The effects of early lead exposure on auditory function in rhesus monkeys
Identifieur interne : 008B85 ( Main/Merge ); précédent : 008B84; suivant : 008B86The effects of early lead exposure on auditory function in rhesus monkeys
Auteurs : Robert E. Lasky [États-Unis] ; Melissa L. Luck [États-Unis] ; Peter Torre Iii [États-Unis] ; Nellie Laughlin [États-Unis]Source :
- Neurotoxicology and Teratology [ 0892-0362 ] ; 2001.
Descripteurs français
- Wicri :
- topic : Plomb, Singe, Niveau sonore.
English descriptors
- KwdEn :
- Abnormal oaes, Abrs, Adult guinea pigs, Animal models, Animal studies, Ariel signal processing board, Auditory, Auditory brainstem, Auditory function, Auditory nerve, Auditory sensitivity, Auditory system, Auditory testing, Auditory-evoked potentials, Bandpass filter, Behavioral thresholds, Biological psychology, Blood samples, Body burden, Body burdens, Brainstem, Brainstem auditory, Brainstem pathways, Canal, Canal microphone, Canal volume, Canal volumes, Cerebral cortex, Click, Click stimuli, Clinical research, Cochlear, Cochlear function, Cohort, Conductive pathology, Control monkeys, Distortion, Distortion product, Distortion product otoacoustic emissions, Distortion products, Dpoae, Dpoae thresholds, Dpoaes, Ecuadoran children, Ecuadoran studies, Elsevier science, Environ, Error bars, Experimental groups, Exposure, Exposure condition, Exposure conditions, Exposure frequency interaction trace, Exposure group, Exposure groups, Exposure histories, Exposure peak, Female rhesus monkeys, First stimulus, Frequency functions, Frequency response, Harlow center, Health perspect, Hearing sensitivity, Hearing thresholds, Human populations, Human studies, Interwave intervals, Laboratory animals, Lasky, Latency, Latency prolongation, Laughlin, Lead, Lilienthal, Little difference, Little effect, Lower frequencies, Macaca, Macaca mulatta, Main colony rooms, Mauchly sphericity test, Middle latency, Middle latency responses, Monkey, Mulatta, Neurobehavioral development, Neurotoxicology, Noise level, Nonhuman primate studies, Nonhuman primates, Oaes, Other hand, Otoacoustic, Otoacoustic emissions, Outcome measures, Outer hair cells, Peak amplitudes, Peak latencies, Peak latency, Postnatal, Postnatal months, Present study, Pure tones, Responses times, Rhesus, Rhesus monkey, Rhesus monkeys, Robust, Robust distortion products, Same level click, Sample size, Sampling rates, Significant differences, Significant likelihood ratio test, Sound input, Species differences, Standard deviation, Standard deviations, Study cohort, Succimer chelation therapy, System effects, Teratology, Tympanometric, Tympanometric data, Tympanometric variables, Tympanometric width, Tympanometry, Weeks postpartum, Winneke, Wisconsin madison, Years postnatally, Young children.
- Teeft :
- Abnormal oaes, Abrs, Adult guinea pigs, Animal models, Animal studies, Ariel signal processing board, Auditory, Auditory brainstem, Auditory function, Auditory nerve, Auditory sensitivity, Auditory system, Auditory testing, Bandpass filter, Behavioral thresholds, Biological psychology, Blood samples, Body burden, Body burdens, Brainstem, Brainstem auditory, Brainstem pathways, Canal, Canal microphone, Canal volume, Canal volumes, Cerebral cortex, Click, Click stimuli, Clinical research, Cochlear, Cochlear function, Cohort, Conductive pathology, Control monkeys, Distortion, Distortion product, Distortion product otoacoustic emissions, Distortion products, Dpoae, Dpoae thresholds, Dpoaes, Ecuadoran children, Ecuadoran studies, Elsevier science, Environ, Error bars, Experimental groups, Exposure, Exposure condition, Exposure conditions, Exposure frequency interaction trace, Exposure group, Exposure groups, Exposure histories, Exposure peak, Female rhesus monkeys, First stimulus, Frequency functions, Frequency response, Harlow center, Health perspect, Hearing sensitivity, Hearing thresholds, Human populations, Human studies, Interwave intervals, Laboratory animals, Lasky, Latency, Latency prolongation, Laughlin, Lilienthal, Little difference, Little effect, Lower frequencies, Macaca, Macaca mulatta, Main colony rooms, Mauchly sphericity test, Middle latency, Middle latency responses, Monkey, Mulatta, Neurobehavioral development, Neurotoxicology, Noise level, Nonhuman primate studies, Nonhuman primates, Oaes, Other hand, Otoacoustic, Otoacoustic emissions, Outcome measures, Outer hair cells, Peak amplitudes, Peak latencies, Peak latency, Postnatal, Postnatal months, Present study, Pure tones, Responses times, Rhesus, Rhesus monkey, Rhesus monkeys, Robust, Robust distortion products, Same level click, Sample size, Sampling rates, Significant differences, Significant likelihood ratio test, Sound input, Species differences, Standard deviation, Standard deviations, Study cohort, Succimer chelation therapy, System effects, Teratology, Tympanometric, Tympanometric data, Tympanometric variables, Tympanometric width, Tympanometry, Weeks postpartum, Winneke, Wisconsin madison, Years postnatally, Young children.
