Titanium alloys (AoN) and their involvement in osseointegration
Identifieur interne : 001C24 ( Pmc/Checkpoint ); précédent : 001C23; suivant : 001C25Titanium alloys (AoN) and their involvement in osseointegration
Auteurs : Matteo Danza [Italie] ; Ilaria Zollino [Italie] ; Valentina Candotto [Italie] ; Francesca Cura [Italie] ; Francesco Carinci [Italie]Source :
- Dental Research Journal [ 1735-3327 ] ; 2012.
Abstract
Osseointegration is essential for a long-term successful and inflammation-free dental implant. Such a result depends on osteoblastic cells growth and differentiation at the tissue-implant interface. The aim of this study was to compare two different AoN titanium layers (GR4 and GR5) to investigate which one had a greater osteoconductive power using human osteoblasts (HOb) culture at two different time-points.
The expression levels of some bone-related (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analyzed using real time reverse transcription-polymerase chain reaction (real time RT-PCR).
Real-time RT-PCR data showed that after 3 days of treatment with TiA4GR, the genes up-regulated were COL3A1, ALPL, SPP1, and RUNX2. Moreover, no difference in gene expression was noticed 4 days later. On the other hand, the genes that overexpressed after 3 days of treatment with AoN5GR were ALPL, SPP1, and RUNX2. In both cases, the expression of COL1A1 and SPARC was negatively regulated.
Our data showed that both titanium surfaces led to osteoblasts recruitment, maturation, and differentiation, thus promoting osseointegration at the tissue-implant interface.
Url:
DOI: 10.4103/1735-3327.109756
PubMed: 23814585
PubMed Central: 3692175
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xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Candotto, Valentina" sort="Candotto, Valentina" uniqKey="Candotto V" first="Valentina" last="Candotto">Valentina Candotto</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, 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osseointegration</title><author><name sortKey="Danza, Matteo" sort="Danza, Matteo" uniqKey="Danza M" first="Matteo" last="Danza">Matteo Danza</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti</wicri:regionArea><wicri:noRegion>Chieti</wicri:noRegion></affiliation></author><author><name sortKey="Zollino, Ilaria" sort="Zollino, Ilaria" uniqKey="Zollino I" first="Ilaria" last="Zollino">Ilaria Zollino</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Candotto, Valentina" sort="Candotto, Valentina" uniqKey="Candotto V" first="Valentina" last="Candotto">Valentina Candotto</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author><author><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara</wicri:regionArea><wicri:noRegion>Ferrara</wicri:noRegion></affiliation></author></analytic><series><title level="j">Dental Research 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Such a result depends on osteoblastic cells growth and differentiation at the tissue-implant interface. The aim of this study was to compare two different AoN titanium layers (GR4 and GR5) to investigate which one had a greater osteoconductive power using human osteoblasts (HOb) culture at two different time-points.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>The expression levels of some bone-related (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analyzed using real time reverse transcription-polymerase chain reaction (real time RT-PCR).</p></sec><sec id="st3"><title>Results:</title><p>Real-time RT-PCR data showed that after 3 days of treatment with TiA4GR, the genes up-regulated were COL3A1, ALPL, SPP1, and RUNX2. Moreover, no difference in gene expression was noticed 4 days later. On the other hand, the genes that overexpressed after 3 days of treatment with AoN5GR were ALPL, SPP1, and RUNX2. In both cases, the expression of COL1A1 and SPARC was negatively regulated.</p></sec><sec id="st4"><title>Conclusion:</title><p>Our data showed that both titanium surfaces led to osteoblasts recruitment, maturation, and differentiation, thus promoting osseointegration at the tissue-implant interface.