Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis
Identifieur interne : 002458 ( Pmc/Corpus ); précédent : 002457; suivant : 002459Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis
Auteurs : Santosh Patil ; Bader Kureyem Al-Zarea ; Sneha Maheshwari ; Rohit SahuSource :
- Journal of Oral Biology and Craniofacial Research [ 2212-4268 ] ; 2015.
Abstract
Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.
42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.
The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.
Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.
Url:
DOI: 10.1016/j.jobcr.2014.12.005
PubMed: 25853042
PubMed Central: 4382509
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis</title><author><name sortKey="Patil, Santosh" sort="Patil, Santosh" uniqKey="Patil S" first="Santosh" last="Patil">Santosh Patil</name><affiliation><nlm:aff id="aff1">Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Al Zarea, Bader Kureyem" sort="Al Zarea, Bader Kureyem" uniqKey="Al Zarea B" first="Bader Kureyem" last="Al-Zarea">Bader Kureyem Al-Zarea</name><affiliation><nlm:aff id="aff1">Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Maheshwari, Sneha" sort="Maheshwari, Sneha" uniqKey="Maheshwari S" first="Sneha" last="Maheshwari">Sneha Maheshwari</name><affiliation><nlm:aff id="aff2">Dental Practitioner, Jodhpur, Rajasthan, India</nlm:aff></affiliation></author><author><name sortKey="Sahu, Rohit" sort="Sahu, Rohit" uniqKey="Sahu R" first="Rohit" last="Sahu">Rohit Sahu</name><affiliation><nlm:aff id="aff3">Post Graduate Student, Dept of Oral Medicine and Radiology, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25853042</idno><idno type="pmc">4382509</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382509</idno><idno type="RBID">PMC:4382509</idno><idno type="doi">10.1016/j.jobcr.2014.12.005</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">002458</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002458</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis</title><author><name sortKey="Patil, Santosh" sort="Patil, Santosh" uniqKey="Patil S" first="Santosh" last="Patil">Santosh Patil</name><affiliation><nlm:aff id="aff1">Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Al Zarea, Bader Kureyem" sort="Al Zarea, Bader Kureyem" uniqKey="Al Zarea B" first="Bader Kureyem" last="Al-Zarea">Bader Kureyem Al-Zarea</name><affiliation><nlm:aff id="aff1">Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia</nlm:aff></affiliation></author><author><name sortKey="Maheshwari, Sneha" sort="Maheshwari, Sneha" uniqKey="Maheshwari S" first="Sneha" last="Maheshwari">Sneha Maheshwari</name><affiliation><nlm:aff id="aff2">Dental Practitioner, Jodhpur, Rajasthan, India</nlm:aff></affiliation></author><author><name sortKey="Sahu, Rohit" sort="Sahu, Rohit" uniqKey="Sahu R" first="Rohit" last="Sahu">Rohit Sahu</name><affiliation><nlm:aff id="aff3">Post Graduate Student, Dept of Oral Medicine and Radiology, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Oral Biology and Craniofacial Research</title><idno type="ISSN">2212-4268</idno><idno type="eISSN">2212-4276</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Aim</title><p>Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.</p></sec><sec><title>Material and methods</title><p>42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.</p></sec><sec><title>Results</title><p>The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.</p></sec><sec><title>Conclusion</title><p>Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Oral Biol Craniofac Res</journal-id><journal-id journal-id-type="iso-abbrev">J Oral Biol Craniofac Res</journal-id><journal-title-group><journal-title>Journal of Oral Biology and Craniofacial Research</journal-title></journal-title-group><issn pub-type="ppub">2212-4268</issn><issn pub-type="epub">2212-4276</issn><publisher><publisher-name>Elsevier</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25853042</article-id><article-id pub-id-type="pmc">4382509</article-id><article-id pub-id-type="publisher-id">S2212-4268(15)00004-4</article-id><article-id pub-id-type="doi">10.1016/j.jobcr.2014.12.005</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Comparative evaluation of natural antioxidants spirulina and aloe vera for the treatment of oral submucous fibrosis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Patil</surname><given-names>Santosh</given-names></name><email>drpsantosh@gmail.com</email><xref rid="aff1" ref-type="aff">a</xref><xref rid="cor1" ref-type="corresp">∗</xref></contrib><contrib contrib-type="author"><name><surname>Al-Zarea</surname><given-names>Bader Kureyem</given-names></name><xref rid="aff1" ref-type="aff">a</xref></contrib><contrib contrib-type="author"><name><surname>Maheshwari</surname><given-names>Sneha</given-names></name><xref rid="aff2" ref-type="aff">b</xref></contrib><contrib contrib-type="author"><name><surname>Sahu</surname><given-names>Rohit</given-names></name><xref rid="aff3" ref-type="aff">c</xref></contrib></contrib-group><aff id="aff1"><label>a</label>Assistant Professor, College of Dentistry, Al Jouf University, Al Jouf, Sakaka, Saudi Arabia</aff><aff id="aff2"><label>b</label>Dental Practitioner, Jodhpur, Rajasthan, India</aff><aff id="aff3"><label>c</label>Post Graduate Student, Dept of Oral Medicine and Radiology, Chattisgarh Dental College and Research Institute, Rajnandgaon, Chattisgarh, India</aff><author-notes><corresp id="cor1"><label>∗</label><italic>Corresponding author</italic>. <email>drpsantosh@gmail.com</email></corresp></author-notes><pub-date pub-type="pmc-release"><day>22</day><month>1</month><year>2015</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on .</pmc-comment>
<pub-date pub-type="ppub"><season>Jan-Apr</season><year>2015</year></pub-date><pub-date pub-type="epub"><day>22</day><month>1</month><year>2015</year></pub-date><volume>5</volume><issue>1</issue><fpage>11</fpage><lpage>15</lpage><history><date date-type="received"><day>11</day><month>7</month><year>2014</year></date><date date-type="accepted"><day>30</day><month>12</month><year>2014</year></date></history><permissions><copyright-statement>Copyright © 2015, Craniofacial Research Foundation. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Craniofacial Research Foundation</copyright-holder></permissions><abstract><sec><title>Aim</title><p>Oral submucous fibrosis (OSMF) is a high risk premalignant condition predominantly seen in the Indian subcontinent. The aim of the present study was to compare the efficacy of spirulina and aloe vera in the management of OSMF.</p></sec><sec><title>Material and methods</title><p>42 subjects with clinico-pathologically diagnosed OSMF were included in the study and divided equally in 2 groups, Group A (spirulina group) and Group B (aloe vera group). Group A was administered 500 mg spirulina in 2 divided doses for 3 months and Group B was given 5 mg aloe vera gel to be applied topically thrice daily for 3 months. Evaluation for different clinical parameters was done at regular intervals and data was analyzed using the Chi-square test. P-value <0.05 was considered to be statistically significant.</p></sec><sec><title>Results</title><p>The patients in Group A showed significant clinical improvement in mouth opening and ulcers/erosions/vesicles (p < 0.05). However, there was no significant improvement in burning sensation (p = 0.06) and pain associated with the lesion (p = 0.04) among the 2 groups.</p></sec><sec><title>Conclusion</title><p>Both the drugs showed improvement in the condition; however spirulina can bring about significant clinical improvements in the symptoms like mouth opening and ulcers/erosion/vesicles. Thus, spirulina appears to be more promising when compared to aloe vera for the treatment of OSMF.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Oral submucous fibrosis</kwd><kwd>Spirulina</kwd><kwd>Aloe vera</kwd><kwd>Antioxidant</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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