copyrightDate><doi><json:string>10.1111/j.1600-0714.1989.tb00756.x</json:string></doi><id>309C0739800CA555C04DE6D7531855168DDCA0E7</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/309C0739800CA555C04DE6D7531855168DDCA0E7/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/309C0739800CA555C04DE6D7531855168DDCA0E7/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/309C0739800CA555C04DE6D7531855168DDCA0E7/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Scoring irradiation mucositis in head and neck cancer patients</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-03"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Scoring irradiation mucositis in head and neck cancer patients</title><author xml:id="author-0000" role="corresp"><persName><forename type="first">F. K. L.</forename><surname>Spijkervet</surname></persName><affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands<address><country key="NL"></country></address></affiliation><affiliation>F. K. L. Spijkervet, Department of Oral & Maxillofacial Surgery, University Hospital, A. Deusinglaan 1, 9713 Av Groningen, The Netherlands.</affiliation></author><author xml:id="author-0001"><persName><forename type="first">H. K. F.</forename><surname>Saene</surname></persName><affiliation>Department of Medical Microbiology, University of Liverpool, England.</affiliation></author><author xml:id="author-0002"><persName><forename type="first">A. K.</forename><surname>Panders</surname></persName><affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">A.</forename><surname>Vermey</surname></persName><affiliation>Department of Surgery Oncology Division, University Hospital Groningen, The Netherlands<address><country key="NL"></country></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">D. M.</forename><surname>Mehta</surname></persName><affiliation>Department of Radiotherapy, University Hospital Groningen, The Netherlands<address><country key="NL"></country></address></affiliation></author><idno type="istex">309C0739800CA555C04DE6D7531855168DDCA0E7</idno><idno type="ark">ark:/67375/WNG-FR14NXJ3-D</idno><idno type="DOI">10.1111/j.1600-0714.1989.tb00756.x</idno><idno type="unit">JOP167</idno><idno type="toTypesetVersion">file:JOP.JOP167.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Oral Pathology & Medicine</title><title level="j" type="alt">JOURNAL ORAL PATHOLOGY MEDICINE</title><idno type="pISSN">0904-2512</idno><idno type="eISSN">1600-0714</idno><idno type="book-DOI">10.1111/(ISSN)1600-0714</idno><idno type="book-part-DOI">10.1111/jop.1989.18.issue-3</idno><idno type="product">JOP</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">18</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="167">167</biblScope><biblScope unit="page" to="171">171</biblScope><biblScope unit="page-count">5</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1989-03"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p>Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">cancer, head and neck</term><term xml:id="k2">irradiation mucositis</term><term xml:id="k3">mouth, diseases</term><term xml:id="k4">scoring system</term></keywords><keywords rend="tocHeading1"><term>Oral medicine</term></keywords><keywords rend="tocHeading2"><term>Original articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/309C0739800CA555C04DE6D7531855168DDCA0E7/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1600-0714</doi><issn type="print">0904-2512</issn><issn type="electronic">1600-0714</issn><idGroup><id type="product" value="JOP"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL ORAL PATHOLOGY MEDICINE">Journal of Oral Pathology & Medicine</title></titleGroup></publicationMeta><publicationMeta level="part" position="03003"><doi origin="wiley">10.1111/jop.1989.18.issue-3</doi><numberingGroup><numbering type="journalVolume" number="18">18</numbering><numbering type="journalIssue" number="3">3</numbering></numberingGroup><coverDate startDate="1989-03">March 1989</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0016700" status="forIssue"><doi origin="wiley">10.1111/j.1600-0714.1989.tb00756.x</doi><idGroup><id type="unit" value="JOP167"></id></idGroup><countGroup><count type="pageTotal" number="5"></count></countGroup><titleGroup><title type="tocHeading1">Oral medicine</title><title type="tocHeading2">Original articles</title></titleGroup><eventGroup><event type="firstOnline" date="2006-04-28"></event><event type="publishedOnlineFinalForm" date="2006-04-28"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:HeaderRef result:HeaderRef" date="2010-03-15"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-31"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="167">167</numbering><numbering type="pageLast" number="171">171</numbering></numberingGroup><correspondenceTo>F. K. L. Spijkervet, Department of Oral & Maxillofacial Surgery, University Hospital, A. Deusinglaan 1, 9713 Av Groningen, The Netherlands.</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JOP.JOP167.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication December 30, 1988.</unparsedEditorialHistory><countGroup><count type="referenceTotal" number="23"></count><count type="linksCrossRef" number="6"></count></countGroup><titleGroup><title type="main">Scoring irradiation mucositis in head and neck cancer patients</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>F. K. L.