Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men
Identifieur interne : 002615 ( Main/Exploration ); précédent : 002614; suivant : 002616Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men
Auteurs : Erik D. Swenson [États-Unis] ; Karen E. Hansen ; Andrea N. Jones ; Zhanhai Li ; Brooke Baltz [États-Unis] ; Arthur A. Schuna ; Mary E. ElliottSource :
- Calcified tissue international [ 0171-967X ] ; 2013.
Abstract
Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.
Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).
Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)
In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.
Url:
DOI: 10.1007/s00223-013-9715-9
PubMed: 23494407
PubMed Central: 4560467
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002691
- to stream Pmc, to step Curation: 002691
- to stream Pmc, to step Checkpoint: 001B10
- to stream Ncbi, to step Merge: 004547
- to stream Ncbi, to step Curation: 004547
- to stream Ncbi, to step Checkpoint: 004547
- to stream Main, to step Merge: 002626
- to stream Main, to step Curation: 002615
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men</title>
<author><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Mercy Arthritis and Osteoporosis Center, Urbandale, IA 50322</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Mercy Arthritis and Osteoporosis Center, Urbandale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Karen E" sort="Hansen, Karen E" uniqKey="Hansen K" first="Karen E." last="Hansen">Karen E. Hansen</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
<affiliation><nlm:aff id="A3">University of Wisconsin Department of Biostatistics and Medical Informatics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baltz, Brooke" sort="Baltz, Brooke" uniqKey="Baltz B" first="Brooke" last="Baltz">Brooke Baltz</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Northwestern Memorial Hospital, Chicago, IL 60611</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern Memorial Hospital, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schuna, Arthur A" sort="Schuna, Arthur A" uniqKey="Schuna A" first="Arthur A." last="Schuna">Arthur A. Schuna</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elliott, Mary E" sort="Elliott, Mary E" uniqKey="Elliott M" first="Mary E." last="Elliott">Mary E. Elliott</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">University of Wisconsin School of Pharmacy</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23494407</idno>
<idno type="pmc">4560467</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4560467</idno>
<idno type="RBID">PMC:4560467</idno>
<idno type="doi">10.1007/s00223-013-9715-9</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">002691</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002691</idno>
<idno type="wicri:Area/Pmc/Curation">002691</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002691</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001B10</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001B10</idno>
<idno type="wicri:Area/Ncbi/Merge">004547</idno>
<idno type="wicri:Area/Ncbi/Curation">004547</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">004547</idno>
<idno type="wicri:doubleKey">0171-967X:2013:Swenson E:characteristics:associated:with</idno>
<idno type="wicri:Area/Main/Merge">002626</idno>
<idno type="wicri:Area/Main/Curation">002615</idno>
<idno type="wicri:Area/Main/Exploration">002615</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men</title>
<author><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Mercy Arthritis and Osteoporosis Center, Urbandale, IA 50322</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Iowa</region>
</placeName>
<wicri:cityArea>Mercy Arthritis and Osteoporosis Center, Urbandale</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Hansen, Karen E" sort="Hansen, Karen E" uniqKey="Hansen K" first="Karen E." last="Hansen">Karen E. Hansen</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
<affiliation><nlm:aff id="A2">University of Wisconsin School of Medicine and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
<affiliation><nlm:aff id="A3">University of Wisconsin Department of Biostatistics and Medical Informatics</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baltz, Brooke" sort="Baltz, Brooke" uniqKey="Baltz B" first="Brooke" last="Baltz">Brooke Baltz</name>
<affiliation wicri:level="2"><nlm:aff id="A4">Northwestern Memorial Hospital, Chicago, IL 60611</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
<wicri:cityArea>Northwestern Memorial Hospital, Chicago</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Schuna, Arthur A" sort="Schuna, Arthur A" uniqKey="Schuna A" first="Arthur A." last="Schuna">Arthur A. Schuna</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Elliott, Mary E" sort="Elliott, Mary E" uniqKey="Elliott M" first="Mary E." last="Elliott">Mary E. Elliott</name>
<affiliation><nlm:aff id="A5">William S. Middleton Veterans Affairs Medical Center</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="A6">University of Wisconsin School of Pharmacy</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Calcified tissue international</title>
<idno type="ISSN">0171-967X</idno>
<idno type="eISSN">1432-0827</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Iowa</li>
</region>
</list>
<tree><noCountry><name sortKey="Elliott, Mary E" sort="Elliott, Mary E" uniqKey="Elliott M" first="Mary E." last="Elliott">Mary E. Elliott</name>
<name sortKey="Hansen, Karen E" sort="Hansen, Karen E" uniqKey="Hansen K" first="Karen E." last="Hansen">Karen E. Hansen</name>
<name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
<name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
<name sortKey="Schuna, Arthur A" sort="Schuna, Arthur A" uniqKey="Schuna A" first="Arthur A." last="Schuna">Arthur A. Schuna</name>
</noCountry>
<country name="États-Unis"><region name="Iowa"><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
</region>
<name sortKey="Baltz, Brooke" sort="Baltz, Brooke" uniqKey="Baltz B" first="Brooke" last="Baltz">Brooke Baltz</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002615 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002615 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Santé |area= EdenteV2 |flux= Main |étape= Exploration |type= RBID |clé= PMC:4560467 |texte= Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23494407" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a EdenteV2
![]() | This area was generated with Dilib version V0.6.32. | ![]() |