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The effects of early lead exposure on auditory function in rhesus monkeys

Identifieur interne : 000A48 ( Istex/Corpus ); précédent : 000A47; suivant : 000A49

The effects of early lead exposure on auditory function in rhesus monkeys

Auteurs : Robert E. Lasky ; Melissa L. Luck ; Peter Torre Iii ; Nellie Laughlin

Source :

RBID : ISTEX:14F41ECC79D3A3A527117600F11309E8E49FCBAA

English descriptors

Abstract

Abstract: Thirty-one female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, and birth to 2 years). Blood lead levels were maintained at 35–40 μg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. Auditory function was assessed in these monkeys at least 1 year after exposure to lead. The outcome measures included tympanometry to assess middle ear function, otoacoustic emissions (OAEs) to assess cochlear function, and auditory brainstem-evoked responses (ABRs) to assess the auditory nerve and brainstem pathways. There were no significant differences among the three experimental groups for any of the tympanometric variables measured suggesting no effect of lead exposure on middle ear function. Suprathreshold and threshold distortion product OAEs (DPOAEs) were comparable among the three groups. Finally, the auditory-evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of lead exposure. The lead exposure in this study had little effect on auditory function.

Url:
DOI: 10.1016/S0892-0362(01)00175-1

Links to Exploration step

ISTEX:14F41ECC79D3A3A527117600F11309E8E49FCBAA

Le document en format XML

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<div type="abstract" xml:lang="en">Abstract: Thirty-one female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, and birth to 2 years). Blood lead levels were maintained at 35–40 μg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. Auditory function was assessed in these monkeys at least 1 year after exposure to lead. The outcome measures included tympanometry to assess middle ear function, otoacoustic emissions (OAEs) to assess cochlear function, and auditory brainstem-evoked responses (ABRs) to assess the auditory nerve and brainstem pathways. There were no significant differences among the three experimental groups for any of the tympanometric variables measured suggesting no effect of lead exposure on middle ear function. Suprathreshold and threshold distortion product OAEs (DPOAEs) were comparable among the three groups. Finally, the auditory-evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of lead exposure. The lead exposure in this study had little effect on auditory function.</div>
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<note>This study was supported by NIH Grant No. RO1 ES0 6918 and a grant from the Center for Clinical Research and Evidence-Based Medicine. This study was conducted in accordance with national and institutional guidelines for the protection of animal welfare.</note>
<note type="content">Fig. 1: The 2f1−f2 Distortion Product×f2 Frequency Functions (often referred to as DPOAEgrams) for the three lead exposure groups. The error bars correspond to one standard deviation.</note>
<note type="content">Fig. 2: The percentage of monkeys in each of the three lead exposure conditions with the five most robust distortion products (as determined by a significant likelihood ratio test) measured.</note>
<note type="content">Fig. 3: The mean DPOAE thresholds recorded in monkeys from the three lead exposure conditions. The error bars correspond to one standard deviation.</note>
<note type="content">Table 1: Mean (S.D.) tympanometric measures as a function of lead exposure condition TPP=tympanometric peak pressure; Veq=equivalent ear canal volume; Ytm=compensated acoustic admittance; TW=tympanometric width.</note>
<note type="content">Table 2: Mean (S.D.) ABR peak latencies (ms) to the 30/s clicks as a function of lead exposure condition</note>
<note type="content">Table 3: Mean (S.D.) ABR peak latencies (ms) to the MLS clicks as a function of lead exposure condition</note>
<note type="content">Table 4: Mean (S.D.) middle latency evoked response peak latencies (ms) to the 10/s clicks as a function of lead exposure condition</note>
<note type="content">Table 5: Mean (S.D.) ABR peak amplitudes (μV) to the 30/s clicks as a function of lead exposure condition</note>
<note type="content">Table 6: Mean (S.D.) ABR peak amplitudes (μV) to the MLS clicks as a function of lead exposure condition</note>
<note type="content">Table 7: Mean (S.D.) middle latency evoked response peak amplitudes (μV) to the 10/s clicks as a function of lead exposure condition</note>
