Equine and porcine bone substitutes in maxillary sinus augmentation: a histological and immunohistochemical analysis of VEGF expression.
Identifieur interne : 000880 ( PubMed/Corpus ); précédent : 000879; suivant : 000881Equine and porcine bone substitutes in maxillary sinus augmentation: a histological and immunohistochemical analysis of VEGF expression.
Auteurs : Stefano Tetè ; Vincenzo Luca Zizzari ; Raffaele Vinci ; Susi Zara ; Umberto Di Tore ; Marco Manica ; Amelia Cataldi ; Carmen Mortellaro ; Adriano Piattelli ; Enrico GherloneSource :
- The Journal of craniofacial surgery [ 1536-3732 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Bone Density (physiology), Bone Regeneration (physiology), Bone Resorption (etiology), Bone Substitutes (chemistry), Bone Substitutes (therapeutic use), Collagen (chemistry), Collagen (therapeutic use), Dental Implantation, Endosseous (methods), Dental Implants, Female, Follow-Up Studies, Horses, Humans, Immunohistochemistry, Jaw, Edentulous (pathology), Jaw, Edentulous (surgery), Male, Maxilla (pathology), Maxilla (surgery), Middle Aged, Osteocytes (pathology), Osteogenesis (physiology), Piezosurgery (methods), Sinus Floor Augmentation (methods), Swine, Vascular Endothelial Growth Factor A (analysis).
- MESH :
- chemical , analysis : Vascular Endothelial Growth Factor A.
- chemical , chemistry : Bone Substitutes, Collagen.
- etiology : Bone Resorption.
- methods : Dental Implantation, Endosseous, Piezosurgery, Sinus Floor Augmentation.
- pathology : Jaw, Edentulous, Maxilla, Osteocytes.
- physiology : Bone Density, Bone Regeneration, Osteogenesis.
- surgery : Jaw, Edentulous, Maxilla.
- chemical , therapeutic use : Bone Substitutes, Collagen.
- Animals, Dental Implants, Female, Follow-Up Studies, Horses, Humans, Immunohistochemistry, Male, Middle Aged, Swine.
Abstract
The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans. Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses. Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens. These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.
DOI: 10.1097/SCS.0000000000000679
PubMed: 24820710
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pubmed:24820710Le document en format XML
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Raffaele," Milan; §Pistoia (private practice); ∥Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara; and ¶Oral Surgery Unit, Regina Margherita Pediatric Hospital, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Zizzari, Vincenzo Luca" sort="Zizzari, Vincenzo Luca" uniqKey="Zizzari V" first="Vincenzo Luca" last="Zizzari">Vincenzo Luca Zizzari</name></author><author><name sortKey="Vinci, Raffaele" sort="Vinci, Raffaele" uniqKey="Vinci R" first="Raffaele" last="Vinci">Raffaele Vinci</name></author><author><name sortKey="Zara, Susi" sort="Zara, Susi" uniqKey="Zara S" first="Susi" last="Zara">Susi Zara</name></author><author><name sortKey="Di Tore, Umberto" sort="Di Tore, Umberto" uniqKey="Di Tore U" first="Umberto" last="Di Tore">Umberto Di Tore</name></author><author><name sortKey="Manica, Marco" sort="Manica, Marco" uniqKey="Manica M" first="Marco" last="Manica">Marco Manica</name></author><author><name sortKey="Cataldi, Amelia" sort="Cataldi, Amelia" uniqKey="Cataldi A" first="Amelia" last="Cataldi">Amelia Cataldi</name></author><author><name sortKey="Mortellaro, Carmen" sort="Mortellaro, Carmen" uniqKey="Mortellaro C" first="Carmen" last="Mortellaro">Carmen Mortellaro</name></author><author><name sortKey="Piattelli, Adriano" sort="Piattelli, Adriano" uniqKey="Piattelli A" first="Adriano" last="Piattelli">Adriano Piattelli</name></author><author><name sortKey="Gherlone, Enrico" sort="Gherlone, Enrico" uniqKey="Gherlone E" first="Enrico" last="Gherlone">Enrico Gherlone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24820710</idno><idno type="pmid">24820710</idno><idno type="doi">10.1097/SCS.0000000000000679</idno><idno type="wicri:Area/PubMed/Corpus">000880</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000880</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Equine and porcine bone substitutes in maxillary sinus augmentation: a histological and immunohistochemical analysis of VEGF expression.