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Tsukimura, N" uniqKey="Tsukimura N">N Tsukimura</name></author><author><name sortKey="Kojima, N" uniqKey="Kojima N">N Kojima</name></author><author><name sortKey="Kubo, K" uniqKey="Kubo K">K Kubo</name></author><author><name sortKey="Att, W" uniqKey="Att W">W Att</name></author><author><name sortKey="Takeuchi, K" uniqKey="Takeuchi K">K Takeuchi</name></author><author><name sortKey="Kameyama, Y" uniqKey="Kameyama Y">Y Kameyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Sinjari, B" uniqKey="Sinjari B">B Sinjari</name></author><author><name sortKey="Di Iorio, D" uniqKey="Di Iorio D">D Di Iorio</name></author><author><name sortKey="Murmura, G" uniqKey="Murmura G">G Murmura</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dea, L" uniqKey="Dea L">L Dea</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Hassanipour, A" uniqKey="Hassanipour A">A Hassanipour</name></author><author><name sortKey="Saggese, V" uniqKey="Saggese V">V Saggese</name></author><author><name sortKey="Palmieri, A" uniqKey="Palmieri A">A Palmieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Hassanipour, A" uniqKey="Hassanipour A">A Hassanipour</name></author><author><name sortKey="Saggese, V" uniqKey="Saggese V">V Saggese</name></author><author><name sortKey="Palmieri, A" uniqKey="Palmieri A">A Palmieri</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Khang, D" uniqKey="Khang D">D Khang</name></author><author><name sortKey="Carpenter, J" uniqKey="Carpenter J">J Carpenter</name></author><author><name sortKey="Chun, Yw" uniqKey="Chun Y">YW Chun</name></author><author><name sortKey="Pareta, R" uniqKey="Pareta R">R Pareta</name></author><author><name sortKey="Webster, Tj" uniqKey="Webster T">TJ Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunelli, G" uniqKey="Brunelli G">G Brunelli</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Candotto, V" uniqKey="Candotto V">V Candotto</name></author><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brunelli, G" uniqKey="Brunelli G">G Brunelli</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Candotto, V" uniqKey="Candotto V">V Candotto</name></author><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Park, Jb" uniqKey="Park J">JB Park</name></author><author><name sortKey="Lakes, Rs" uniqKey="Lakes R">RS Lakes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rolf, S" uniqKey="Rolf S">S Rolf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fathi, H" uniqKey="Fathi H">H Fathi</name></author><author><name sortKey="Mortazavi, V" uniqKey="Mortazavi V">V Mortazavi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanali, S" uniqKey="Fanali S">S Fanali</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Brugnati, C" uniqKey="Brugnati C">C Brugnati</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lucchese, A" uniqKey="Lucchese A">A Lucchese</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Saggese, V" uniqKey="Saggese V">V Saggese</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fanali, S" uniqKey="Fanali S">S Fanali</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Zollino, I" uniqKey="Zollino I">I Zollino</name></author><author><name sortKey="Brugnati, C" uniqKey="Brugnati C">C Brugnati</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Scarano, A" uniqKey="Scarano A">A Scarano</name></author><author><name sortKey="Murmura, G" uniqKey="Murmura G">G Murmura</name></author><author><name sortKey="Carinci, F" uniqKey="Carinci F">F Carinci</name></author><author><name sortKey="Lauritano, D" uniqKey="Lauritano D">D Lauritano</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zernik, J" uniqKey="Zernik J">J Zernik</name></author><author><name sortKey="Twarog, K" uniqKey="Twarog K">K Twarog</name></author><author><name sortKey="Upholt, Wb" uniqKey="Upholt W">WB Upholt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harada, H" uniqKey="Harada H">H Harada</name></author><author><name sortKey="Tagashira, S" uniqKey="Tagashira S">S Tagashira</name></author><author><name sortKey="Fujiwara, M" uniqKey="Fujiwara M">M Fujiwara</name></author><author><name sortKey="Ogawa, S" uniqKey="Ogawa S">S Ogawa</name></author><author><name sortKey="Katsumata, T" uniqKey="Katsumata T">T Katsumata</name></author><author><name sortKey="Yamaguchi, A" uniqKey="Yamaguchi A">A Yamaguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Weber, Gf" uniqKey="Weber G">GF Weber</name></author><author><name sortKey="Ashkar, S" uniqKey="Ashkar S">S Ashkar</name></author><author><name sortKey="Glimcher, Mj" uniqKey="Glimcher M">MJ Glimcher</name></author><author><name sortKey="Cantor, H" uniqKey="Cantor H">H Cantor</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="iso-abbrev">Dent Res J (Isfahan)</journal-id><journal-id journal-id-type="publisher-id">DRJ</journal-id><journal-title-group><journal-title>Dental Research Journal</journal-title></journal-title-group><issn