Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital
Identifieur interne : 004C23 ( Main/Exploration ); précédent : 004C22; suivant : 004C24Osteonecrosis of jaws related to intravenous bisphosphonates: the experience of a Jordanian teaching hospital
Auteurs : Zaid H. Baqain ; Faleh A. Sawair ; Zaid Tamimi ; Nazzal Bsoul ; Ghazi Al Edwan ; Jamal K. Almasad ; Abdalla A. AbbadiSource :
- Annals of The Royal College of Surgeons of England [ 0035-8843 ] ; 2010.
Abstract
We describe our experience with oncology patients on a frequent dosing schedule of intravenous (i.v.) bisphosphonates at the Jordan University Hospital (JUH).
Patients treated by i.v. bisphosphonates in the medical oncology unit at the JUH were examined for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Diagnosis was made according to the guidelines of the American Association of Oral and Maxillofacial Surgeons (AAOMS) original position paper.
Of the 41 patients, four developed BRONJ, two in maxilla, one in mandible and one bimaxillary. Patients with BRONJ were older; mean age was 69.3 ±3.1 years compared to 62.8 ± 12.5 years (
The results of this case series demonstrated that age and poor oral health status are significant risk factors of BRONJ for oncology patients on long-term frequent dosing schedule of i.v. bisphosphonates.
Url:
DOI: 10.1308/003588410X12699663903395
PubMed: 20522306
PubMed Central: 3182791
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><sec><title>INTRODUCTION</title>
<p>We describe our experience with oncology patients on a frequent dosing schedule of intravenous (i.v.) bisphosphonates at the Jordan University Hospital (JUH).</p>
</sec>
<sec><title>PATIENTS AND METHODS</title>
<p>Patients treated by i.v. bisphosphonates in the medical oncology unit at the JUH were examined for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Diagnosis was made according to the guidelines of the American Association of Oral and Maxillofacial Surgeons (AAOMS) original position paper.</p>
</sec>
<sec><title>RESULTS</title>
<p>Of the 41 patients, four developed BRONJ, two in maxilla, one in mandible and one bimaxillary. Patients with BRONJ were older; mean age was 69.3 ±3.1 years compared to 62.8 ± 12.5 years (<italic>P</italic>
= 0.022). Dental co-morbidities were more commonly present in patients with the disease (P = 0.038). Patients who developed BRONJ were on treatment for a longer duration of time; the mean duration of treatment was 23.5 ± 8.4 months compared to 11.9 ± 13.4 months (<italic>P</italic>
= 0.10).</p>
</sec>
<sec><title>CONCLUSIONS</title>
<p>The results of this case series demonstrated that age and poor oral health status are significant risk factors of BRONJ for oncology patients on long-term frequent dosing schedule of i.v. bisphosphonates.</p>
</sec>
</div>
</front>
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<affiliations><list></list>
<tree><noCountry><name sortKey="Abbadi, Abdalla A" sort="Abbadi, Abdalla A" uniqKey="Abbadi A" first="Abdalla A" last="Abbadi">Abdalla A. Abbadi</name>
<name sortKey="Al Edwan, Ghazi" sort="Al Edwan, Ghazi" uniqKey="Al Edwan G" first="Ghazi" last="Al Edwan">Ghazi Al Edwan</name>
<name sortKey="Almasad, Jamal K" sort="Almasad, Jamal K" uniqKey="Almasad J" first="Jamal K" last="Almasad">Jamal K. Almasad</name>
<name sortKey="Baqain, Zaid H" sort="Baqain, Zaid H" uniqKey="Baqain Z" first="Zaid H" last="Baqain">Zaid H. Baqain</name>
<name sortKey="Bsoul, Nazzal" sort="Bsoul, Nazzal" uniqKey="Bsoul N" first="Nazzal" last="Bsoul">Nazzal Bsoul</name>
<name sortKey="Sawair, Faleh A" sort="Sawair, Faleh A" uniqKey="Sawair F" first="Faleh A" last="Sawair">Faleh A. Sawair</name>
<name sortKey="Tamimi, Zaid" sort="Tamimi, Zaid" uniqKey="Tamimi Z" first="Zaid" last="Tamimi">Zaid Tamimi</name>
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