</title><author><name sortKey="Tete, Stefano" sort="Tete, Stefano" uniqKey="Tete S" first="Stefano" last="Tetè">Stefano Tetè</name><affiliation><nlm:affiliation>From the *Departments of Medical, Oral and Biotechnological Sciences and †Pharmacy, University "G. d'Annunzio," Chieti-Pescara; ‡Department of Dentistry, University "Ateneo Vita-Salute S. Raffaele," Milan; §Pistoia (private practice); ∥Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara; and ¶Oral Surgery Unit, Regina Margherita Pediatric Hospital, Turin, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Zizzari, Vincenzo Luca" sort="Zizzari, Vincenzo Luca" uniqKey="Zizzari V" first="Vincenzo Luca" last="Zizzari">Vincenzo Luca Zizzari</name></author><author><name sortKey="Vinci, Raffaele" sort="Vinci, Raffaele" uniqKey="Vinci R" first="Raffaele" last="Vinci">Raffaele Vinci</name></author><author><name sortKey="Zara, Susi" sort="Zara, Susi" uniqKey="Zara S" first="Susi" last="Zara">Susi Zara</name></author><author><name sortKey="Di Tore, Umberto" sort="Di Tore, Umberto" uniqKey="Di Tore U" first="Umberto" last="Di Tore">Umberto Di Tore</name></author><author><name sortKey="Manica, Marco" sort="Manica, Marco" uniqKey="Manica M" first="Marco" last="Manica">Marco Manica</name></author><author><name sortKey="Cataldi, Amelia" sort="Cataldi, Amelia" uniqKey="Cataldi A" first="Amelia" last="Cataldi">Amelia Cataldi</name></author><author><name sortKey="Mortellaro, Carmen" sort="Mortellaro, Carmen" uniqKey="Mortellaro C" first="Carmen" last="Mortellaro">Carmen Mortellaro</name></author><author><name sortKey="Piattelli, Adriano" sort="Piattelli, Adriano" uniqKey="Piattelli A" first="Adriano" last="Piattelli">Adriano Piattelli</name></author><author><name sortKey="Gherlone, Enrico" sort="Gherlone, Enrico" uniqKey="Gherlone E" first="Enrico" last="Gherlone">Enrico Gherlone</name></author></analytic><series><title level="j">The Journal of craniofacial surgery</title><idno type="eISSN">1536-3732</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Bone Density (physiology)</term><term>Bone Regeneration (physiology)</term><term>Bone Resorption (etiology)</term><term>Bone Substitutes (chemistry)</term><term>Bone Substitutes (therapeutic use)</term><term>Collagen (chemistry)</term><term>Collagen (therapeutic use)</term><term>Dental Implantation, Endosseous (methods)</term><term>Dental Implants</term><term>Female</term><term>Follow-Up Studies</term><term>Horses</term><term>Humans</term><term>Immunohistochemistry</term><term>Jaw, Edentulous (pathology)</term><term>Jaw, Edentulous (surgery)</term><term>Male</term><term>Maxilla (pathology)</term><term>Maxilla (surgery)</term><term>Middle Aged</term><term>Osteocytes (pathology)</term><term>Osteogenesis (physiology)</term><term>Piezosurgery (methods)</term><term>Sinus Floor Augmentation (methods)</term><term>Swine</term><term>Vascular Endothelial Growth Factor A (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Vascular Endothelial Growth Factor A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Bone Substitutes</term><term>Collagen</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Bone Resorption</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Dental Implantation, Endosseous</term><term>Piezosurgery</term><term>Sinus Floor Augmentation</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Jaw, Edentulous</term><term>Maxilla</term><term>Osteocytes</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Bone Density</term><term>Bone Regeneration</term><term>Osteogenesis</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Jaw, Edentulous</term><term>Maxilla</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Substitutes</term><term>Collagen</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dental Implants</term><term>Female</term><term>Follow-Up Studies</term><term>Horses</term><term>Humans</term><term>Immunohistochemistry</term><term>Male</term><term>Middle Aged</term><term>Swine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans. Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses. Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens. These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24820710</PMID><DateCompleted><Year>2015</Year><Month>07</Month><Day>02</Day></DateCompleted><DateRevised><Year>2014</Year><Month>05</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1536-3732</ISSN><JournalIssue CitedMedium="Internet"><Volume>25</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>The Journal of craniofacial surgery</Title><ISOAbbreviation>J Craniofac Surg</ISOAbbreviation></Journal><ArticleTitle>Equine and porcine bone substitutes in maxillary sinus augmentation: a histological and immunohistochemical analysis of VEGF expression.