Titanium alloys (AoN) and their involvement in osseointegration
Identifieur interne : 002F19 ( Main/Exploration ); précédent : 002F18; suivant : 002F20Titanium alloys (AoN) and their involvement in osseointegration
Auteurs : Matteo Danza [Italie] ; Ilaria Zollino [Italie] ; Valentina Candotto [Italie] ; Francesca Cura [Italie] ; Francesco Carinci [Italie]Source :
- Dental Research Journal [ 1735-3327 ] ; 2012.
Abstract
Osseointegration is essential for a long-term successful and inflammation-free dental implant. Such a result depends on osteoblastic cells growth and differentiation at the tissue-implant interface. The aim of this study was to compare two different AoN titanium layers (GR4 and GR5) to investigate which one had a greater osteoconductive power using human osteoblasts (HOb) culture at two different time-points.
The expression levels of some bone-related (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analyzed using real time reverse transcription-polymerase chain reaction (real time RT-PCR).
Real-time RT-PCR data showed that after 3 days of treatment with TiA4GR, the genes up-regulated were COL3A1, ALPL, SPP1, and RUNX2. Moreover, no difference in gene expression was noticed 4 days later. On the other hand, the genes that overexpressed after 3 days of treatment with AoN5GR were ALPL, SPP1, and RUNX2. In both cases, the expression of COL1A1 and SPARC was negatively regulated.
Our data showed that both titanium surfaces led to osteoblasts recruitment, maturation, and differentiation, thus promoting osseointegration at the tissue-implant interface.
Url:
DOI: 10.4103/1735-3327.109756
PubMed: 23814585
PubMed Central: 3692175
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002B77
- to stream Pmc, to step Curation: 002B77
- to stream Pmc, to step Checkpoint: 001C24
- to stream Ncbi, to step Merge: 004787
- to stream Ncbi, to step Curation: 004787
- to stream Ncbi, to step Checkpoint: 004787
- to stream Main, to step Merge: 002F34
- to stream Main, to step Curation: 002F19
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Titanium alloys (AoN) and their involvement in osseointegration</title><author><name sortKey="Danza, Matteo" sort="Danza, Matteo" uniqKey="Danza M" first="Matteo" last="Danza">Matteo Danza</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Zollino, Ilaria" sort="Zollino, Ilaria" uniqKey="Zollino I" first="Ilaria" last="Zollino">Ilaria Zollino</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Candotto, Valentina" sort="Candotto, Valentina" uniqKey="Candotto V" first="Valentina" last="Candotto">Valentina Candotto</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23814585</idno><idno type="pmc">3692175</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692175</idno><idno type="RBID">PMC:3692175</idno><idno type="doi">10.4103/1735-3327.109756</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">002B77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002B77</idno><idno type="wicri:Area/Pmc/Curation">002B77</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002B77</idno><idno type="wicri:Area/Pmc/Checkpoint">001C24</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">001C24</idno><idno type="wicri:Area/Ncbi/Merge">004787</idno><idno type="wicri:Area/Ncbi/Curation">004787</idno><idno type="wicri:Area/Ncbi/Checkpoint">004787</idno><idno type="wicri:doubleKey">1735-3327:2012:Danza M:titanium:alloys:aon</idno><idno type="wicri:Area/Main/Merge">002F34</idno><idno type="wicri:Area/Main/Curation">002F19</idno><idno type="wicri:Area/Main/Exploration">002F19</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Titanium alloys (AoN) and their involvement in osseointegration</title><author><name sortKey="Danza, Matteo" sort="Danza, Matteo" uniqKey="Danza M" first="Matteo" last="Danza">Matteo Danza</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Zollino, Ilaria" sort="Zollino, Ilaria" uniqKey="Zollino I" first="Ilaria" last="Zollino">Ilaria Zollino</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Candotto, Valentina" sort="Candotto, Valentina" uniqKey="Candotto V" first="Valentina" last="Candotto">Valentina Candotto</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research Journal</title><idno type="ISSN">1735-3327</idno><idno type="eISSN">2008-0255</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Background:</title><p>Osseointegration is essential for a long-term successful and inflammation-free dental implant. Such a result depends on osteoblastic cells growth and differentiation at the tissue-implant interface. The aim of this study was to compare two different AoN titanium layers (GR4 and GR5) to investigate which one had a greater osteoconductive power using human osteoblasts (HOb) culture at two different time-points.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>The expression levels of some bone-related (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analyzed using real time reverse transcription-polymerase chain reaction (real time RT-PCR).</p></sec><sec id="st3"><title>Results:</title><p>Real-time RT-PCR data showed that after 3 days of treatment with TiA4GR, the genes up-regulated were COL3A1, ALPL, SPP1, and RUNX2. Moreover, no difference in gene expression was noticed 4 days later. On the other hand, the genes that overexpressed after 3 days of treatment with AoN5GR were ALPL, SPP1, and RUNX2. In both cases, the expression of COL1A1 and SPARC was negatively regulated.