Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles
Identifieur interne : 001C51 ( Main/Exploration ); précédent : 001C50; suivant : 001C52Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles
Auteurs : Kyung-Wook KimSource :
- Maxillofacial Plastic and Reconstructive Surgery [ 2288-8101 ] ; 2014.
Abstract
This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice.
Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix grafting and evaluated histologically by H&E and Masson trichrome staining. The specimens were also evaluated histomorphometrically.
The demineralized dentin matrix induced bone and cartilage formation independently in soft tissues. Histological examination showed bone-forming cells such as osteoblasts and fibroblasts at two, four, and eight weeks.
These results suggest that demineralized human dentin matrix has osteoinductive ability, and is a good alternative to autogenous bone graft materials.
Url:
DOI: 10.14402/jkamprs.2014.36.2.50
PubMed: 27489810
PubMed Central: 4281903
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles</title>
<author><name sortKey="Kim, Kyung Wook" sort="Kim, Kyung Wook" uniqKey="Kim K" first="Kyung-Wook" last="Kim">Kyung-Wook Kim</name>
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<series><title level="j">Maxillofacial Plastic and Reconstructive Surgery</title>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose:</title>
<p>This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice.</p>
</sec>
<sec><title>Methods:</title>
<p>Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix grafting and evaluated histologically by H&E and Masson trichrome staining. The specimens were also evaluated histomorphometrically.</p>
</sec>
<sec><title>Results:</title>
<p>The demineralized dentin matrix induced bone and cartilage formation independently in soft tissues. Histological examination showed bone-forming cells such as osteoblasts and fibroblasts at two, four, and eight weeks.</p>
</sec>
<sec><title>Conclusion:</title>
<p>These results suggest that demineralized human dentin matrix has osteoinductive ability, and is a good alternative to autogenous bone graft materials.</p>
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