Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis
Identifieur interne : 001320 ( Main/Merge ); précédent : 001319; suivant : 001321Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis
Auteurs : Santosh Patil [Arabie saoudite] ; Bader Kureyem Al-Zarea [Arabie saoudite] ; Sneha Maheshwari [Inde] ; Rohit Sahu [Inde]Source :
- Journal of Oral Biology and Craniofacial Research [ 2212-4268 ] ; 2015.
Abstract
Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.
42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.
The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.
Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.
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DOI: 10.1016/j.jobcr.2014.12.005
PubMed: 25853042
PubMed Central: 4382509
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Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka</wicri:regionArea><wicri:noRegion>Sakaka</wicri:noRegion></affiliation></author><author><name sortKey="Maheshwari, Sneha" sort="Maheshwari, Sneha" uniqKey="Maheshwari S" first="Sneha" last="Maheshwari">Sneha Maheshwari</name><affiliation wicri:level="1"><nlm:aff id="aff2">Dental Practitioner, Jodhpur, Rajasthan, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Dental Practitioner, Jodhpur, Rajasthan</wicri:regionArea><wicri:noRegion>Rajasthan</wicri:noRegion></affiliation></author><author><name sortKey="Sahu, Rohit" sort="Sahu, Rohit" uniqKey="Sahu R" first="Rohit" last="Sahu">Rohit Sahu</name><affiliation wicri:level="1"><nlm:aff id="aff3">Post Graduate Student, Dept of Oral Medicine and Radiology, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India</nlm:aff><country 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Sakaka</wicri:regionArea><wicri:noRegion>Sakaka</wicri:noRegion></affiliation></author><author><name sortKey="Al Zarea, Bader Kureyem" sort="Al Zarea, Bader Kureyem" uniqKey="Al Zarea B" first="Bader Kureyem" last="Al-Zarea">Bader Kureyem Al-Zarea</name><affiliation wicri:level="1"><nlm:aff id="aff1">Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka</wicri:regionArea><wicri:noRegion>Sakaka</wicri:noRegion></affiliation></author><author><name sortKey="Maheshwari, Sneha" sort="Maheshwari, Sneha" uniqKey="Maheshwari S" first="Sneha" last="Maheshwari">Sneha Maheshwari</name><affiliation wicri:level="1"><nlm:aff id="aff2">Dental Practitioner, Jodhpur, Rajasthan, India</nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Dental Practitioner, Jodhpur, 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when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.</p></sec><sec><title>Material and methods</title><p>42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.</p></sec><sec><title>Results</title><p>The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.</p></sec><sec><title>Conclusion</title><p>Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.</p></sec></div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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