</givenNames><familyName>Spijkervet</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>H. K. F.</givenNames><familyNamePrefix>van</familyNamePrefix><familyName>Saene</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>A. K.</givenNames><familyName>Panders</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>A.</givenNames><familyName>Vermey</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4"><personName><givenNames>D. M.</givenNames><familyName>Mehta</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="NL"><unparsedAffiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Department of Medical Microbiology, University of Liverpool, England.</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="NL"><unparsedAffiliation>Department of Surgery Oncology Division, University Hospital Groningen, The Netherlands</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="NL"><unparsedAffiliation>Department of Radiotherapy, University Hospital Groningen, The Netherlands</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">cancer, head and neck</keyword><keyword xml:id="k2">irradiation mucositis</keyword><keyword xml:id="k3">mouth, diseases</keyword><keyword xml:id="k4">scoring system</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Scoring irradiation mucositis in head and neck cancer patients</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Scoring irradiation mucositis in head and neck cancer patients</title></titleInfo><name type="personal"><namePart type="given">F. K. L.</namePart><namePart type="family">Spijkervet</namePart><affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</affiliation><affiliation>Correspondence address: F. K. L. Spijkervet, Department of Oral & Maxillofacial Surgery, University Hospital, A. Deusinglaan 1, 9713 Av Groningen, The Netherlands.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H. K. F.</namePart><namePart type="family">van Saene</namePart><affiliation>Department of Medical Microbiology, University of Liverpool, England.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A. K.</namePart><namePart type="family">Panders</namePart><affiliation>Department of Oral and Maxillofacial Surgery, University Hospital Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Vermey</namePart><affiliation>Department of Surgery Oncology Division, University Hospital Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">D. M.</namePart><namePart type="family">Mehta</namePart><affiliation>Department of Radiotherapy, University Hospital Groningen, The Netherlands</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">1989-03</dateIssued><edition>Accepted for publication December 30, 1988.</edition><copyrightDate encoding="w3cdtf">1989</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="references">23</extent><extent unit="linksCrossRef">6</extent></physicalDescription><abstract lang="en">Irradiation mucositis is defined as an inflammatory‐like process of the oropharyngeal mucosa following therapeutic irradiation of patients who have head and neck cancer. Clinically, it is a serious side effect because severe mucositis can cause generalized problems (weight loss, nasogastric tube feedings) and interferes with the well‐being of the patient seriously. Grading mucositis is important for the evaluation of preventive and therapeutic measures. The object of this study was to develop a scoring method based on local mucositis signs only. Four clinical local signs of mucositis were used in this score: white discoloration, erythema, pseudomembranes and ulceration. Mucositis of the oral cavity was calculated during conventional irradiation protocol for 8 distinguishable areas using the 4 signs and their extent. A prospective evaluation of this method in 15 irradiated head and neck cancer patients displayed an S‐curve reflecting a symptomless first irradiation week, followed by a rapid and steady increase of white discoloration, erythema and pseudomembranes during the second and third week. Oral candidiasis, generalized symptoms such as weight loss and the highest mucositis scores were seen after 3 weeks irradiation. The novel mucositis scoring method may be of value in studying the effect of hygiene programs, topical application of disinfectans or antibiotics on oral mucositis.</abstract><subject lang="en"><genre>keywords</genre><topic>cancer, head and neck</topic><topic>irradiation mucositis</topic><topic>mouth, diseases</topic><topic>scoring system</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Oral Pathology & Medicine</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0904-2512</identifier><identifier type="eISSN">1600-0714</identifier><identifier type="DOI">10.1111/(ISSN)1600-0714</identifier><identifier type="PublisherID">JOP</identifier><part><date>1989</date><detail type="volume"><caption>vol.</caption><number>18</number></detail><detail type="issue"><caption>no.</caption><number>3</number></detail><extent unit="pages"><start>167</start><end>171</end><total>5</total></extent></part></relatedItem><identifier type="istex">309C0739800CA555C04DE6D7531855168DDCA0E7</identifier><identifier type="ark">ark:/67375/WNG-FR14NXJ3-D</identifier><identifier type="DOI">10.1111/j.1600-0714.1989.tb00756.x</identifier><identifier type="ArticleID">JOP167</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/309C0739800CA555C04DE6D7531855168DDCA0E7/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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