Nicorandil can induce severe oral ulceration
Identifieur interne : 008939 ( Main/Exploration ); précédent : 008938; suivant : 008940Nicorandil can induce severe oral ulceration
Auteurs : Crispian Scully ; Antonio Mano Azul ; Alexander Crighton ; David Felix ; Anne Field ; Stephen R. PorterSource :
- Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology [ 1079-2104 ] ; 2001.
Descripteurs français
- Wicri :
- topic : Maladie cardio-vasculaire.
English descriptors
- KwdEn :
- Adverse effects, Angina, Angina pectoris, Aphthous, Aphthous ulcers, Buccal, Buccal mucosa, Buccal mucosa tongue, Buccal tongue, Cardiovascular disease, Cutaneous, Diameter ulcer, European countries, Full blood count, Genital, Genital lesions, Glyceryl trinitrate spray, Incisional biopsy, Inhibitor, Ischemic heart disease, Isosorbide mononitrate, Labial, Lesion, Medical history, Mouth ulcers, Nicorandil, Nicorandil therapy, Nonspecific features, Normal limits, Ocular, Oral biol, Oral medicine, Oral pathol, Oral surg, Oral surgery, Oral ulceration, Pathology february, Pathology volume, Previous history, Scully, Severe mouth ulceration, Soft palate, Ulcer, Ulceration.
- Teeft :
- Adverse effects, Angina, Angina pectoris, Aphthous, Aphthous ulcers, Buccal, Buccal mucosa, Buccal mucosa tongue, Buccal tongue, Cardiovascular disease, Cutaneous, Diameter ulcer, European countries, Full blood count, Genital, Genital lesions, Glyceryl trinitrate spray, Incisional biopsy, Inhibitor, Ischemic heart disease, Isosorbide mononitrate, Labial, Lesion, Medical history, Mouth ulcers, Nicorandil, Nicorandil therapy, Nonspecific features, Normal limits, Ocular, Oral biol, Oral medicine, Oral pathol, Oral surg, Oral surgery, Oral ulceration, Pathology february, Pathology volume, Previous history, Scully, Severe mouth ulceration, Soft palate, Ulcer, Ulceration.
Abstract
Abstract: Objective: To increase physicians’ and dentists’ awareness that nicorandil is a potential inducer of severe mouth ulceration. Study Design: Nine new cases of ulceration from 3 European countries were included in this study. Results: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. Conclusions: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:189-93)
Url:
DOI: 10.1067/moe.2001.110306
Affiliations:
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Le document en format XML
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<term>Angina</term>
<term>Angina pectoris</term>
<term>Aphthous</term>
<term>Aphthous ulcers</term>
<term>Buccal</term>
<term>Buccal mucosa</term>
<term>Buccal mucosa tongue</term>
<term>Buccal tongue</term>
<term>Cardiovascular disease</term>
<term>Cutaneous</term>
<term>Diameter ulcer</term>
<term>European countries</term>
<term>Full blood count</term>
<term>Genital</term>
<term>Genital lesions</term>
<term>Glyceryl trinitrate spray</term>
<term>Incisional biopsy</term>
<term>Inhibitor</term>
<term>Ischemic heart disease</term>
<term>Isosorbide mononitrate</term>
<term>Labial</term>
<term>Lesion</term>
<term>Medical history</term>
<term>Mouth ulcers</term>
<term>Nicorandil</term>
<term>Nicorandil therapy</term>
<term>Nonspecific features</term>
<term>Normal limits</term>
<term>Ocular</term>
<term>Oral biol</term>
<term>Oral medicine</term>
<term>Oral pathol</term>
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<term>Oral surgery</term>
<term>Oral ulceration</term>
<term>Pathology february</term>
<term>Pathology volume</term>
<term>Previous history</term>
<term>Scully</term>
<term>Severe mouth ulceration</term>
<term>Soft palate</term>
<term>Ulcer</term>
<term>Ulceration</term>
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<term>Buccal mucosa</term>
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<term>Buccal tongue</term>
<term>Cardiovascular disease</term>
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<term>European countries</term>
<term>Full blood count</term>
<term>Genital</term>
<term>Genital lesions</term>
<term>Glyceryl trinitrate spray</term>
<term>Incisional biopsy</term>
<term>Inhibitor</term>
<term>Ischemic heart disease</term>
<term>Isosorbide mononitrate</term>
<term>Labial</term>
<term>Lesion</term>
<term>Medical history</term>
<term>Mouth ulcers</term>
<term>Nicorandil</term>
<term>Nicorandil therapy</term>
<term>Nonspecific features</term>
<term>Normal limits</term>
<term>Ocular</term>
<term>Oral biol</term>
<term>Oral medicine</term>
<term>Oral pathol</term>
<term>Oral surg</term>
<term>Oral surgery</term>
<term>Oral ulceration</term>
<term>Pathology february</term>
<term>Pathology volume</term>
<term>Previous history</term>
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<term>Severe mouth ulceration</term>
<term>Soft palate</term>
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<front><div type="abstract" xml:lang="en">Abstract: Objective: To increase physicians’ and dentists’ awareness that nicorandil is a potential inducer of severe mouth ulceration. Study Design: Nine new cases of ulceration from 3 European countries were included in this study. Results: Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. Conclusions: A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:189-93)</div>
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<name sortKey="Field, Anne" sort="Field, Anne" uniqKey="Field A" first="Anne" last="Field">Anne Field</name>
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