Equine and porcine bone substitutes in maxillary sinus augmentation: a histological and immunohistochemical analysis of VEGF expression.
Identifieur interne : 001B15 ( Main/Merge ); précédent : 001B14; suivant : 001B16Equine and porcine bone substitutes in maxillary sinus augmentation: a histological and immunohistochemical analysis of VEGF expression.
Auteurs : Stefano Tetè [Italie] ; Vincenzo Luca Zizzari ; Raffaele Vinci ; Susi Zara ; Umberto Di Tore ; Marco Manica ; Amelia Cataldi ; Carmen Mortellaro ; Adriano Piattelli ; Enrico GherloneSource :
- The Journal of craniofacial surgery [ 1536-3732 ] ; 2014.
Descripteurs français
- KwdFr :
- Adulte d'âge moyen, Animaux, Collagène (), Collagène (usage thérapeutique), Densité osseuse (physiologie), Equus caballus, Facteur de croissance endothéliale vasculaire de type A (analyse), Femelle, Humains, Immunohistochimie, Implants dentaires, Maxillaire (), Maxillaire (anatomopathologie), Mâchoire édentée (), Mâchoire édentée (anatomopathologie), Mâle, Ostéocytes (anatomopathologie), Ostéogenèse (physiologie), Piézochirurgie (), Pose d'implant dentaire endo-osseux (), Rehaussement du plancher du sinus (), Régénération osseuse (physiologie), Résorption osseuse (étiologie), Substituts osseux (), Substituts osseux (usage thérapeutique), Suidae, Études de suivi.
- MESH :
- analyse : Facteur de croissance endothéliale vasculaire de type A.
- anatomopathologie : Maxillaire, Mâchoire édentée, Ostéocytes.
- physiologie : Densité osseuse, Ostéogenèse, Régénération osseuse.
- usage thérapeutique : Collagène, Substituts osseux.
- étiologie : Résorption osseuse.
- Adulte d'âge moyen, Animaux, Collagène, Equus caballus, Femelle, Humains, Immunohistochimie, Implants dentaires, Maxillaire, Mâchoire édentée, Mâle, Piézochirurgie, Pose d'implant dentaire endo-osseux, Rehaussement du plancher du sinus, Substituts osseux, Suidae, Études de suivi.
English descriptors
- KwdEn :
- Animals, Bone Density (physiology), Bone Regeneration (physiology), Bone Resorption (etiology), Bone Substitutes (chemistry), Bone Substitutes (therapeutic use), Collagen (chemistry), Collagen (therapeutic use), Dental Implantation, Endosseous (methods), Dental Implants, Female, Follow-Up Studies, Horses, Humans, Immunohistochemistry, Jaw, Edentulous (pathology), Jaw, Edentulous (surgery), Male, Maxilla (pathology), Maxilla (surgery), Middle Aged, Osteocytes (pathology), Osteogenesis (physiology), Piezosurgery (methods), Sinus Floor Augmentation (methods), Swine, Vascular Endothelial Growth Factor A (analysis).
- MESH :
- chemical , analysis : Vascular Endothelial Growth Factor A.
- chemical , chemistry : Bone Substitutes, Collagen.
- etiology : Bone Resorption.
- methods : Dental Implantation, Endosseous, Piezosurgery, Sinus Floor Augmentation.
- pathology : Jaw, Edentulous, Maxilla, Osteocytes.
- physiology : Bone Density, Bone Regeneration, Osteogenesis.
- surgery : Jaw, Edentulous, Maxilla.
- chemical , therapeutic use : Bone Substitutes, Collagen.
- Animals, Dental Implants, Female, Follow-Up Studies, Horses, Humans, Immunohistochemistry, Male, Middle Aged, Swine.
Abstract
The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans. Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses. Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens. These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.
DOI: 10.1097/SCS.0000000000000679
PubMed: 24820710
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Raffaele," Milan; §Pistoia (private practice); ∥Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara; and ¶Oral Surgery Unit, Regina Margherita Pediatric Hospital, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>From the *Departments of Medical, Oral and Biotechnological Sciences and †Pharmacy, University "G. d'Annunzio," Chieti-Pescara; ‡Department of Dentistry, University "Ateneo Vita-Salute S. 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Raffaele," Milan; §Pistoia (private practice); ∥Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara; and ¶Oral Surgery Unit, Regina Margherita Pediatric Hospital, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>From the *Departments of Medical, Oral and Biotechnological Sciences and †Pharmacy, University "G. d'Annunzio," Chieti-Pescara; ‡Department of Dentistry, University "Ateneo Vita-Salute S. 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xml:lang="fr"><term>Densité osseuse</term><term>Ostéogenèse</term><term>Régénération osseuse</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Density</term><term>Bone Regeneration</term><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous</term><term>Maxilla</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Substitutes</term><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Collagène</term><term>Substituts osseux</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Résorption osseuse</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dental Implants</term><term>Female</term><term>Follow-Up Studies</term><term>Horses</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Swine</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term><term>Animaux</term><term>Collagène</term><term>Equus caballus</term><term>Femelle</term><term>Humains</term><term>Immunohistochimie</term><term>Implants dentaires</term><term>Maxillaire</term><term>Mâchoire édentée</term><term>Mâle</term><term>Piézochirurgie</term><term>Pose d'implant dentaire endo-osseux</term><term>Rehaussement du plancher du sinus</term><term>Substituts osseux</term><term>Suidae</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans. Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses. Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens. These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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