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<ce:simple-para>Thirty-one female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, and birth to 2 years). Blood lead levels were maintained at 35–40 μg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. Auditory function was assessed in these monkeys at least 1 year after exposure to lead. The outcome measures included tympanometry to assess middle ear function, otoacoustic emissions (OAEs) to assess cochlear function, and auditory brainstem-evoked responses (ABRs) to assess the auditory nerve and brainstem pathways. There were no significant differences among the three experimental groups for any of the tympanometric variables measured suggesting no effect of lead exposure on middle ear function. Suprathreshold and threshold distortion product OAEs (DPOAEs) were comparable among the three groups. Finally, the auditory-evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of lead exposure. The lead exposure in this study had little effect on auditory function.</ce:simple-para>
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<abstract lang="en">Abstract: Thirty-one female rhesus monkeys were randomly assigned to three lead exposure conditions (none, birth to 1 year, and birth to 2 years). Blood lead levels were maintained at 35–40 μg/dl beginning shortly after birth and continuing for 1 or 2 years postnatally. Auditory function was assessed in these monkeys at least 1 year after exposure to lead. The outcome measures included tympanometry to assess middle ear function, otoacoustic emissions (OAEs) to assess cochlear function, and auditory brainstem-evoked responses (ABRs) to assess the auditory nerve and brainstem pathways. There were no significant differences among the three experimental groups for any of the tympanometric variables measured suggesting no effect of lead exposure on middle ear function. Suprathreshold and threshold distortion product OAEs (DPOAEs) were comparable among the three groups. Finally, the auditory-evoked response at levels from the auditory nerve to the cerebral cortex did not significantly differ as a function of lead exposure. The lead exposure in this study had little effect on auditory function.</abstract>
<note>This study was supported by NIH Grant No. RO1 ES0 6918 and a grant from the Center for Clinical Research and Evidence-Based Medicine. This study was conducted in accordance with national and institutional guidelines for the protection of animal welfare.</note>
<note type="content">Fig. 1: The 2f1−f2 Distortion Product×f2 Frequency Functions (often referred to as DPOAEgrams) for the three lead exposure groups. The error bars correspond to one standard deviation.</note>
<note type="content">Fig. 2: The percentage of monkeys in each of the three lead exposure conditions with the five most robust distortion products (as determined by a significant likelihood ratio test) measured.</note>
<note type="content">Fig. 3: The mean DPOAE thresholds recorded in monkeys from the three lead exposure conditions. The error bars correspond to one standard deviation.</note>
<note type="content">Table 1: Mean (S.D.) tympanometric measures as a function of lead exposure condition TPP=tympanometric peak pressure; Veq=equivalent ear canal volume; Ytm=compensated acoustic admittance; TW=tympanometric width.</note>
<note type="content">Table 2: Mean (S.D.) ABR peak latencies (ms) to the 30/s clicks as a function of lead exposure condition</note>
<note type="content">Table 3: Mean (S.D.) ABR peak latencies (ms) to the MLS clicks as a function of lead exposure condition</note>
<note type="content">Table 4: Mean (S.D.) middle latency evoked response peak latencies (ms) to the 10/s clicks as a function of lead exposure condition</note>
<note type="content">Table 5: Mean (S.D.) ABR peak amplitudes (μV) to the 30/s clicks as a function of lead exposure condition</note>
<note type="content">Table 6: Mean (S.D.) ABR peak amplitudes (μV) to the MLS clicks as a function of lead exposure condition</note>
<note type="content">Table 7: Mean (S.D.) middle latency evoked response peak amplitudes (μV) to the 10/s clicks as a function of lead exposure condition</note>
<subject lang="en">
<genre>Keywords</genre>
<topic>Lead</topic>
<topic>Rhesus monkeys</topic>
<topic>Tympanometry</topic>
<topic>Distortion product otoacoustic emissions</topic>
<topic>Auditory-evoked potentials</topic>
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<identifier type="DOI">10.1016/S0892-0362(01)00175-1</identifier>
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<accessCondition type="use and reproduction" contentType="copyright">©2001 Elsevier Science Inc.</accessCondition>
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