Abstract
Abstract: Thirty-one female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, and birth to 2 years). Blood lead levels were maintained at 35–40 μg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. Auditory function was assessed in these monkeys at least 1 year after exposure to lead. The outcome measures included tympanometry to assess middle ear function, otoacoustic emissions (OAEs) to assess cochlear function, and auditory brainstem-evoked responses (ABRs) to assess the auditory nerve and brainstem pathways. There were no significant differences among the three experimental groups for any of the tympanometric variables measured suggesting no effect of lead exposure on middle ear function. Suprathreshold and threshold distortion product OAEs (DPOAEs) were comparable among the three groups. Finally, the auditory-evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of lead exposure. The lead exposure in this study had little effect on auditory function.
Url:
DOI: 10.1016/S0892-0362(01)00175-1
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<term>Adult guinea pigs</term>
<term>Animal models</term>
<term>Animal studies</term>
<term>Ariel signal processing board</term>
<term>Auditory</term>
<term>Auditory brainstem</term>
<term>Auditory function</term>
<term>Auditory nerve</term>
<term>Auditory sensitivity</term>
<term>Auditory system</term>
<term>Auditory testing</term>
<term>Auditory-evoked potentials</term>
<term>Bandpass filter</term>
<term>Behavioral thresholds</term>
<term>Biological psychology</term>
<term>Blood samples</term>
<term>Body burden</term>
<term>Body burdens</term>
<term>Brainstem</term>
<term>Brainstem auditory</term>
<term>Brainstem pathways</term>
<term>Canal</term>
<term>Canal microphone</term>
<term>Canal volume</term>
<term>Canal volumes</term>
<term>Cerebral cortex</term>
<term>Click</term>
<term>Click stimuli</term>
<term>Clinical research</term>
<term>Cochlear</term>
<term>Cochlear function</term>
<term>Cohort</term>
<term>Conductive pathology</term>
<term>Control monkeys</term>
<term>Distortion</term>
<term>Distortion product</term>
<term>Distortion product otoacoustic emissions</term>
<term>Distortion products</term>
<term>Dpoae</term>
<term>Dpoae thresholds</term>
<term>Dpoaes</term>
<term>Ecuadoran children</term>
<term>Ecuadoran studies</term>
<term>Elsevier science</term>
<term>Environ</term>
<term>Error bars</term>
<term>Experimental groups</term>
<term>Exposure</term>
<term>Exposure condition</term>
<term>Exposure conditions</term>
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<term>Exposure groups</term>
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<term>Exposure peak</term>
<term>Female rhesus monkeys</term>
<term>First stimulus</term>
<term>Frequency functions</term>
<term>Frequency response</term>
<term>Harlow center</term>
<term>Health perspect</term>
<term>Hearing sensitivity</term>
<term>Hearing thresholds</term>
<term>Human populations</term>
<term>Human studies</term>
<term>Interwave intervals</term>
<term>Laboratory animals</term>
<term>Lasky</term>
<term>Latency</term>
<term>Latency prolongation</term>
<term>Laughlin</term>
<term>Lead</term>
<term>Lilienthal</term>
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<term>Little effect</term>
<term>Lower frequencies</term>
<term>Macaca</term>
<term>Macaca mulatta</term>
<term>Main colony rooms</term>
<term>Mauchly sphericity test</term>
<term>Middle latency</term>
<term>Middle latency responses</term>
<term>Monkey</term>
<term>Mulatta</term>
<term>Neurobehavioral development</term>
<term>Neurotoxicology</term>
<term>Noise level</term>
<term>Nonhuman primate studies</term>
<term>Nonhuman primates</term>
<term>Oaes</term>
<term>Other hand</term>
<term>Otoacoustic</term>
<term>Otoacoustic emissions</term>
<term>Outcome measures</term>
<term>Outer hair cells</term>
<term>Peak amplitudes</term>
<term>Peak latencies</term>
<term>Peak latency</term>
<term>Postnatal</term>
<term>Postnatal months</term>
<term>Present study</term>
<term>Pure tones</term>
<term>Responses times</term>
<term>Rhesus</term>
<term>Rhesus monkey</term>
<term>Rhesus monkeys</term>
<term>Robust</term>
<term>Robust distortion products</term>
<term>Same level click</term>
<term>Sample size</term>
<term>Sampling rates</term>
<term>Significant differences</term>
<term>Significant likelihood ratio test</term>
<term>Sound input</term>
<term>Species differences</term>
<term>Standard deviation</term>
<term>Standard deviations</term>
<term>Study cohort</term>
<term>Succimer chelation therapy</term>
<term>System effects</term>
<term>Teratology</term>
<term>Tympanometric</term>
<term>Tympanometric data</term>
<term>Tympanometric variables</term>
<term>Tympanometric width</term>
<term>Tympanometry</term>
<term>Weeks postpartum</term>
<term>Winneke</term>
<term>Wisconsin madison</term>
<term>Years postnatally</term>
<term>Young children</term>
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<term>Abrs</term>
