Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis
Identifieur interne : 000430 ( Main/Exploration ); précédent : 000429; suivant : 000431Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during Candida albicans-Associated Denture Stomatitis
Auteurs : Junko Yano [États-Unis] ; Alika Yu [États-Unis] ; Paul L. Fidel [États-Unis] ; Mairi C. Noverr [États-Unis]Source :
- PLoS ONE [ 1932-6203 ] ; 2016.
Abstract
Denture stomatitis (DS) is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. The disease is caused by
Url:
DOI: 10.1371/journal.pone.0159692
PubMed: 27453977
PubMed Central: 4959791
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during <italic>Candida albicans</italic>-Associated Denture Stomatitis</title><author><name sortKey="Yano, Junko" sort="Yano, Junko" uniqKey="Yano J" first="Junko" last="Yano">Junko Yano</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Yu, Alika" sort="Yu, Alika" uniqKey="Yu A" first="Alika" last="Yu">Alika Yu</name><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Fidel, Paul L" sort="Fidel, Paul L" uniqKey="Fidel P" first="Paul L." last="Fidel">Paul L. Fidel</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Noverr, Mairi C" sort="Noverr, Mairi C" uniqKey="Noverr M" first="Mairi C." last="Noverr">Mairi C. Noverr</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27453977</idno><idno type="pmc">4959791</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4959791</idno><idno type="RBID">PMC:4959791</idno><idno type="doi">10.1371/journal.pone.0159692</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000765</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000765</idno><idno type="wicri:Area/Pmc/Curation">000765</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000765</idno><idno type="wicri:Area/Pmc/Checkpoint">000382</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000382</idno><idno type="wicri:Area/Ncbi/Merge">006916</idno><idno type="wicri:Area/Ncbi/Curation">006916</idno><idno type="wicri:Area/Ncbi/Checkpoint">006916</idno><idno type="wicri:Area/Main/Merge">000430</idno><idno type="wicri:Area/Main/Curation">000430</idno><idno type="wicri:Area/Main/Exploration">000430</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Transcription Factors Efg1 and Bcr1 Regulate Biofilm Formation and Virulence during <italic>Candida albicans</italic>-Associated Denture Stomatitis</title><author><name sortKey="Yano, Junko" sort="Yano, Junko" uniqKey="Yano J" first="Junko" last="Yano">Junko Yano</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Yu, Alika" sort="Yu, Alika" uniqKey="Yu A" first="Alika" last="Yu">Alika Yu</name><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Fidel, Paul L" sort="Fidel, Paul L" uniqKey="Fidel P" first="Paul L." last="Fidel">Paul L. Fidel</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author><author><name sortKey="Noverr, Mairi C" sort="Noverr, Mairi C" uniqKey="Noverr M" first="Mairi C." last="Noverr">Mairi C. Noverr</name><affiliation wicri:level="2"><nlm:aff id="aff001"><addr-line>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Oral and Craniofacial Biology, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation><affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Prosthodontics, Dental School, Louisiana State University Health Sciences Center, New Orleans, Louisiana</wicri:regionArea><placeName><region type="state">Louisiane</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Denture stomatitis (DS) is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. The disease is caused by <italic>Candida albicans</italic>, which readily colonizes and form biofilms on denture materials. While evidence for biofilms on abiotic and biotic surfaces initiating <italic>Candida</italic> infections is accumulating, a role for biofilms in DS remains unclear. Using an established model of DS in immunocompetent animals, the purpose of this study was to determine the role of biofilm formation in mucosal damage during pathogenesis using <italic>C</italic>. <italic>albicans</italic> or mutants defective in morphogenesis (<italic>efg1</italic><sup><italic>-/-</italic></sup>) or biofilm formation (<italic>bcr1</italic><sup><italic>-/-</italic></sup><italic>)</italic>. For <italic>in vivo</italic> analyses, rats fitted with custom dentures, consisting of fixed and removable