</p></sec><sec id="st4"><title>Conclusion:</title><p>Our data showed that both titanium surfaces led to osteoblasts recruitment, maturation, and differentiation, thus promoting osseointegration at the tissue-implant interface.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tsukimura, N" uniqKey="Tsukimura N">N Tsukimura</name></author><author><name sortKey="Kojima, N" uniqKey="Kojima N">N Kojima</name></author><author><name sortKey="Kubo, K" uniqKey="Kubo K">K Kubo</name></author><author><name sortKey="Att, W" uniqKey="Att W">W Att</name></author><author><name sortKey="Takeuchi, K" uniqKey="Takeuchi K">K Takeuchi</name></author><author><name sortKey="Kameyama, Y" uniqKey="Kameyama Y">Y Kameyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Sinjari, B" uniqKey="Sinjari B">B Sinjari</name></author><author><name sortKey="Di Iorio, D" uniqKey="Di Iorio D">D Di Iorio</name></author><author><name sortKey="Murmura, G" uniqKey="Murmura G">G Murmura</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dea, L" uniqKey="Dea L">L Dea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Hassanipour, A" uniqKey="Hassanipour A">A Hassanipour</name></author><author><name sortKey="Saggese, V" uniqKey="Saggese V">V Saggese</name></author><author><name sortKey="Palmieri, A" uniqKey="Palmieri A">A Palmieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Hassanipour, A" uniqKey="Hassanipour A">A Hassanipour</name></author><author><name sortKey="Saggese, V" uniqKey="Saggese V">V Saggese</name></author><author><name sortKey="Palmieri, A" uniqKey="Palmieri A">A Palmieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khang, D" uniqKey="Khang D">D Khang</name></author><author><name sortKey="Carpenter, J" uniqKey="Carpenter J">J Carpenter</name></author><author><name sortKey="Chun, Yw" uniqKey="Chun Y">YW Chun</name></author><author><name sortKey="Pareta, R" uniqKey="Pareta R">R Pareta</name></author><author><name sortKey="Webster, Tj" uniqKey="Webster T">TJ Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunelli, G" uniqKey="Brunelli G">G Brunelli</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Candotto, V" uniqKey="Candotto V">V Candotto</name></author><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunelli, G" uniqKey="Brunelli G">G Brunelli</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Candotto, V" uniqKey="Candotto V">V Candotto</name></author><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jb" uniqKey="Park J">JB Park</name></author><author><name sortKey="Lakes, Rs" uniqKey="Lakes R">RS Lakes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rolf, S" uniqKey="Rolf S">S Rolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fathi, H" uniqKey="Fathi H">H Fathi</name></author><author><name sortKey="Mortazavi, V" uniqKey="Mortazavi V">V Mortazavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanali, S" uniqKey="Fanali S">S Fanali</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Brugnati, C" uniqKey="Brugnati C">C Brugnati</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucchese, A" uniqKey="Lucchese A">A Lucchese</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Saggese, V" uniqKey="Saggese V">V Saggese</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanali, S" uniqKey="Fanali S">S Fanali</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Brugnati, C" uniqKey="Brugnati C">C Brugnati</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Murmura, G" uniqKey="Murmura G">G Murmura</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zernik, J" uniqKey="Zernik J">J Zernik</name></author><author><name sortKey="Twarog, K" uniqKey="Twarog K">K Twarog</name></author><author><name sortKey="Upholt, Wb" uniqKey="Upholt W">WB Upholt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harada, H" uniqKey="Harada H">H Harada</name></author><author><name sortKey="Tagashira, S" uniqKey="Tagashira S">S Tagashira</name></author><author><name sortKey="Fujiwara, M" uniqKey="Fujiwara M">M Fujiwara</name></author><author><name sortKey="Ogawa, S" uniqKey="Ogawa S">S Ogawa</name></author><author><name sortKey="Katsumata, T" uniqKey="Katsumata T">T Katsumata</name></author><author><name sortKey="Yamaguchi, A" uniqKey="Yamaguchi A">A Yamaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Gf" uniqKey="Weber G">GF Weber</name></author><author><name sortKey="Ashkar, S" uniqKey="Ashkar S">S Ashkar</name></author><author><name sortKey="Glimcher, Mj" uniqKey="Glimcher M">MJ Glimcher</name></author><author><name sortKey="Cantor, H" uniqKey="Cantor H">H Cantor</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Danza, Matteo" sort="Danza, Matteo" uniqKey="Danza M" first="Matteo" last="Danza">Matteo Danza</name></noRegion><name sortKey="Candotto, Valentina" sort="Candotto, Valentina" uniqKey="Candotto V" first="Valentina" last="Candotto">Valentina Candotto</name><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><name sortKey="Zollino, Ilaria" sort="Zollino, Ilaria" uniqKey="Zollino I" first="Ilaria" last="Zollino">Ilaria Zollino</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/EdenteV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002F19 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002F19 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= EdenteV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3692175
|texte= Titanium alloys (AoN) and their involvement in osseointegration
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23814585" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a EdenteV2
| This area was generated with Dilib version V0.6.32. |  |