<term>Adult guinea pigs</term>
<term>Animal models</term>
<term>Animal studies</term>
<term>Ariel signal processing board</term>
<term>Auditory</term>
<term>Auditory brainstem</term>
<term>Auditory function</term>
<term>Auditory nerve</term>
<term>Auditory sensitivity</term>
<term>Auditory system</term>
<term>Auditory testing</term>
<term>Bandpass filter</term>
<term>Behavioral thresholds</term>
<term>Biological psychology</term>
<term>Blood samples</term>
<term>Body burden</term>
<term>Body burdens</term>
<term>Brainstem</term>
<term>Brainstem auditory</term>
<term>Brainstem pathways</term>
<term>Canal</term>
<term>Canal microphone</term>
<term>Canal volume</term>
<term>Canal volumes</term>
<term>Cerebral cortex</term>
<term>Click</term>
<term>Click stimuli</term>
<term>Clinical research</term>
<term>Cochlear</term>
<term>Cochlear function</term>
<term>Cohort</term>
<term>Conductive pathology</term>
<term>Control monkeys</term>
<term>Distortion</term>
<term>Distortion product</term>
<term>Distortion product otoacoustic emissions</term>
<term>Distortion products</term>
<term>Dpoae</term>
<term>Dpoae thresholds</term>
<term>Dpoaes</term>
<term>Ecuadoran children</term>
<term>Ecuadoran studies</term>
<term>Elsevier science</term>
<term>Environ</term>
<term>Error bars</term>
<term>Experimental groups</term>
<term>Exposure</term>
<term>Exposure condition</term>
<term>Exposure conditions</term>
<term>Exposure frequency interaction trace</term>
<term>Exposure group</term>
<term>Exposure groups</term>
<term>Exposure histories</term>
<term>Exposure peak</term>
<term>Female rhesus monkeys</term>
<term>First stimulus</term>
<term>Frequency functions</term>
<term>Frequency response</term>
<term>Harlow center</term>
<term>Health perspect</term>
<term>Hearing sensitivity</term>
<term>Hearing thresholds</term>
<term>Human populations</term>
<term>Human studies</term>
<term>Interwave intervals</term>
<term>Laboratory animals</term>
<term>Lasky</term>
<term>Latency</term>
<term>Latency prolongation</term>
<term>Laughlin</term>
<term>Lilienthal</term>
<term>Little difference</term>
<term>Little effect</term>
<term>Lower frequencies</term>
<term>Macaca</term>
<term>Macaca mulatta</term>
<term>Main colony rooms</term>
<term>Mauchly sphericity test</term>
<term>Middle latency</term>
<term>Middle latency responses</term>
<term>Monkey</term>
<term>Mulatta</term>
<term>Neurobehavioral development</term>
<term>Neurotoxicology</term>
<term>Noise level</term>
<term>Nonhuman primate studies</term>
<term>Nonhuman primates</term>
<term>Oaes</term>
<term>Other hand</term>
<term>Otoacoustic</term>
<term>Otoacoustic emissions</term>
<term>Outcome measures</term>
<term>Outer hair cells</term>
<term>Peak amplitudes</term>
<term>Peak latencies</term>
<term>Peak latency</term>
<term>Postnatal</term>
<term>Postnatal months</term>
<term>Present study</term>
<term>Pure tones</term>
<term>Responses times</term>
<term>Rhesus</term>
<term>Rhesus monkey</term>
<term>Rhesus monkeys</term>
<term>Robust</term>
<term>Robust distortion products</term>
<term>Same level click</term>
<term>Sample size</term>
<term>Sampling rates</term>
<term>Significant differences</term>
<term>Significant likelihood ratio test</term>
<term>Sound input</term>
<term>Species differences</term>
<term>Standard deviation</term>
<term>Standard deviations</term>
<term>Study cohort</term>
<term>Succimer chelation therapy</term>
<term>System effects</term>
<term>Teratology</term>
<term>Tympanometric</term>
<term>Tympanometric data</term>
<term>Tympanometric variables</term>
<term>Tympanometric width</term>
<term>Tympanometry</term>
<term>Weeks postpartum</term>
<term>Winneke</term>
<term>Wisconsin madison</term>
<term>Years postnatally</term>
<term>Young children</term>
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<term>Singe</term>
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<front><div type="abstract" xml:lang="en">Abstract: Thirty-one female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, and birth to 2 years). Blood lead levels were maintained at 35–40 μg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. Auditory function was assessed in these monkeys at least 1 year after exposure to lead. The outcome measures included tympanometry to assess middle ear function, otoacoustic emissions (OAEs) to assess cochlear function, and auditory brainstem-evoked responses (ABRs) to assess the auditory nerve and brainstem pathways. There were no significant differences among the three experimental groups for any of the tympanometric variables measured suggesting no effect of lead exposure on middle ear function. Suprathreshold and threshold distortion product OAEs (DPOAEs) were comparable among the three groups. Finally, the auditory-evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of lead exposure. The lead exposure in this study had little effect on auditory function.</div>
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