parts, were inoculated with wild-type <italic>C</italic>. <italic>albicans</italic>, mutants or reconstituted strains and monitored weekly for fungal burden (denture and palate), body weight and tissue damage (LDH) for up to 8 weeks. <italic>C</italic>. <italic>albicans</italic> wild-type and reconstituted mutants formed biofilms on dentures and palatal tissues under <italic>in vitro</italic>, <italic>ex vivo</italic> and <italic>in vivo</italic> conditions as indicated by microscopy demonstrating robust biofilm architecture and extracellular matrix (ECM). In contrast, both <italic>efg1</italic><sup><italic>-/-</italic></sup> and <italic>bcr1</italic><sup><italic>-/-</italic></sup> mutants exhibited poor biofilm growth with little to no ECM. In addition, quantification of fungal burden showed reduced colonization throughout the infection period on dentures and palates of rats inoculated with <italic>efg1</italic><sup><italic>-/-</italic></sup>, but not <italic>bcr1</italic><sup>-/-</sup>, compared to controls. Finally, rats inoculated with <italic>efg1</italic><sup><italic>-/-</italic></sup> and <italic>bcr1</italic><sup><italic>-/-</italic></sup> mutants had minimal palatal tissue damage/weight loss while those inoculated with wild-type or reconstituted mutants showed evidence of tissue damage and exhibited stunted weight gain. These data suggest that biofilm formation is associated with tissue damage during DS and that Efg1 and Bcr1, both central regulators of virulence in <italic>C</italic>. <italic>albicans</italic>, have pivotal roles in pathogenesis of DS.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Budtz Jorgensen, E" uniqKey="Budtz Jorgensen E">E Budtz-Jorgensen</name></author><author><name sortKey="Stenderup, A" uniqKey="Stenderup A">A Stenderup</name></author><author><name sortKey="Grabowski, M" uniqKey="Grabowski M">M Grabowski</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arendorf, Tm" uniqKey="Arendorf T">TM Arendorf</name></author><author><name sortKey="Walker, Dm" uniqKey="Walker D">DM Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cumming, Cg" uniqKey="Cumming C">CG Cumming</name></author><author><name sortKey="Wight, C" uniqKey="Wight C">C Wight</name></author><author><name sortKey="Blackwell, Cl" uniqKey="Blackwell C">CL Blackwell</name></author><author><name sortKey="Wray, D" uniqKey="Wray D">D Wray</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budtz Jorgensen, E" uniqKey="Budtz Jorgensen E">E Budtz-Jorgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pires, Fr" uniqKey="Pires F">FR Pires</name></author><author><name sortKey="Santos, Eb" uniqKey="Santos E">EB Santos</name></author><author><name sortKey="Bonan, Pr" uniqKey="Bonan P">PR Bonan</name></author><author><name sortKey="De Almeida, Op" uniqKey="De Almeida O">OP De Almeida</name></author><author><name sortKey="Lopes, Ma" uniqKey="Lopes M">MA Lopes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shulman, Jd" uniqKey="Shulman J">JD Shulman</name></author><author><name sortKey="Rivera Hidalgo, F" uniqKey="Rivera Hidalgo F">F Rivera-Hidalgo</name></author><author><name sortKey="Beach, Mm" uniqKey="Beach M">MM Beach</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zissis, A" uniqKey="Zissis A">A Zissis</name></author><author><name sortKey="Yannikakis, S" uniqKey="Yannikakis S">S Yannikakis</name></author><author><name sortKey="Harrison, A" uniqKey="Harrison A">A Harrison</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pereira, Ca" uniqKey="Pereira C">CA Pereira</name></author><author><name sortKey="Toledo, Bc" uniqKey="Toledo B">BC Toledo</name></author><author><name sortKey="Santos, Ct" uniqKey="Santos C">CT Santos</name></author><author><name sortKey="Pereira Costa, Ac" uniqKey="Pereira Costa A">AC Pereira Costa</name></author><author><name sortKey="Back Brito, Gn" uniqKey="Back Brito G">GN Back-Brito</name></author><author><name sortKey="Kaminagakura, E" uniqKey="Kaminagakura E">E Kaminagakura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webb, Bc" uniqKey="Webb B">BC Webb</name></author><author><name sortKey="Thomas, Cj" uniqKey="Thomas C">CJ Thomas</name></author><author><name sortKey="Willcox, Md" uniqKey="Willcox M">MD Willcox</name></author><author><name sortKey="Harty, Dw" uniqKey="Harty D">DW Harty</name></author><author><name