pub-type="ppub">1735-3327</issn><issn pub-type="epub">2008-0255</issn><publisher><publisher-name>Medknow Publications & Media Pvt Ltd</publisher-name><publisher-loc>India</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23814585</article-id><article-id pub-id-type="pmc">3692175</article-id><article-id pub-id-type="publisher-id">DRJ-9-207</article-id><article-id pub-id-type="doi">10.4103/1735-3327.109756</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Titanium alloys (AoN) and their involvement in osseointegration</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Danza</surname><given-names>Matteo</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Zollino</surname><given-names>Ilaria</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Candotto</surname><given-names>Valentina</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Cura</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Carinci</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="aff2">2</xref><xref ref-type="corresp" rid="cor1"></xref></contrib></contrib-group><aff id="aff1"><label>1</label>Department of Oral Science, Nano and Biotechnologies, University of Chieti, Chieti, Italy</aff><aff id="aff2"><label>2</label>Department of Medical-Surgical Sciences of Communication and Behavior, Section of Maxillofacial and Plastic Surgery, University of Ferrara, Ferrara, Italy</aff><aff id="aff3"><label>3</label>Department of Histology, Embryology and Applied Biology, University of Bologna, Bologna, Italy</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Prof. Francesco Carinci, Department of D.M.C.C.C., Section of Maxillofacial and Plastic Surgery, University of Ferrara, Corso Giovecca 203,44100 Ferrara, Italy. <bold>E-mail:</bold><email xlink:href="crc@unife.it">crc@unife.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>12</month><year>2012</year></pub-date><volume>9</volume><issue>Suppl 2</issue><fpage>S207</fpage><lpage>S210</lpage><history><date date-type="received"><month>8</month><year>2012</year></date><date date-type="accepted"><month>10</month><year>2012</year></date></history><permissions><copyright-statement>Copyright: © Dental Research Journal</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec id="st1"><title>Background:</title><p>Osseointegration is essential for a long-term successful and inflammation-free dental implant. Such a result depends on osteoblastic cells growth and differentiation at the tissue-implant interface. The aim of this study was to compare two different AoN titanium layers (GR4 and GR5) to investigate which one had a greater osteoconductive power using human osteoblasts (HOb) culture at two different time-points.</p></sec><sec id="st2"><title>Materials and Methods:</title><p>The expression levels of some bone-related (ALPL, COL1A1, COL3A1, SPP1, RUNX2, and SPARC) were analyzed using real time reverse transcription-polymerase chain reaction (real time RT-PCR).</p></sec><sec id="st3"><title>Results:</title><p>Real-time RT-PCR data showed that after 3 days of treatment with TiA4GR, the genes up-regulated were COL3A1, ALPL, SPP1, and RUNX2. Moreover, no difference in gene expression was noticed 4 days later. On the other hand, the genes that overexpressed after 3 days of treatment with AoN5GR were ALPL, SPP1, and RUNX2. In both cases, the expression of COL1A1 and SPARC was negatively regulated.</p></sec><sec id="st4"><title>Conclusion:</title><p>Our data showed that both titanium surfaces led to osteoblasts recruitment, maturation, and differentiation, thus promoting osseointegration at the tissue-implant interface.</p></sec></abstract><kwd-group><kwd>Gene expression</kwd><kwd>osteoinduction</kwd><kwd>titanium alloys</kwd></kwd-group></article-meta></front></pmc><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Danza, Matteo" sort="Danza, Matteo" uniqKey="Danza M" first="Matteo" last="Danza">Matteo Danza</name></noRegion><name sortKey="Candotto, Valentina" sort="Candotto, Valentina" uniqKey="Candotto V" first="Valentina" last="Candotto">Valentina Candotto</name><name sortKey="Carinci, Francesco" sort="Carinci, Francesco" uniqKey="Carinci F" first="Francesco" last="Carinci">Francesco Carinci</name><name sortKey="Cura, Francesca" sort="Cura, Francesca" uniqKey="Cura F" first="Francesca" last="Cura">Francesca Cura</name><name sortKey="Zollino, Ilaria" sort="Zollino, Ilaria" uniqKey="Zollino I" first="Ilaria" last="Zollino">Ilaria Zollino</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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