Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men
Identifieur interne : 004547 ( Ncbi/Merge ); précédent : 004546; suivant : 004548Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men
Auteurs : Erik D. Swenson [États-Unis] ; Karen E. Hansen ; Andrea N. Jones ; Zhanhai Li ; Brooke Baltz [États-Unis] ; Arthur A. Schuna ; Mary E. ElliottSource :
- Calcified tissue international [ 0171-967X ] ; 2013.
Abstract
Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.
Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).
Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)
In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.
Url:
DOI: 10.1007/s00223-013-9715-9
PubMed: 23494407
PubMed Central: 4560467
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<author><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
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<author><name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
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<author><name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">7905481</journal-id>
<journal-id journal-id-type="pubmed-jr-id">2713</journal-id>
<journal-id journal-id-type="nlm-ta">Calcif Tissue Int</journal-id>
<journal-id journal-id-type="iso-abbrev">Calcif. Tissue Int.</journal-id>
<journal-title-group><journal-title>Calcified tissue international</journal-title>
</journal-title-group>
<issn pub-type="ppub">0171-967X</issn>
<issn pub-type="epub">1432-0827</issn>
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<article-meta><article-id pub-id-type="pmid">23494407</article-id>
<article-id pub-id-type="pmc">4560467</article-id>
<article-id pub-id-type="doi">10.1007/s00223-013-9715-9</article-id>
<article-id pub-id-type="manuscript">NIHMS716746</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Characteristics Associated with Bone Mineral Density Responses to Alendronate in Men</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Swenson</surname>
<given-names>Erik D.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hansen</surname>
<given-names>Karen E.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Jones</surname>
<given-names>Andrea N.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Li</surname>
<given-names>Zhanhai</given-names>
</name>
<xref ref-type="aff" rid="A3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baltz</surname>
<given-names>Brooke</given-names>
</name>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Schuna</surname>
<given-names>Arthur A.</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Elliott</surname>
<given-names>Mary E.</given-names>
</name>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Mercy Arthritis and Osteoporosis Center, Urbandale, IA 50322</aff>
<aff id="A2"><label>2</label>
University of Wisconsin School of Medicine and Public Health</aff>
<aff id="A3"><label>3</label>
University of Wisconsin Department of Biostatistics and Medical Informatics</aff>
<aff id="A4"><label>4</label>
Northwestern Memorial Hospital, Chicago, IL 60611</aff>
<aff id="A5"><label>5</label>
William S. Middleton Veterans Affairs Medical Center</aff>
<aff id="A6"><label>6</label>
University of Wisconsin School of Pharmacy</aff>
<author-notes><corresp id="FN1">Corresponding Author: Mary E. Elliott, Pharm.D., Ph.D., Associate Professor, University of Wisconsin School of Pharmacy, 777 Highland Avenue, Madison, WI 53705, <email>meelliott@pharmacy.wisc.edu</email>
, Telephone: 608-265-9765, FAX: 608-265-5421</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>31</day>
<month>8</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>15</day>
<month>3</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="ppub"><month>6</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>04</day>
<month>9</month>
<year>2015</year>
</pub-date>
<volume>92</volume>
<issue>6</issue>
<fpage>548</fpage>
<lpage>556</lpage>
<pmc-comment>elocation-id from pubmed: 10.1007/s00223-013-9715-9</pmc-comment>
<abstract><sec id="S1"><title>Background</title>
<p id="P1">Some patients experience reduced bone mineral density (BMD) despite bisphosphonate therapy. We performed a retrospective chart review study to detect factors associated with decreased BMD in men prescribed alendronate.</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Two investigators reviewed eligible medical records and used a standardized form to record potential characteristics predicting men’s response to alendronate. We analyzed patient characteristics associated with annualized change in hip and spine BMD (D-BMD).</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Among 115 eligible men, 19 (17%) experienced significantly decreased BMD at the hip or spine, defined as a change exceeding precision error. Eleven men (10%) fractured during therapy. Spine D-BMD was positively associated with adherence to alendronate (R = 0.23, p=0.02) and inversely associated with baseline body weight (R = −0.21, p=0.03). Hip D-BMD was positively associated with annualized weight change (R = 0.19, p=0.0498) and negatively associated with patient age and number of concomitant medications (R = −0.21, p=0.03; R = −0.20, p = 0.03, respectively). In stepwise linear models, spine D-BMD was positively associated with alendronate adherence and multivitamin use, and negatively with baseline body weight. Hip D-BMD was negatively associated with age. Fracture during treatment was associated with fracture prior to therapy (p=0.03)</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">In this small study of men prescribed alendronate, BMD response showed a positive association with adherence to therapy, weight gain, and use of a multivitamin. By contrast, older age, higher baseline body weight, and higher number of medications were each associated with a decrease in BMD. Larger studies are needed to confirm and extend these findings.</p>
</sec>
</abstract>
<kwd-group><kwd>adherence</kwd>
<kwd>efficacy</kwd>
<kwd>men</kwd>
<kwd>osteoporosis</kwd>
<kwd>treatment</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Illinois</li>
<li>Iowa</li>
</region>
</list>
<tree><noCountry><name sortKey="Elliott, Mary E" sort="Elliott, Mary E" uniqKey="Elliott M" first="Mary E." last="Elliott">Mary E. Elliott</name>
<name sortKey="Hansen, Karen E" sort="Hansen, Karen E" uniqKey="Hansen K" first="Karen E." last="Hansen">Karen E. Hansen</name>
<name sortKey="Jones, Andrea N" sort="Jones, Andrea N" uniqKey="Jones A" first="Andrea N." last="Jones">Andrea N. Jones</name>
<name sortKey="Li, Zhanhai" sort="Li, Zhanhai" uniqKey="Li Z" first="Zhanhai" last="Li">Zhanhai Li</name>
<name sortKey="Schuna, Arthur A" sort="Schuna, Arthur A" uniqKey="Schuna A" first="Arthur A." last="Schuna">Arthur A. Schuna</name>
</noCountry>
<country name="États-Unis"><region name="Iowa"><name sortKey="Swenson, Erik D" sort="Swenson, Erik D" uniqKey="Swenson E" first="Erik D." last="Swenson">Erik D. Swenson</name>
</region>
<name sortKey="Baltz, Brooke" sort="Baltz, Brooke" uniqKey="Baltz B" first="Brooke" last="Baltz">Brooke Baltz</name>
</country>
</tree>
</affiliations>
</record>
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