sortKey="Knox, Kw" uniqKey="Knox K">KW Knox</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollack, B" uniqKey="Pollack B">B Pollack</name></author><author><name sortKey="Buck, If" uniqKey="Buck I">IF Buck</name></author><author><name sortKey="Kalnins, L" uniqKey="Kalnins L">L Kalnins</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budtz Jorgensen, E" uniqKey="Budtz Jorgensen E">E Budtz-Jorgensen</name></author><author><name sortKey="Kelstrup, J" uniqKey="Kelstrup J">J Kelstrup</name></author><author><name sortKey="Poulsen, S" uniqKey="Poulsen S">S Poulsen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Budtz Jorgensen, E" uniqKey="Budtz Jorgensen E">E Budtz-Jorgensen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergendal, T" uniqKey="Bergendal T">T Bergendal</name></author><author><name sortKey="Holmberg, K" uniqKey="Holmberg K">K Holmberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bergendal, T" uniqKey="Bergendal T">T Bergendal</name></author><author><name sortKey="Holmberg, K" uniqKey="Holmberg K">K Holmberg</name></author><author><name sortKey="Nord, Ce" uniqKey="Nord C">CE Nord</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanden Abbeele, A" uniqKey="Vanden Abbeele A">A Vanden Abbeele</name></author><author><name sortKey="De Meel, H" uniqKey="De Meel H">H de Meel</name></author><author><name sortKey="Ahariz, M" uniqKey="Ahariz M">M Ahariz</name></author><author><name sortKey="Perraudin, Jp" uniqKey="Perraudin J">JP Perraudin</name></author><author><name sortKey="Beyer, I" uniqKey="Beyer I">I Beyer</name></author><author><name sortKey="Courtois, P" uniqKey="Courtois P">P Courtois</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramage, G" uniqKey="Ramage G">G Ramage</name></author><author><name sortKey="Tomsett, K" uniqKey="Tomsett K">K Tomsett</name></author><author><name sortKey="Wickes, Bl" uniqKey="Wickes B">BL Wickes</name></author><author><name sortKey="Lopez Ribot, Jl" uniqKey="Lopez Ribot J">JL Lopez-Ribot</name></author><author><name sortKey="Redding, Sw" uniqKey="Redding S">SW Redding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Redding, S" uniqKey="Redding S">S Redding</name></author><author><name sortKey="Bhatt, B" uniqKey="Bhatt B">B Bhatt</name></author><author><name sortKey="Rawls, Hr" uniqKey="Rawls H">HR Rawls</name></author><author><name sortKey="Siegel, G" uniqKey="Siegel G">G Siegel</name></author><author><name sortKey="Scott, K" uniqKey="Scott K">K Scott</name></author><author><name sortKey="Lopez Ribot, J" uniqKey="Lopez Ribot J">J Lopez-Ribot</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Radford, Dr" uniqKey="Radford D">DR Radford</name></author><author><name sortKey="Challacombe, Sj" uniqKey="Challacombe S">SJ Challacombe</name></author><author><name sortKey="Walter, Jd" uniqKey="Walter J">JD Walter</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nett, Je" uniqKey="Nett J">JE Nett</name></author><author><name sortKey="Marchillo, K" uniqKey="Marchillo K">K Marchillo</name></author><author><name sortKey="Spiegel, Ca" uniqKey="Spiegel C">CA Spiegel</name></author><author><name sortKey="Andes, Dr" uniqKey="Andes D">DR Andes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chandra, J" uniqKey="Chandra J">J Chandra</name></author><author><name sortKey="Mccormick, Ts" uniqKey="Mccormick T">TS McCormick</name></author><author><name sortKey="Imamura, Y" uniqKey="Imamura Y">Y Imamura</name></author><author><name sortKey="Mukherjee, Pk" uniqKey="Mukherjee P">PK Mukherjee</name></author><author><name sortKey="Ghannoum, Ma" uniqKey="Ghannoum M">MA Ghannoum</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dwivedi, P" uniqKey="Dwivedi P">P Dwivedi</name></author><author><name sortKey="Thompson, A" uniqKey="Thompson A">A Thompson</name></author><author><name sortKey="Xie, Z" uniqKey="Xie Z">Z Xie</name></author><author><name sortKey="Kashleva, H" uniqKey="Kashleva H">H Kashleva</name></author><author><name sortKey="Ganguly, S" uniqKey="Ganguly S">S Ganguly</name></author><author><name sortKey="Mitchell, Ap" uniqKey="Mitchell A">AP Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katragkou, A" uniqKey="Katragkou A">A Katragkou</name></author><author><name sortKey="Kruhlak, Mj" uniqKey="Kruhlak M">MJ Kruhlak</name></author><author><name sortKey="Simitsopoulou, M" uniqKey="Simitsopoulou M">M