</ArticleTitle><Pagination><MedlinePgn>835-9</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/SCS.0000000000000679</ELocationID><Abstract><AbstractText>The aim of this work was to investigate the morphological structure and the expression of vascular endothelial growth factor (VEGF) after maxillary sinus augmentation through equine and porcine bone substitutes in humans. Ten patients showing edentulous posterior maxilla underwent maxillary sinus augmentation through particulate equine bone substitute and 10 patients through particulate porcine bone substitute. At the moment of implants insertion, 6 months after grafting, bone specimens were withdrawn and processed for morphological and immunohistochemical analyses. Notwithstanding the almost comparable clinical performances of both bone substitutes, histological results showed a better integration when an equine bone substitute was used compared to a porcine one. In particular, evident signs of particles resorption were observed in equine bone substitute group specimens compared to porcine ones. Immunohistochemical analysis showed a statistically significant increase of VEGF expression in equine compared to porcine bone substitute group specimens. These results showed both bone substitutes to achieve comparable clinical performance, indicating their successful use for bone regenerative procedures. However, in the same experimental time, equine group specimens showed evident resorption phenomena, whereas no or little signs of resorption were evident in the porcine group specimens. However, a more rapid and intense vascularization was achieved in equine bone substitute group, as demonstrated by immunohistochemical analysis for VEGF expression. Even if differences in vascularization significantly affect the clinical performance of a heterologous bone substitute, its ability to be resorbed is also very important in influencing long-term integration and long-term predictability of implant-prosthetic rehabilitation in regenerated sites.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Tetè</LastName><ForeName>Stefano</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>From the *Departments of Medical, Oral and Biotechnological Sciences and †Pharmacy, University "G. d'Annunzio," Chieti-Pescara; ‡Department of Dentistry, University "Ateneo Vita-Salute S. Raffaele," Milan; §Pistoia (private practice); ∥Department of Medical Science, Faculty of Medicine, University of Eastern Piedmont, Novara; and ¶Oral Surgery Unit, Regina Margherita Pediatric Hospital, Turin, Italy.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zizzari</LastName><ForeName>Vincenzo Luca</ForeName><Initials>VL</Initials></Author><Author ValidYN="Y"><LastName>Vinci</LastName><ForeName>Raffaele</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Zara</LastName><ForeName>Susi</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Di Tore</LastName><ForeName>Umberto</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Manica</LastName><ForeName>Marco</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Cataldi</LastName><ForeName>Amelia</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Mortellaro</LastName><ForeName>Carmen</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Piattelli</LastName><ForeName>Adriano</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Gherlone</LastName><ForeName>Enrico</ForeName><Initials>E</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Craniofac Surg</MedlineTA><NlmUniqueID>9010410</NlmUniqueID><ISSNLinking>1049-2275</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018786">Bone Substitutes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015921">Dental 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MajorTopicYN="N">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018786" MajorTopicYN="N">Bone Substitutes</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003094" MajorTopicYN="N">Collagen</DescriptorName><QualifierName UI="Q000737" MajorTopicYN="N">chemistry</QualifierName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003758" MajorTopicYN="N">Dental Implantation, Endosseous</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015921" MajorTopicYN="N">Dental Implants</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006736" MajorTopicYN="N">Horses</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007575" MajorTopicYN="N">Jaw, Edentulous</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008437" MajorTopicYN="N">Maxilla</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010011" MajorTopicYN="N">Osteocytes</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010012" MajorTopicYN="N">Osteogenesis</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059745" MajorTopicYN="N">Piezosurgery</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D059546" MajorTopicYN="N">Sinus Floor Augmentation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013552" MajorTopicYN="N">Swine</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D042461" MajorTopicYN="N">Vascular Endothelial Growth Factor A</DescriptorName><QualifierName UI="Q000032" MajorTopicYN="Y">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>5</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>7</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24820710</ArticleId><ArticleId IdType="doi">10.1097/SCS.0000000000000679</ArticleId><ArticleId IdType="pii">00001665-201405000-00027</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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