Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update
Identifieur interne : 000E67 ( Main/Exploration ); précédent : 000E66; suivant : 000E68Osteoradionecrosis of the Jaws: Clinico-Therapeutic Management: A Literature Review and Update
Auteurs : Koteswara Rao Nadella [Inde] ; Rama Mohan Kodali [Inde] ; Leela Krishna Guttikonda [Inde] ; Ashok Jonnalagadda [Inde]Source :
- Journal of Maxillofacial & Oral Surgery [ 0972-8279 ] ; 2015.
Abstract
Osteoradionecrosis is one of the most serious oral complications of head and neck cancer treatment. It is a severe delayed radiation-induced injury, characterized by bone tissue necrosis and failure to heal for at least 3 months. In most cases osteoradionecrosis gradually progresses, becoming more extensive and painful that leads to infection and pathological fracture. The present paper provides a literature review and update on the risk factors underlying osteoradionecrosis, its clinical and diagnostic particulars, prevention and most widely accepted treatment options including the latest treatment modalities. Lastly, a new early management protocol is proposed based on the current clinical criteria relating to osteonecrosis secondary to treatment with bisphosphonates, together with the adoption of new therapies supported by increased levels of evidence.
Url:
DOI: 10.1007/s12663-015-0762-9
PubMed: 26604460
PubMed Central: 4648774
Affiliations:
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The present paper provides a literature review and update on the risk factors underlying osteoradionecrosis, its clinical and diagnostic particulars, prevention and most widely accepted treatment options including the latest treatment modalities. Lastly, a new early management protocol is proposed based on the current clinical criteria relating to osteonecrosis secondary to treatment with bisphosphonates, together with the adoption of new therapies supported by increased levels of evidence.
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