Simitsopoulou</name></author><author><name sortKey="Chatzimoschou, A" uniqKey="Chatzimoschou A">A Chatzimoschou</name></author><author><name sortKey="Taparkou, A" uniqKey="Taparkou A">A Taparkou</name></author><author><name sortKey="Cotten, Cj" uniqKey="Cotten C">CJ Cotten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Katragkou, A" uniqKey="Katragkou A">A Katragkou</name></author><author><name sortKey="Simitsopoulou, M" uniqKey="Simitsopoulou M">M Simitsopoulou</name></author><author><name sortKey="Chatzimoschou, A" uniqKey="Chatzimoschou A">A Chatzimoschou</name></author><author><name sortKey="Georgiadou, E" uniqKey="Georgiadou E">E Georgiadou</name></author><author><name sortKey="Walsh, Tj" uniqKey="Walsh T">TJ Walsh</name></author><author><name sortKey="Roilides, E" uniqKey="Roilides E">E Roilides</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name></author><author><name sortKey="Yu, A" uniqKey="Yu A">A Yu</name></author><author><name sortKey="Johnson, Cc" uniqKey="Johnson C">CC Johnson</name></author><author><name sortKey="Lilly, Ea" uniqKey="Lilly E">EA Lilly</name></author><author><name sortKey="Noverr, Mc" uniqKey="Noverr M">MC Noverr</name></author><author><name sortKey="Fidel, Pl" uniqKey="Fidel P">PL Fidel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Cc" uniqKey="Johnson C">CC Johnson</name></author><author><name sortKey="Yu, A" uniqKey="Yu A">A Yu</name></author><author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name></author><author><name sortKey="Fidel, Pl" uniqKey="Fidel P">PL Fidel</name></author><author><name sortKey="Noverr, Mc" uniqKey="Noverr M">MC Noverr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nobile, Cj" uniqKey="Nobile C">CJ Nobile</name></author><author><name sortKey="Andes, Dr" uniqKey="Andes D">DR Andes</name></author><author><name sortKey="Nett, Je" uniqKey="Nett J">JE Nett</name></author><author><name sortKey="Smith, Fj" uniqKey="Smith F">FJ Smith</name></author><author><name sortKey="Yue, F" uniqKey="Yue F">F Yue</name></author><author><name sortKey="Phan, Qt" uniqKey="Phan Q">QT Phan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nobile, Cj" uniqKey="Nobile C">CJ Nobile</name></author><author><name sortKey="Nett, Je" uniqKey="Nett J">JE Nett</name></author><author><name sortKey="Andes, Dr" uniqKey="Andes D">DR Andes</name></author><author><name sortKey="Mitchell, Ap" uniqKey="Mitchell A">AP Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramage, G" uniqKey="Ramage G">G Ramage</name></author><author><name sortKey="Vandewalle, K" uniqKey="Vandewalle K">K VandeWalle</name></author><author><name sortKey="Lopez Ribot, Jl" uniqKey="Lopez Ribot J">JL Lopez-Ribot</name></author><author><name sortKey="Wickes, Bl" uniqKey="Wickes B">BL Wickes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harriott, Mm" uniqKey="Harriott M">MM Harriott</name></author><author><name sortKey="Lilly, Ea" uniqKey="Lilly E">EA Lilly</name></author><author><name sortKey="Rodriguez, Te" uniqKey="Rodriguez T">TE Rodriguez</name></author><author><name sortKey="Fidel, Pl" uniqKey="Fidel P">PL Fidel</name></author><author><name sortKey="Noverr, Mc" uniqKey="Noverr M">MC Noverr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Norice, Ct" uniqKey="Norice C">CT Norice</name></author><author><name sortKey="Smith, Fj" uniqKey="Smith F">FJ Smith</name></author><author><name sortKey="Solis, N" uniqKey="Solis N">N Solis</name></author><author><name sortKey="Filler, Sg" uniqKey="Filler S">SG Filler</name></author><author><name sortKey="Mitchell, Ap" uniqKey="Mitchell A">AP Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, H" uniqKey="Lee H">H Lee</name></author><author><name sortKey="Yu, A" uniqKey="Yu A">A Yu</name></author><author><name sortKey="Johnson, Cc" uniqKey="Johnson C">CC Johnson</name></author><author><name sortKey="Lilly, Ea" uniqKey="Lilly E">EA Lilly</name></author><author><name sortKey="Noverr, Mc" uniqKey="Noverr M">MC Noverr</name></author><author><name sortKey="Fidel, Pl" uniqKey="Fidel P">PL Fidel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nobile, Cj" uniqKey="Nobile C">CJ Nobile</name></author><author><name sortKey="Fox, Ep" uniqKey="Fox E">EP Fox</name></author><author><name sortKey="Nett, Je" uniqKey="Nett J">JE Nett</name></author><author><name sortKey="Sorrells, Tr" uniqKey="Sorrells T">TR Sorrells</name></author><author><name sortKey="Mitrovich, Qm" uniqKey="Mitrovich Q">QM Mitrovich</name></author><author><name sortKey="Hernday, Ad" uniqKey="Hernday A">AD Hernday</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lo, Hj" uniqKey="Lo H">HJ Lo</name></author><author><name sortKey="Kohler, Jr" uniqKey="Kohler J">JR Kohler</name></author><author><name sortKey="Didomenico, B" uniqKey="Didomenico B">B DiDomenico</name></author><author><name sortKey="Loebenberg, D" uniqKey="Loebenberg D">D Loebenberg</name></author><author><name sortKey="Cacciapuoti, A" uniqKey="Cacciapuoti A">A Cacciapuoti</name></author><author><name sortKey="Fink, Gr" uniqKey="Fink G">GR Fink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, H" uniqKey="Park H">H Park</name></author><author><name sortKey="Myers, Cl" uniqKey="Myers C">CL Myers</name></author><author><name sortKey="Sheppard, Dc" uniqKey="Sheppard D">DC Sheppard</name></author><author><name sortKey="Phan, Qt" uniqKey="Phan Q">QT Phan</name></author><author><name sortKey="Sanchez, Aa" uniqKey="Sanchez A">AA Sanchez</name></author><author><name sortKey="J, Ee" uniqKey="J E">EE J</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nobile, Cj" uniqKey="Nobile C">CJ Nobile</name></author><author><name sortKey="Mitchell, Ap" uniqKey="Mitchell A">AP Mitchell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Veerdonk, Fl" uniqKey="Van De Veerdonk F">FL van de Veerdonk</name></author><author><name sortKey="Joosten, La" uniqKey="Joosten L">LA Joosten</name></author><author><name sortKey="Shaw, Pj" uniqKey="Shaw P">PJ Shaw</name></author><author><name sortKey="Smeekens, Sp" uniqKey="Smeekens S">SP Smeekens</name></author><author><name sortKey="Malireddi, Rk" uniqKey="Malireddi R">RK Malireddi</name></author><author><name sortKey="Van Der Meer, Jw" uniqKey="Van Der Meer 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uniqKey="Naglik J">JR Naglik</name></author><author><name sortKey="Moyes, D" uniqKey="Moyes D">D Moyes</name></author><author><name sortKey="Makwana, J" uniqKey="Makwana J">J Makwana</name></author><author><name sortKey="Kanzaria, P" uniqKey="Kanzaria P">P Kanzaria</name></author><author><name sortKey="Tsichlaki, E" uniqKey="Tsichlaki E">E Tsichlaki</name></author><author><name sortKey="Weindl, G" uniqKey="Weindl G">G Weindl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Peters, Bm" uniqKey="Peters B">BM Peters</name></author><author><name sortKey="Palmer, Ge" uniqKey="Palmer G">GE Palmer</name></author><author><name sortKey="Nash, Ak" uniqKey="Nash A">AK Nash</name></author><author><name sortKey="Lilly, Ea" uniqKey="Lilly E">EA Lilly</name></author><author><name sortKey="Fidel, Pl" uniqKey="Fidel P">PL Fidel</name></author><author><name sortKey="Noverr, Mc" uniqKey="Noverr M">MC Noverr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pierce, Jv" uniqKey="Pierce J">JV Pierce</name></author><author><name sortKey="Kumamoto, Ca" uniqKey="Kumamoto C">CA Kumamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bissell, Re" uniqKey="Bissell R">RE Bissell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cawson, Ra" uniqKey="Cawson R">RA Cawson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, X" uniqKey="Song X">X Song</name></author><author><name sortKey="Sun, J" uniqKey="Sun J">J Sun</name></author><author><name sortKey="Store, G" uniqKey="Store G">G Store</name></author><author><name sortKey="Hansen, Bf" uniqKey="Hansen B">BF Hansen</name></author><author><name sortKey="Olsen, I" uniqKey="Olsen I">I Olsen</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Louisiane</li></region></list><tree><country name="États-Unis"><region name="Louisiane"><name sortKey="Yano, Junko" sort="Yano, Junko" uniqKey="Yano J" first="Junko" last="Yano">Junko Yano</name></region><name sortKey="Fidel, Paul L" sort="Fidel, Paul L" uniqKey="Fidel P" first="Paul L." last="Fidel">Paul L. Fidel</name><name sortKey="Noverr, Mairi C" sort="Noverr, Mairi C" uniqKey="Noverr M" first="Mairi C." last="Noverr">Mairi C. Noverr</name><name sortKey="Noverr, Mairi C" sort="Noverr, Mairi C" uniqKey="Noverr M" first="Mairi C." last="Noverr">Mairi C. Noverr</name><name sortKey="Yu, Alika" sort="Yu, Alika" uniqKey="Yu A" first="Alika" last="Yu">Alika Yu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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